The document provides an extensive overview of the cardiovascular system, focusing on the anatomy and physiology of the heart, including its major arteries and veins, the pathway of blood flow, and the cardiac cycle. It details the functions of various coronary arteries and how different segments of the heart are supplied with blood, as well as the intrinsic conduction system regulating heartbeats. Additionally, it discusses factors affecting cardiac output and stroke volume alongside the structure of the heart and its coverings.

1. External Heart: Arteries that Supply
the Heart
• Coronary circulation is the functional blood
supply to the heart muscle itself (i.e. the fuel
for the heart)
• Collateral routes ensure blood delivery to
heart
• even if major vessels are occluded/clogged

2. Different parts of the heart are supplied by
different coronary artery segments
Heart chambers in geometric
models are subdivided into
perfusion zones using
anatomic knowledge in the
FMA ontology

3. CORONARY ARTERIES SUPPLYING THE
HEART WITH OXYGEN-RICH BLOOD
Right
Coronary
Artery
(RCA)
Right
Coronary
Artery
(RCA)
Left Main
Coronary
Artery (LMCA)
Left Main
Coronary
Artery (LMCA)
Left Anterior
Descending
Artery (LAD)
Left Anterior
Descending
Artery (LAD)
Posterior
Descending Artery
(PDA)
Posterior
Descending Artery
(PDA)
Left Circumflex
Coronary Artery
(LCx)
Left Circumflex
Coronary Artery
(LCx)

4. Arterial Coronary Circulation

5. External Heart: Arteries that Supply
the Heart
• Right coronary artery (in atrioventricular
groove)
– Supplies the right atrium and nearly all the
right ventricle
– marginal –supply the myocardium of the
– lateral right side of the heart
– posterior interventricular artery – supply the
– interventricular septum and adjacent portions
of the ventricular walls

6. External Heart: Arteries that Supply
the Heart
• Left coronary artery:
– Circumflex supplies the left atrium and the
posterior wall of the left ventricle
– Anterior interventricular artery supplies the
anterior wall of both ventricles

7. CERTAIN HEART WALL SEGMENTS ARE FED BY
CERTAIN CORONARY ARTERIES AS SPECIFIED BELOW:
BASE
MID
APEX
A4C
A2C
PARASTERNAL
LONG-AXIS
Key:
Red = LAD
Yellow = LCx
Green = RCA
LAD = Left Anterior Descending Coronary Artery, LCx = Left Circumflex Coronary
Artery, RCA = Right Coronary Artery

8. DIVIDING THE LEFT VENTRICLE INTO KEY SEGMENTS
Apical
Third
Apical
Third Mid
Third
Mid
Third
Basal
Third
Basal
Third

9. FURTHER DIVIDING THE LEFT VENTRICULAR WALLS
INTO 17 SPECIFIC SEGMENTS DEFINED AS:
AnteriorAnterior
AnterolateralAnterolateral
InferolateralInferolateral
InferiorInferior
InferoseptalInferoseptal
AnteroseptalAnteroseptal
ApexApex
AnteriorAnterior
AnteroseptalAnteroseptal
InferoseptalInferoseptal
AnterolateralAnterolateral
InferolateralInferolateral
InferiorInferior
AnteriorAnterior
SeptalSeptal
LateralLateral
InferiorInferior
ApexApex
BasalBasal
Mid-
Cavity
Mid-
Cavity
ApicalApical
1. Basal Anterior
2. Basal Anteroseptal
3. Basal Inferoseptal
4. Basal Inferior
5. Basal Inferolateral
6. Basal Anterolateral
7. Mid Anterior
8. Mid Anteroseptal
9. Mid Inferoseptal
10. Mid Inferior
11. Mid Inferolateral
12. Mid Anterolateral
13. Apical Anterior
14. Apical Septal
15. Apical Inferior
16. Apical Lateral
17. Apex
1. Basal Anterior
2. Basal Anteroseptal
3. Basal Inferoseptal
4. Basal Inferior
5. Basal Inferolateral
6. Basal Anterolateral
7. Mid Anterior
8. Mid Anteroseptal
9. Mid Inferoseptal
10. Mid Inferior
11. Mid Inferolateral
12. Mid Anterolateral
13. Apical Anterior
14. Apical Septal
15. Apical Inferior
16. Apical Lateral
17. Apex

10. PUTTING IT TOGETHER: HEART WALL SEGMENTS
AND CORRESPONDING CORONARY ARTERIES
Coronary
Artery: Segments:
LAD 1, 2, 7, 8, 13, 14, 17
RCA 3, 4, 9, 10, 15
LCX 5, 6, 11, 12, 16
Coronary
Artery: Segments:
LAD 1, 2, 7, 8, 13, 14, 17
RCA 3, 4, 9, 10, 15
LCX 5, 6, 11, 12, 16
LAD = Left Anterior Descending
Artery
RCA = Right Coronary Artery
LCX = Left Circumflex Artery
LAD = Left Anterior Descending
Artery
RCA = Right Coronary Artery
LCX = Left Circumflex Artery
AnteriorAnterior
AnterolateralAnterolateral
InferolateralInferolateral
InferiorInferior
InferoseptalInferoseptal
AnteroseptalAnteroseptal
ApexApex
AnteriorAnterior
AnteroseptalAnteroseptal
InferoseptalInferoseptal
AnterolateralAnterolateral
InferolateralInferolateral
InferiorInferior
AnteriorAnterior
SeptalSeptal
LateralLateral
InferiorInferior
ApexApex

11. ANOTHER PERSPECTIVE – 17 SEGMENT
MODEL OF LEFT VENTRICLE
1. Basal Anterior
2. Basal Anteroseptal
3. Basal Inferoseptal
4. Basal Inferior
5. Basal Inferolateral
6. Basal Anterolateral
7. Mid Anterior
8. Mid Anteroseptal
9. Mid Inferoseptal
10. Mid Inferior
11. Mid Inferolateral
12. Mid Anterolateral
13. Apical Anterior
14. Apical Septal
15. Apical Inferior
16. Apical Lateral
17. Apex
1. Basal Anterior
2. Basal Anteroseptal
3. Basal Inferoseptal
4. Basal Inferior
5. Basal Inferolateral
6. Basal Anterolateral
7. Mid Anterior
8. Mid Anteroseptal
9. Mid Inferoseptal
10. Mid Inferior
11. Mid Inferolateral
12. Mid Anterolateral
13. Apical Anterior
14. Apical Septal
15. Apical Inferior
16. Apical Lateral
17. Apex

12. SAMPLE – SEGMENTAL SCORING
Ortiz-Perez, J. T. et al. J Am Coll Cardiol Img 2008;1:282-293

13. Representative Segmentation and Pattern of Contrast
HE Over 17-Segments of the LAD, RCA, and LCX
Arteries
Ortiz-Perez, J. T. et al. J Am Coll Cardiol Img 2008;1:282-293

14. HEART ANATOMY – COVERINGS OF THE HEART
• Coverings of the Heart: Anatomy
• Pericardium – a double-walled sac around the
• heart composed of:
• A superficial fibrous pericardium
• A deep two-layer serous pericardium
• The parietal layer lines the internal surface
• of the fibrous pericardium
• The visceral layer or epicardium lines the
• surface of the heart
• They are separated by the fluid-filled
• pericardial cavity
• Coverings of the Heart: Physiology
• The pericardium:
• Protects the heart

15. COVERINGS OF THE HEART:
PHYSIOLOGY
• The pericardium:
– Protects and anchors the heart
– Prevents overfilling of the heart with blood
– Allows for the heart to work in a relatively
– friction-free environment

16. PERICARDIUM OF THE HEART
• Pericardium (3 layers)
• 1) Outer-fibrous pericardium
– Serous pericardium
• 2) parietal
• 3) visceral (epicardium)
• Pericardial Cavity
– between layers of serous pericardium
– serous fluid
– lubricate heart while beating

17. Pericardial Layers of the Heart

18. Heart Wall – Layers of the Heart
• Epicardium – visceral layer of the serous
• pericardium
• Myocardium – cardiac muscle layer forming
• the bulk of the heart
• Fibrous skeleton of the heart – crisscrossing,
• interlacing layer of connective tissue
• Endocardium – endothelial layer of the inner
• myocardial surface
• Cardiac Muscle Bundles
• External

19. Cardiac Muscle 1000X
intercalated disc
striations nucleus

20. Purkinje fibers 40X

21. EXTERNAL FEATURES OF THE HEART
• Interventricular sulcus
• Coronal/Coronary sulcus
• Auricles of atria
• Apex
• Base
• Coronary vessels
• Ligamentum Arteriosum

22. External Heart: Major Vessels of
the Heart (Anterior View)
• External Heart: Major Vessels of
the Heart (Anterior View)
• Vessels returning blood to the heart include:
– Superior and inferior vena cava
– Right and left pulmonary veins
• Vessels conveying blood away from the heart:
– Pulmonary trunk, which splits into right and
– left pulmonary arteries
– Ascending aorta (three branches) –
– brachiocephalic, left common carotid, and
– subclavian arteries

23. External Heart: Veins that Drain the
Heart

24. External Heart: Major Vessels of
the Heart (Posterior View)
Vessels returning blood to the heart include:
•Right and left pulmonary veins
• Superior and inferior vena cava
• Vessels conveying blood away from the heart
include:
• Aorta
• Right and left pulmonary arteries

25. FLOW OF BLOOD
• O2-poor blood (S+I VC, Coronary Sinus) enters Rt Atrium
• Travels through Tricuspid Valve into Rt Ventricle
• Pumped out through Pulmonary Semilunar Valve into
Pulmonary trunk (branches into Pulmonary Arteries) and to
lungs
•After circulating through lungs, O2-rich blood returns to the
heart through 4 Pulmonary veins
• The O2-rich blood enters the Left Atrium
• Travels through Bicuspid/Mitral Valve into Left Ventricle
• Pumped out through Aortic Semilunar Valve into Aorta to be
distributed to rest of body by descending aorta and branches
of aortic arch

26. Pathway of Blood Through the
Heart and Lungs
Right atrium > tricuspid valve > right ventricle >
pulmonary semilunar valve > pulmonary arteries >
Lungs > pulmonary veins > left atrium >
Mitral valve > left ventricle > Left ventricle >
aortic semilunar valve > aorta > systemic circulation

27. THE PATHWAY OF THE HEART

28. Cardiovascular Flow of Blood
• HeartArteries(conducting-distributing)
ArteriolesCapillaries of tissues
• At Capillaries O2 is delivered and CO2 picked
up
•CapillariesVenulesVeinsHeart

29. DETAILED IMAGES OF THE HEART’S
ANATOMY – CHORDAE TENDONAE

30. THE CARDIAC CYCLE

31. Semilunar Valve Function

32. Cardiac Intrinsic Conduction
IMPORTANT - Various
nodes and intrinsic Heart
Rate Generated:
• SA Node – 60 – 100
Beats/min
• AV Node – 40 – 60
Beats/min
• Bundle of His – 40 – 60
Beats/min
•Purkinje Fibers – Last
resort – 20 – 40
Beats/min
IMPORTANT - Various
nodes and intrinsic Heart
Rate Generated:
• SA Node – 60 – 100
Beats/min
• AV Node – 40 – 60
Beats/min
• Bundle of His – 40 – 60
Beats/min
•Purkinje Fibers – Last
resort – 20 – 40
Beats/min

33. Heart Excitation Related to ECG
atrial excitation begins
Impulse delayed
at AV node
Impulse passes to
heart apex; ventricular
excitation begins
Ventricular excitation
complete
SA node AV node Purkinje
fibers
Bundle
branches

34. Electrocardiography
Electrical activity is recorded by
electrocardiogram (ECG)
• P wave corresponds to depolarization of SA
•node
•QRS complex corresponds to ventricular
•depolarization
•T wave corresponds to ventricular
repolarization
•Atrial repolarization record is masked by the
•larger QRS complex

35. Electrocardiography

36. Electrocardiography
PR interval
•Atrial depolarization and contraction
•QT interval
•Ventricular depolarization, contraction and
repolarization
•PR segment
•Atrial contraction
•ST segment
•Ventricular contraction
•ECG Tracings
•Heart

37. ECG Tracings
Heart

38. Cardiac Cycle
Cardiac cycle refers to all
events associated
with blood flow through
the heart
•Systole – contraction of heart muscle
•Diastole – relaxation of heart muscle

39. Phases of the Cardiac Cycle
Phases of the Cardiac Cycle
• Isovolumetric relaxation – early diastole
• Ventricles relax
• Backflow of blood in aorta and pulmonary trunk closes semilunar valves
• Dicrotic notch – brief rise in aortic pressure caused by backflow of blood. This
backflow
• causes the valve to close and creates a slight
pressure rebound

40. Phases of the Cardiac Cycle

41. THE CARDIAC CYCLE

42. Cardiodynamics
Cardiac output (CO) : the amount of blood
pumped by each ventricle in one minute
•Cardiac output equals heart rate times stroke
volume
Cardiac output (ml/min) =
Heart Rate (HR) (beats/min) X
Stroke Volume (SV) (ml/beat)

43. Cardiodynamics
Heart rate (HR) : number of heart beats in a
minute
•Stroke volume (SV) – amount of blood
ejected from the ventricles with each beat
•SV = EDV - ESV

44. Cardiac Output:
Example
CO (ml/min) = HR (75 beats/min) x
SV (70 ml/beat)
•CO = 5250 ml/min (5.25 L/min)

45. Cardiodynamics
Ventricular pressure increases forcing blood
through the semilunar valves: ventricular
Ejection
•End-systolic volume (ESV)
•Amount of blood that remains in the
ventricles after the contraction and closing of
the semilunar valves

46. Factors Affecting stroke volume
(EDV-ESV)
EDV (end diastolic volume) is affected by
•Venous return - amount of blood returning to
the heart or blood flow during filling time
•High venous return= high EDV
•Slow heartbeat and exercise increase venous
return to the heart, increasing SV

47. Factors Affecting stroke volume
(EDV-ESV)
Filling time -duration of ventricular diastole
•Depends on the heart rate
•Blood loss and extremely rapid heartbeat
decrease SV
•The longer the filling time the higher the
EDV will be

48. Factors Affecting stroke volume
(EDV-ESV)
Preload
• Stretchiness of the ventricles during
Diastole
• Directly proportional to the EDV
• Frank-Starling principle (“more in = more out”)
or increased EDV=increased SV

49. Factors Affecting stroke volume
(EDV-ESV)
ESV (end systolic volume). It is influenced by:
•Contractility
• Force produced during a contraction
• Positive inotropic (increase Calcium entry)
• Increased sympathetic stimuli
• Certain hormones, some drugs
• Increase SV by decreasing ESV

50. Factors Affecting stroke volume
(EDV-ESV)
Afterload
•The pressure that must be overcome for the
ventricles to eject blood (back pressure
exerted by blood in the large arteries leaving
the heart)
• Increased afterload will increase ESV and
decrease SV
• Increased by factors that restricts arterial blood
flow

51. PRELOAD AND AFTERLOAD DEPICTED

52. STRESS PERFUSION IMAGES

53. Stress-
Perfusion
Rest-
Perfusion
Baseline
LV contrast
uptake
RV contrast
uptake
Myocardial
contrast uptake
Viability and
coronary
angiography

57. Walls of the ventricles:
Left wall is thicker!

59. Find:
1. Walls of the ventricles
2. Auricles
3. Inner walls of the atria
4. Fossa ovalis
5. Trabeculae carnae
6. Atrioventricular valve
(a) "Bicuspid valve"
(b) "Tricuspid valve"
7. Chordae tendonae
8. Papillary muscles
9. Aortic & pulmonary valves

60. Coronary arteries are the FIRST
branches of the aorta!
1. Coronary arteries
(a) Left coronary artery
(b) Right coronary artery
(c) Interventricular branches
(d) Right marginal branch
2. Cardiac veins

61. Heart in VENTRAL
view.
(You see mostly
right ventricle!)

62. Heart in DORSAL view.
(You see mostly left
ventricle.)

63. Intrinsic regulation of heart beat
1. Sinoatrial node is
PACEMAKER OF
HEART, and beginning
of process. Geenrates
periodic impulses that
initiate contraction of
right atrium.
2. Signal then runs to
Atrioventricular node.
Message is passed along
a track of Purkinje fibers
called the...
3. Atrioventricular bundle.
Atrioventricular bundle
then splits into right and
left limbs/branches that
pass to individual inner
ventricular walls on right
and left.

66. Maximum Heartrate Calculation
(Suggested) MAXIMUM HEARTRATE can be calculated by the
formula:
208 - (0.7)(your age) = normal maximum
heartrate.

67. Heartrate
Resting heartrate average is variable
depending on ages, sex, weight, etc.
MAXIMUM HEARTRATE used to be
calculated by the formula:
220 - your age = normal maximum
heartrate.
(This is now known to be oversimplified
and incorrect.)