Fast dissolving tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. In the present study, an attempt was made to design and evaluate fast dissolving tablets of Amlodipine besylate, which is used commonly for the treatment of angina pectoris. The tablets were prepared by direct compression method followed by sublimation method using super disintegrants sodium starch glycolate, crosspovidone and croscarmellose sodium. The prepared powder blends were evaluated for preformulation parameters. The tablets were evaluated for thickness, hardness, weight variation, drug content uniformity, friability and in vitro drug release studies. In vitro drug release studies were performed by using USP type II apparatus paddle method at 50 rpm in 900 ml of 0.1N HCl as dissolution medium for 30 minutes at 37±0.5°C. The formulation F9 containing Croscarmellose sodium 7 showed better disintegration and dissolution up to 30 minutes. Hence, formulation F9 was considered as optimized formulation which showed the best drug release profile up to 30 minutes. The results of mathematical model fitting of data obtained indicated that, the best fit model in all the cases the release was found to be by diffusion and fickian release. The results of FTIR analysis showed that there was no physical and chemical interaction between drug and other excipients. The study indicates that the fast dissolving tablets of Amlodipine besylate can effectively reduce the adverse effects and frequency of administration of the drug. Aparna. P | Dr. Subash Chandran M. P | Remya S B "Formulation and Evaluation of Amlodipine Fast Dissolving Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29563.pdfPaper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/29563/formulation-and-evaluation-of-amlodipine-fast-dissolving-tablets/aparna-p
Superdisintegrants in Orally Administered Products of Pharmaceuticals A Reviewijtsrd
Superdisintegrants are developed to improve the palatability in orally administered products and to advancing the development of various formulations with increase performance and acceptability. Superdisintegrants are used to revise the potency of solid dosage form .This is accomplish by decreasing the disintegration time which in turn improvement the drug dissolution rate. Diverse categories of Superdisintegrants such as synthetic, semi synthetic, natural and cross processed blend etc. The present study comprises the various kinds of Superdisintegrants which are being used in formulations to provide the safer effective drug delivery with patient’s compliance. Snehal N. Dhoot | Sharda P. Shahane | Kiran. P. Gaikwad | Leena P. Joge | Jaya P. Ambhore "Superdisintegrants in Orally Administered Products of Pharmaceuticals: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4 , June 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50282.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50282/superdisintegrants-in-orally-administered-products-of-pharmaceuticals-a-review/snehal-n-dhoot
Evaluation methods for drug excipients and container interactionSagar Savale
Excipients are one of the three components that in combination produce the medicine that the patient will take.
In therapeutic terms, the API is of primary importance because without it there is no treatment and no product.
In term of drug manufacturing all three of them are equally important so we cannot neglect anyone of them.
The interactions between excipients and the other two components (the API and the manufacturing process), and/or between two or more excipients, are fundamental to the transformation of an API into a medicinal product.
$ CONTENTS $
#Introduction
#Objective of granulation
#Essential properties of granules
#Mechanism of bond formation
#Mechanism of granule formation
#Method of granulation
#Modern equipments in granulation technology
Superdisintegrants in Orally Administered Products of Pharmaceuticals A Reviewijtsrd
Superdisintegrants are developed to improve the palatability in orally administered products and to advancing the development of various formulations with increase performance and acceptability. Superdisintegrants are used to revise the potency of solid dosage form .This is accomplish by decreasing the disintegration time which in turn improvement the drug dissolution rate. Diverse categories of Superdisintegrants such as synthetic, semi synthetic, natural and cross processed blend etc. The present study comprises the various kinds of Superdisintegrants which are being used in formulations to provide the safer effective drug delivery with patient’s compliance. Snehal N. Dhoot | Sharda P. Shahane | Kiran. P. Gaikwad | Leena P. Joge | Jaya P. Ambhore "Superdisintegrants in Orally Administered Products of Pharmaceuticals: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4 , June 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50282.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50282/superdisintegrants-in-orally-administered-products-of-pharmaceuticals-a-review/snehal-n-dhoot
Evaluation methods for drug excipients and container interactionSagar Savale
Excipients are one of the three components that in combination produce the medicine that the patient will take.
In therapeutic terms, the API is of primary importance because without it there is no treatment and no product.
In term of drug manufacturing all three of them are equally important so we cannot neglect anyone of them.
The interactions between excipients and the other two components (the API and the manufacturing process), and/or between two or more excipients, are fundamental to the transformation of an API into a medicinal product.
$ CONTENTS $
#Introduction
#Objective of granulation
#Essential properties of granules
#Mechanism of bond formation
#Mechanism of granule formation
#Method of granulation
#Modern equipments in granulation technology
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
Pharmaceutical aerosols have been playing a crucial role in the health and wellbeing of millions of people throughout the world for many years. These products include pressurized metered dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, sublingual’s, skin sprays (coolants, anaesthetics, etc.) and dental sprays. The technology’s continual advancement, the ease of use, and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years.
Many of the tests required for the evaluation of MDIs are similar to those used for other dosage forms. These include description, identification, and assay of the active ingredient; microbial limits; moisture content; net weight, degradation products and impurities (if any); extractable; and any other tests deemed appropriate for the active ingredient.
Milling is mechanical process of reducing the particle size of
solids.
Various terms has been used cursing,
disintegration, dispersion, grinding, and pulverization
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
Pharmaceutical aerosols have been playing a crucial role in the health and wellbeing of millions of people throughout the world for many years. These products include pressurized metered dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, sublingual’s, skin sprays (coolants, anaesthetics, etc.) and dental sprays. The technology’s continual advancement, the ease of use, and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years.
Many of the tests required for the evaluation of MDIs are similar to those used for other dosage forms. These include description, identification, and assay of the active ingredient; microbial limits; moisture content; net weight, degradation products and impurities (if any); extractable; and any other tests deemed appropriate for the active ingredient.
Milling is mechanical process of reducing the particle size of
solids.
Various terms has been used cursing,
disintegration, dispersion, grinding, and pulverization
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Formulation Development and Evaluation of Mouth Dissolving Film of Ziprasidon...ijtsrd
The primary objective of this work was to develop a mouth dissolving film with Ziprasidone HCI, along with bioenhancer quercetin and basic ingredients like polymers, plasticizers, sweetener, saliva stimulating agent and flavor. The films were prepared by solvent casting I method. Quercetin enhances dissolution of drug which results in increase in CDR upto 99 . HPMC E5 cps, which was not able to impart thickness to the film, HPMC E15 shown good flexibility. The plasticizer propylene glycol which was not able to impart flexibility and folding endurance to the film. PEG 400 produced good folding endurance, tensile strength and percent elongation. The optimized formulation F3 was shown good mouth feel, folding endurance, instant drug release as well as good mechanical properties. The F3, shown less disintegration time of 31 seconds and 95 drug released within 3 minutes. Therefore it was concluded that rapid drug release was achieved for immediate onset of action using quercetin as natural bioenhancer which is beneficial and gives maximum drug release when compared to conventional dosage form. Jaydeep Jadhav "Formulation Development and Evaluation of Mouth Dissolving Film of Ziprasidone Using Natural Bioenhancer" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50464.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50464/formulation-development-and-evaluation-of-mouth-dissolving-film-of-ziprasidone-using-natural-bioenhancer/jaydeep-jadhav
Preparation and Evaluation of Immediate Release Tabletsijtsrd
Background Tablet is that the preferred among all dosage forms existing today thanks to its convenience of self administration, compactness and simple manufacturing however in many cases immediate onset of action is required than conventional therapy. There are novel kinds of dosage form.The scenario of pharmaceutical drug delivery are expeditiously challenging, but conventional pharmaceutical dosage forms are still dominating. Immediate release dosage forms are those wherein =85 of labeled amount dissolves within 30 min. Superd is integrants are accustomed improve the efficacy of solid dosage forms. orms that act very quickly after administration To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. There are novel forms of dosage forms that act very quickly after administration. the fundamental approach utilized in development tablets is that the use of superdisintegrants like Cross linked carboxymelhylcellulose Croscarmeliose , Sodium starch glycolate Primogel, Explotab , Polyvinylpyrrolidone Polyplasdone etc. which give instantaneous disintegration of tablet after administration. Immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. Dosage form can be suspensions with typical dispersion agents like hydroxypropylmethylcellulose, dioctylsulfosuccinate etc. a replacement dosage form allows a manufacturer to increasemarket exclusivity, while offering its patient population a more convenient dosage form or dosing regimen.These superdisintegrants provide instantaneous disintegration of the tablet after administration within the stomach. This article provide an exhaustive account illustrating the significances of superdisintegrant within the immediate release of tablets and therefore the mechanism of disintegration together with various conventional techniques and novel granulation technology wont to prepare immediate release tablets. ach. Thus, decreasing the disintegration time which successively enhances drug dissolution rate. Results From this review, we can ready to develop and evaluate immediate release tablets.also we must always understand role of immediate release tablets.Conclusion Most of the patients need quick therapeutic action of the drug, leading to poor compliance with conventional drug therapy which results in reduced overall therapy effectiveness. For this we will conclude that immediate release tablets are simpler. because immediate release tablet shows quick effect. Sakshi Ghuge | Prof. Smita More "Preparation and Evaluation of Immediate Release Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, URL: https://www.ijtsrd.com/papers/ijtsrd35867.pdf Paper URL : https://www.ijtsrd.com/pharmacy/pharmaceutics/35867/preparation-and-evaluation-of-immediate-release-tablets/sakshi-ghuge
ABSTRACT
The aim of the present research work was to enhance the solubility of
Carvedilol by solid dispersion method and to formulate a mouth
dissolving tablet. Drugs are more frequently taken by oral
administration. The solubility of Carvedilol enhanced with different
ratios of PVP by the solvent evaporation method .In-vitro release
profile of solid dispersion obtained in SGF without enzymes and Ph
6.8 phosphate buffer indicate that 100% drug release found within 20
min. These solid dispersion were directly compressed into tablets using
Crospovidone, sodium starch glycol ate, croscarmellose sodium and
polyacrylic potassium in different concentrations as a super
disintegrants. The prepared tablets containing the solid dispersion of
Carvedilol having sufficient strength of 2.5-4 kg/cm2. The
disintegrated in the oral cavity with in 21 sec. contain Crospovidone
(5%) as super disintegrant.
KEYWORDS: Carvedilol, PVP, Super Disintegrants, Mouth Dissolving Tablet.
The oral route is the most favorable route for administration of drugs because of accurate dosage, low cost of therapy, self medication, non-invasive method, and ease of administration leading to a high level of patient compliance. Of the oral Dosage forms, solid dosage form is the preferred class of product as tablet represents a unit dosage form in which one dose of drug is placed accurately.
Formulation development and invitro evaluation of lamotrigine fast dissolving...SriramNagarajan19
The present study was to formulate and evaluate oral fast dissolving Oral tablet containing Lamotrigine. Present study reveals that all the nine formulated tablet showed satisfactory tablet parameters. It can be concluded that, Oral fast dissolving tablet -containing Lamotrigine can be prepared by direct compression method. 10% CCS (FV) tablet exhibited required disintegration time and dissolution time. The drug release was about 98.7 % in 15min. The accelerated stability studies of the optimized F5 formulation indicates that the formulated oral fast dissolving tablet were unaffected after 3 months storage under accelerated conditions as there were no signs of visually distinguishable changes in appearance, disintegration time and cumulative percentage of drug release. From the present investigation it can be concluded that oral fast dissolving tablet formulation can be a potential novel drug dosage form for pediatric, geriatric and also for general population.
Formulation and Evaluation of Floating Tablet of Metoprolol Succinateijtsrd
The aim of the present work is Formulation and Evaluation of Floating Tablet of Metoprolol Succinate. Metoprolol Succinate is a BCS class I drug used in the treatment of Angina pectoric, Heart attack, Hypertension and has short half life 3 7hours. In the present study it was planned to prepare sustained release floating tablets of Metoprolol succinate by using HPMC E5 and Gum Karaya excipients. The procured sample of drug was authenticated by pre formulation study like melting point, IR spectra, UV analysis were done. Results of pre formulation studies show that Metoprolol Succinate was pure and complies with standard. Prior to compression, the powder blend were evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausners ratio. Results of pre formulation studies show that Metoprolol Succinate was pure and complies with standard. Formulations were evaluated for various evaluation parameters like hardness, thickness, weight variation, friability, drug content, floating lag time, floating time, swelling index and in vitro drug release. From the results of evaluation parameters it was observed that formulation F6 shows best results for floating lag time 4min floating time up to 12 hours and consistent drug release 96.15 as compared to other formulations. So formulation F6 was finalized as a optimized formulation for further study. On the basic of above finding it was concluded that sustained release floating drug delivery system was successfully achieved. Neeta. V. Jadhav | Prof. Mr. Prashant Khade | Dr. Ashok Bhosale "Formulation and Evaluation of Floating Tablet of Metoprolol Succinate" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50409.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50409/formulation-and-evaluation-of-floating-tablet-of-metoprolol-succinate/neeta-v-jadhav
‘Six Sigma Technique’ A Journey Through its Implementationijtsrd
The manufacturing industries all over the world are facing tough challenges for growth, development and sustainability in today’s competitive environment. They have to achieve apex position by adapting with the global competitive environment by delivering goods and services at low cost, prime quality and better price to increase wealth and consumer satisfaction. Cost Management ensures profit, growth and sustainability of the business with implementation of Continuous Improvement Technique like Six Sigma. This leads to optimize Business performance. The method drives for customer satisfaction, low variation, reduction in waste and cycle time resulting into a competitive advantage over other industries which did not implement it. The main objective of this paper ‘Six Sigma Technique A Journey Through Its Implementation’ is to conceptualize the effectiveness of Six Sigma Technique through the journey of its implementation. Aditi Sunilkumar Ghosalkar "‘Six Sigma Technique’: A Journey Through its Implementation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64546.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64546/‘six-sigma-technique’-a-journey-through-its-implementation/aditi-sunilkumar-ghosalkar
Edge Computing in Space Enhancing Data Processing and Communication for Space...ijtsrd
Edge computing, a paradigm that involves processing data closer to its source, has gained significant attention for its potential to revolutionize data processing and communication in space missions. With the increasing complexity and data volume generated by modern space missions, traditional centralized computing approaches face challenges related to latency, bandwidth, and security. Edge computing in space, involving on board processing and analysis of data, offers promising solutions to these challenges. This paper explores the concept of edge computing in space, its benefits, applications, and future prospects in enhancing space missions. Manish Verma "Edge Computing in Space: Enhancing Data Processing and Communication for Space Missions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64541.pdf Paper Url: https://www.ijtsrd.com/computer-science/artificial-intelligence/64541/edge-computing-in-space-enhancing-data-processing-and-communication-for-space-missions/manish-verma
Dynamics of Communal Politics in 21st Century India Challenges and Prospectsijtsrd
Communal politics in India has evolved through centuries, weaving a complex tapestry shaped by historical legacies, colonial influences, and contemporary socio political transformations. This research comprehensively examines the dynamics of communal politics in 21st century India, emphasizing its historical roots, socio political dynamics, economic implications, challenges, and prospects for mitigation. The historical perspective unravels the intricate interplay of religious identities and power dynamics from ancient civilizations to the impact of colonial rule, providing insights into the evolution of communalism. The socio political dynamics section delves into the contemporary manifestations, exploring the roles of identity politics, socio economic disparities, and globalization. The economic implications section highlights how communal politics intersects with economic issues, perpetuating disparities and influencing resource allocation. Challenges posed by communal politics are scrutinized, revealing multifaceted issues ranging from social fragmentation to threats against democratic values. The prospects for mitigation present a multifaceted approach, incorporating policy interventions, community engagement, and educational initiatives. The paper conducts a comparative analysis with international examples, identifying common patterns such as identity politics and economic disparities. It also examines unique challenges, emphasizing Indias diverse religious landscape, historical legacy, and secular framework. Lessons for effective strategies are drawn from international experiences, offering insights into inclusive policies, interfaith dialogue, media regulation, and global cooperation. By scrutinizing historical epochs, contemporary dynamics, economic implications, and international comparisons, this research provides a comprehensive understanding of communal politics in India. The proposed strategies for mitigation underscore the importance of a holistic approach to foster social harmony, inclusivity, and democratic values. Rose Hossain "Dynamics of Communal Politics in 21st Century India: Challenges and Prospects" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64528.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/history/64528/dynamics-of-communal-politics-in-21st-century-india-challenges-and-prospects/rose-hossain
Assess Perspective and Knowledge of Healthcare Providers Towards Elehealth in...ijtsrd
Background and Objective Telehealth has become a well known tool for the delivery of health care in Saudi Arabia, and the perspective and knowledge of healthcare providers are influential in the implementation, adoption and advancement of the method. This systematic review was conducted to examine the current literature base regarding telehealth and the related healthcare professional perspective and knowledge in the Kingdom of Saudi Arabia. Materials and Methods This systematic review was conducted by searching 7 databases including, MEDLINE, CINHAL, Web of Science, Scopus, PubMed, PsycINFO, and ProQuest Central. Studies on healthcare practitioners telehealth knowledge and perspectives published in English in Saudi Arabia from 2000 to 2023 were included. Boland directed this comprehensive review. The researchers examined each connected study using the AXIS tool, which evaluates cross sectional systematic reviews. Narrative synthesis was used to summarise and convey the data. Results Out of 1840 search results, 10 studies were included. Positive outlook and limited knowledge among providers were seen across trials. Healthcare professionals like telehealth for its ability to improve quality, access, and delivery, save time and money, and be successful. Age, gender, occupation, and work experience also affect health workers knowledge. In Saudi Arabia, healthcare professionals face inadequate expert assistance, patient privacy, internet connection concerns, lack of training courses, lack of telehealth understanding, and high costs while performing telemedicine. Conclusions Healthcare practitioners telehealth perceptions and knowledge were examined in this systematic study. Its collection of concerned experts different personal attitudes and expertise would help enhance telehealths implementation in Saudi Arabia, develop its healthcare delivery alternative, and eliminate frequent problems. Badriah Mousa I Mulayhi | Dr. Jomin George | Judy Jenkins "Assess Perspective and Knowledge of Healthcare Providers Towards Elehealth in Saudi Arabia: A Systematic Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64535.pdf Paper Url: https://www.ijtsrd.com/medicine/other/64535/assess-perspective-and-knowledge-of-healthcare-providers-towards-elehealth-in-saudi-arabia-a-systematic-review/badriah-mousa-i-mulayhi
The Impact of Digital Media on the Decentralization of Power and the Erosion ...ijtsrd
The impact of digital media on the distribution of power and the weakening of traditional gatekeepers has gained considerable attention in recent years. The adoption of digital technologies and the internet has resulted in declining influence and power for traditional gatekeepers such as publishing houses and news organizations. Simultaneously, digital media has facilitated the emergence of new voices and players in the media industry. Digital medias impact on power decentralization and gatekeeper erosion is visible in several ways. One significant aspect is the democratization of information, which enables anyone with an internet connection to publish and share content globally, leading to citizen journalism and bypassing traditional gatekeepers. Another aspect is the disruption of conventional media industry business models, as traditional organizations struggle to adjust to the decrease in advertising revenue and the rise of digital platforms. Alternative business models, such as subscription models and crowdfunding, have become more prevalent, leading to the emergence of new players. Overall, the impact of digital media on the distribution of power and the weakening of traditional gatekeepers has brought about significant changes in the media landscape and the way information is shared. Further research is required to fully comprehend the implications of these changes and their impact on society. Dr. Kusum Lata "The Impact of Digital Media on the Decentralization of Power and the Erosion of Traditional Gatekeepers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64544.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/political-science/64544/the-impact-of-digital-media-on-the-decentralization-of-power-and-the-erosion-of-traditional-gatekeepers/dr-kusum-lata
Online Voices, Offline Impact Ambedkars Ideals and Socio Political Inclusion ...ijtsrd
This research investigates the nexus between online discussions on Dr. B.R. Ambedkars ideals and their impact on social inclusion among college students in Gurugram, Haryana. Surveying 240 students from 12 government colleges, findings indicate that 65 actively engage in online discussions, with 80 demonstrating moderate to high awareness of Ambedkars ideals. Statistically significant correlations reveal that higher online engagement correlates with increased awareness p 0.05 and perceived social inclusion. Variations across colleges and a notable effect of college type on perceived social inclusion highlight the influence of contextual factors. Furthermore, the intersectional analysis underscores nuanced differences based on gender, caste, and socio economic status. Dr. Kusum Lata "Online Voices, Offline Impact: Ambedkar's Ideals and Socio-Political Inclusion - A Study of Gurugram District" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64543.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/political-science/64543/online-voices-offline-impact-ambedkars-ideals-and-sociopolitical-inclusion--a-study-of-gurugram-district/dr-kusum-lata
Problems and Challenges of Agro Entreprenurship A Studyijtsrd
Noting calls for contextualizing Agro entrepreneurs problems and challenges of the agro entrepreneurs and for greater attention to the Role of entrepreneurs in agro entrepreneurship research, we conduct a systematic literature review of extent research in agriculture entrepreneurship to overcome the study objectives of complications of agro entrepreneurs through various factors, Development of agriculture products is a key factor for the overall economic growth of agro entrepreneurs Agro Entrepreneurs produces firsthand large scale employment, utilizes the labor and natural resources, This research outlines the problems of Weather and Soil Erosions, Market price fluctuation, stimulates labor cost problems, reduces concentration of Price volatility, Dependency on Intermediaries, induces Limited Bargaining Power, and Storage and Transportation Costs. This paper mainly devoted to highlight Problems and challenges faced for the sustainable of Agro Entrepreneurs in India. Vinay Prasad B "Problems and Challenges of Agro Entreprenurship - A Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64540.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64540/problems-and-challenges-of-agro-entreprenurship--a-study/vinay-prasad-b
Comparative Analysis of Total Corporate Disclosure of Selected IT Companies o...ijtsrd
Disclosure is a process through which a business enterprise communicates with external parties. A corporate disclosure is communication of financial and non financial information of the activities of a business enterprise to the interested entities. Corporate disclosure is done through publishing annual reports. So corporate disclosure through annual reports plays a vital role in the life of all the companies and provides valuable information to investors. The basic objectives of corporate disclosure is to give a true and fair view of companies to the parties related either directly or indirectly like owner, government, creditors, shareholders etc. in the companies act, provisions have been made about mandatory and voluntary disclosure. The IT sector in India is rapidly growing, the trend to invest in the IT sector is rising and employment opportunities in IT sectors are also increasing. Therefore the IT sector is expected to have fair, full and adequate disclosure of all information. Unfair and incomplete disclosure may adversely affect the entire economy. A research study on disclosure practices of IT companies could play an important role in this regard. Hence, the present research study has been done to study and review comparative analysis of total corporate disclosure of selected IT companies of India and to put forward overall findings and suggestions with a view to increase disclosure score of these companies. The researcher hopes that the present research study will be helpful to all selected Companies for improving level of corporate disclosure through annual reports as well as the government, creditors, investors, all business organizations and upcoming researcher for comparative analyses of level of corporate disclosure with special reference to selected IT companies. Dr. Vaibhavi D. Thaker "Comparative Analysis of Total Corporate Disclosure of Selected IT Companies of India" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64539.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64539/comparative-analysis-of-total-corporate-disclosure-of-selected-it-companies-of-india/dr-vaibhavi-d-thaker
The Impact of Educational Background and Professional Training on Human Right...ijtsrd
This study investigated the impact of educational background and professional training on human rights awareness among secondary school teachers in the Marathwada region of Maharashtra, India. The key findings reveal that higher levels of education, particularly a master’s degree, and fields of study related to education, humanities, or social sciences are associated with greater human rights awareness among teachers. Additionally, both pre service teacher training and in service professional development programs focused on human rights education significantly enhance teacher’s knowledge, skills, and competencies in promoting human rights principles in their classrooms. Baig Ameer Bee Mirza Abdul Aziz | Dr. Syed Azaz Ali Amjad Ali "The Impact of Educational Background and Professional Training on Human Rights Awareness among Secondary School Teachers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64529.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/64529/the-impact-of-educational-background-and-professional-training-on-human-rights-awareness-among-secondary-school-teachers/baig-ameer-bee-mirza-abdul-aziz
A Study on the Effective Teaching Learning Process in English Curriculum at t...ijtsrd
“One Language sets you in a corridor for life. Two languages open every door along the way” Frank Smith English as a foreign language or as a second language has been ruling in India since the period of Lord Macaulay. But the question is how much we teach or learn English properly in our culture. Is there any scope to use English as a language rather than a subject How much we learn or teach English without any interference of mother language specially in the classroom teaching learning scenario in West Bengal By considering all these issues the researcher has attempted in this article to focus on the effective teaching learning process comparing to other traditional strategies in the field of English curriculum at the secondary level to investigate whether they fulfill the present teaching learning requirements or not by examining the validity of the present curriculum of English. The purpose of this study is to focus on the effectiveness of the systematic, scientific, sequential and logical transaction of the course between the teachers and the learners in the perspective of the 5Es programme that is engage, explore, explain, extend and evaluate. Sanchali Mondal | Santinath Sarkar "A Study on the Effective Teaching Learning Process in English Curriculum at the Secondary Level of West Bengal" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd62412.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/62412/a-study-on-the-effective-teaching-learning-process-in-english-curriculum-at-the-secondary-level-of-west-bengal/sanchali-mondal
The Role of Mentoring and Its Influence on the Effectiveness of the Teaching ...ijtsrd
This paper reports on a study which was conducted to investigate the role of mentoring and its influence on the effectiveness of the teaching of Physics in secondary schools in the South West Region of Cameroon. The study adopted the convergent parallel mixed methods design, focusing on respondents in secondary schools in the South West Region of Cameroon. Both quantitative and qualitative data were collected, analysed separately, and the results were compared to see if the findings confirm or disconfirm each other. The quantitative analysis found that majority of the respondents 72 of Physics teachers affirmed that they had more experienced colleagues as mentors to help build their confidence, improve their teaching, and help them improve their effectiveness and efficiency in guiding learners’ achievements. Only 28 of the respondents disagreed with these statements. With majority respondents 72 agreeing with the statements, it implies that in most secondary schools, experienced Physics teachers act as mentors to build teachers’ confidence in teaching and improving students’ learning. The interview qualitative data analysis summarized how secondary school Principals use meetings with mentors and mentees to promote mentorship in the school milieu. This has helped strengthen teachers’ classroom practices in secondary schools in the South West Region of Cameroon. With the results confirming each other, the study recommends that mentoring should focus on helping teachers employ social interactions and instructional practices feedback and clarity in teaching that have direct measurable impact on students’ learning achievements. Andrew Ngeim Sumba | Frederick Ebot Ashu | Peter Agborbechem Tambi "The Role of Mentoring and Its Influence on the Effectiveness of the Teaching of Physics in Secondary Schools in the South West Region of Cameroon" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64524.pdf Paper Url: https://www.ijtsrd.com/management/management-development/64524/the-role-of-mentoring-and-its-influence-on-the-effectiveness-of-the-teaching-of-physics-in-secondary-schools-in-the-south-west-region-of-cameroon/andrew-ngeim-sumba
Design Simulation and Hardware Construction of an Arduino Microcontroller Bas...ijtsrd
This study primarily focuses on the design of a high side buck converter using an Arduino microcontroller. The converter is specifically intended for use in DC DC applications, particularly in standalone solar PV systems where the PV output voltage exceeds the load or battery voltage. To evaluate the performance of the converter, simulation experiments are conducted using Proteus Software. These simulations provide insights into the input and output voltages, currents, powers, and efficiency under different state of charge SoC conditions of a 12V,70Ah rechargeable lead acid battery. Additionally, the hardware design of the converter is implemented, and practical data is collected through operation, monitoring, and recording. By comparing the simulation results with the practical results, the efficiency and performance of the designed converter are assessed. The findings indicate that while the buck converter is suitable for practical use in standalone PV systems, its efficiency is compromised due to a lower output current. Chan Myae Aung | Dr. Ei Mon "Design Simulation and Hardware Construction of an Arduino-Microcontroller Based DC-DC High-Side Buck Converter for Standalone PV System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64518.pdf Paper Url: https://www.ijtsrd.com/engineering/mechanical-engineering/64518/design-simulation-and-hardware-construction-of-an-arduinomicrocontroller-based-dcdc-highside-buck-converter-for-standalone-pv-system/chan-myae-aung
Sustainable Energy by Paul A. Adekunte | Matthew N. O. Sadiku | Janet O. Sadikuijtsrd
Energy becomes sustainable if it meets the needs of the present without compromising the ability of future generations to meet their own needs. Some of the definitions of sustainable energy include the considerations of environmental aspects such as greenhouse gas emissions, social, and economic aspects such as energy poverty. Generally far more sustainable than fossil fuel are renewable energy sources such as wind, hydroelectric power, solar, and geothermal energy sources. Worthy of note is that some renewable energy projects, like the clearing of forests to produce biofuels, can cause severe environmental damage. The sustainability of nuclear power which is a low carbon source is highly debated because of concerns about radioactive waste, nuclear proliferation, and accidents. The switching from coal to natural gas has environmental benefits, including a lower climate impact, but could lead to delay in switching to more sustainable options. “Carbon capture and storage” can be built into power plants to remove the carbon dioxide CO2 emissions, but this technology is expensive and has rarely been implemented. Leading non renewable energy sources around the world is fossil fuels, coal, petroleum, and natural gas. Nuclear energy is usually considered another non renewable energy source, although nuclear energy itself is a renewable energy source, but the material used in nuclear power plants is not. The paper addresses the issue of sustainable energy, its attendant benefits to the future generation, and humanity in general. Paul A. Adekunte | Matthew N. O. Sadiku | Janet O. Sadiku "Sustainable Energy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64534.pdf Paper Url: https://www.ijtsrd.com/engineering/electrical-engineering/64534/sustainable-energy/paul-a-adekunte
Concepts for Sudan Survey Act Implementations Executive Regulations and Stand...ijtsrd
This paper aims to outline the executive regulations, survey standards, and specifications required for the implementation of the Sudan Survey Act, and for regulating and organizing all surveying work activities in Sudan. The act has been discussed for more than 5 years. The Land Survey Act was initiated by the Sudan Survey Authority and all official legislations were headed by the Sudan Ministry of Justice till it was issued in 2022. The paper presents conceptual guidelines to be used for the Survey Act implementation and to regulate the survey work practice, standardizing the field surveys, processing, quality control, procedures, and the processes related to survey work carried out by the stakeholders and relevant authorities in Sudan. The conceptual guidelines are meant to improve the quality and harmonization of geospatial data and to aid decision making processes as well as geospatial information systems. The established comprehensive executive regulations will govern and regulate the implementation of the Sudan Survey Geomatics Act in all surveying and mapping practices undertaken by the Sudan Survey Authority SSA and state local survey departments for public or private sector organizations. The targeted standards and specifications include the reference frame, projection, coordinate systems, and the guidelines and specifications that must be followed in the field of survey work, processes, and mapping products. In the last few decades, there has been a growing awareness of the importance of geomatics activities and measurements on the Earths surface in space and time, together with observing and mapping the changes. In such cases, data must be captured promptly, standardized, and obtained with more accuracy and specified in much detail. The paper will also highlight the current situation in Sudan, the degree to which survey standards are used, the problems encountered, and the errors that arise from not using the standards and survey specifications. Kamal A. A. Sami "Concepts for Sudan Survey Act Implementations - Executive Regulations and Standards" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63484.pdf Paper Url: https://www.ijtsrd.com/engineering/civil-engineering/63484/concepts-for-sudan-survey-act-implementations--executive-regulations-and-standards/kamal-a-a-sami
Towards the Implementation of the Sudan Interpolated Geoid Model Khartoum Sta...ijtsrd
The discussions between ellipsoid and geoid have invoked many researchers during the recent decades, especially during the GNSS technology era, which had witnessed a great deal of development but still geoid undulation requires more investigations. To figure out a solution for Sudans local geoid, this research has tried to intake the possibility of determining the geoid model by following two approaches, gravimetric and geometrical geoid model determination, by making use of GNSS leveling benchmarks at Khartoum state. The Benchmarks are well distributed in the study area, in which, the horizontal coordinates and the height above the ellipsoid have been observed by GNSS while orthometric heights were carried out using precise leveling. The Global Geopotential Model GGM represented in EGM2008 has been exploited to figure out the geoid undulation at the benchmarks in the study area. This is followed by a fitting process, that has been done to suit the geoid undulation data which has been computed using GNSS leveling data and geoid undulation inspired by the EGM2008. Two geoid surfaces were created after the fitting process to ensure that they are identical and both of them could be counted for getting the same geoid undulation with an acceptable accuracy. In this respect, statistical operation played an important role in ensuring the consistency and integrity of the model by applying cross validation techniques splitting the data into training and testing datasets for building the geoid model and testing its eligibility. The geometrical solution for geoid undulation computation has been utilized by applying straightforward equations that facilitate the calculation of the geoid undulation directly through applying statistical techniques for the GNSS leveling data of the study area to get the common equation parameters values that could be utilized to calculate geoid undulation of any position in the study area within the claimed accuracy. Both systems were checked and proved eligible to be used within the study area with acceptable accuracy which may contribute to solving the geoid undulation problem in the Khartoum area, and be further generalized to determine the geoid model over the entire country, and this could be considered in the future, for regional and continental geoid model. Ahmed M. A. Mohammed. | Kamal A. A. Sami "Towards the Implementation of the Sudan Interpolated Geoid Model (Khartoum State Case Study)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63483.pdf Paper Url: https://www.ijtsrd.com/engineering/civil-engineering/63483/towards-the-implementation-of-the-sudan-interpolated-geoid-model-khartoum-state-case-study/ahmed-m-a-mohammed
Activating Geospatial Information for Sudans Sustainable Investment Mapijtsrd
Sudan is witnessing an acceleration in the processes of development and transformation in the performance of government institutions to raise the productivity and investment efficiency of the government sector. The development plans and investment opportunities have focused on achieving national goals in various sectors. This paper aims to illuminate the path to the future and provide geospatial data and information to develop the investment climate and environment for all sized businesses, and to bridge the development gap between the Sudan states. The Sudan Survey Authority SSA is the main advisor to the Sudan Government in conducting surveying, mappings, designing, and developing systems related to geospatial data and information. In recent years, SSA made a strategic partnership with the Ministry of Investment to activate Geospatial Information for Sudans Sustainable Investment and in particular, for the preparation and implementation of the Sudan investment map, based on the directives and objectives of the Ministry of Investment MI in Sudan. This paper comes within the framework of activating the efforts of the Ministry of Investment to develop technical investment services by applying techniques adopted by the Ministry and its strategic partners for advancing investment processes in the country. Kamal A. A. Sami "Activating Geospatial Information for Sudan's Sustainable Investment Map" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63482.pdf Paper Url: https://www.ijtsrd.com/engineering/information-technology/63482/activating-geospatial-information-for-sudans-sustainable-investment-map/kamal-a-a-sami
Educational Unity Embracing Diversity for a Stronger Societyijtsrd
In a rapidly changing global landscape, the importance of education as a unifying force cannot be overstated. This paper explores the crucial role of educational unity in fostering a stronger and more inclusive society through the embrace of diversity. By examining the benefits of diverse learning environments, the paper aims to highlight the positive impact on societal strength. The discussion encompasses various dimensions, from curriculum design to classroom dynamics, and emphasizes the need for educational institutions to become catalysts for unity in diversity. It highlights the need for a paradigm shift in educational policies, curricula, and pedagogical approaches to ensure that they are reflective of the diverse fabric of society. This paper also addresses the challenges associated with implementing inclusive educational practices and offers practical strategies for overcoming barriers. It advocates for collaborative efforts between educational institutions, policymakers, and communities to create a supportive ecosystem that promotes diversity and unity. Mr. Amit Adhikari | Madhumita Teli | Gopal Adhikari "Educational Unity: Embracing Diversity for a Stronger Society" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64525.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/64525/educational-unity-embracing-diversity-for-a-stronger-society/mr-amit-adhikari
Integration of Indian Indigenous Knowledge System in Management Prospects and...ijtsrd
The diversity of indigenous knowledge systems in India is vast and can vary significantly between different communities and regions. Preserving and respecting these knowledge systems is crucial for maintaining cultural heritage, promoting sustainable practices, and fostering cross cultural understanding. In this paper, an overview of the prospects and challenges associated with incorporating Indian indigenous knowledge into management is explored. It is found that IIKS helps in management in many areas like sustainable development, tourism, food security, natural resource management, cultural preservation and innovation, etc. However, IIKS integration with management faces some challenges in the form of a lack of documentation, cultural sensitivity, language barriers legal framework, etc. Savita Lathwal "Integration of Indian Indigenous Knowledge System in Management: Prospects and Challenges" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63500.pdf Paper Url: https://www.ijtsrd.com/management/accounting-and-finance/63500/integration-of-indian-indigenous-knowledge-system-in-management-prospects-and-challenges/savita-lathwal
DeepMask Transforming Face Mask Identification for Better Pandemic Control in...ijtsrd
The COVID 19 pandemic has highlighted the crucial need of preventive measures, with widespread use of face masks being a key method for slowing the viruss spread. This research investigates face mask identification using deep learning as a technological solution to be reducing the risk of coronavirus transmission. The proposed method uses state of the art convolutional neural networks CNNs and transfer learning to automatically recognize persons who are not wearing masks in a variety of circumstances. We discuss how this strategy improves public health and safety by providing an efficient manner of enforcing mask wearing standards. The report also discusses the obstacles, ethical concerns, and prospective applications of face mask detection systems in the ongoing fight against the pandemic. Dilip Kumar Sharma | Aaditya Yadav "DeepMask: Transforming Face Mask Identification for Better Pandemic Control in the COVID-19 Era" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64522.pdf Paper Url: https://www.ijtsrd.com/engineering/electronics-and-communication-engineering/64522/deepmask-transforming-face-mask-identification-for-better-pandemic-control-in-the-covid19-era/dilip-kumar-sharma
Streamlining Data Collection eCRF Design and Machine Learningijtsrd
Efficient and accurate data collection is paramount in clinical trials, and the design of Electronic Case Report Forms eCRFs plays a pivotal role in streamlining this process. This paper explores the integration of machine learning techniques in the design and implementation of eCRFs to enhance data collection efficiency. We delve into the synergies between eCRF design principles and machine learning algorithms, aiming to optimize data quality, reduce errors, and expedite the overall data collection process. The application of machine learning in eCRF design brings forth innovative approaches to data validation, anomaly detection, and real time adaptability. This paper discusses the benefits, challenges, and future prospects of leveraging machine learning in eCRF design for streamlined and advanced data collection in clinical trials. Dhanalakshmi D | Vijaya Lakshmi Kannareddy "Streamlining Data Collection: eCRF Design and Machine Learning" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63515.pdf Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/63515/streamlining-data-collection-ecrf-design-and-machine-learning/dhanalakshmi-d
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
2. International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID – IJTSRD29563 | Volume – 4 | Issue – 1 | November-December 2019 Page 429
The basic approach in development of FDT is the use of
super disintegrants like cross povidone (2-5%), sodium
starch glycolate (2-8%), crosscarmellose sodium which
provide instantaneous disintegration of tablet after
putting on tongue their by release the drug in saliva5.
The other ingredients are micro crystalline cellulose as
tablet disintegrant, mannitol as diluent, talc and
magnesium stearate as lubricant, and camphor as
sublimating agent which increases the porosity of the
tablet6. Direct compression was used for the preparation
of FDT7. The technologies used for manufacturing fast
dissolving tablets are freeze-drying, spray-drying, tablet
moulding, sublimation, sugar-based excipients, tablet
compression, and disintegration addition8.
MATERIALS AND METHODS
Materials
Amlodipine Besylate was purchased from Yarrowchem
Products, Mumbai, India. Crosspovidone, Sodium starch
glycolate, Crosscarmellose sodium, Mannitol, Micro
crystalline cellulose, Camphor, Magnesium stearate and
talc all of them are purchased from Yarrowchem Products,
Mumbai, India. All the excipient and reagents used are
analytical grade.
Methods
Preparation of FDT of Amlodipine besylate
Amlodipine besylate FDTs were prepared by direct
compression method followed by sublimation method.
The superdisintegrants such as Crosspovidone,Sodium
starch glycolate,Cros carmellose sodium used in varying
concentrations (3,5,7%). In this study camphor is used as
a sublimating agent. All the ingredients were passed
through the sieve no 60. The drug/polymer mixture was
prepared by homogeneously mixing the Croscarmellose
sodium, crospovidone, sodium starch glycolate,
microcrystalline cellulose, mannitol and Amlodipine. All
the ingredients of the fast dissolving tablet of amlodipine
were weighed, sifted and mixed in mortar with the help of
pestel, and finally magnesium stearate and talc were
added as lubricating agent and camphor were added as
sublimating agent. The 150 mg mixture was then
compressed using an 8 mm punch in a single stroke on
single punch tablet machine. Each tablet weighed 150 mg.
The force of compression was adjusted so that hardness of
all the prepared tablets ranges from 2-4 kg/cm2. Camphor
was sublimated in vacuum at 80°c for 30 minutes after
preparation of tablets (Fig: 1).
EVALUATION OF FAST DISSOLVING TABLET
General Appearance
The general appearance of a tablet, its visual identity and
overall elegance, is essential for consumer acceptance. The
control of the general appearance of a tablet includes the
measurements of a number of attributes such as a tablets
size, shape, colour, presence or absence of an odour, taste,
of any identifying markings. The prepared tablet was
evaluated for its colour, shape, odor, taste, surface etc.
Thickness9
The thickness of a tablet is the only dimensional variable
related to the process. At a constant compressive load,
tablet thickness varies with change in die fill, with particle
size distribution and packing of the particle mix being
compressed, and with tablet weight, while with a constant
die fill, thickness varies with variations in compressive
load. Tablet thickness should be controlled within ± 5 %
variation of a standard value. Any variation in tablet
thickness within a particular lot of tablets or between
manufacture’s lots should not be apparent to the unaided
eye of consumer acceptance of the product. In addition,
thickness must be controlled to facilitate packing.
Thickness of tablets indicates the strength to withstand
compression force applied during manufacturing process.
Thickness of tablets was measured by verniercalliper. It is
expressed in millimetre.
Weight variation10
With a tablet designed to contain a specific amount of drug
in a specific amount of tablet formula, the weight of the
tablet being made is routinely measured to ensure that a
tablet contains the proper amount of drug. The weight
variation test is done by weighing 10 tablets individually
and calculating the average weight, and comparing the
individual tablet’s weight to the average. The limits for
weight variation are given in the table 1.
S1. No Average Weight
Maximum percentage
difference allowed
1 130 or less 10
2 130-324 7.5
3 More than 324 5
Table1: Weight variation range
Hardness/Crushing strength11
Tablet requires a certain amount of strength or hardness
and resistance to friability, to withstand mechanical
shocks of handling in manufacture, packaging and
shipping. The hardness can be tested using Monsanto
hardness tester or Pfizer. Here Monsanto was used. The
tablet to be tested was held between a fixed and a moving
jaw of Monsanto Hardness Tester. The force applied to the
edge of the tablet was gradually increased by moving the
screw knob forward until the tablet breaks. The reading
was noted from the scale which indicates the pressure
required to break the tablet. The hardness of a tablet
depends on the weight of the material used, space
between the upper and lower punches at the time of
compression and pressure applied during compression.
The hardness also depends on the nature and quantity of
recipients used during formulation. If the finished tablet is
too hard, it may not disintegrate in the required period of
time and if the tablet is too soft it may not withstand the
handing during packing and transporting.
Friability9
Tablet’s hardness is not an absolute indicator of strength
since in some formulations, when compressed into very
hard tablets, tend to cap on attrition, losing their crown
portions. Friability test can be performed to evaluate the
ability of the tablets to withstand abrasion in packing,
handling and transporting. The Friabulator consists of a
plastic chamber divided into two parts and revolves at 25
rpm. A fixed number of tablets are weighed, placed in the
tumbling chamber and rotated for four minutes of 100
revolutions. During each revolution the tablets fall from a
distance of six inches to undergo shock. After 100
revolutions the tablets are again weighed. The loss in
weight indicates the friability. The acceptable limits of
weight loss should not be more than 0.8% t.
3. International Journal of Trend in Scientific Research and Development (IJTSRD) @ www.ijtsrd.com eISSN: 2456-6470
@ IJTSRD | Unique Paper ID – IJTSRD29563 | Volume – 4 | Issue – 1 | November-December 2019 Page 430
The friability (f) is given by
f = 1-
୵୭
୵
X 100
Where,
wo = initial weight of the sample before friability test
w = weight of the samples after friability test
Drug content9
The potency of tablet is expressed in terms of grams,
milligrams or micrograms of drug per tablet and is given
as the label strength of the product. So to evaluate the
tablet’s potency, the amount of drug per tablet needs to be
monitored from tablet to tablet, and batch to batch. For
the drug content uniformity test ten tablets were weighed
and pulverised to a fine powder.A quantity of powder
equivalent to 5 mg of amlodipine was taken and dissolved
in suitable quantity of pH 1.2 solutions and liquid was
filtered using whatman filter paper and diluted. The
amlodipine content was determined by measuring the
absorbance at 239 nm using UV spectrophotometer.
Wetting Time12
The wetting time of the tablets can be measured by using
five circular tissue papers of 10 cm diameter are placed in
a petridish with a 10 cm diameter. 10 mL of water-
containing amaranth a water soluble dye is added to
petridish. A tablet is carefully placed on the surface of the
tissue paper. The time required for water to reach upper
surface of the tablet is noted as a wetting time.
Water Absorption Ratio12
A piece of tissue paper folded twice was placed in a small
petri dish containing 6 ml of water. A tablet was put on the
tissue paper and allowed to completely wet. The wetted
tablet was then weighted. Water absorption ratio, R was
determined using following equation.
R = 100 × Wa – Wb/Wa
Where, Wa = Weight of tablet after water absorption
Wb = Weight of tablet before water absorption.
Disintegration9
A generally accepted fact is that for a drug to be readily
available in the body it must be in solution form. For most
tablets, the first important step towards dissolution is the
breakdown of tablet into smaller particles or granules.
This process is known as disintegration. Disintegration is
still be used as a tool of quality control of tablets and
capsules.
Procedure
The test was carried out on 6 tablets using Tablet
disintegration tester. Distilled water at 37°C ± 2°C was
used as a disintegration media and the time in second
taken for complete disintegration of the tablet with no
palable mass remaining in the apparatus was measured in
seconds.
Dissolution13
Dissolution is a physiochemical process by which a solid
substance enters the solvent phase to yield a solution.
Dissolution (release of drug from the dosage form) is a key
prerequisite for any orally administered drug to be
systemically effective .In case of oral drug products, the
release properties are mainly influenced by disintegration
of the solid dosage form into granules, deaggregation of
granules to yield fine particles and dissolution of drug
from the fine particles into solution.
Drug dissolution is a multistep process involving
heterogenous reactions at solid-liquid phase boundaries.
The heterogenous reactions that constitute the overall
mass transfer process are considered to take place in two
steps
1. Convective transport of the soluble solid through
hydrodynamic boundary layers surrounding solid-
liquid interphase to the bulk phase
2. A reaction at the solid –liquid interphase(Interfacial
transport)
Procedure
Apparatus : USP Type 2 (paddle)
Agitation speed (rpm) : 50
Medium : 0.1 N HCl
Temperature : 37 ± 0.5 ̊ C
Time : 5, 10, 15, 20, 25, 30 minutes
Wavelength : 239 nm
Steps
900 ml of 0.1 N HCl was taken in the basket. Temperature
was maintained at 37 ± 5 ̊ C. One tablet was placed in the
basket. The basket was rotated at 50 rpm. 1 ml of sample
from each basket was withdrawn at the intervals of 5, 10,
15, 20, 25, 30 minutes. Replace the basket with equal
volume of 0.1 N HCl .The samples withdrawn was filtered
and diluted to 10 ml with 0.1 N HCl. The absorbance of
these solutions is measured at 239 nm. The amount and
percentage of drug release can be calculated from the
given formula.
݁ݏ݈ܽ݁݁ݎ ݃ݑݎ݀ ݂ ݐ݊ݑ݉ܣ
=
݊݅ݐܽݎݐ݊݁ܿ݊ܥ × ݐܽܤℎ ݁݉ݑ݈ݒ × ݎݐ݂ܿܽ ݊݅ݐݑ݈݅ܦ
1000
% ݁ݏ݈ܽ݁݁ݎ ݃ݑݎܦ ݂ =
݁ݏ݈ܽ݁݁ݎ ݃ݑݎ݀ ݂ ݐ݊ݑ݉ܣ
݈݀݁݀ܽ ݃ݑݎܦ
× 100
Kinetic study14
Dissolution profile modeling
There are several linear and non-linear kinetic models to
describe release mechanisms and to compare test and
reference dissolution profiles are as follows:
Zero order kinetics
Drug dissolution from pharmaceutical dosage forms that
do not disaggregate and release the drug slowly (assuming
that area does not change and no equilibrium conditions
are obtained) can be represented by the following
equation:
W0 – Wt = K0t
Where W0 is the initial amount of drug in the
pharmaceutical dosage form, Wt is the amount of drug in
the pharmaceutical dosage form at time t and k is
proportionality constant.
Dividing this equation by W0 and simplifying:
ft = k0t
Where ft = 1 – (Wt / W0 ) and ft represents the fraction of
drug dissolved in time t and k0 the apparent dissolution
rate constant or zero order release constant
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First order kinetics
This type of model to analyze drug dissolution study was first proposed by Gibaldi and Feldman and later by Wagner. The
relation expressing this model:
Log Qt = Log Q0 + K1t/2.303
Where Qt is the amount of drug released in time t, Q0 is initial amount of drug in the solution and K1 is the first order
release rate constant.
Korsmeyer Peppas model
Korsmeyer developed a simple semi empirical model, relating exponentially the drug release to the elapsed time (t).
Qt/Qα = Kktn
Where Kk is a constant incorporating structural and geometric characteristic of the drug dosage form and n is the release
exponent, indicative of the drug release mechanism as shown in the table 2:
Table2: Drug transport mechanism
Sl. No Release exponent(n) Drug transport mechanism Rate as a function of time
1 0.5 Fickian diffusion t-.0.5
2 0.5 ˂n ˂ 1.0 Anomalous transport tn-1
3 1.0 Case II transport Zero order release
4 Higher than 1.0 Super case II transport tn-1
The Release exponent can be obtained from the slope and the Constant (Kk) obtained from the intercept of the graphical
relation between logarithmic versions of left side of the equation versus log t.
Higuchi Model
Qt = KHt1/2
Where Qt = the amount of drug released at time t and
KH = the Higuchi release rate;
This is the most widely used model to describe drug release from pharmaceutical matrices. A linear relationship with the
square root of time versus the concentration indicates that the drug release follows strict Fickian diffusion.
RESULTS AND DISCUSSION
The powder blend for all formulation containing various concentration of Crossspovidone (3,5,7%), Sodium starch
glycolate (3,5,7%) and cross carmellose sodium (3,5,7%) as superdisintegrant was prepared shown in the Table 3, and
then the FTIR studies were carried out on the basis of as the method specified(Fig.7-10), FTIR spectrum of drug shows the
prominent peaks with respect to the functional groups. The FTIR spectrum of physical mixture of drug with polymer and
drug with excipient concludes that there is no significant interaction between the drug, polymer and excipients. In the
spectrum of drug-polymer mixture, the characteristic peak of drug was not altered. The soluble diluents, such as mannitol
and microcrystalline cellulose were selected as diluents considering its advantages in terms of easy availability and
negative heat of dissolution. Post formulation studies of the formulated batches are shown in the Table 5 and 6. From the
physical evaluation of all the batches formulated shown in Table 4, it was concluded that the tablets of all the batches had
desirable physical properties. Hardness varies from 2.8 -3.7 Kg/cm2
. The thickness varies from 2.9-3.3 mm. The friability
was varies from 0.40 -0.72 %, which indicates that all the batches had sufficient mechanical strength to withstand
mechanical abrasion. All batches of formulation passes the weight variation test as per the limits prescribed in IP. The
wetting time (Fig: 2) of all the batches were also considerably reduced in tablets. A tablet is carefully placed on the surface
of the tissue paper. The time required for water to reach upper surface of the tablet is noted as a wetting time. It is clear
that the wetting time varies depend on the concentration of the superdisintegrants used for the study. The drug content
uniformity of all the batches was in the limit of 95 - 98 %. The water absorption ratio of all the batches were tested by the
method it is clear that the order of swelling observed in these polymers could indicate the rates at which the preparation
are able to absorbed water and swell. Maximum liquid uptake and swelling polymers were achieved after 2 -8 minutes.
The swelling index was calculated with respect to time .As the time increases, the swelling index was increased because
weight gain by the tablet was increased proportionally with rate of hydration. Later it decreased due to the dissolution of
outer most gelled layer of tablet into dissolution medium. Batches F1 to F9 showed good mechanical integrity, but the
disintegration time was in the range of 15 to 40 seconds. The results shown that sublimation of camphor from tablets
resulted in faster disintegration. In vitro release studies were carried out using USP Type 2 tablet dissolution test
apparatus paddle method at 37±0.5 °C, taking 900 ml of pH-1.2 dissolution medium. Speed of rotation of the paddle was
set at 50 rpm. Aliquots of 1 ml were withdrawn after 5, 10, 15, 20, 25, 30 min and analyzed spectrophotometrically at 239
nm. The percentage drug release of formulations F1-F3 formulated with different concentrations of same superdisintegrant
crosspovidone showed the drug release 79.09 %, 81.90 % and 82.09 % respectively at the end of 30 minutes(Fig:3). From
formulations F4-F6 with another superdisintegrant sodium starch glycolate were showed 82.29 %, 83.60 % and 86.29 %
respectively at the end of 30 minutes(Fig:4). From formulations F7- F9 formulated with superdisintegrant croscarmellose
sodium were showed the results as 89.10 %, 91.19 % and 92.29 % respectively at the end of 30 minutes(Fig:5). F9 shows
the percentage drug release of 92.29 % at the end of 30 minutes. So F9 selected as the optimized formulation in this study.
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The dissolution profile of most satisfactory formulation F9 was fitted to zero order, first order, Higuchi model, Korsmeyer-
Peppas model and Hixson-Crowell model to ascertain the kinetic modeling of the drug release(Fig:6). The kinetic
treatment of the drug release data of F9 followed first order drug release and Korsmeyer-Peppas profile with R2 values
0.989 and 0.993 respectively(Table:7&8). It indicated that drug release was dissolution controlled and directly
proportional to log cumulative percentage drug release.
Fig:1: Fast dissolving tablets of Amlodipine.
Fig:2: Before and after wetting time of FDTs
Fig: 3: Dissolution profile of Formulations F1-F3. Fig: 4: Dissolution profile of Formulations F4-F6.
0
20
40
60
80
100
0 10 20 30 40
Percentagedrugrelease(%)
Time(min)
F1-F3
F1
F2
F3
0
20
40
60
80
100
0 10 20 30 40
Percentagedrugrelease(%)
Time(min)
F4-F6
F4
F5
F6
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Fig: 5: Dissolution profile of Formulations F7
Fig: 6: Kinetic study
0
20
40
60
80
100
Percentagedrugrelease(%)
y = 2.6784x + 23.875
R² = 0.8186
0
20
40
60
80
100
120
0 20 40
cumulative%drugrelease
Time (hrs.)
Zero order
y = 61.773x +
1.8272
R² = 0.9939
0
20
40
60
80
100
0.000 1.000 2.000
logcumulative%drugrelease
log time
Kors-peppas
0.000
0.500
1.000
1.500
2.000
2.500
3.000
0
CBR(Wo)-CBR(Wt)
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29563 | Volume – 4 | Issue – 1 | November-
Fig: 5: Dissolution profile of Formulations F7-F9.
Fig: 6: Kinetic study of formulation F9
0
20
40
60
80
100
0 10 20 30 40
Time(min)
F7-F9
F7
F8
F9
y = 2.6784x + 23.875
R² = 0.8186
Zero order
Linear (Zero
order)
0.000
0.500
1.000
1.500
2.000
2.500
0 20
LogCumulative%drug
remaining
time (hrs.)
First order
y = 61.773x +
1.8272
R² = 0.9939
peppas
Kors-peppas
Linear (Kors-
peppas) 0
50
100
150
0.000 2.000 4.000
cumulative%drugreleased
SQRT of Time
y = 0.0833x + 0.3207
R² = 0.96
0 20 40
Time (hrs.)
Hixson Crowell
hixson
Linear (hixson)
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y = -0.0356x +
1.9464
R² = 0.9892
40
time (hrs.)
First order
First order
Linear (First
order)
y = 16.835x + 5.7992
R² = 0.9792
6.000
SQRT of Time Higuchi
Higuchi
Linear
(Higuchi)
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Time
(Hr)
cumulative
% drug
released
% drug
remaining
Square
root
time
log Cumu %
drug
remainining
log
time
log
Cumu %
drug
released
% Drug
released
Cube Root
of % drug
RemainingWt
Wo-
Wt
0 0 100 0.000 2.000 0.000 0.000 100 4.642 0.000
5 50.09 49.91 2.236 1.698 0.699 1.700 50.09 3.682 0.960
10 61.20 38.8 3.162 1.589 1.000 1.787 11.11 3.385 1.257
15 74.39 25.61 3.873 1.408 1.176 1.872 13.19 2.948 1.694
20 81.29 18.71 4.472 1.272 1.301 1.910 6.9 2.655 1.987
25 89.10 10.9 5.000 1.037 1.398 1.950 7.81 2.217 2.425
30 92.29 7.71 5.477 0.887 1.477 1.965 3.19 1.976 2.666
Table 7: Kinetic analysis data of F9
FORMULATION Kinetic Models
F9 Zero order First order Kors Peppas Plot Hixon crowell Higuchi
R2 value 0.818 0.989 0.993 0.960 0.979
Table8: Regression values of kinetic models
CONCLUSION
Fast dissolving tablets of Amlodipine besylate was
prepared by direct compression and followed by
sublimation method using three different
superdisintegrants such as Croscarmellose Sodium,
Crospovidone and Sodium Starch Glycolate with other
standard excipients. FTIR studies showed that there was
no marked interaction between fast dissolving tablets and
superdisintegrants. In vitro drug release from the tablets
shows significantly improved drug dissolution. Optimized
formulation F9 showed a drug release of 92.29 % and
showed the minimum disintegration time was 15 seconds.
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