Chapter 5 of 'Engineering Economy' focuses on evaluating project profitability through methods such as present worth (PW), future worth (FW), annual worth (AW), internal and external rates of return (IRR and ERR), and payback period. The Preferred method is present worth, which shows the net cash flow in relation to a minimum attractive rate of return (MARR). The chapter also discusses examples such as bond valuation and capitalized worth, illustrating how to apply these economic analysis techniques.