A 24-year-old female presented with vomiting, diarrhea, and lethargy for 6 weeks. On examination, she appeared sick and dehydrated. Initial lab work showed elevated blood sugar, low bicarbonate, and other signs of dehydration. Further testing found extremely elevated thyroid hormones. The diagnosis was hyperthyroidism likely due to Graves' disease. She was treated for dehydration and her condition improved. Additional testing confirmed the diagnosis of Graves' disease.
A complete presentation on hypothroidism endocrine disorder based on latest editon of harrison and reference books. this presentation will help to learn about this second most common endocrine disorder.
it was a case study on hypothyroidism in pediatric patient pharmaceutical care plan ,Diagnostic Technics ,treatment and patient counseling was given to the patient representative.
Diseases of the thyroid gland involve:
an insufficient production of the thyroid hormone (hypothyroidism),
excessive production (hyperthyroidism), or an enlargement of the gland (goitre).
A power point presentation on thyroid hormones and thyroid inhibitors on subject of pharmacology suitable for reading by undergraduate medical students.
Hypothyroidism is a disorder that occurs when the thyroid gland does not make enough thyroid hormone to meet the body’s needs.
Hyperthyroidism is a disorder that occurs when the thyroid gland makes more thyroid hormone than the body needs.
A complete presentation on hypothroidism endocrine disorder based on latest editon of harrison and reference books. this presentation will help to learn about this second most common endocrine disorder.
it was a case study on hypothyroidism in pediatric patient pharmaceutical care plan ,Diagnostic Technics ,treatment and patient counseling was given to the patient representative.
Diseases of the thyroid gland involve:
an insufficient production of the thyroid hormone (hypothyroidism),
excessive production (hyperthyroidism), or an enlargement of the gland (goitre).
A power point presentation on thyroid hormones and thyroid inhibitors on subject of pharmacology suitable for reading by undergraduate medical students.
Hypothyroidism is a disorder that occurs when the thyroid gland does not make enough thyroid hormone to meet the body’s needs.
Hyperthyroidism is a disorder that occurs when the thyroid gland makes more thyroid hormone than the body needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
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The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. Case history
24 F presented with vomiting , diarrhea , lethargy for
the period of 6 weeks.
No travel, Nil fever, Not on any medications.
Recent history of boyfriend separation , Hx of
anxiety.
Has visited her GP 3 weeks ago was started on
antidepressant but did not take it.
Her GP died the week ago so did not visit her.
3. On examination- lean , sick looking, constant
vomiting, not settling down on the bed, rolling
around, sunken eyes, wants to drink water
Vitals- PR- 140/min, regular, BP- 110/66mmhg
Systemic exam- tachycardia, rest WNL
Rest of her examination- unremarkable
Has about 5% dehydration
6. What do you think is the diagnosis ??
Need any other investigations????
How do you manage ?????
7. After 2 hrs of treatment she settled well, but her HR was still 140/minute, she looked
more confortable, and she is more alert, and cheerful.
RPT VBG- PH-7.35
PCO2- 32
PO2 -70
Bicarb -17
sodium-134
potas- 4.1
Glu-9.3
Lact- 0.6
9. What do you want to do??????
What is your differentials????
10. Her bloods came back : T3 >46
Cortisol serum – 1000
B HCG – negative
Calcium and rest of her bloods – WNL
What is your diagnosis???
11.
12. Hyper Thyroidism
Means overactive thyroid and produces free thyroid
hormones ,T3 and or T4
Grave’s disease is the most common cause of
hyperthyroidism.
This is one cause of thyrotoxicosis.
The management and therapy differ for
thyrotoxicosis from hyperthyroidism and
thyrotoxicosis caused by other conditions.
13. Explanation
• Thyroglobulin is synthesized in the rough endoplasmic reticulum and follows the secretory pathway to enter the colloid in the lumen of the thyroid follicle by
exocytosis.
• Meanwhile a sodium – iodine (Na/I) symporter pumps Iodide (I-) actively into the cell, which previously has crossed the endothelium by largely unknown
mechanisms.
• This iodide enters the follicular lumen from the cytoplasm by the transporter pendrin, in a purportedly passive manner.
• In the colloid, iodide (I-) is oxidized to iodine (I0) by an enzyme called thyroid peroxidase
• Iodine (I0) is very reactive and iodinates the thyroglobulin at tyrosyl residues in its protein chain (in total containing approximately 120 tyrosyl residues).
• In conjugation, adjacent tyrosyl residues are paired together.
• The entire complex re-enters the follicular cell by endocytosis.
• Proteolysis by various proteases liberates thyroxine and triiodothyronine molecules, which enter the blood by largely unknown mechanisms.
14. Clinical features of hyperthyroidism
Skin- sweating, heat intolerance, onycholysis ,
hyperpigmentation, Pruritus and hives
Vitiligo , alopecia areata, thinning of hair.
Eyes – Stare and lid lag, only Grave’s patients have
opthalmopathy – inflammation of the extra ocular
muscles and orbital fat and connective tissue, which
results in proptosis, impairment of eye muscle and
conjunctival edema.
CVS – Increased cardiac output, PR- high, Pulse pressure is
widened, PVR is decreased, High or normal output CCF can
occur on these patients.
AF can occur in 10-20% of people ( role of anticoagulation)
15. Metabolic/endocrine:
Serum lipids- low serum total and HDL.
Hyperglycemia – Associated with both increased
sensitivity of pancreatic beta cells to glucose,
resulting in increased insulin secretion and
antagonizing to the peripheral action of insulin.
Which will result in impaired GTT.
Adrenal Function – CBG will decrease resulting in
lower total serum cortisol concentrations.
Respiratory – Dyspnea on exertion , pulmonary
arterial systolic pressure is increased.
GIT – weight loss, hyper metabolism, and increased
gut motility, diarrhea.
16. Hematologic – RBC mass is increased , with the plasma
volume is increased too, they can be prothrombotic ( rise in
factors VIII, IX, Fibrinogen, Von willibrand factor, and
plasminogen activator, inhibitor.
Genitourinary – urinary frequency and nocturia.
Bone – stimulates bone resorption so indirectly serum
calcium level may increase.
Neuropsychiatric – may experience behavioral and
personality changes (psychosis, agitation and depression).
19. If TSH is low and only serum T3 is high, then the
patient most likely has Graves disease or an
autonomously functioning thyroid adenoma.
If TSH is low , Free T4 is high, and T3 is normal –
patient may have hyperthyroidism with concurrent
nonthyroidal illness, amiodarone induced thyroid
dysfunction.
If Free T4 and T3 are elevated and serum TSH is
normal or elevated, then we need MRI as it may be a
pituitary tumor.
20. Thyroid storm
Thyrotoxic crisis (or thyroid storm) is a rare but severe
complication of hyperthyroidism, which may occur when a
thyrotoxic patient becomes very sick or physically stressed.
Its symptoms can include: an increase in body temperature to
over 40 degrees Celsius (104 degrees Fahrenheit), tachycardia,
arrhythmia, vomiting, diarrhea, dehydration, coma, and death.
Thyroid storm requires prompt treatment and hospitalization.
The main treatment is to decrease the circulating thyroid
hormone levels and decrease their formation.
21. Propylthiouracil and methimazole are two agents that decrease
thyroid hormone synthesis and are usually prescribed in fairly
high doses.
To inhibit thyroid hormone release from the thyroid gland,
sodium iodide, potassium iodide, and/or Lugol's solution can be
given.
Beta blockers such as propranolol can help to control the heart
rate, and intravenous steroids may be used to help support the
circulation.
Earlier in the 20th century the mortality of thyroid storm
approached 100%. However, now, with the use of aggressive
therapy as described above, the death rate from thyroid storm is
less than 20%.
22. Anti thyroid drugs
Thyrostatics are drugs that inhibit the production of thyroid hormones such
as CARBIMAZOLE, METHAMIZOLE and PROPYLTHIOURACIL.
Thyrostatics are believed to work by inhibiting the iodination of
thyroglobulin by thyroperoxidase, and, thus, the formation of tetraiodothyronine (T4).
Propylthiouracil also works outside the thyroid gland, preventing
conversion of (mostly inactive) T4 to the active form T3.
Thyroid tissue usually contains a substantial reserve of thyroid hormone,
thyrostatics can take weeks to become effective, and the dose often needs
to be carefully titrated over a period of months, with regular doctor visits
and blood tests to monitor results.
A very high dose is often needed early in the treatment.
23. Beta blockers
Propranolol – has two roles two different isomers
L propranolol – causes beta blockade
D propranolol – inhibits Thyroxin deiodinase there by blocking
the conversion of T4 to T3.
Food and diet – not to have food enriched in iodine
Surgery – Thyroidectomy.
Radioiodine - common outcome following radioactive iodine
therapy is a swing from hyperthyroidism to simple treatable
hypothyroidism.