Microwave-assisted extraction is an efficient extraction method that allows compounds to be extracted more rapidly from plants with similar or better yields than conventional extraction methods. It works by transferring microwave energy to the solvent and plant matrix, rapidly heating them and breaking open the plant cells to release compounds into the solvent. Supercritical fluid extraction uses solvents like carbon dioxide above their critical temperature and pressure, giving them liquid-like densities and gas-like transport properties for efficient, non-toxic extraction.
Role of Pharmacognosy in various systems of medicineRamaiah Maddi
Role of Pharmacognosy in Allopathy (Modern medicine)
Role of Pharmacognosy in Ayurveda
Role of Pharmacognosy in Unani System of Medicine
Role of Pharmacognosy in Siddha System of Medicine
Role of Pharmacognosy in Homeopathy
Role of Pharmacognosy in Chinese Medicine System
Role of Pharmacognosy in various systems of medicineRamaiah Maddi
Role of Pharmacognosy in Allopathy (Modern medicine)
Role of Pharmacognosy in Ayurveda
Role of Pharmacognosy in Unani System of Medicine
Role of Pharmacognosy in Siddha System of Medicine
Role of Pharmacognosy in Homeopathy
Role of Pharmacognosy in Chinese Medicine System
method to separate compounds based on their relative solubilities in two different immiscible liquids, usually water and an organic solvent. It is an extraction of a substance from one liquid into another liquid phase.
This presentation comprehensively tells about not only the classical methods of extraction but also the modern methods by which herbal products can be easily and efficiently extracted for further use in isolation and formulation
what is extraction. what are the conventional methods what are their drawbacks. what are the advanced techniques used to overcome those drawbacks. major focus on Microwave assisted extraction. its factors advantages types and applications
Extraction is a process of separation or isolation of pharmaceutical active ingredients
from plant or animal drugs with the help of solvent.
On the basis of the physical nature of crude drug to be extracted i.e. liquid or solid ,the extraction process may be:
Liquid –Liquid Extraction Or
Solid –Liquid Extraction.
The solvent used for extraction is called as ‘Menstruum’ and the residue left after extracting desired constituents is called ‘Marc’.
Required Ideal Properties of Menstruum :
Should be inert and non –toxic
Should extract only the desirable constituent of the crude drug .
Should be cheap and easily available
THE PRESENTATION ABOUT COUNTER CURRENT EXTRACTION GIVINGBDETAIL ON ITS INTRODUCTION, THEORY, EQUATION, EXAMPLES ARE SIMPLIFIED IN EASY WAY TO THE STUDENTS AND READERS LEARNING A TOPIC AT A PLACE ACCORDING TO PCI SYLLABUS FOLLOWED BY CHEMISTRY STUDENTS OF OTHER BRANCHES.
Isolation, Identification and Analysis of Phytoconstituents.pptxZuli Shingala
general Isolation methods for alkaloids
isolation, identification and analysis of phytoconstituents like Caffeine, Atropine, Glycyrrhetinic acid, Podophyllotoxin
Clove (Syzygium aromaticum) is medicinally powerful herb. Cloves are also known as Clovos, Lavang, Laung. In india, cloves are grown in Nilgiries, Tensaki Hills of Tamil Nadu state, Kottayam and Kollam district of kerala. It holds several phytochemicals. Major phytochemicals includes Eugenol, Eugenyl acetate and Beta-caryophyllene. Clove contains essential oils in its buds, leaves, stem and fruits. Clove owns major pharmacological activities like antioxidant, antimicrobial, anti-inflammatory, anticarcinogenic, antibacterial, antipyretic and analgesic, etc.
method to separate compounds based on their relative solubilities in two different immiscible liquids, usually water and an organic solvent. It is an extraction of a substance from one liquid into another liquid phase.
This presentation comprehensively tells about not only the classical methods of extraction but also the modern methods by which herbal products can be easily and efficiently extracted for further use in isolation and formulation
what is extraction. what are the conventional methods what are their drawbacks. what are the advanced techniques used to overcome those drawbacks. major focus on Microwave assisted extraction. its factors advantages types and applications
Extraction is a process of separation or isolation of pharmaceutical active ingredients
from plant or animal drugs with the help of solvent.
On the basis of the physical nature of crude drug to be extracted i.e. liquid or solid ,the extraction process may be:
Liquid –Liquid Extraction Or
Solid –Liquid Extraction.
The solvent used for extraction is called as ‘Menstruum’ and the residue left after extracting desired constituents is called ‘Marc’.
Required Ideal Properties of Menstruum :
Should be inert and non –toxic
Should extract only the desirable constituent of the crude drug .
Should be cheap and easily available
THE PRESENTATION ABOUT COUNTER CURRENT EXTRACTION GIVINGBDETAIL ON ITS INTRODUCTION, THEORY, EQUATION, EXAMPLES ARE SIMPLIFIED IN EASY WAY TO THE STUDENTS AND READERS LEARNING A TOPIC AT A PLACE ACCORDING TO PCI SYLLABUS FOLLOWED BY CHEMISTRY STUDENTS OF OTHER BRANCHES.
Isolation, Identification and Analysis of Phytoconstituents.pptxZuli Shingala
general Isolation methods for alkaloids
isolation, identification and analysis of phytoconstituents like Caffeine, Atropine, Glycyrrhetinic acid, Podophyllotoxin
Clove (Syzygium aromaticum) is medicinally powerful herb. Cloves are also known as Clovos, Lavang, Laung. In india, cloves are grown in Nilgiries, Tensaki Hills of Tamil Nadu state, Kottayam and Kollam district of kerala. It holds several phytochemicals. Major phytochemicals includes Eugenol, Eugenyl acetate and Beta-caryophyllene. Clove contains essential oils in its buds, leaves, stem and fruits. Clove owns major pharmacological activities like antioxidant, antimicrobial, anti-inflammatory, anticarcinogenic, antibacterial, antipyretic and analgesic, etc.
Modern and effective methods in the development of natural productsTejasSonawane19
The file is all about the modern and effective method for the development of natural products . and to explore the traditional system globally . the one who wants to make his product effective and stable he must follow these methods .
Microwave Assisted Extraction of Pigments for better yield and quality.pptxRosemaryMXavier
Extraction is the process in which one or more components are get separated selectively from a liquid or a solid mixture by means of an immiscible solvent. Solvent used for the extraction is known as menstrum. The inert fibrous and other insoluble materials remaining after extraction is called as marc. Its major application is in isolation of phytoconstituents and nutraceuticals.
The different type of extraction methods includes infusion, decoction, maceration, soxhlet extraction, digestion and percolation
Drawbacks of traditional extraction methods
1. Time consuming
2. Rate of mass transfer goes on decreasing, since the solvent is getting saturated
3. Large amount of solvent is required
4. Difficulty in solvent recovery
5. The methods like digestion and decoction are not suitable for thermolabile compounds etc.
These limitations of traditional extraction technologies led to the development of innovative extraction techniques like
• Microwave assisted extraction
• Ultrasound assisted extraction
• Supercritical fluid extraction
• Accelerated solvent extraction etc.
Microwave theory
Microwaves are the non- ionizing electromagnetic radiations comes under the frequency range of 300MHz- 300GHz, positioned in between the radio and infrared rays. The microwaves are made up of two oscillating electrical and magnetic fields perpendicular to each other.
Principle of microwave heating
The principle of microwave heating includes ionic conduction and dipole rotation. Microwave heating is a multi-physics phenomenon that involves electromagnetic waves and heat transfer. Any material that is exposed to electromagnetic radiation will be heated up. The rapidly varying electric and magnetic fields lead to four sources of heating.
• Any electric field applied to a conductive material will cause current to flow.
• In addition, a time-varying electric field will cause dipolar molecules, such as water, to oscillate back and forth.
• A time-varying magnetic field applied to a conductive material will also induce current flow.
• There can also be hysteresis losses in certain types of magnetic materials.
Microwave assisted extraction
Microwave assisted extraction is a technique for the extraction of active components from plant materials, using microwave energy. The electromagnetic radiation of microwave results in the destruction of cell wall matrix and quickly increase the solvent penetration into the plant cells and lead to the leaching of ingredients during the microwave heating process (Maran et al., 2013).
Factors influencing MAE
1. Solvent
a. Solubility of the analyte
b. Ability to absorb microwave power and pass it in the form of heat depends on the dissipation factor
2. Microwave power – optimized to minimize the extraction time and solvent requirement
3. Extraction time- The amount of the analyte extracted can be improved with increasing extraction time with the associated risk of degradation of thermolabile components
4.Temperature - Increase solubility
Methods Of Extractions of crude drugs.pdfArunShah49
This document is made to help different personals to enhance their knowledge about crude drug processing and their proper usage for better therapeutic yeild. In this document one can find the detailed study of some of the popular and effective methods of extraction for crude drugs like as Soxhlet extraction, Countercurrent Extraction and Ultrasonication Assisted extraction methods. Hope this would be helpful for the students and other personals willing to learn about extraction methods related to crude drugs.
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Product recovery and purification, such as centrifugal, chromatography, crystallization, dialysis, drying, electrophoresis, filtration, precipitation, etc., are essential finishing steps to any commercial fermentation process.
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Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
2. MICROWAVE ASSISTED
EXTRACTION
Microwave-assisted extraction is an efficient
method for deriving natural compounds from
raw plants.
Microwave extraction allows organic
compounds to be extracted more rapidly,
with similar or better yield as compared to
conventional extraction methods.
Plant Solvent
Microwave
extraction
Conventional
extraction
Time
(min)
Yield (%) Time (min)
Yield
(%)
Silybus
marianum
Ethanol
4 1.37 55 1.28
Artemisia
annua
Chlorofor
m
2 024 60 0.15
3. MICROWAVE ASSISTED
EXTRACTION
Basic of this technique is
rapid transfer of energy to solvent and solid plant matrix
resulting to subsequent heating of the solvent and solid matrix,
efficiently and homogeneously.
Components of the sample or solvents absorb microwave
energy in accordance to their dielectric constants.
When plant material is immersed inside a microwave
transparent solvent, the heat of microwave radiation directly
reaches to the solid without being absorbed by the solvent,
resulting in instantaneous heating of the residual moisture in
the solid.
Heating causes the moisture to evaporate and creates a high
vapour pressure that breaks the cell wall of substrate and
releases the content into solvent.
The extracting selectivity and the ability of the solvent to
interact with microwaves can be modulated by using
mixtures of solvents.
One of the most commonly used mixtures is hexane-
Theory
4. MICROWAVE ASSISTED
EXTRACTION
Both systems are
available as multi-
mode and single-
mode.
A multi-mode
system allows evenly
radiation of sample
by random
dispersion of
microwaves.
Single-mode (aka
focused system)
allows focused
radiation on a
restricted zone by a
much stronger
electric field.
Open vessel and closed vessel system
INSTRUMENTS
Both multi-mode and focused system comprises of the following
four components:
Microwave generator: magnetron which generates microwave
energy
Wave guide: propagates microwave to microwave cavity
6. MICROWAVE ASSISTED
EXTRACTION
The MAE process is as follows:
Microwave radiation
Moisture get heated up
Moisture evaporates
Generation of tremendous pressure on cell wall
Swelling of plant cell
Rupture of the cell
Leaching out of phyto-constituents
This phenomenon can be intensified if the plant
matrix is impregnated with solvents with higher
heating efficiency under microwave.
Process
7. MICROWAVE ASSISTED
EXTRACTION
Advantages
It reduces solvent consumption,
It has a shorter operational time,
It possess moderately high recoveries,
Has a good reproducibility and minimal sample
manipulation for extraction process.
Disadvantages
Furthermore, the efficiency of microwaves can
be very poor when either the target compounds
or the solvents are non-polar, or when they are
volatile.
8. Supercritical Fluid Extraction
For every substance, there is a critical temperature
(Tc) and pressure (Pc) above which no applied pressure
can force the substance into its liquid phase. If the
temperature and pressure of a substance are both
higher than the Tc and Pc for that substance, the
substance is defined as a supercritical fluid.
Triple point
0.01oC/ 42 bar
Critical point
374oC/ 218 bar
9. PROPERTIES OF SCFS
At the critical point, the
density of the gas and
liquid phases is the same;
there is no distinction
between the phases. i.e.
between those of the pure
liquid and gas.
Supercritical posses
densities that are liquid-
like and transport
properties that are gas-
like.
these offers good
penetrative ability and
good extractive ability.
For CO2:
Triple point: pressure: 52.8bar
temperature: -56.60C
Critical point pressure: 73.8bar
temperature: 31.06 0C
Supercritical Fluid Extraction
10. Choice of SCFs solvent
Good solublizing and penetrating property
Inert to the product
Easy separation from the product
Cheap
Low CP because of economic reasons
Supercritical Fluid Extraction
11. Carbon dioxide is the most commonly used SCF, due
primarily to its low critical parameters (31.1°C, 73.8
bar),
low cost and non-toxicity.
However, several other SCFs have been used in both
commercial and development processes. The critical
properties of some commonly used SCFs are ;
Fluid Critical Temperature (0 C) Critical Pressure (bar)
Carbon dioxide 30.41 73.8
Ethane 30.54 48.8
Ethylene 28.24 50.4
Propane 36.98 42.5
Propylene 36.49 46.0
Trifluoromethane (Fluoroform) 29.93 48.6
Chlorotrifluoromethane 30.20 38.7
Supercritical Fluid Extraction
12. SUPERCRITICAL FLUID
EXTRACTION PROCESS
An extraction medium (going to be SCF) stored in the feed tank
and liquid SCF is pumped from a reservoir ; it is heated and
pressurized to reach the supercritical conditions to extractor.
13. Supercritical SCF enters
the extraction chamber
where contact with crude
drug bed occurs and the
more volatile substances
are dissolved into the
supercritical fluid.
Solute and SCF leave
extractor and extract is
precipitated in
separators, where SCF
becomes gaseous.
Gas is recycled by
condensation before
returning to liquid
reservoir.
SUPERCRITICAL FLUID
EXTRACTION PROCESS
14. ADVANTAGES & DISADVANTAGES OF SCFE
Some of the advantages and disadvantages of SCFs compared to
conventional liquid solvents for separations:
• Dissolving power of the SCF is controlled by pressure and/or
temperature
• SCF is easily recoverable from the extract due to its volatility
• Non-toxic solvents/gases leave no harmful residue
• High boiling components are extracted at relatively low
temperatures
• Separations not possible by more traditional processes can
sometimes be effected
• Thermally labile compounds can be extracted with minimal
damage as low temperatures can be employed by the extraction
Advantages
Disadvantages
Elevated pressure required
High capital investment for equipment
15. APPLICATIONS OF SUPERCRITICAL FLUID
EXTRACTION
Supercritical Fluids
(SCF’s) are
increasingly
replacing the organic
solvents that are
used in industrial
purifications and
recrystallization
operations because
of regulatory and
environmental
pressures on
hydrocarbons and
ozone depleting
emissions.
16. APPLICATIONS OF SUPERCRITICAL FLUID
EXTRACTION
Food and flavouring
SFE is applied in food and flavouring industry due to no
residual solvent.
Decaffeinication of tea and coffee.
extraction of essential oils and aroma materials from spices.
in extracting some edible oils and producing cholesterine-free egg
powder.
Pharmaceutical industy
Producing of active ingradients from herbal plants for avoiding
thermo or chemical degradation. Elimination of residual
solvents from the products.
Other plant extractions
Production of denicotined tobacco.
Enviromental protection
17. APPLICATIONS OF SUPERCRITICAL FLUID
EXTRACTION
Applications of SCF include
recovery of organics from oil shale
separations of biological fluids
bioseparation
petroleum recovery
crude dewaxing
coal processing (reactive extraction and liquefaction)
selective extraction of fragrances, oils and impurities
from agricultural and food products
pollution control
combustion and many other applications.