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Diagnostic evaluation of hypertension Hany A. AbdelWahab (Assistant lecturer of cardiology) Zagazig University October, 2011
Aim of the diagnostic procedures  1) Establishing blood pressure levels. 2) Identifying secondary causes of hypertension. 3) Evaluating the overall cardiovascular risk by searching for other risk factors, target organ damage and concomitant diseases.
The diagnostic procedures comprise: 1) Repeated blood pressure measurements. 2) Medical history. 3) Physical examination. 4) Investigations.
BLOOD PRESSURE MEASUREMENTS
[object Object],[object Object]
Take at least two measurements spaced by 1– 2 minutes, and additional measurements if the first two are quite different.,[object Object],[object Object],[object Object]
Measure BP 1 and 5 min after assumption of the standing position if postural hypotension is suspected like in elderly & diabetic patients.
Measure heart rate by pulse palpation (at least 30 sec) after the second measurement in the sitting position.,[object Object]
[object Object], 1) Correlates with hypertension-related organ damage and its changes by treatment more closely than does office blood pressure.  2) It can predict cardiovascular risk greater than office blood pressure values in populations as well as in untreated and treated hypertensives. 3) Measures the extent of blood pressure reduction by treatment more accurately than clinic blood pressure.
[object Object]
The prognostic value of nighttime BP has been found to be superior to that of daytime blood pressure.
Subjects in whom nocturnal decrease in blood pressure is blunted (non dippers) have been reported to have a greater prevalence of organ damage and a less favourable outcome.,[object Object]
4- Resistance to drug treatment is suspected. 5- Hypotensive episodes are suspected, particularly in elderly and diabetic patients. 6- Office BP is elevated in pregnant women and preeclampsia is suspected.
Home BP measurement
[object Object]
Thesemeasurements should be encouraged in order to:
Provide more information on the BP lowering effect of treatment at trough.
Improve patient’s adherence to treatment regimens.
If there are doubts on technical reliability/ environmentalconditions of ambulatory BP data.,[object Object]
Blood pressure thresholds (mmHg) for definition ofhypertension with different types of measurement
Isolated office (white coat) hypertension ,[object Object]
Isolated office hypertension may be present in about 15% of the general population and that it may account for a noticeable fraction (one third or more) of hypertensive patients.,[object Object],[object Object]
Isolated ambulatory (masked) hypertension ,[object Object],[object Object]
Such individuals have been shown to have greater than normal prevalence of organ damage, with an increased prevalence of metabolic risk factors compared with subjects with a truly normal blood pressure.,[object Object]
Guidelines for Family and Clinical History Duration and previous level of high blood pressure. Indications of secondary hypertension: 	- Family history of renal disease (polycystic kidney). 	- Renal disease, urinary tract infection, haematuria, analgesic abuse (parenchymal renal disease). 	- Drug/substance intake: oral contraceptives, liquorice, carbenoxolone, nasal drops, cocaine, amphetamines, steroids, NSAIDs, erythropoietin, cyclosporine. 	- Episodes of sweating, headache, anxiety, palpitation (phaeochromocytoma). 	- Episodes of muscle weakness and tetany (aldosteronism).
Risk factors: 	- Family and personal history of hypertension and 	cardiovascular disease. 	- Family and personal history of dyslipidaemia.	 	- Family and personal history of diabetes mellitus. 	- Smoking. 	- Dietary habits. 	- Obesity & amount of physical exercise.  	- Snoring; sleep apnea ( information also from partner) 	- Personality.
Symptoms of target organ damage: 	- Brain and eyes: headache, vertigo, impaired vision, TIAs & sensory or motor deficit. 	- Heart: palpitation, chest pain, shortness of breath &swollen ankles. 	- Kidney: thirst, polyuria, nocturia & haematuria. 	- Peripheral arteries: cold extremities & intermittent 	claudications. Previous antihypertensive therapy: 	- Drug(s) used, efficacy and adverse effects.
Physical examination
Physical Examination for SecondaryHypertension, Target organ Damage and Visceral Obesity  Signs suggesting secondary hypertension ,[object Object]
Skin stigmata of neurofibromatosis (phaeochromocytoma).
Palpation of enlarged kidneys (polycystic kidney).
Auscultation of abdominal murmurs (renovascular hypertension).
Auscultation of precordial or chest murmurs & delayed femoral pulses  (aortic coarctation or aortic disease).,[object Object]
Retina: fundoscopic abnormalities.
Heart: apical impulse, abnormal cardiac rhythms, ventricular gallop, pulmonary rales & peripheral oedema.
Peripheral arteries: absence, reduction, or asymmetry of pulses, cold extremities, ischaemic skin lesions.,[object Object]
Increased body mass index:body weight (Kg)/ height (m²) Overweight ≥25 Kg/m²  &  Obesity ≥30 Kg/m²
investigations
Laboratory Investigations Routine tests ,[object Object]
Fasting lipid profile:
Serum total cholesterol
Serum LDL-cholesterol
Serum HDL-cholesterol
Serum triglycerides
Serum potassium.
Serum uric acid.,[object Object]
Estimated creatinine clearance (Cockroft-Gault formula) or glomerular filtration rate (MDRD formula).

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