This document discusses different methods for mapping disease data, including scatter mapping, choropleth mapping, and disease mapping. It describes using rates to map disease data by dividing case counts by population at risk. Examples are provided of mapping lung cancer rates in the US to show higher rates in Appalachian regions and lower rates in parts of the West. The document discusses evaluating spatial clusters using techniques like Moran's I and issues with using crude rates for small, sparse populations. It introduces empirical Bayesian estimation methods that "borrow strength" from neighboring areas to produce more stable risk estimates for mapping.
VISION / AMBITION
-Australia the first drone-sensed nation (cm-scale)
-Pre-competitive data release for industry, environmental management, education & research
-Conventional survey & remote sensing techniques at ultra-high resolution and flexibility (time-series, rapid response etc)
-Next gen “UNDERCOVER” techniques (minerals and water resources)
VISION / AMBITION
-Australia the first drone-sensed nation (cm-scale)
-Pre-competitive data release for industry, environmental management, education & research
-Conventional survey & remote sensing techniques at ultra-high resolution and flexibility (time-series, rapid response etc)
-Next gen “UNDERCOVER” techniques (minerals and water resources)
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
International Journal of Modern Engineering Research (IJMER) covers all the fields of engineering and science: Electrical Engineering, Mechanical Engineering, Civil Engineering, Chemical Engineering, Computer Engineering, Agricultural Engineering, Aerospace Engineering, Thermodynamics, Structural Engineering, Control Engineering, Robotics, Mechatronics, Fluid Mechanics, Nanotechnology, Simulators, Web-based Learning, Remote Laboratories, Engineering Design Methods, Education Research, Students' Satisfaction and Motivation, Global Projects, and Assessment…. And many more.
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
International Journal of Modern Engineering Research (IJMER) covers all the fields of engineering and science: Electrical Engineering, Mechanical Engineering, Civil Engineering, Chemical Engineering, Computer Engineering, Agricultural Engineering, Aerospace Engineering, Thermodynamics, Structural Engineering, Control Engineering, Robotics, Mechatronics, Fluid Mechanics, Nanotechnology, Simulators, Web-based Learning, Remote Laboratories, Engineering Design Methods, Education Research, Students' Satisfaction and Motivation, Global Projects, and Assessment…. And many more.
Exploratory Data Analysis for Biotechnology and Pharmaceutical SciencesParag Shah
This presentation will give perfect understanding of data, data types, level of measurements, exploratory data analysis and more importantly, when to use which type of summary statistics and graphs
STAT 350 (Spring 2017) Homework 11 (20 points + 1 point BONUS).docxwhitneyleman54422
STAT 350 (Spring 2017) Homework 11 (20 points + 1 point BONUS) 1
Practice Problems: 12.5 (p. 588), 12.9 (p.588)
(4 pts.) 1. For each of the following graphs, identify the form, direction (if possible) and relative
strength. In addition, state if you think that there is an association between X and Y. No
explanation is required.
a) b)
c) d)
STAT 350 (Spring 2017) Homework 11 (20 points + 1 point BONUS) 2
(14 pts.) 2. Deep-water (>300m) wave forecasts are important for large cargo ships. One
method of prediction suggests that the wind speed (x, in knots) is linearly related to the wave
height (y, in feet). A random sample of buoys was obtained, and the wind speed and wave
height was measured at each. The summary data is shown below.
n = 20, SXX = 91.75, SYY = 15.952, SXY= 36.4, x̄ = 9.25, ȳ = 1.68
The scatter plot of the data is shown below:
(2 pts.) a) Find the estimated regression line for the regression of Wave Height as a function of
Wind Speed.
(1 pt.) b) Does the y-intercept have any physical meaning?
(1 pt.) c) How much change in wave height is expected when the wind speed increases by one
knot? Please explain your answer.
(1 pt.) d) What is the expected value of wave height when the wind speed is 8.6 knots (10
mph)?
(6 pts.) e) Complete the following ANOVA table.
Source of variation Degrees of Freedom Sum of squares Mean square
Regression
Error
Total
(1 pt.) f) What is the estimated variance?
(1 pt.) g) What is the proportion of the wave height that is explained by wind speed?
(1 pt.) h) From the information in the previous parts of this question, do you believe that there is
an association between wave height and wind speed? Please explain your answer. No
additional calculations are required.
STAT 350 (Spring 2017) Homework 11 (20 points + 1 point BONUS) 3
(2 pts.) 3. Some physicians use the cholesterol ratio (CR = total cholesterol/HDL cholesterol) as
a measure of a patient’s risk of heart disease. In addition, the triglyceride concentration (TG)
is associated with coronary artery disease in many patients. In a study of the relationship
between these two variables, a random sample of adults was obtained, and the triglyceride
level denoted as x1 in mg/dL and cholesterol ratio (y) was obtained for each person. The
scatterplot and regression line of ln(triglyceride level - 129) denoted as x2 vs. cholesterol ratio
is below.
The ANOVA summary table is
Source of Variation Sum of Squares Degrees of freedom Mean Square
Regression 103.16 1 103.16
Error 3.20 23 0.14
Total 106.36 24
(1 pt.) a) What is the coefficient of determination?
(1 pt.) b) Do you think that an increase in the triglyceride level causes an increase in the
cholesterol level? Please explain your answer.
(1 pt.) BONUS: Why do you think that they had to take the logarithm of the triglyceride level?
Additional Problems: Note, the book gives.
Kirsimarja Raitasalo, THL: Miksi päihdehaittoja on tärkeää ehkäistä kouluissa ja oppilaitoksissa - Nuorten päihteidenkäytön yleiskuva. Ehkäisevä päihdetyö lasten ja nuorten hyvinvoinnin tukijana kouluissa ja oppilaitoksissa -verkkoaineisto sujuvamman työn tueksi -webinaari, 10.10.2022
Marke Hietanen-Peltola & Johanna Jahnukainen, THL: Miten opiskeluhuoltopalvelut tukevat hyvinvointia ja ehkäisevät päihdehaittoja. Ehkäisevä päihdetyö lasten ja nuorten hyvinvoinnin tukijana kouluissa ja oppilaitoksissa -verkkoaineisto sujuvamman työn tueksi -webinaari, 10.10.2022.
Riina Länsikallio, OPH: Päihdekasvatus ja ehkäisevä päihdetyö kouluissa ja oppilaitoksissa. Ehkäisevä päihdetyö lasten ja nuorten hyvinvoinnin tukijana kouluissa ja oppilaitoksissa -verkkoaineisto sujuvamman työn tueksi -webinaari, 10.10.2022
Jaana Markkula, THL, Ehkäisevä päihdetyö lasten ja nuorten hyvinvoinnin tukijana kouluissa ja oppilaitoksissa -verkkoaineisto sujuvamman työn tueksi -webinaari, 10.10.2022
What is the current Synthetic opioid situation in Europe? How can countries be better prepared and equipped for a continued rise in synthetic opioid prevalence, use, and incidents?
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
Struggling with intense fears that disrupt your life? At Renew Life Hypnosis, we offer specialized hypnosis to overcome fear. Phobias are exaggerated fears, often stemming from past traumas or learned behaviors. Hypnotherapy addresses these deep-seated fears by accessing the subconscious mind, helping you change your reactions to phobic triggers. Our expert therapists guide you into a state of deep relaxation, allowing you to transform your responses and reduce anxiety. Experience increased confidence and freedom from phobias with our personalized approach. Ready to live a fear-free life? Visit us at Renew Life Hypnosis..
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
Navigating the Health Insurance Market_ Understanding Trends and Options.pdfEnterprise Wired
From navigating policy options to staying informed about industry trends, this comprehensive guide explores everything you need to know about the health insurance market.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
1. DISEASE MAPPING
Eric Delmelle
Geography & Earth Sciences, University of North Carolina at Charlotte,N.C.,U.S.A.
University of Eastern Finland (UEF) October 22 2018
Presentation of IMPRO project funded by Strategic Research Council
2. Introduction
• Different ways to map health related data
• Scattermap
• Areal data (choropleth mapping)
• Cases aggregated to geographic units
• Generally mapped as rates, using
population at risk as a denominator
• In the case of breast cancer deaths,
count of cancer deaths divided by
females (can be more restrictive for
the age segment).
Disease mapping Introduction
3. Rationale
• GIScientists and epidemiologists are interested to map the
variation of these rates across a specific region.
Disease mapping
• The map indicates that individuals
dying from tracheal, bronchus and lung
cancer are mostly concentrated in the
Appalachian regions (very rural, with
deprived access to care).
• Very low rates Southern Idaho, and
Utah, but also parts of Arizona, New
Mexico and Colorado. Note that
Southern Idaho and Utah are mostly
Mormon, where smoking is certainly
not encouraged.
Introduction
4. Rationale
Another example for the
Eastern USA, just focusing on
average annual rates for lung
and tracheal cancer rates
among males from 2011 to
2015, and using the 65+ male
census population as the
denominator
Disease mapping Introduction
5. Rationale
Disease mapping
• Clearly we saw some patterns, very
high in the Appalachian, but lower
along the coast.
• We also see thatVirginia has lower
rates.
• There could be some reasons for
this, such as prevention measures
that can vary by state.
• Although smoking is the main factor
contributing to lung cancer, living in
a heavy coal-mining area such as
Kentucky is found to be an
additional risk factor as residents in
these areas are exposed to
pollution from mining activities.
Introduction
6. Estimating spatial patterns/clusters
Disease mapping
• Evaluate whether regions of high rate have a tendency to cluster, using
techniques such as Moran’s I.
• Moran’s I will evaluate whether neighboring census units (in our case, counties)
tend to exhibit similar (high, or low) values.
• Adjacency matrix W; that is for each geographic unit, determine its neighbors, for
instance through an adjacency matrix (0 or 1 – resulting in wij), or the number
of closest neighbors (Rook versus Queen).This can easily be done within a
commercial GIS or Geoda.
Patterns and clustering
7. Estimating spatial patterns/clusters
Disease mapping
• Once this is complete, we can evaluate the Moran’s I.
𝐼 =
𝑁
𝑊
𝑤𝑖𝑗(𝑂𝑖 − 𝑂)(𝑂𝑗 − 𝑂𝑗𝑖
𝑂𝑗 − 𝑂
2
𝑖
With N the number of geographic units and O the rate.The term wij
denotes the adjacency value between i and j and W the sum.
Patterns and clustering
8. Estimating local spatial patterns/clusters
Disease mapping
• Unfortunately, the Moran’s I statistic does not tell us where clusters may be
located. Anselin developed a local version of the test, taking on the same values.
• The results can be particularly useful for health purposes.
Patterns and clustering
9. Estimating local spatial patterns/clusters
Disease mapping
• The local Moran’s I also returns a map of its significance
Patterns and clustering
10. Issues with rates
Disease mapping
• Oftentimes, assumption of normality. But not so evident when you use
proportion or count. – rather use Poisson or binomial distribution…the
variance may be related to the mean value.
Rates
Crude rate
𝑟𝑖 =
𝑂𝑖
𝑃𝑖
with 𝑂𝑖 observed count at i and 𝑃𝑖 the population at risk at i.
The use of crude rates and ratios to estimate rare disease risks in small
areas is often problematic since these measures are typically subject to
large chance variation.
Disease maps that are based directly on these crude estimates are difficult
to interpret and often misleading unreliable rates that occur for sparsely
populated areas and/or rare cancers
11. Issues with rates
Disease mapping Rates
Standard Mortality Rate (SMR) – also called excess or relative risk
Then, the expected number
of events in i 𝐸𝑖 (also noted 𝜇𝑖)
is given as:
Idea is to compare observed mortality rate to a national (or regional) standard.
We will compare the number of events to the expected count of events.
𝜋 =
𝑂𝑖𝑖∈𝐼
𝑃𝑖𝑖∈𝐼
Reference rate
𝐸𝑖 = 𝜋 ∗ 𝑃𝑖
𝑆𝑀𝑅𝑖 =
𝑂𝑖
𝐸𝑖
SMR
13. Issues with rates
Disease mapping Rates
• A very high relative risk (or SMR) could also happen if you have one case, and
expect 0.1 (near 1,000). Interestingly enough, this would lead to the same SMR:
(𝑂𝑖=100, 𝐸𝑖=50) and (𝑂𝑖=3, 𝐸𝑖=1.5) – same SMR.
• But if I add just one case to the second scenario, I would end up with wild SMR.
This suggests that the reliability of the estimates can vary widely and we need to
take the reliability into account.
• Probability mapping maps the probability of getting a count more ‘extreme’ than
the one we actually observed – assumption is that the count in each area is
Poisson distribution with mean value 𝜇𝑖
14. Issues with rates
Disease mapping Rates
• Extreme ratios associated with areas with the smallest populations.
• Solutions. Disease mapping methods, usually using Bayesian inference, seek to
borrow strength across areas to produce stable risk estimates. Essentially, we try
to improve the reliability of observed rates by using (or “borrowing”) information
from neighboring entities (Waller and Gotway 2004).
• The model is fit using data, and estimates of relative risks based on posterior
distributions for the random effects are derived.
• The resulting estimates for disease risks in small areas are based on pooling
information from related areas.
• Maps based on these estimates are often more interpretable and informative
(Lawson et al., 1999; Elliott et al., 2 000).
15. Empirical Bayesian Estimates
Disease mapping EBS
• Let’s suppose that we are trying to estimate the observed rate, say 𝜃𝑖 Then, we
can re-write this as:
• With 𝛾𝑖 and 𝜑𝑖 the mean and the variance of the prior probability distribution,
respectively.The first part of Equation puts emphasis on the observed rate, while
the second emphasizes prior belief.
𝜃𝑖 = 𝑤𝑖 ∗ 𝑟𝑖 + (1 − 𝑤𝑖) ∗ 𝛾𝑖
16. Empirical Bayesian Estimates
Disease mapping EBS
• The term 𝑤𝑖 is defined as follows:
• So then how to get 𝛾𝑖 and 𝜑𝑖? A first estimate would be that 𝛾𝑖 = 𝛾 and 𝜑𝑖 = 𝜑
for all areas.This means that the prior is gamma distributed with two parameters
𝑣 (scale) and 𝛼 (shape).We can deduct that 𝛾 =
𝑣
𝛼
and 𝜑 =
𝑣
𝛼2.
𝑤𝑖 =
𝜑𝑖
𝜑𝑖 +
𝛾𝑖
𝑛𝑖
18. Local Empirical Bayesian Estimates
Disease mapping EBS
Strength is borrowed from to correct for variance instability is localized as
opposed to global (i.e., based on all observations)
19. Local Empirical Bayesian Estimates
Disease mapping EBS
Strength is borrowed from to correct for variance instability is localized as
opposed to global (i.e., based on all observations)
20. Local Empirical Bayesian Estimates
Disease mapping EBS
Strength is borrowed from to correct for variance instability is localized as
opposed to global (i.e., based on all observations)
21. Questions
Department of Geography and Earth Sciences
University of North Carolina at Charlotte
Charlotte, NC 28223
Tel: (704) 687-5991
Email: Eric.Delmelle@uncc.edu
Disease mapping