Hypothyroidism can be primary, meaning it is caused by a problem in the thyroid gland itself, or secondary, caused by a lack of TSH from the pituitary gland. Primary causes include congenital defects, iodine deficiency, autoimmune disorders like Hashimoto's thyroiditis, and surgery or radiation treatment of the thyroid. Secondary hypothyroidism is caused by problems of the pituitary gland or peripheral resistance to thyroid hormone. Diagnosis is made through blood tests showing low T3 and T4 and high TSH for primary hypothyroidism. Treatment is lifelong thyroid hormone replacement, usually levothyroxine. Dosage depends on age, severity, and other factors.
A complete presentation on hypothroidism endocrine disorder based on latest editon of harrison and reference books. this presentation will help to learn about this second most common endocrine disorder.
A complete presentation on hypothroidism endocrine disorder based on latest editon of harrison and reference books. this presentation will help to learn about this second most common endocrine disorder.
Thyroid and its pathology (Hypothyroidism).Vikas Reddy
GREEK :- THYREOS – SHIELD ; EIDOS – FORM
1.LOCATION:- Anterior to trachea in between the cricoid cartilage and the suprasternal notch.
2.SHAPE:- It has 2 lobes connected with an isthmus, each lobe in turn has two poles.
3.Weighs around 10-20 gm, highly vascular and soft in consistency.
4. 4 Parathyroid glands which secrete PTH are located posterior to each pole of thyroid
The RLN traverse the lateral border of thyroid gland and must be identified during thyroid surgery to avoid injury and vocal cord paralysis.
Develops from the floor of primitive pharynx during the 3rd week of gestation.
Fetal cells in which developmental transcription factors TTF-1,TTF-2 & PAX-8 are expressed selectively form the thyroid gland ,secondly they result in induction of thyroid specific genes
Tg,TPO,NIS,TSH-R.
Mutations-THYROID AGENESIS & DYSHORMONOGENESIS(CONG. HYPOTHYROIDISM).
The developing gland migrates along the thyroglossal duct to reach its final location in the neck.
LINGUAL THYROID AND THYROGLOSSAL DUCT CYST.
Thyroid hormone synthesis begins at about 11 weeks of gestation.
Until 11 week of gestation and even later, it is the maternal thyroid hormones which cross the placenta to reach the fetus and aid its development.
Therefore a child born to a hypothyroid mother would suffer from features of congenital hypothyroidism.
Secondly if the mother has TSH-R blocking antibodies or has received anti thyroid therapy during pregnancy, might lead to transient congenital hypothyroidism.
Thyroiditis is a general term that refers to “inflammation of the thyroid gland”. Thyroiditis includes a group of individual disorders causing thyroidal inflammation but presenting in different ways. For example, Hashimoto's thyroiditis is the most common cause of hypothyroidism in the United States.
What is Hypothyroidism, Hypothyroidism definition, Characteristics for Hypothyroidism, Physical examination for Hypothyroidism, Investigations for characteristics, Thyroid panel, Medications for characteristics, Patient education for Hypothyroidism.
Thyroid and its pathology (Hypothyroidism).Vikas Reddy
GREEK :- THYREOS – SHIELD ; EIDOS – FORM
1.LOCATION:- Anterior to trachea in between the cricoid cartilage and the suprasternal notch.
2.SHAPE:- It has 2 lobes connected with an isthmus, each lobe in turn has two poles.
3.Weighs around 10-20 gm, highly vascular and soft in consistency.
4. 4 Parathyroid glands which secrete PTH are located posterior to each pole of thyroid
The RLN traverse the lateral border of thyroid gland and must be identified during thyroid surgery to avoid injury and vocal cord paralysis.
Develops from the floor of primitive pharynx during the 3rd week of gestation.
Fetal cells in which developmental transcription factors TTF-1,TTF-2 & PAX-8 are expressed selectively form the thyroid gland ,secondly they result in induction of thyroid specific genes
Tg,TPO,NIS,TSH-R.
Mutations-THYROID AGENESIS & DYSHORMONOGENESIS(CONG. HYPOTHYROIDISM).
The developing gland migrates along the thyroglossal duct to reach its final location in the neck.
LINGUAL THYROID AND THYROGLOSSAL DUCT CYST.
Thyroid hormone synthesis begins at about 11 weeks of gestation.
Until 11 week of gestation and even later, it is the maternal thyroid hormones which cross the placenta to reach the fetus and aid its development.
Therefore a child born to a hypothyroid mother would suffer from features of congenital hypothyroidism.
Secondly if the mother has TSH-R blocking antibodies or has received anti thyroid therapy during pregnancy, might lead to transient congenital hypothyroidism.
Thyroiditis is a general term that refers to “inflammation of the thyroid gland”. Thyroiditis includes a group of individual disorders causing thyroidal inflammation but presenting in different ways. For example, Hashimoto's thyroiditis is the most common cause of hypothyroidism in the United States.
What is Hypothyroidism, Hypothyroidism definition, Characteristics for Hypothyroidism, Physical examination for Hypothyroidism, Investigations for characteristics, Thyroid panel, Medications for characteristics, Patient education for Hypothyroidism.
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2012 Clinical Practice guidelines for hypothyroidism in adults: American Asso...Jibran Mohsin
This is presentation format of 2012 Clinical Practice guidelines for hypothyroidism in adults: American Association of Clinical Endocrinologists (AACE) / American Thyroid Association (ATA)
Hypothyroidism Diagnosis, Etiopathogenesis and TreatmentPranatiChavan
Hypothyroidism is a condition in which the thyroid gland doesn't produce enough thyroid hormone.
Hypothyroidism's deficiency of thyroid hormones can disrupt such things as heart rate, body temperature and all aspects of metabolism. Hypothyroidism is most prevalent in older women.
Major symptoms include fatigue, cold sensitivity, constipation, dry skin and unexplained weight gain.
Treatment consists of thyroid hormone replacement.
Q: A 70 y.o. man is brought to ER by his nephew because he was found poorly responsive at home. The nephew had not checked on the patient for two weeks. The patient lives alone and has been noted by his nephew to be more confused and less active over the past few months.
The nephew was uncertain about the patient's past medical history. He recalls that the patient takes several pills per day for some 'heart issues,' blood pressure, and headaches.
He also recalls that the patient was seen in ER recently for muscle pains and was given opioid analgesics.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
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Model Attribute Check Company Auto PropertyCeline George
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7. investigations
Classical findings of primary hypothyroidism are reduced levels of
T3 and T4 and increased levels of TSH.
Secondary hypothyroidism T3, T4, TSH all are reduced, along with
other pituitary hormones.
Other abnormal investigations are
Anemia –macrocytic or microcytic (mennoraghia).
ECG-- bradycardia, low voltage complexes.
Increase in CK from muscle.
Hypercholesterolemia.
Antibodies to thyroid peroxidase are positive in spontaneous
atrophic thyroiditis and hashimoto’s thyroiditis.
8. treatment
• DRUG OF CHOICE: thyroxine
• Drug should be taken 30 minutes before a meal
• Dose depends on:
a) severity of deficiency
b) Age of patient
c) Fitness of patient
9. • INITIATION OF THERAPY:
Based on age
Young and middle aged adults:100
mcg daily
Healthy elderly: 50 mcg daily
With cardiac disease: 25-50 mcg daily
10. Based on severity of disease
Clinical hypothyroidism
i. No residual thyroid function: 100-150
mcg/d
ii. Underlying autonomous function of gland
is present: 75-125mcg/d
Subclinical hypothyroidism:
11. • This term is used when TSH is elevated
(>10microUnits per litre) and T3, T4 are normal
with vague symptoms.
• This condition should be treated only if there are
• High titers of antibodies
• Lipid abnormalities
• Associated with goiter
• If above indications are not present then patient
should be followed up with TSH andT3, T4 every
3-6 months.
DOSE: 25-50 microgram/d
Subclinical hypothyroidism
12. • DOSE ADUSTMENT AND FOLLOW-UP
Primary hypothyroidism:
GOAL-maintain plasma TSH within normal
range
Plasma TSH is measured 6-8 weeks after
initiation of therapy
Dose is adjusted in 12-25 mcg increments at 6-
8 week intervals till plasma TSH is normal
Annual TSH measurement is adequate
thereafter
Overcorrection of TSH levels will increase the
risk of atrial fibrillation and osteoporosis
13. Secondary hypothyroidism
GOAL: maintain plasma free T4 levels near the
upper limit of the reference range
Dose is adjusted in 12-25 mcg increments a 6-8
week intervals till plasma TSH is normal
Annual TSH measurement is adequate
thereafter
Subclinical hypothyroidism
Goal:normalise TSH
Annual evaluation if not treated
14. MYXOEDEMA COMA
Myxedema coma is a medical emergency.
Commonly seen in elderly patients with longstanding
hypothyroidism.
Common precipitating factors are sedatives , anaesthetics,
pneumonia,CCF, MI, GI bleed, CVA
Mortality rates are 50%
15. Clinical manifestations:
Hypothermia
Altered consciousness- result of delayed cerebration .
Hypoventilation -
Bradycardia
Hypoglycemia and SIADH.
16. Management
Levothyroxine (T4)
loading dose.:500mcg I.V. bolus
continued at a dose of 50 to 100 mcg/d.
.
alternative :
liothyronine (T3) :10 to 25 mcg every 8 to
12h .
Inj. Hydrocortisone 50mg I.V 6hrly should be
given and can be stopped if cortisol levels are
normal.
17. Other measures include:
---Oxygen and gradual rewarming.
---Glucose and sodium correction.
---Ventilatory support if required.
• Medication blood levels should be monitored, when
avavilable, to guide dosage.
18. THYROIDITIS
Thyroiditis most often results from an infective or
autoimmune process
Classification of thyroiditis
Acute thyroiditis - Bacterial, viral,
Subacute thyroiditis - de Quervain's thyroiditis
Chronic thyroiditis - Autoimmune - Hashimoto’s
(chronic lymphocytic), Riedel thyroiditis
19. HASHIMOTO’S THYROIDITIS
It is autoimmune thyroiditis.
Common in middle aged females.
Histologically, there is marked lymphocytic
infiltration to the extent of formation of
germinal centers. Askanazy cells are present.
Gland is diffusely enlarged and is firm.
Patient may be euthyroid or hypothyroid.
AntiTPO Ab is positive and thyroid scan
uptake is low.
Treatment is required only if there is
hypothyroidism or goiter.
20. Non thyroidal illnesses
T4 to T3 and binding to TBG
TFT: low T3
Normal T4
Normal TSH
THE SICK EUTHYROID SYNDROME