This document describes an experiment to study the anti-ulcer activity of drugs like ranitidine and cimetidine using a pylorus ligation rat model. Rats were divided into control, cimetidine, and ranitidine groups. The pylorus of rats were ligated for 4 hours to induce ulcers. Drugs were administered before ligation. After ligation, gastric contents were analyzed for volume, pH, and acidity. Stomachs were examined for ulcers. Cimetidine and ranitidine showed reduced gastric acid secretion and fewer ulcers compared to controls, demonstrating their antiulcer activity.