This document describes an experiment to study the anti-ulcer activity of drugs using a NSAID-induced ulcer model in rats. The experiment involves pretreating rats with cimetidine or ranitidine before administering ulcerogenic NSAIDs like aspirin or indomethacin. The rats are then sacrificed and their stomachs examined for ulcers. Parameters like gastric volume, acidity, and ulcer index are measured and compared between treated and untreated groups to determine the antisecretory and ulcer protective effects of cimetidine and ranitidine. The results show that cimetidine and ranitidine reduce gastric acid secretion and inhibit ulcer formation in NSAID-treated rats.