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Thyroid Hormones Females
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4. Third step: iodination of tyrosine. iodination of tyrosine takes place in the intact thyroglobulin molecule in the follicular space. Third position of aromatic ring is iodinated first to form MIT, Than the 5 th position to form DIT. Fourth step: Coupling of iodotyrosyls. DIT + DIT T 4 DIT + MIT T 3 Under normal conditions 99% of the hormone produced by thyroid gland is T 4 3,5,3’,5’ Tetraiodothyronine 3,5,3’ Tri-iodothyronine
5. Step-1 Uptake and concentration of iodine Step-2 Activation of iodine Step-3 Iodination of tyrosine Step-4 Coupling of iodotyrosyls Thyroid follicular cell Follicular space
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