This study compared outcomes of external fixation and volar plating for displaced intra-articular distal radius fractures. 110 patients were randomized to external fixation or volar plating. At 6 months, volar plating showed lower pain and higher range of motion, but by 1 year, external fixation led to greater improvements in range of motion, grip strength, and outcomes, especially in patients under 50. The study concluded external fixation may be superior for treating these fractures.
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
describing the decision making process in deciding which implant to use for trochanteric fractures and its complications - done for Basic AO course in Bengbu, China
An Introduction, History, Diagnosis, Current Guidelines on Treatment of trochanteric fractures of femur. Presentation also contain an introduction of Dynamic Hip Screw and Surgical Techniques.
OSTEOLYSIS AND LOOSENING OF total hip arthroplasty IMPLANTS.pptx by dr vasu ...Vasu Srivastava
Aseptic Loosening of implants is caused by osteolysis. It is most significant factor limiting longevity of THA. Revision for loosening is 4x higher than next leading cause (dislocation at 13.6%), and its particularly problematic in younger patients [2].
Osteolysis is bone resorption caused by the body’s response to particulate debris generated as the THA implant wears out. Motion between any two components of the prosthesis (ie the femoral head and the acetabuluar liner, the head-neck junction of the femoral stem, or the liner and shell of the acetabulum) generates debris that floats around the joint. This debris stimulates a host response. Particles of metal, poly, or cement can all cause osteolysis, albeit different types of reaction. Osteolysis is important because it leads to implant loosening and/or periprosthetic fractures.
While osteolysis is the primary cause of loosening, infection must be part of the differential diagnosis.
Historical Perspective: Osteolysis was first described by Harris in 1976 and it was attributed to “cement disease” [3], because it was observed around the femoral component, and this was what started the drive for cementless implants. Yet after significant R&D, and development of cementless implants, osteolysis was still seen around the implants [4], and the histology was similar between cemented [5] and cementless implants [6]. Surgeons then looked for another cause of osteolysis and recognized that it was produced by wear particles.
STAGES OF OSTEOLYSIS
1) Debris production (ie poly wear) is the initial stage (we talk about metal debris in a separate section because it behaves totally differently, see section). Particulate debris in THA is produced by Abrasive and Adhesive wear (whereas the TKA produces delaminating wear: small fissures form within the poly).
▪ Adhesive wear is two surfaces bonding together causing the softer material to “peel” off as a thin film onto the harder surface during motion.
Volumetric wear is a specific type of adhesive wear, and it occurs as the femoral head articulates with the cup liner, and the amount of wear is proportional to the femoral head radius squared (therefore larger femoral head = more wear..this is why the initial Charnley implants, which used conventional poly, used a size 22 femoral head). Linear wear is caused by focused stress on a isolated part of the poly due to abnormal loading.
▪ Abrasive wear occurs when a harder surface (which is never completely smooth) cuts or ploughs through a softer surface, like a cheese grater. Both cause particle formation. Most wear occurs superiorly in the cup (or at the rim in cases of impingement).
The conventional PE wear from articulating with a Cobalt-chrome head is 0.10 mm/year. The ultramolecular weight poly (UMWPE, also known as highly-crosslinked poly) wear is about 0.02 mm/year. What is the difference between conventional and UMWPE?
describing the decision making process in deciding which implant to use for trochanteric fractures and its complications - done for Basic AO course in Bengbu, China
An Introduction, History, Diagnosis, Current Guidelines on Treatment of trochanteric fractures of femur. Presentation also contain an introduction of Dynamic Hip Screw and Surgical Techniques.
OSTEOLYSIS AND LOOSENING OF total hip arthroplasty IMPLANTS.pptx by dr vasu ...Vasu Srivastava
Aseptic Loosening of implants is caused by osteolysis. It is most significant factor limiting longevity of THA. Revision for loosening is 4x higher than next leading cause (dislocation at 13.6%), and its particularly problematic in younger patients [2].
Osteolysis is bone resorption caused by the body’s response to particulate debris generated as the THA implant wears out. Motion between any two components of the prosthesis (ie the femoral head and the acetabuluar liner, the head-neck junction of the femoral stem, or the liner and shell of the acetabulum) generates debris that floats around the joint. This debris stimulates a host response. Particles of metal, poly, or cement can all cause osteolysis, albeit different types of reaction. Osteolysis is important because it leads to implant loosening and/or periprosthetic fractures.
While osteolysis is the primary cause of loosening, infection must be part of the differential diagnosis.
Historical Perspective: Osteolysis was first described by Harris in 1976 and it was attributed to “cement disease” [3], because it was observed around the femoral component, and this was what started the drive for cementless implants. Yet after significant R&D, and development of cementless implants, osteolysis was still seen around the implants [4], and the histology was similar between cemented [5] and cementless implants [6]. Surgeons then looked for another cause of osteolysis and recognized that it was produced by wear particles.
STAGES OF OSTEOLYSIS
1) Debris production (ie poly wear) is the initial stage (we talk about metal debris in a separate section because it behaves totally differently, see section). Particulate debris in THA is produced by Abrasive and Adhesive wear (whereas the TKA produces delaminating wear: small fissures form within the poly).
▪ Adhesive wear is two surfaces bonding together causing the softer material to “peel” off as a thin film onto the harder surface during motion.
Volumetric wear is a specific type of adhesive wear, and it occurs as the femoral head articulates with the cup liner, and the amount of wear is proportional to the femoral head radius squared (therefore larger femoral head = more wear..this is why the initial Charnley implants, which used conventional poly, used a size 22 femoral head). Linear wear is caused by focused stress on a isolated part of the poly due to abnormal loading.
▪ Abrasive wear occurs when a harder surface (which is never completely smooth) cuts or ploughs through a softer surface, like a cheese grater. Both cause particle formation. Most wear occurs superiorly in the cup (or at the rim in cases of impingement).
The conventional PE wear from articulating with a Cobalt-chrome head is 0.10 mm/year. The ultramolecular weight poly (UMWPE, also known as highly-crosslinked poly) wear is about 0.02 mm/year. What is the difference between conventional and UMWPE?
Protocol Overview
The meadow saffron often called an autumn-blooming crocus is the source of Colchicine, and is
used as an herbal treatment of gout. Early signs of poisoning include burning feeling in mouth,
difficulty swallowing, and intense thirst. Ingestion of colchicine typically leads to profuse vomiting
and diarrhea, which can be bloody, severe abdominal pain and paralysis, followed by
hypovolemic shock and multisystem organ failure within 24-72 hours.
Early Outcome of Discectomy with Interspinous Process Distraction Device a Re...CrimsonPublishersOPROJ
Early Outcome of Discectomy with Interspinous Process Distraction Device a Retrospective Cross-Sectional Study by Gunaseelan Ponnusamy* in Crimson Publishers: Orthopedic Research and Reviews Journal
Presentation delivered at 2020 AAOS annual meeting by Dr Adnan Saithna, Professor of Orthopedic Surgery, Overland Park, Kansas. This randomised controlled study demonstrates that combined ACL and anterolateral ligament reconstruction is not associated with an increased risk of adverse events when compared to isolated ACL reconstruction
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
To compare the different approaches and effects of pararectus approach, modified stoppa approach and ilioinguinal approach in the treatment of acetabular fractures.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
: To compare the different approaches and effects
of pararectus approach, modified stoppa approach and ilioinguinal
approach in the treatment of acetabular fractures.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
To compare the different approaches and effects
of pararectus approach, modified stoppa approach and ilioinguinal
approach in the treatment of acetabular fractures.
Comparison of Clinical Efficacy of Surgical Approaches for Acetabular Fracturessemualkaira
Through regression sorting, 44 patients with acetabular fractures who were hospitalized in our unit from September 2012 to September 2017 were summarized. Three surgical methods were used, and the operation time, intraoperative blood loss, postoperative complications, fracture reduction satisfaction and hip function were recorded in the three groups.
44.Rohini Kanitkar Kamat et al. A Comparative Assessment of the Efficiency of ThreeDimensional plates over single Superior Border Plating in the management of Mandibular Angle Fractures. J Res Adv Dent 2020;10:3s:17-22.
Background: Distal femur fractures make up 6 to 7% of all femur fractures. Various plating options for distal femur fracture are conventional buttress plates, fixed-angle devices, and locking plates. This study was planned to evaluate and explore locking compression plate fixation in distal end femur fractures which is expected to provide a stable fixation with minimum exposure, early mobilization, less complications and a better quality of life.
Methods: The study was conducted as prospective clinical study in 20 skeletally mature patients with x-ray evidence of distal femur fracture fulfilling inclusion and exclusion criteria, operated with distal femur LCP plating. Patients were assessed radiologically and classified according to distal femur fracture classification and outcome graded as excellent, good, fair and poor based on Lysholm Knee Score.
Results: Out of 15 excellent outcome cases, 3 cases were type A1 fracture, 1 case had type A3, 2 cases had type B1 and B2 each, 5 cases had type C2 and 2 cases had type C3 fracture. 1 case with good outcome was type C3. 1 case with fair outcome was type B2. While 3 cases with poor outcome were type A1, A2 and C3.
Conclusions: The DF-LCP is an ideal implant to use for fractures of the distal femur. However, accurate positioning and fixation are required to produce satisfactory results. We recommend use of this implant in Type A and C, osteoporotic and periprosthetic fractures.
Keywords: Distal femur, DF-LCP, Lysholm score, Periprosthetic fracture
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
4. to compare the efficacy of
external fixation and volar plating
on the functional parameter of displaced intra-
articular (Cooney’s type IV) distal end radius
fractures using the Green and O’Brien scoring
system.
5. Complex anatomy
Can not use same approach and materials for different
types of fractures
Strategic placement of the selected materials more
important than the characteristics of these materials
particularly in intra-articular fractures
6. External fixation
Advantages:
Maintain the continuity of reduction under c-arm
Improved reduction by ligamentotaxis
protect the reduction until healing occurs.
The relative ease of application,
Minimal surgical exposure
Reduced surgical trauma
Kapoor H, Agarwal A, Dhaon BK (2000) Displaced intra-articular fractures
of distal radius: a comparative evaluation of results following closed reduction,
external fixation and open reductionwith internal fixation. Injury 31:75–79
Disadvantages
Neuropathy of median and superficial radial nerve
Pin tract infection
Pin loosening
Non union and malunion
Loss of radial height and radial tilt
Collapse of ulnar border
Complications of Treating Distal Radius Fractures with External Fixation: A Community Experience John T Anderson, MD, Resident in
Orthopaedic Surgery,* George L Lucas, MD, Professor & Chairman, Section of Orthopaedic Surgery,** and Bruce R Buhr, MD, Clinical
Assistant Professor. Iowa Orthop J. 2004; 24: 53–59.
7. Volar Locking Plate
Advantages:-
Direct visualization and manipulation of the fracture fragments
Stable rigid fixation
Possibility of immediate postoperative motion.
Minimize screw loosening in the distal fragments
Useful to buttress small articular fragments
Successfully control shortening and angular displacement,especially in
osteoporotic bone
Disadvantages:
Longer surgical time
Iatrogenic injuries
symptomatic tenosynovites (protruding of screws) (sugun et al., 2011)
9. Universal (Cooney’s) Classification
Of Distal End Radius
Cooney WP. Fracture of the distal radius. A modern treatment-based classification.
Orthop Clin North Am. 1993; 24(2):211-216
10. Prospective randomized study but not blinded.
The patients were randomized into two groups using random number tables
generated online (http://www.graphpad.com/quickcalcs/)
The external fixation technique was chosen for group 1 and volar locking
plates were chosen for group 2. All surgical procedures were performed by a
single author (RS) at a single institute using standard protocols
The mean follow up period for patients was up to 6 months and 1 year after
surgery
The assessment of pain, range of motion, grip strength and activity were
assessed at each follow-up visit and scored according to the Green and O’Brien
scoring system
11. Inclusion Criteria
between June 2010 and May 2012
mean age 39.12 +/- 13 years
Cooney’s type IV fracture
110 patients:
-61 female
-49 males
12. Exclusion Criteria
Patients with any other associated injury/fracture
Bilateral distal radius fractures
Open fractures of distal radius
Associated head injury
13.
14. Group 1: The external fixation
Two 2.5-mm schanz pins in the second metacarpal and two 3.5-mm
pins in the radius proximal to the fracture.
After application of a frame, reduction was checked in the c-arm
Reduction was achieved via manual traction and closed reduction
method in all cases
A below elbow plaster of paris slab was applied in all patients for
1 week.
The external fixator was removed in all patients after 8 weeks.
No extra wire was used in any patient.
15. Group 2: volar locked plating
The FCR approach for distal radius
Under control of c-arm
Cast applied to prevent free mobilization
16. The patients of both groups were discharged after 2 days
proper antibiotic coverage (3rd generation cephalosporin for 3
days)
The patients were recalled for suture removal and to see the
reduction in fracture radiologically after 10 days. Acceptable criteria
for fracture reduction were:
1- radial inclination of >15
2- radial shortening <5mm compared to the contralateral side
3- sagittal tilt between 15 dorsal and 20 volar tilt
4- intra-articular step off <2 mm.
All the patients
17. Followed for 6 months and 1 year after surgery.
Assessed for pain, grip strength, wrist range of motion
(rom) and activity.
Scored according to the Green And O’brien scoring system.
All the patients
18. All data were entered in SPSS 20.0 (IBM SPSS Inc. USA).
The mean values of scores between the two techniques
were compared by Student’s t-test
scores at different intervals within the same group were
compared by paired Sample t-test.
19.
20. Follow-up data could be obtained for :-
109 patients after 6 months.
100 patients (91.7 %) after 1 year.
22. Mean surgery time was 35.1±2.5 in the external fixation
group and 56.5±2.7 min in the volar plate fixation group
Reduction in fracture was achieved in all patients in both
groups and no patient required revision surgery
One patient in the volar locking plate group developed
Complex regional pain syndrome that improved Within 2
months by physical therapy and pain medication.
Swelling, inflammation and occasional pain were observed
In two patients in the external fixation group and one
Patient in the volar locking plate group.
23. External fixator group:-
A significant reduction in pain, increased ROM, grip
strength, activity and final score after 1 year follow-up
compared to that at 6 month follow-up
24. Volar locking plate group:-
No change in pain, ROM and grip strength; however,
there was a significant change in activity and final score at
1 year compared to 6 month follow-up
25. At 6 month follow up:
low pain and high ROM in patients treated with volar locking plates
compared to those treated by external fixation
At 1 year follow up:
a significant increase in only ROM, grip strength and final outcome in
patients treated with external fixation compared to patients treated
with volar locking plates.
No difference was found in pain and activity between patients
in either group.
26. Comparison of Green and O’Brien score in two techniques
at 1 year follow-up in two age group:
External fixator group:
Patients aged <50 years had a better outcome than patients aged
>50
years in all parameters studied at the end of 1 year.
volar plating group:
there was no change in pain, ROM grip strength and activity in these
two age groups
27.
28. • Prospective randomized study
• Follow up period is sufficient for the outcome.
• No conflict of interest
• The study was authorized by the local ethical
committee
• Fair sample of patients
Good points:
29. Negative points:
Authors involved in evaluating patients, not
blinded to the study
Didn’t mention about confounding factors like
smoking or diabetes.
No mention of co-morbidities of patient
33. After acceptable radiological reduction Was achieved in all
patients, external fixation has superiority over volar
locked plating techniques at final outcome.
At 1 year follow-up. Patients aged <50 years had better
Results when treated with external Fixation.
Study recommend external fixation technique in treating
displaced intra-articular distal end radius Fractures
(cooney’s type IV).