The endocrine system: is a network of glands that produce and release hormones directly into the bloodstream to control many important body functions.
Hypothyroidism.
Hyperthyroidism.
The document provides information about the thyroid gland including:
1. The thyroid gland is located in the front of the neck below the larynx and produces thyroid hormones which regulate metabolism and other bodily functions.
2. The thyroid takes up iodine from foods and converts it to thyroid hormones T4 and T3 through a process of iodination and coupling within thyroid follicles.
3. Thyroid hormone production is regulated by TSH from the pituitary gland and a negative feedback loop monitors thyroid hormone levels in the bloodstream.
The document summarizes thyroid hormones and anti-thyroid drugs. It discusses the thyroid gland's structure and location in the neck. The thyroid secretes T4, T3, and calcitonin hormones which regulate growth, metabolism, and other bodily functions. The synthesis of T4 and T3 involves iodide uptake, oxidation, iodination, and coupling steps. Anti-thyroid drugs like propylthiouracil and carbimazole inhibit hormone synthesis. Radioactive iodine isotopes can destroy thyroid tissue to treat hyperthyroidism while drugs like propylthiouracil and carbimazole are used to inhibit hormone synthesis.
The document discusses thyroid metabolic hormones and their functions. It covers:
- Synthesis and secretion of thyroid hormones thyroxine and triiodothyronine by the thyroid gland under control of TSH.
- Physiologic functions of thyroid hormones which increase metabolic rate by activating genes in cells.
- Regulation of thyroid hormone secretion by TSH and TRH from the hypothalamus and pituitary, and by negative feedback from thyroid hormones.
- Diseases of the thyroid including hyperthyroidism which causes excessive thyroid hormone secretion and hypothyroidism which causes inadequate secretion.
The thyroid gland is the largest gland in the body. It produces thyroid hormones like thyroxine (T4) and triiodothyronine (T3) that target cells throughout the body and affect metabolic rate, protein synthesis, and many other systems and functions. The document discusses the effects of thyroid hormones on various body systems as well as conditions that can result from too little or too much thyroid hormone production like hypothyroidism and hyperthyroidism.
The thyroid gland secretes two major hormones: thyroxine (T4) and triiodothyronine (T3). These hormones increase the metabolic rate of the body and are controlled by thyroid-stimulating hormone (TSH) from the pituitary gland. The thyroid traps iodine from the blood and uses it to synthesize T4 and T3 within thyroglobulin follicles. Most secreted hormone is T4, which is later converted to the more potent T3 in tissues. Thyroid hormones increase metabolism, growth, and heart rate by activating nuclear transcription of genes in cells throughout the body. TSH secretion from the pituitary is regulated by thyrotropin-releasing hormone from the hyp
PHYSIOLOGY
OF
THYROID
HORMONES
Understand the significance of the conversion of tetraiodothyronine (T4) to triiodothyronine (T3) and reverse T3 (rT3) in extrathyroidal tissues.
Understand how thyroid hormones produce their cellular effects.
Describe the physiological effects of thyroid hormones in the body.
Outline the mechanisms for regulation of thyroid hormone.
Correlate knowledge to hypo- and hypersecretion of thyroid hormones
The thyroid gland produces thyroid hormones that regulate metabolism. It takes up iodine to produce thyroglobulin, which is the precursor for the active hormones T3 and T4. Production of thyroid hormones is regulated by TSH from the pituitary, which is itself regulated by TRH from the hypothalamus in a negative feedback loop. Both hypothyroidism and hyperthyroidism can result from problems in this regulatory system and cause a variety of symptoms and health effects.
The document provides information about the thyroid gland including:
1. The thyroid gland is located in the front of the neck below the larynx and produces thyroid hormones which regulate metabolism and other bodily functions.
2. The thyroid takes up iodine from foods and converts it to thyroid hormones T4 and T3 through a process of iodination and coupling within thyroid follicles.
3. Thyroid hormone production is regulated by TSH from the pituitary gland and a negative feedback loop monitors thyroid hormone levels in the bloodstream.
The document summarizes thyroid hormones and anti-thyroid drugs. It discusses the thyroid gland's structure and location in the neck. The thyroid secretes T4, T3, and calcitonin hormones which regulate growth, metabolism, and other bodily functions. The synthesis of T4 and T3 involves iodide uptake, oxidation, iodination, and coupling steps. Anti-thyroid drugs like propylthiouracil and carbimazole inhibit hormone synthesis. Radioactive iodine isotopes can destroy thyroid tissue to treat hyperthyroidism while drugs like propylthiouracil and carbimazole are used to inhibit hormone synthesis.
The document discusses thyroid metabolic hormones and their functions. It covers:
- Synthesis and secretion of thyroid hormones thyroxine and triiodothyronine by the thyroid gland under control of TSH.
- Physiologic functions of thyroid hormones which increase metabolic rate by activating genes in cells.
- Regulation of thyroid hormone secretion by TSH and TRH from the hypothalamus and pituitary, and by negative feedback from thyroid hormones.
- Diseases of the thyroid including hyperthyroidism which causes excessive thyroid hormone secretion and hypothyroidism which causes inadequate secretion.
The thyroid gland is the largest gland in the body. It produces thyroid hormones like thyroxine (T4) and triiodothyronine (T3) that target cells throughout the body and affect metabolic rate, protein synthesis, and many other systems and functions. The document discusses the effects of thyroid hormones on various body systems as well as conditions that can result from too little or too much thyroid hormone production like hypothyroidism and hyperthyroidism.
The thyroid gland secretes two major hormones: thyroxine (T4) and triiodothyronine (T3). These hormones increase the metabolic rate of the body and are controlled by thyroid-stimulating hormone (TSH) from the pituitary gland. The thyroid traps iodine from the blood and uses it to synthesize T4 and T3 within thyroglobulin follicles. Most secreted hormone is T4, which is later converted to the more potent T3 in tissues. Thyroid hormones increase metabolism, growth, and heart rate by activating nuclear transcription of genes in cells throughout the body. TSH secretion from the pituitary is regulated by thyrotropin-releasing hormone from the hyp
PHYSIOLOGY
OF
THYROID
HORMONES
Understand the significance of the conversion of tetraiodothyronine (T4) to triiodothyronine (T3) and reverse T3 (rT3) in extrathyroidal tissues.
Understand how thyroid hormones produce their cellular effects.
Describe the physiological effects of thyroid hormones in the body.
Outline the mechanisms for regulation of thyroid hormone.
Correlate knowledge to hypo- and hypersecretion of thyroid hormones
The thyroid gland produces thyroid hormones that regulate metabolism. It takes up iodine to produce thyroglobulin, which is the precursor for the active hormones T3 and T4. Production of thyroid hormones is regulated by TSH from the pituitary, which is itself regulated by TRH from the hypothalamus in a negative feedback loop. Both hypothyroidism and hyperthyroidism can result from problems in this regulatory system and cause a variety of symptoms and health effects.
The thyroid gland is a butterfly-shaped organ located in the neck that produces thyroid hormones which regulate metabolism. It begins developing early in gestation and starts producing clinically significant levels of thyroid hormones between 18-20 weeks of gestation. The thyroid secretes thyroxine (T4) and triiodothyronine (T3), the active form, which regulate metabolic rate. Disorders can result from too much or too little thyroid hormone production and include Graves' disease, goiter, hyperthyroidism, hypothyroidism, and cancer.
The document discusses the physiology of thyroid and parathyroid hormones. It describes how iodine is required for the formation of thyroid hormones thyroxine and triiodothyronine within the thyroid gland. The hormones are synthesized from tyrosine residues on thyroglobulin, stored in follicles, and released into blood. They increase metabolism and cellular activity by activating gene transcription in tissues. Effects include increased growth, carbohydrate and fat metabolism, basal metabolic rate, blood flow, and heart rate.
The thyroid gland regulates calcium homeostasis through a complex interplay of parathyroid hormone (PTH), calcitonin, and calcitriol (vitamin D). PTH increases blood calcium by promoting bone resorption and renal reabsorption. Calcitonin decreases blood calcium by inhibiting bone resorption. Calcitriol stimulates intestinal calcium absorption. Together, these hormones tightly control blood calcium levels through effects on bone, kidney, and intestine. Imbalances can lead to hyperparathyroidism, hypoparathyroidism, or vitamin D deficiency disorders.
The document discusses thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) blood tests. TSH is produced in the brain and triggers the thyroid gland to produce T3 and T4, which regulate metabolism. The tests are used to diagnose hyperthyroidism and hypothyroidism, and monitor treatment. Reference ranges, test procedures, and potential signs and symptoms of thyroid disorders are provided.
This document discusses the thyroid gland and thyroid disorders. It covers:
- Hyperthyroidism (overactive thyroid) causes like Graves' disease, symptoms like weight loss and exophthalmos, and treatments like antithyroid drugs and surgery.
- Hypothyroidism (underactive thyroid) causes like Hashimoto's thyroiditis, symptoms like weight gain and myxedema in adults or cretinism in children, and treatment with thyroid hormone replacement.
- Goiter (enlarged thyroid) which can occur in both hyperthyroidism and hypothyroidism, depending on if hormone levels are increased or decreased.
Thyroid function tests help to determine if your thyroid is not working correctly. If blood levels of thyroid hormone are high, the brain senses this and sends a message to stop producing TSH.
This document provides an overview of the thyroid gland and thyroid hormones. It discusses the functional anatomy and gross anatomy of the thyroid, as well as the histological structure. It explains the biosynthesis and storage of thyroid hormones, their secretion, transport, and metabolism. It covers the regulation of thyroid hormone secretion and applied aspects like hyperthyroidism and hypothyroidism. Key points covered include the roles and actions of the thyroid hormones T3 and T4, iodine metabolism in the thyroid, and thyroid function tests.
The thyroid gland secretes two main hormones: triiodothyronine (T3) and thyroxine (T4). Their synthesis requires iodine and occurs through four steps: uptake of iodine, activation of iodine, iodination of tyrosine residues on thyroglobulin, and coupling of iodotyrosines. The hormones are stored, secreted into blood when stimulated by TSH, and transported bound to carrier proteins. They are degraded through deiodination and excretion in the bile and urine. T3 and T4 increase metabolic rate and oxygen consumption, promote protein synthesis, and regulate glucose and lipid metabolism.
Thyroid hormones T3 and T4 are produced by the thyroid gland and regulate metabolism. T4 is converted to the more active T3 in tissues. Their production requires iodine and is regulated by TSH from the pituitary which is inhibited by thyroid hormone feedback. Thyroid hormones act through nuclear receptors to increase gene transcription and metabolism. Deficiency causes hypothyroidism while excess causes hyperthyroidism, and both can impact growth, development and multiple body systems.
The document discusses thyroid hormones, their biosynthesis, regulation, actions, and peripheral conversion. Some key points:
- Thyroid hormones T4 and T3 are synthesized in thyroid follicles from iodine and tyrosine. T4 is the main secretory product while T3 is the biologically active form.
- TSH stimulates thyroid hormone synthesis and secretion. T4 is converted to T3 in tissues by deiodinase enzymes.
- Thyroid hormones are transported bound to carrier proteins and the free forms enter cells to increase metabolism.
- Thyroid hormone levels are regulated by a negative feedback loop involving the hypothalamus, pituitary and thyroid gland.
The thyroid gland is located in the neck below the larynx. It produces hormones that regulate metabolism. The document discusses hyperthyroidism and hypothyroidism, which are excess and insufficient thyroid hormone production respectively. Graves' disease is an autoimmune cause of hyperthyroidism where antibodies stimulate the thyroid gland to produce too much hormone. Symptoms of Graves' disease include weight loss, rapid heartbeat, anxiety, and bulging eyes. Treatment options include antithyroid medications, beta blockers, radioactive iodine therapy, or surgery to remove the thyroid gland.
Thyroid hormone (The Guyton and Hall physiology)Maryam Fida
THYROID HORMONE
Location:
The thyroid gland located below the larynx on each side of and anterior to the trachea.
Largest Endocrine Hormone
Secretion:
secretes:
1. thyroxine (T4)
2. triiodothyronine (T3)
3. Also secretes calcitonin (an important hormone for calcium metabolism)
Cell: Thyrotopes
secretion is controlled by thyroid-stimulating hormone (TSH) from the anterior pituitary gland.
93% T4 & 7% T3
T4→T3 in tissues
Qualitatively same
Differ in Rapidity & Intensity of action.
T3 is 4 times more potent than T4, but decrease conc. In blood & decrease half life.
T3 and T4 combine mainly with thyroxine-binding globulin.
More than 90% of Thyroid hormone that binds with cellular receptors is T3.
T4
No effect for 2-3 days after injection
Long Latent Period.
Activity peaks in 10-12 days & ↓↓ with a half life of 15 days.
In some cases it takes 6 weeks-2 months.
T3
4 times rapid
Latent Period 6-12 hours
Peak in 2-3 days
Composed of large numbers of closed follicles filled with colloid and lined with cuboidal epithelial cells that secrete into the interior of the follicles
The major component of colloid is the large glycoprotein Thyroglobulin contains the thyroid hormones within its molecule.
50mg/year, 1mg/week
Ingested iodine in the form of iodides
Iodides ingested orally are absorbed from GIT
⅕ removed from the blood by thyroid cells for synthesis of hormones; rest excreted through kidneys.
Basal membrane of thyroid cells has an active pump to push iodides to interior (Iodine Pump).
Normally 30% more conc. Inside
Max. active 250% more conc. Inside
The rate of Iodine trapping is influenced by conc. of TSH
TSH stimulates and hypophysectomy greatly diminishes the activity of the iodide pump in thyroid cells.
The document provides information about thyroid gland disorders including hypothyroidism and hyperthyroidism. It discusses the anatomy and blood supply of the thyroid gland. It describes Hashimoto's thyroiditis as the most common cause of hypothyroidism due to an autoimmune reaction. Graves' disease is outlined as the most common cause of hyperthyroidism, also caused by an autoimmune process involving thyroid stimulating antibodies. The clinical features, investigations, and treatment approaches for hypothyroidism and hyperthyroidism are summarized.
The thyroid gland produces thyroid hormones that regulate metabolism. The thyroid synthesizes and releases triiodothyronine (T3) and thyroxine (T4), which are influenced by TSH from the pituitary and regulated by the hypothalamus. Hyperthyroidism results from excessive secretion of T3 and T4 due to Graves' disease or toxic nodular goiter. Hypothyroidism slows metabolism due to decreased T3 and T4 from conditions like surgical removal or inflammation of the thyroid. Common thyroid tumors include benign adenomas and malignant papillary or follicular carcinomas. Thyroiditis is inflammation of the thyroid and can be acute from infection, subacute from viruses, or autoimmune
The thyroid gland is responsible for regulating how your body uses energy.The thyroid also produces hormones critical to proper cell and system functioning. The Thyroid Panel screens for thyroid disease, hyperthyroidism and hypothyroidism by examining your body’s production of the thyroid hormones TSH, T3 and T4.
This document provides an overview of thyroid hormone physiology. It discusses the anatomy and iodine uptake of the thyroid gland. The biosynthesis and secretion of thyroid hormones T4 and T3 is described, including their transport through the bloodstream. The document outlines the activation and degradation of thyroid hormones in target tissues via deiodinase enzymes. It discusses the physiological effects of thyroid hormones in increasing metabolism and temperature. The control and regulation of thyroid hormones by the hypothalamic-pituitary-thyroid axis is summarized. Finally, the document briefly discusses thyroid disease states like hyperthyroidism and hypothyroidism, as well as thyroid function tests and antithyroid medications.
The document summarizes the physiology of the thyroid gland. It discusses the anatomy of the thyroid gland, the synthesis and secretion of thyroid hormones, and the regulation of thyroid hormone secretion. It describes the major actions of thyroid hormones on metabolism, body systems, and growth. It also discusses diseases associated with underactivity and overactivity of the thyroid gland, such as hypothyroidism (underactivity) and hyperthyroidism (overactivity).
This document discusses thyroid function tests used to evaluate thyroid status. It describes the thyroid hormones T4 and T3, their binding proteins, and differences between the hormones. Thyroid disorders like hypothyroidism and hyperthyroidism are explained along with their causes and symptoms. Various thyroid tests are outlined that measure thyroid hormone levels, evaluate the hypothalamic-pituitary-thyroid axis through TSH and TRH tests, assess thyroid gland function using radioactive iodine uptake, and detect anti-thyroid antibodies. Reference ranges are provided for interpretation of different thyroid function test results in conditions like hypothyroidism, hyperthyroidism, and euthyroid sick syndrome.
The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3.The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production.
Hyperthyroidism refers to excessive secretion of thyroid hormones due to overactivity of the thyroid gland. Common causes include Graves' disease, toxic multinodular goiter, and toxic adenoma. Symptoms include nervousness, palpitations, heat intolerance, weight loss, and tremors. Diagnosis involves blood tests to measure thyroid hormones and TSH levels. Treatment options include anti-thyroid medications, radioactive iodine therapy, and surgery. Hypothyroidism is underactivity of the thyroid gland resulting in low thyroid hormone levels and symptoms like fatigue, weight gain, dry skin and constipation. Primary causes are autoimmune disease and treatment for hyperthyroidism. Treatment is thyroid hormone replacement medication.
The document discusses hyperthyroidism and hypothyroidism.
Hyperthyroidism results from excess thyroid hormone in the blood and common causes include Graves' disease, toxic adenomas, and thyroiditis. Symptoms include nervousness, rapid heart rate, weight loss, and eye changes. Diagnosis involves thyroid function tests and treatment options are anti-thyroid medications, radioactive iodine, beta blockers, or surgery.
Hypothyroidism is caused by an underactive thyroid gland and risks factors include older age and autoimmune diseases. Symptoms are fatigue, weight gain, dry skin and constipation. Diagnosis is via thyroid hormone levels and treatment is thyroid hormone replacement medication.
The thyroid gland is a butterfly-shaped organ located in the neck that produces thyroid hormones which regulate metabolism. It begins developing early in gestation and starts producing clinically significant levels of thyroid hormones between 18-20 weeks of gestation. The thyroid secretes thyroxine (T4) and triiodothyronine (T3), the active form, which regulate metabolic rate. Disorders can result from too much or too little thyroid hormone production and include Graves' disease, goiter, hyperthyroidism, hypothyroidism, and cancer.
The document discusses the physiology of thyroid and parathyroid hormones. It describes how iodine is required for the formation of thyroid hormones thyroxine and triiodothyronine within the thyroid gland. The hormones are synthesized from tyrosine residues on thyroglobulin, stored in follicles, and released into blood. They increase metabolism and cellular activity by activating gene transcription in tissues. Effects include increased growth, carbohydrate and fat metabolism, basal metabolic rate, blood flow, and heart rate.
The thyroid gland regulates calcium homeostasis through a complex interplay of parathyroid hormone (PTH), calcitonin, and calcitriol (vitamin D). PTH increases blood calcium by promoting bone resorption and renal reabsorption. Calcitonin decreases blood calcium by inhibiting bone resorption. Calcitriol stimulates intestinal calcium absorption. Together, these hormones tightly control blood calcium levels through effects on bone, kidney, and intestine. Imbalances can lead to hyperparathyroidism, hypoparathyroidism, or vitamin D deficiency disorders.
The document discusses thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) blood tests. TSH is produced in the brain and triggers the thyroid gland to produce T3 and T4, which regulate metabolism. The tests are used to diagnose hyperthyroidism and hypothyroidism, and monitor treatment. Reference ranges, test procedures, and potential signs and symptoms of thyroid disorders are provided.
This document discusses the thyroid gland and thyroid disorders. It covers:
- Hyperthyroidism (overactive thyroid) causes like Graves' disease, symptoms like weight loss and exophthalmos, and treatments like antithyroid drugs and surgery.
- Hypothyroidism (underactive thyroid) causes like Hashimoto's thyroiditis, symptoms like weight gain and myxedema in adults or cretinism in children, and treatment with thyroid hormone replacement.
- Goiter (enlarged thyroid) which can occur in both hyperthyroidism and hypothyroidism, depending on if hormone levels are increased or decreased.
Thyroid function tests help to determine if your thyroid is not working correctly. If blood levels of thyroid hormone are high, the brain senses this and sends a message to stop producing TSH.
This document provides an overview of the thyroid gland and thyroid hormones. It discusses the functional anatomy and gross anatomy of the thyroid, as well as the histological structure. It explains the biosynthesis and storage of thyroid hormones, their secretion, transport, and metabolism. It covers the regulation of thyroid hormone secretion and applied aspects like hyperthyroidism and hypothyroidism. Key points covered include the roles and actions of the thyroid hormones T3 and T4, iodine metabolism in the thyroid, and thyroid function tests.
The thyroid gland secretes two main hormones: triiodothyronine (T3) and thyroxine (T4). Their synthesis requires iodine and occurs through four steps: uptake of iodine, activation of iodine, iodination of tyrosine residues on thyroglobulin, and coupling of iodotyrosines. The hormones are stored, secreted into blood when stimulated by TSH, and transported bound to carrier proteins. They are degraded through deiodination and excretion in the bile and urine. T3 and T4 increase metabolic rate and oxygen consumption, promote protein synthesis, and regulate glucose and lipid metabolism.
Thyroid hormones T3 and T4 are produced by the thyroid gland and regulate metabolism. T4 is converted to the more active T3 in tissues. Their production requires iodine and is regulated by TSH from the pituitary which is inhibited by thyroid hormone feedback. Thyroid hormones act through nuclear receptors to increase gene transcription and metabolism. Deficiency causes hypothyroidism while excess causes hyperthyroidism, and both can impact growth, development and multiple body systems.
The document discusses thyroid hormones, their biosynthesis, regulation, actions, and peripheral conversion. Some key points:
- Thyroid hormones T4 and T3 are synthesized in thyroid follicles from iodine and tyrosine. T4 is the main secretory product while T3 is the biologically active form.
- TSH stimulates thyroid hormone synthesis and secretion. T4 is converted to T3 in tissues by deiodinase enzymes.
- Thyroid hormones are transported bound to carrier proteins and the free forms enter cells to increase metabolism.
- Thyroid hormone levels are regulated by a negative feedback loop involving the hypothalamus, pituitary and thyroid gland.
The thyroid gland is located in the neck below the larynx. It produces hormones that regulate metabolism. The document discusses hyperthyroidism and hypothyroidism, which are excess and insufficient thyroid hormone production respectively. Graves' disease is an autoimmune cause of hyperthyroidism where antibodies stimulate the thyroid gland to produce too much hormone. Symptoms of Graves' disease include weight loss, rapid heartbeat, anxiety, and bulging eyes. Treatment options include antithyroid medications, beta blockers, radioactive iodine therapy, or surgery to remove the thyroid gland.
Thyroid hormone (The Guyton and Hall physiology)Maryam Fida
THYROID HORMONE
Location:
The thyroid gland located below the larynx on each side of and anterior to the trachea.
Largest Endocrine Hormone
Secretion:
secretes:
1. thyroxine (T4)
2. triiodothyronine (T3)
3. Also secretes calcitonin (an important hormone for calcium metabolism)
Cell: Thyrotopes
secretion is controlled by thyroid-stimulating hormone (TSH) from the anterior pituitary gland.
93% T4 & 7% T3
T4→T3 in tissues
Qualitatively same
Differ in Rapidity & Intensity of action.
T3 is 4 times more potent than T4, but decrease conc. In blood & decrease half life.
T3 and T4 combine mainly with thyroxine-binding globulin.
More than 90% of Thyroid hormone that binds with cellular receptors is T3.
T4
No effect for 2-3 days after injection
Long Latent Period.
Activity peaks in 10-12 days & ↓↓ with a half life of 15 days.
In some cases it takes 6 weeks-2 months.
T3
4 times rapid
Latent Period 6-12 hours
Peak in 2-3 days
Composed of large numbers of closed follicles filled with colloid and lined with cuboidal epithelial cells that secrete into the interior of the follicles
The major component of colloid is the large glycoprotein Thyroglobulin contains the thyroid hormones within its molecule.
50mg/year, 1mg/week
Ingested iodine in the form of iodides
Iodides ingested orally are absorbed from GIT
⅕ removed from the blood by thyroid cells for synthesis of hormones; rest excreted through kidneys.
Basal membrane of thyroid cells has an active pump to push iodides to interior (Iodine Pump).
Normally 30% more conc. Inside
Max. active 250% more conc. Inside
The rate of Iodine trapping is influenced by conc. of TSH
TSH stimulates and hypophysectomy greatly diminishes the activity of the iodide pump in thyroid cells.
The document provides information about thyroid gland disorders including hypothyroidism and hyperthyroidism. It discusses the anatomy and blood supply of the thyroid gland. It describes Hashimoto's thyroiditis as the most common cause of hypothyroidism due to an autoimmune reaction. Graves' disease is outlined as the most common cause of hyperthyroidism, also caused by an autoimmune process involving thyroid stimulating antibodies. The clinical features, investigations, and treatment approaches for hypothyroidism and hyperthyroidism are summarized.
The thyroid gland produces thyroid hormones that regulate metabolism. The thyroid synthesizes and releases triiodothyronine (T3) and thyroxine (T4), which are influenced by TSH from the pituitary and regulated by the hypothalamus. Hyperthyroidism results from excessive secretion of T3 and T4 due to Graves' disease or toxic nodular goiter. Hypothyroidism slows metabolism due to decreased T3 and T4 from conditions like surgical removal or inflammation of the thyroid. Common thyroid tumors include benign adenomas and malignant papillary or follicular carcinomas. Thyroiditis is inflammation of the thyroid and can be acute from infection, subacute from viruses, or autoimmune
The thyroid gland is responsible for regulating how your body uses energy.The thyroid also produces hormones critical to proper cell and system functioning. The Thyroid Panel screens for thyroid disease, hyperthyroidism and hypothyroidism by examining your body’s production of the thyroid hormones TSH, T3 and T4.
This document provides an overview of thyroid hormone physiology. It discusses the anatomy and iodine uptake of the thyroid gland. The biosynthesis and secretion of thyroid hormones T4 and T3 is described, including their transport through the bloodstream. The document outlines the activation and degradation of thyroid hormones in target tissues via deiodinase enzymes. It discusses the physiological effects of thyroid hormones in increasing metabolism and temperature. The control and regulation of thyroid hormones by the hypothalamic-pituitary-thyroid axis is summarized. Finally, the document briefly discusses thyroid disease states like hyperthyroidism and hypothyroidism, as well as thyroid function tests and antithyroid medications.
The document summarizes the physiology of the thyroid gland. It discusses the anatomy of the thyroid gland, the synthesis and secretion of thyroid hormones, and the regulation of thyroid hormone secretion. It describes the major actions of thyroid hormones on metabolism, body systems, and growth. It also discusses diseases associated with underactivity and overactivity of the thyroid gland, such as hypothyroidism (underactivity) and hyperthyroidism (overactivity).
This document discusses thyroid function tests used to evaluate thyroid status. It describes the thyroid hormones T4 and T3, their binding proteins, and differences between the hormones. Thyroid disorders like hypothyroidism and hyperthyroidism are explained along with their causes and symptoms. Various thyroid tests are outlined that measure thyroid hormone levels, evaluate the hypothalamic-pituitary-thyroid axis through TSH and TRH tests, assess thyroid gland function using radioactive iodine uptake, and detect anti-thyroid antibodies. Reference ranges are provided for interpretation of different thyroid function test results in conditions like hypothyroidism, hyperthyroidism, and euthyroid sick syndrome.
The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3.The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production.
Hyperthyroidism refers to excessive secretion of thyroid hormones due to overactivity of the thyroid gland. Common causes include Graves' disease, toxic multinodular goiter, and toxic adenoma. Symptoms include nervousness, palpitations, heat intolerance, weight loss, and tremors. Diagnosis involves blood tests to measure thyroid hormones and TSH levels. Treatment options include anti-thyroid medications, radioactive iodine therapy, and surgery. Hypothyroidism is underactivity of the thyroid gland resulting in low thyroid hormone levels and symptoms like fatigue, weight gain, dry skin and constipation. Primary causes are autoimmune disease and treatment for hyperthyroidism. Treatment is thyroid hormone replacement medication.
The document discusses hyperthyroidism and hypothyroidism.
Hyperthyroidism results from excess thyroid hormone in the blood and common causes include Graves' disease, toxic adenomas, and thyroiditis. Symptoms include nervousness, rapid heart rate, weight loss, and eye changes. Diagnosis involves thyroid function tests and treatment options are anti-thyroid medications, radioactive iodine, beta blockers, or surgery.
Hypothyroidism is caused by an underactive thyroid gland and risks factors include older age and autoimmune diseases. Symptoms are fatigue, weight gain, dry skin and constipation. Diagnosis is via thyroid hormone levels and treatment is thyroid hormone replacement medication.
Hyperthyroidism refers to overactivity of the thyroid gland resulting in excessive secretion of thyroid hormones throughout the body. Some common causes include Graves' disease, toxic adenomas, and thyroiditis. Symptoms include nervousness, palpitations, heat intolerance, tremor, and weight loss. Diagnosis involves tests of thyroid and pituitary hormones. Treatment options are radioactive iodine to destroy the thyroid gland, anti-thyroid medications, beta-blockers to control symptoms, or surgery to remove part or all of the thyroid. Nursing care focuses on managing nutrition, activity tolerance, risk of injury from eye involvement, and hyperthermia due to the increased metabolic rate.
Hypothyroidism is a disorder that occurs when the thyroid gland does not make enough thyroid hormone to meet the body’s needs.
Hyperthyroidism is a disorder that occurs when the thyroid gland makes more thyroid hormone than the body needs.
Graves' disease is an autoimmune disease where the immune system attacks the thyroid gland, causing it to produce too much thyroxine. Some common symptoms include anxiety, eye irritation, increased sweating, and weight loss. The disease is triggered by antibodies that stimulate thyroid cells to overproduce hormones. Treatments include antithyroid medications, radioactive iodine, or surgery to destroy the thyroid gland, followed by thyroid hormone replacement medication. Eye problems related to Graves' disease may also require additional treatments.
The thyroid gland is located in the neck and produces hormones that regulate metabolism. It contains two main hormones: T3 and T4. The thyroid is controlled by the hypothalamus and pituitary gland. Hypothyroidism is caused by an underactive thyroid and results in low hormone levels and symptoms like fatigue and weight gain. It is typically treated with levothyroxine hormone replacement therapy. Hyperthyroidism is caused by an overactive thyroid and results in high hormone levels and symptoms like weight loss and palpitations.
The document discusses disorders of the thyroid gland, including hypothyroidism and hyperthyroidism. It begins by reviewing the anatomy and physiology of the thyroid gland and hypothalamic-pituitary-thyroid feedback system. Hypothyroidism can be congenital or acquired, and if during childhood causes cretinism. Acquired hypothyroidism in adults is called myxedema. Hyperthyroidism results from increased thyroid hormone secretion and can be caused by Graves' disease. Thyroid storm is a life-threatening exacerbation of hyperthyroidism.
Hyperthyroidism refers to overactivity of the thyroid gland resulting in excessive secretion of thyroid hormones. The thyroid gland produces thyroid hormones which regulate metabolism. Common causes of hyperthyroidism include Graves' disease, multinodular goiter, and thyroiditis. Signs and symptoms include nervousness, palpitations, heat intolerance, tremors, and weight loss. Diagnosis involves thyroid function tests and scans. Treatment options include anti-thyroid medications, radioactive iodine, and surgery. Nursing care focuses on managing nutrition, activity tolerance, risk for injury, hyperthermia, and social interaction issues.
This document summarizes diseases of the thyroid gland, including hyperthyroidism and hypothyroidism. It discusses the causes, symptoms, diagnostic tests, and treatments for each condition. Graves' disease is described as the most common cause of hyperthyroidism, resulting from antibodies that continuously stimulate the thyroid. Hypothyroidism can be caused by Hashimoto's thyroiditis or iodine deficiency and results in decreased metabolic rate. Long term thyroid hormone replacement therapy is used to treat hypothyroidism. Cretinism is also discussed as severe hypothyroidism during development that causes physical and mental growth retardation.
This document discusses various drugs that inhibit thyroid hormone production, including their mechanisms of action, indications, and side effects. It also covers thyroid dysfunctions like hyperthyroidism and hypothyroidism, their causes, symptoms, and treatment options. Key drugs discussed are propylthiouracil, methimazole, potassium perchlorate, sodium iodide-131, and inorganic iodides. Conditions covered in detail include Graves' disease, toxic nodular goiter, Hashimoto's thyroiditis, and lymphocytic thyroiditis.
Hyperthyroidism is a condition where the thyroid gland produces excess thyroid hormones. It can be caused by Graves' disease, thyroid nodules, thyroiditis, or too much thyroid medication. Symptoms include rapid heartbeat, nervousness, weight loss, and eye problems. Diagnosis involves blood tests to check thyroid hormone levels and imaging tests of the thyroid gland. Treatment options include antithyroid drugs, radioactive iodine therapy, beta blockers, or surgery to remove the thyroid. A rare and life-threatening complication is thyroid storm, where a large amount of hormones are suddenly released, requiring emergency treatment to lower hormone levels and heart rate.
lecture class for 4th year MBBS students. this lecture is based on the book 'Robbins' Pathologic basis of disease'. This is delivered by Dr. Umme Kulsum Munmun, Assistant professor (pathology) to the 4th year MBBS students of Chandpur Meducal College, Bangladesh
The document discusses hypothyroidism, which is an underactive thyroid gland that cannot produce enough thyroid hormone for the body to function normally. It describes the symptoms of hypothyroidism such as feeling tired, dry skin, forgetfulness, and constipation. The main causes of hypothyroidism include autoimmune disease, surgical removal of the thyroid gland, radiation treatment, and certain medications. Hypothyroidism is typically diagnosed through blood tests to measure thyroid hormone levels. The standard treatment is daily thyroid hormone replacement medication to control the symptoms indefinitely.
This document discusses thyroid function tests, which measure thyroid hormone levels to diagnose thyroid disorders like hypothyroidism and hyperthyroidism. It covers the types of tests, normal hormone rates, interpreting results, preparation, and risks. It also describes the thyroid gland's hormone functions, common thyroid diseases like hypothyroidism and hyperthyroidism, their symptoms and treatments. Dietary modifications for managing thyroid conditions are also outlined.
its all about thyroid gland,functions of thyroid gland,disorders of thyroid gland,signs and symptoms and medications.hope it will be useful for you.thank you,
The document discusses thyroid hormone disorders. It begins by describing the thyroid gland and its hormones. The thyroid regulates metabolism through thyroid stimulating hormone and secretes thyroid hormones T3 and T4. Hypothyroidism occurs when thyroid hormone production is inadequate, while hyperthyroidism is excessive thyroid hormone release. Common causes of hypothyroidism include Hashimoto's thyroiditis and thyroid removal. Graves' disease and toxic adenomas are common causes of hyperthyroidism. Laboratory tests can distinguish between hypo- and hyperthyroid states based on TSH, T3 and T4 levels.
Medical Surgical Nursing PERITONEAL DIALYSIS 2024.ppsxSalah Nazar
type of dialysis that uses peritoneal semipermeable membrane to remove excessive wastes and fluids from the blood in peritoneal vessels to a dialysate solution that implant into peritoneal cavity than drain it outside the body.
Dialysate Solution: the liquid material that passes through the peritoneal membrane in dialysis process
In 1958, Ida Jean Orlando began developing the nursing process still evident in nursing care today. According to Orlando’s theory, the patient’s behavior sets the nursing process in motion. Through the nurse’s knowledge to analyze and diagnose the behavior to determine the patient’s needs.
Application of the fundamental principles of critical thinking, client-centered approaches to treatment, goal-oriented tasks, evidence-based practice (EBP) recommendations, and nursing intuition, the nursing process functions as a systematic guide to client-centered care with five subsequent steps. These are assessment, diagnosis, planning, implementation, and evaluation (ADPIE).
The nursing process is defined as a systematic, rational method of planning that guides all nursing actions in delivering holistic and patient-focused care. The nursing process is a form of scientific reasoning and requires the nurse’s critical thinking to provide the best care possible to the client
The following are the purposes of the nursing process:
To identify the client’s health status and actual or potential health care problems or needs (through assessment).
To establish plans to meet the identified needs.
To deliver specific nursing interventions to meet those needs.
To apply the best available caregiving evidence and promote human functions and responses to health and illness (ANA, 2010).
To protect nurses against legal problems related to nursing care when the standards of the nursing process are followed correctly.
To help the nurse perform in a systematically organized way their practice.
To establish a database about the client’s health status, health concerns, response to illness, and the ability to manage health care needs.
The document describes the four main components of a physical examination:
1. Inspection involves visual examination of the body part. For the abdomen, it notes the shape, skin abnormalities, masses, and movement with respiration.
2. Palpation uses touch, mostly for the abdomen to check for masses, tenderness, or enlarged organs like the liver or kidneys.
3. Percussion taps the body to determine the size, consistency and borders of organs, and presence of fluid, by the sounds produced.
4. Auscultation listens to body sounds like lungs, heart, intestines using a stethoscope to evaluate frequency, intensity, duration, number and quality of sounds. It can also listen
This document discusses appendicitis, including the anatomy of the appendix, causes of appendicitis, clinical manifestations, complications, and management. The appendix is a small sac attached to the cecum. Appendicitis is inflammation of the appendix, which is the most common reason for emergency abdominal surgery. It can occur at any age but is more common in ages 10-30. Acute appendicitis causes sudden severe symptoms within 48 hours, while chronic appendicitis goes undiagnosed for weeks to years. Symptoms include right lower quadrant pain, fever, nausea, and tenderness. Management involves appendectomy, antibiotics, and postoperative care including monitoring for complications like perforation.
This document discusses hepatitis, including its causes, types, transmission, signs and symptoms, and nursing care. The main causes of hepatitis are viral infections, including hepatitis A, B, C, D, E, and G. Hepatitis A is transmitted through contaminated food or water, while hepatitis B, C, and D are transmitted through bodily fluids. Common signs and symptoms include fever, fatigue, nausea, abdominal pain, and jaundice. Nursing care for hepatitis involves monitoring vital signs, providing bed rest, managing fluids and diet, avoiding toxins, administering medications, and assessing the abdomen and mental status.
Peritoneal Dialysis (PD): type of dialysis that uses peritoneal semipermeable membrane to remove excessive wastes and fluids from the blood in peritoneal vessels to a dialysate solution that implant into peritoneal cavity than drain it outside the body.
use artificial kidney to remove waste products and excess water from the patient’s blood
Three primary methods are used to gain access to the blood
Nursing Management of Hemodialysis
This document was prepared by MSN Salah Nazar Abdulwahhab. It appears to be some type of report or analysis created by an individual with the title of MSN, which likely stands for Master of Science in Nursing. Unfortunately no other contextual information is provided in the very brief single sentence document.
Hypertension, or high blood pressure, is defined as a systolic blood pressure over 140 mm Hg or a diastolic pressure over 90 mm Hg. It can be classified based on these levels into normal, prehypertension, stage 1, and stage 2. Primary hypertension, which accounts for 95% of cases, has no identifiable cause and results from an interaction of genetic and lifestyle factors, while secondary hypertension has an identifiable underlying cause. Hypertension often has no symptoms but can sometimes cause headaches, vision problems, chest pain, or other issues. Uncontrolled high blood pressure can damage organs over time and lead to heart attacks, strokes, kidney failure, and other complications. Diagnosis involves blood and urine tests and blood pressure monitoring
This document provides an overview of appendicitis and hernia. It describes the anatomy of the appendix and causes of appendicitis. The clinical manifestations of appendicitis include abdominal pain and fever. Complications can include perforation. Treatment involves appendectomy. Nursing care focuses on pre-operative assessment and IV fluids/antibiotics, as well as post-operative monitoring for complications. Hernias are described as protrusions through weak areas of the abdominal wall. Common types and general causes are outlined. Clinical signs include bulging that reduces with lying down. Treatment options include surgery to repair or reinforce the abdominal wall.
This document discusses key concepts in medical surgical nursing and the nursing process. It defines health according to the WHO as complete physical, mental and social well-being. It outlines Maslow's hierarchy of basic human needs and defines nursing as focused on maintaining or recovering optimal health. The nursing process consists of 5 steps - assessment, diagnosis, planning, implementation, and evaluation. Assessment involves collecting data on a patient's health needs. Nursing diagnosis is a clinical judgment about a patient's response to health problems. Planning identifies priorities, goals and interventions. Evaluation determines if goals were achieved.
Medical surgical nursing health and nursing processSalah Nazar
This document discusses key concepts in medical surgical nursing and the nursing process. It defines health according to the WHO as complete physical, mental and social well-being. It outlines Maslow's hierarchy of basic human needs and defines nursing as focused on maintaining or recovering optimal health. The nursing process is explained as having 5 steps: assessment, diagnosis, planning, implementation, and evaluation. Assessment involves data collection to identify patient needs. Nursing diagnosis is a clinical judgment about a patient's response to health problems. Planning identifies priorities, goals and interventions. Evaluation determines response to interventions and goal achievement.
The nervous system consists of two main parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS contains the brain and spinal cord, which coordinate sensory input and motor output. The PNS has the somatic nervous system, which connects to skeletal muscles, and the autonomic nervous system, which regulates involuntary functions like breathing and digestion. Nerve cells called neurons are the basic building blocks and transmit electrical signals through structures like axons, dendrites, and synapses. The brain is divided into sections that control different functions like movement, senses, and higher thinking. The spinal cord relays signals between the brain and body. The PNS includes cranial and spinal nerves throughout the body
The respiratory system has several functions including breathing, gas exchange, sound production, and smelling. It consists of the upper respiratory tract including the nose, sinuses, pharynx and larynx, and the lower respiratory tract within the thorax including the trachea, bronchi, and lungs. The lungs contain alveoli which are the sites of gas exchange between the bloodstream and body tissues.
The urinary system is composed of the kidneys, ureters, urinary bladder, and urethra. The kidneys filter around 180 liters of blood per day to produce around 1-2 liters of urine, removing waste and regulating fluid, electrolyte, and acid-base balance. The basic functional unit of the kidney is the nephron, which filters blood to form urine. The ureters then transport urine from the kidneys to the urinary bladder, a temporary storage organ. From here, urine exits the body through the urethra upon voluntary muscle control. Together these organs work to maintain homeostasis by filtering waste from the blood and regulating fluid balance.
The skeletal system document discusses the bones that make up the pelvic girdle and lower limbs. The pelvic girdle consists of two hip bones called the coxal bones, which are each made up of three parts - the ilium, ischium, and pubis. These bones connect the lower limbs to the axial skeleton. Each lower limb contains the femur, patella, tibia, fibula, tarsal bones of the ankle, metatarsal bones of the foot, and phalanges of the toes. The document outlines the key features and functions of each of these bones.
The skeletal system consists of 206 bones that provide structure, protection, movement, and support for the body. The axial skeleton includes the bones of the skull, vertebral column, and thoracic cage. The thoracic cage (rib cage) surrounds and protects the heart and lungs and consists of ribs, thoracic vertebrae, sternum, and costal cartilages. The appendicular skeleton includes the bones of the upper and lower limbs and consists of the shoulder girdle, upper extremities, pelvic girdle, and lower extremities. The shoulder girdle includes the clavicles and scapulae and provides attachment points for muscles that help move the arms.
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Endocrine disorders [ Thyroid Gland ]
1. Medical Surgical Nursing
Endocrine Disorders
الصحة معهدالعالي
المادة مدرس
م.إختصاص جامعي
الوهاب عبد نزار صـالح
تمـريض علــوم ماجـستير
Salah Nazar Abdulwahhab M.Sc. Nursing
www.slideshare.net
1
2. Endocrine System
The endocrine system: is a network of
glands that produce and release
hormones directly into the
bloodstream to control many
important body functions
2
3. Thyroid Gland
The thyroid gland: butterfly-shaped gland consists of two lobes connected in the middle by
isthmus located in front of and sides of the trachea just below the larynx [Adam's apple].
Hormones that produced by thyroid gland and circulate directly in the bloodstream.
1- Triiodothyronine (T3): has three iodine atoms
2- Thyroxine (T4): has four iodine atoms
3- Calcitonin: Calcium metabolism (Ca2+)
3
4. Thyroid Hormones Functions
Act nearly on every cell in the body.
1. Increase the basal metabolic rate
2. Affect protein synthesis
3. Help regulate long bone growth (synergy with growth hormone)
4. Neural maturation
5. Increase body sensitivity to adrenaline
6. Development and differentiation of all cells of the human body
7. Regulate protein, fat, and carbohydrate metabolism
8. Stimulate vitamin metabolism.
9. Heat generation
4
5. Hypothyroidism
Hypothyroidism: the thyroid gland does not produce enough thyroid hormone, this leads to
slow down of the body activity
Goiter: is a swelling in the neck resulting from an enlarged thyroid gland, it is associated
with a thyroid disorder and over 90% of goiter cases are caused by iodine deficiency
Causes of Hypothyroidism
1- Hashimoto’s disease [chronic lymphocytic thyroiditis].
2- Thyroiditis.
3- Congenital or family history of hypothyroidism.
4- Surgical removal of part or all of the thyroid .
5- Radiation to the thyroid, neck, or chest.
6- Some medications side effect, as in amiodarone.
7- Disorder of the pituitary gland
8- Little iodine in diet
9- Older age more than 60
10- Autoimmune diseases.
5
6. Signs & Symptoms of Hypothyroidism
1. Fatigue
2. Cold intolerance
3. Decreased sweating
4. Weight gain
5. Joint & muscle pain
6. Constipation
7. Dry skin
8. Dry & thinning hair
9. Depression
10. A puffy face
11. Bradycardia
12. Menstrual disturbance
The Treatment of Hypothyroidism
synthetic thyroxin, [Levothyroxine] a medication that is identical to the hormone T46
7. Hyperthyroidism
Hyperthyroidism: is the condition that occurs due to excessive production of thyroid
hormone by the thyroid gland.
Thyrotoxicosis: is elevated level of free thyroid hormone in serum (from any source)
and suppression of thyroid-stimulating hormone (TSH).
Thyroid storm: is a life-threatening complication of hyperthyroidism (over activity of
the thyroid gland). It is characterized by: [high fever (above 40 °C)], fast and often
irregular heart beat, vomiting, diarrhea, agitation, hypertension with a wide pulse
pressure occurs in early to mid crisis, hypotension and shock in late stage
7
8. Causes of Hyperthyroidism
1- Graves’ disease [toxic diffuse goiter], is an autoimmune disorder
2- Thyroid nodules
3- Thyroiditis
4- Pituitary tumor may secrete excess TSH [Thyroid-stimulating
hormone]
5- Thyroid tumor
6- Overmedicating with synthetic thyroid hormone
7- Consuming too much iodine [iodine-containing medications or
some seafood].
8- Radiation exposure
9- Heredity
10- Older age more than 60
11- Women are (5 to 10) times more likely than men
8
10. Hyperthyroidism Treatment
1- Antithyroid medications: prevent the thyroid to produce excess amounts of T3 and
T4 hormones. (methimazole).
2- Radioactive Iodine Therapy.
3- Thyroid Surgery (partial or total thyroidectomy)
10
11. Thyroidectomy Postoperative Nursing Care
1- Monitor signs of respiratory obstruction
2- Keep the incision site clean and dry
3- Monitor signs of hemorrhage
4- Keep patient in high Fowler's position [60 – 90]
degree
5- Check for laryngeal nerve damage by asking the
patient to speak
6- Monitor signs of thyroid storm
7- Assess for hypocalcaemia (occur when
parathyroid glands damage)
8- Administer medications as ordered
11