Tadalafil is a phosphodiesterase type 5 inhibitor used to treat erectile dysfunction. It has a longer duration of action than other PDE5 inhibitors like sildenafil and vardenafil, remaining effective for 36 hours after dosing. Studies show tadalafil significantly improves erectile function in men with diabetes and may provide additional benefits like improved beta-cell function and metabolic syndrome. Tadalafil is also being investigated for treating conditions like pulmonary arterial hypertension.

1. DR B. K. IYER MEDICAL ADVISOR SHELYS PHARMACEUTICALS, TANZANIA Erectile dysfunction! A growing problem

3. IIEF5 parameters

7. Distinguishing psychogenic and organic ED Droupy S et al. (2006) How, why and when should urologists evaluate male sexual function? Nat Clin Pract Urol 3: 84 – 94 doi:10.1038/ ncpuro406

9. WITH FOCUS ON TADALAFIL PDE5 inhibitors

13. MOA of PDE5 5 inhibitors

15. Comparison of sildenafil, vardenafil, tadalafil PDE5 inhibitor Duration Sildenafil 12 hours Vardenafil 4-5 hours Tadalafil 36 hours Vardenafil, however, is the most potent (lowest maximal concentration) and binds to PDE5 more rapidly than the others, thus it has a potential time of onset of 10 minutes.

20. Tadalafil – performance on IIEF5 parameters Overall baseline Placebo, n-122 Tadalafil, n-126

21. Tadalafil - performance on dosage increase

22. Tadalafil - performance on dosage increase

24. CLASS EFFECT OR MOLECULE EFFECT? Bonus effects of Tadalafil

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