Lab diagnosis of Sexually transmitted Infections (STIs)Mostafa Mahmoud
This lecture was presented to the physicians dealing with the various infectious diseases specially in STIs in Riyadh Region, MOH. The lecture concentrates about the various methodology applied to diagnose STIs in the laboratory with the advantages and disadvantages of each. Hope to make benefits to all.
This is a powerpoint presentation on the epidermal keratinization and its associated disorders, presented by Dr. Jerriton, Dermatology resident of SVMCH, Pondicherry.
Lab diagnosis of Sexually transmitted Infections (STIs)Mostafa Mahmoud
This lecture was presented to the physicians dealing with the various infectious diseases specially in STIs in Riyadh Region, MOH. The lecture concentrates about the various methodology applied to diagnose STIs in the laboratory with the advantages and disadvantages of each. Hope to make benefits to all.
This is a powerpoint presentation on the epidermal keratinization and its associated disorders, presented by Dr. Jerriton, Dermatology resident of SVMCH, Pondicherry.
Presented by Dr. Seraj Ahmad Jahanfar; Emergency and Critical Care physician at French Medical Institute for Mother and Children in Kabul, Afghanistan.
Non-Gonococcal urethritis. main causative organisms are Chlamydiae, Mycoplasma, Ureaplasma. various other bacteria and viruses can cause this. this powerpoint is made in systemic manner and will be helpful for Postgraduate students.
The drugs included in the presentation are Methotrexate, Cyclosporine, Azathioprine, Cyclophosphamide, Mycophenolate mofetil and Intravenous Immunoglobulin.
It is useful mainly for dermatologists.
Fungal skin infections are commonly affect the outer layer of the skin, nails and hair. Most of the fungi causing infections are usually dermatophytes (tinea), yeast (candida) and molds
A concised information regarding use of photo therapy in dermatology. made by me as a part of MD dermatology residency. includes additional information about sunscreens.
Visceral leishmaniasis (VL), also known as kala-azar, is the most severe form of leishmaniasis caused by the protozoan parasite Leishmania donovani and transmitted by the infected sandflies. It characterized by irregular bouts of fever, substantial weight loss, swelling of the spleen and liver, and anaemia.
Presented by Dr. Seraj Ahmad Jahanfar; Emergency and Critical Care physician at French Medical Institute for Mother and Children in Kabul, Afghanistan.
Non-Gonococcal urethritis. main causative organisms are Chlamydiae, Mycoplasma, Ureaplasma. various other bacteria and viruses can cause this. this powerpoint is made in systemic manner and will be helpful for Postgraduate students.
The drugs included in the presentation are Methotrexate, Cyclosporine, Azathioprine, Cyclophosphamide, Mycophenolate mofetil and Intravenous Immunoglobulin.
It is useful mainly for dermatologists.
Fungal skin infections are commonly affect the outer layer of the skin, nails and hair. Most of the fungi causing infections are usually dermatophytes (tinea), yeast (candida) and molds
A concised information regarding use of photo therapy in dermatology. made by me as a part of MD dermatology residency. includes additional information about sunscreens.
Visceral leishmaniasis (VL), also known as kala-azar, is the most severe form of leishmaniasis caused by the protozoan parasite Leishmania donovani and transmitted by the infected sandflies. It characterized by irregular bouts of fever, substantial weight loss, swelling of the spleen and liver, and anaemia.
A comprehensive description of leischmaniasis with its types, transmission, epidemiology, pathogenesis, prevention and control. It also includes details regarding lab diagnosis, disease agent, vector and host.
Se describe la leucemia cutis en cuanto a sus manifestaciones cutáneas y a las características diagnósticas observadas en la microscopía en dicha enfermedad.
Se debe sospechar esta enfermedad en pacientes con diátesis hemorrágica, y muchos otros signos y síntomas, además de la relación con otras enfermedades como procesos infecciosos / inmunocomprometidos, pioderma gangrenoso, eritema nodoso, paniculitis, eritema multiforme, urticaria, otras dermatosis refractarias al tratamiento convencional inicial.
Hay infiltración de células leucémicas, y también otras alteraciones no específicas. Esto llevará a cambiar el pronóstico del estado de salud del paciente.
Existe la variante aleucémica.
Es una presentación infrecuente en la que la piel está infiltrada por células leucémicas, en ausencia de leucemia demostrable en sangre periférica o en médula ósea.
Es imprescindible realizar estudio histológico de la piel e inmunofenotipificación.
Más información en:
www.patologica.com
Patologica.com
www.apatologica.blogspot.com
www.apatologica.blogspot.co.uk
www.apatologica.blogspot.com.es
Referencias:
Agrawal AK, Guo H, Golden C. Siblings presenting with progressive congenital aleukemic leukemia cutis. Pediatr Blood Cancer. 2011;57(2):338-40.
Birgit Federmann, Manuel Abele, David Santiago Rosero Cuesta, Wichard Vogel, Leonardo Boiocchi, Lothar Kanz, Leticia Quintanilla-Martinez, Attilio Orazi, Irina Bonzheim, Falko Fend.The detection of SRSF2 mutations in routinely processed bone marrow biopsies is useful in the diagnosis of chronic myelomonocytic leukaemia. Human Pathology 2014;45(12):2471–2479.
Iitani MM, Abe R, Yanagi T, et al. Aleukemic leukemia cutis with extensive bone involvement. J Am Acad Dermatol. 2010 Sep;63(3):539-41.
Martínez-Poventud G, Fradera J, Pérez S, et al. Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. PRHSJ. 2008;27(3):256-8.
Najem N, Zadeh VB, Badawi M, et al. Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. Pediatr Dermatol. 2011;28(5):535-7.
Yoder FW, Schuen RL. Aleukemic leukemia cutis. Arch Dermatol. 1976; 112: 367-9.
Yonal I, Hindilerden F, Coskun R, et al. Aleukemic Leukemia Cutis Manifesting with Disseminated Nodular Eruptions and a Plaque Preceding Acute Monocytic Leukemia: A Case Report. Case Rep Oncol. 2011;4:547–54.
history of TB,epidemiology, clinical features, lab diagnosis, treatment, MDR TB, XDR TB, TDR TB, and mechanism of drug resistant, methods of identification of resistant drugs
Malaria diagnosis and management case based study tGovindRankawat1
P. Vivax schizont
The diagnosis of P. vivax malaria is later confirmed by review of a blood smear available from the first episode (Figure), and by a PCR positive for P. vivax on blood collected during the current episode.
The microscopic diagnosis of P. vivax is based on the following:
The infected red cells are enlarged and deformed;
The schizont shown contains 20 merozoites (schizonts of P. malariae and P. ovale have fewer merozoites; and in P. falciparum, schizonts are not usually seen in the peripheral blood);
The round gametocyte shown, contained in an enlarged red cell. (In this case, the typical Schüffner’s dots were not visible, probably due to staining problems.)
updated info from reliable source .
it helps in understanding complications due to covid . it is handy for interns and postgraduates to act when cases come ,
Infertility is defined as the inability of a couple to conceive after at least one year of regular unprotected intercourse.
Male infertility refers to a male's inability to cause pregnancy in a fertile female.
IDD situation in our country has improved
A good number of thyroid disorder patients are either undiagnosed and or untreated
Thyroid disorder in pregnancy- Rate high
As a sound thyroid functioning status is crucial for growth, development in children; reproduction, psychological and general wellbeing in adults, we must be proactive in screening, diagnosing and treating our patients.
Over the past several years it has been proved that maternal thyroid disorder influence the outcome of mother and fetus, during and also after pregnancy. The most frequent thyroid disorder in pregnancy is maternal hypothyroidism. It is associated with fetal loss, placental abruptions, pre-eclampsia, preterm delivery and reduced intellectual function in the offspring.1 In pregnancy, overt hypothyroidism is seen in 0.2% cases2 and sub clinical hypothyroidism in 2.3% cases3. Fetal loss, fetal growth restriction, pre-eclampsia and preterm delivery are the usual complications of overt hyperthyroidism (low TSH and high T3, T4) seen in 2 of 1000 pregnancies whereas mild or sub clinical hyperthyroidism (suppressed TSH alone) is seen in
1.7% of pregnancies and not associated with adverse outcomes4. Autoimmune positive euthyroid pregnancy shows doubling of incidence of miscarriage and preterm delivery. Worldwide more than 20 million people develop neurological sequel due to intra uterine, iodine deprivation5. Other problems of thyroid disorders in pregnancy are post partum thyroiditis, thyroid nodules and cancer, hyper emesis gravidarum etc. Debates and disputes persist regarding several protocol and management plan in this specific spectrum of diseases.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Hemodialysis: Chapter 3, Dialysis Water Unit - Dr.Gawad
Diagnosis ka pkdl by dr shahjada_selim
1. Diagnosis of Kala-azar
and PKDL
Dr Shahjada Selim
MBBS MD (EM)
Registrar (Medicine), ShSMCH, Dhaka
email: selimshahjada@gmail.com
2. Clinical Case definition for Kala-azar and PKDL
The diagnosis of Kala-azar will be based on the
following criteria in a symptomatic case.
History of fever for more than 2 weeks
Residing/ traveling in endemic areas
Any one of the following symptoms and signs:
Splenomegaly
Weight loss
Anemia
And ‘rk39’ test positive.
3. Post Kala-azar Dermal Leishmaniasis
(PKDL)
PKDL should be considered if all of the following
features are present.
Residing / travelling in the endemic areas
History of treatment for Kala-azar any time in the past1
.
Suggestive skin lesion without loss of sensation, which may be macular,
papular, nodular or mixed.
Exclusion of other causes of skin disease eg. Leprosy, Vitiligo, Pityriasis,
Ring worm etc.
Rk39 positive2
/ Slit skin smear positive/ PCR positive.
1
In rare instances h/o treatment of Kala-azar may be absent in PKDL.
2
In Rare instances in PKDL rk39 may be negative and should be diagnosed
by slit skin smear.
7. Case definition for reporting
Following clinical case definitions will be used for reporting
and follow up. The case definitions will be as follows-
Primary Kala-azar (PKA):
An individual who is diagnosed to have KA with the
above mentioned case definition and no history of
treatment for KA before will be considered as
primary Kala-azar (PKA).
8. Clinical Case Definition
Kala-azar Treatment Failure (KATF):
An individual, who is diagnosed to have KA with the above
mentioned case definition and history of treatment for KA
within last one year, will be reported as KATF. All efforts
should be made to diagnose KATF parasitologically by
examination of splenic smear or bone marrow or PCR.
9. Clinical Case Definition
Relapse Kala-azar (RKA):
An individual who is diagnosed to have KA with
the above mentioned case definition and history of
treatment for KA anytime in the past but not
within last one year will be reported as RKA. All
efforts should be made to diagnose KATF
parasitologically by examination of splenic smear
or bone marrow or PCR.
10. Post Kala-azar Dermal Leishmaniasis (PKDL):
An individual who is diagnosed to have PKDL with the above
mentioned case definition will be reported as PKDL.
Cutaneous Leishmaniasis (CL):
CL should be suspected in a person or a case of skin ulcer
(single or multiple) that travelled an endemic area (Middle
East, South America, Africa etc.). CL should always be
confirmed by demonstration of parasite from the lesion by slit
skin smear or parasite DNA in tissue specimen.
Clinical Case Definition
11. Diagnosis of Kala-azar in special situations
The diagnosis of Kala-azar can be difficult in special
situations. The common special situations are Kala-azar-TB
co-infection, Kala-azar-HIV co-infection, Kala-azar in
pregnancy etc. All efforts should be made to diagnose KA
in special situation by parasitological examination of
splenic smear or bone marrow or PCR. In cases of Kala-
azar HIV co-infection 'rK39' test may be negative. Patients
with Kala-azar in special situations should be referred to the
required level of facility as appropriate.
12. Location for Kala-azar and PKDL diagnosis
A) Level 1
In endemic areas in (union sub centre, community clinic or others)
1. Identify cases of fever of more than 2 weeks duration
2. Identify cases who have macular, papular or nodular skin lesions but no other
signs
3. Refer the patients with above problems to Upazila health complex for evaluation,
testing and treatment for Kala-azar or PKDL.
In endemic areas in upazila health complex
1. Check patients with fever of more than 2 weeks associated with splenomegaly
2. Check patients with macular, nodular or mixed lesions without loss of sensation.
Perform ‘rK39’ test :
(a) On all patients with fever of more than 2 weeks and have splenomegaly
(b) Patients with macular, papular or nodular or mixed lesions and no loss of
sensation.
3.Treat patients of Kala-azar with first line drugs
4. Refer PKDL cases whose need tissue biopsy and unresponsive cases of Kala-
azar to level III facility.
13. Location for Kala-azar and PKDL diagnosis
B) Level II
1. Check patients with fever of more than 2 weeks associated with splenomegaly.
2. Check patients with macular, nodular or mixed lesions without loss of sensation.
Perform ‘rK39’ test :
(a) On all patients with fever of more than 2 weeks and have splenomegaly
(b) Patients with macular or nodular or mixed lesions and no loss of sensation.
3. Treat patients of Kala-azar with first line drugs
4. Refer PKDL cases to who need tissue biopsy and unresponsive cases of Kala-azar to level
III facility.
C) Level III
1. Treat unresponsive Kala-azar or KATF cases and refer back of PKDL cases to level I and II
for treatment after tissue diagnosis.
2. Perform the slit skin smear/biopsy in suspected cases of PKDL that are ‘rK39’ test negative
3. Perform bone marrow / splenic aspiration in patients where these are indicated, as a part of
drug monitoring studies or as a part of quality assessment
4. Treat any complications associated with bone marrow/ splenic aspirate
D) Level IV (specialized laboratories)
1. Perform PCR test for establishing the diagnosis of PKDL in cases that are suspected to have
the disease but ‘rK39’test is negative
2. Diagnosis of HIV-Kala-azar co-infection may be done by bone marrow/ splenic aspirate
14. Associated Laboratory Investigations
• Complete Blood Count & Peripheral Blood Film
• High ESR
• Progressive Neutropenia
• Relative Lymphocytosis
•Serum Creatinine
•Serum ALT
• BT CT
•Abdominal Ultrasonogram