Presented by Dr. Seraj Ahmad Jahanfar; Emergency and Critical Care physician at French Medical Institute for Mother and Children in Kabul, Afghanistan.
Definition of erythema infectiosum, the causative factor, clinical presentation, the three stages of rash, the slipped cheek, the sequences of the rash, the diagnosis of the fifth disease, the differential diagnosis of fifth disease, the treatment of erythema infectiosum, the prognosis of fifth disease , congenital erythema infectiosum, the complications of fifth disease , Human parvovirus B19
Definition of erythema infectiosum, the causative factor, clinical presentation, the three stages of rash, the slipped cheek, the sequences of the rash, the diagnosis of the fifth disease, the differential diagnosis of fifth disease, the treatment of erythema infectiosum, the prognosis of fifth disease , congenital erythema infectiosum, the complications of fifth disease , Human parvovirus B19
Erythema infectiosum made Very simple!!!!!!DrYusraShabbir
A brief description of viral infection causing the disease Erythema Infectiosum or the fifth disease. Affects infants and babies. Useful for medical students, doctors, dermatologist, and nurses. Helpful in preparing for exams. It describes the disease, and its clinical features, what happens in pregnancy and treatment timeline. Useful for USMLE, MCPS, FCPS and MRCP exams.
is an upper respiratory tract bacterial infection associated with a characteristic rash, which is caused by an infection with pyrogenic exotoxin (erythrogenic toxin) -producing GAS in individuals who do not have antitoxin antibodies In the past.
scarlet fever was thought to reflect infection of an individual lacking toxin-specific immunity with a toxin-producing strain of GAS.
Subsequent studies have suggested that development of the scarlet fever rash may reflect a hypersensitivity reaction requiring prior exposure to the toxin.
Erythema infectiosum made Very simple!!!!!!DrYusraShabbir
A brief description of viral infection causing the disease Erythema Infectiosum or the fifth disease. Affects infants and babies. Useful for medical students, doctors, dermatologist, and nurses. Helpful in preparing for exams. It describes the disease, and its clinical features, what happens in pregnancy and treatment timeline. Useful for USMLE, MCPS, FCPS and MRCP exams.
is an upper respiratory tract bacterial infection associated with a characteristic rash, which is caused by an infection with pyrogenic exotoxin (erythrogenic toxin) -producing GAS in individuals who do not have antitoxin antibodies In the past.
scarlet fever was thought to reflect infection of an individual lacking toxin-specific immunity with a toxin-producing strain of GAS.
Subsequent studies have suggested that development of the scarlet fever rash may reflect a hypersensitivity reaction requiring prior exposure to the toxin.
A brief discussion on different Viral ex anthems especially measles. In a simple and easy manner, the measles virus is explained with its clinical features, treatment, investigations, and vaccination. Helpful for clinicians, dermatologists and pediatricians. Helpful for exam preparation for FCPS, MCPS, MRCP and USMLE in the field of dermatology. Also helpful for med students and nurses.
Smallest known DNA viruses.
Structure
Non-enveloped
18-26 nm diameter
Single-stranded DNA, 5.6 kb
Icosahedral
Parvovirinae (vertebrates)
Parvovirus
Erythrovirus
Dependovirus (requires helper virus, such as an adenovirus)
Bocavirus
Amdovirus
Densovirinae (invertebrates)`
B19 virus most common.
Diseases
Erythema infectiosum (cutaneous rash)
Polyarthropathy syndrome (acute or chronic)
Transient aplastic crisis (severe acute anemia)
Pure red cell aplasia (chronic anemia)
Hydrops fetalis (fetal anemia)
Simplest animal viruses infecting humans, responsible for - childhood exanthema - erythema infectiosum (fifth disease).
Smallest viruses (18–26 nm size)
Non-enveloped with icosahedral symmetry
Only DNA viruses - possess single-stranded DNA
Depend upon the host cell enzymes for replication
Transmission - Respiratory route, followed by blood transfusion and transplacental route.
Infects precursors of RBCs: Parvovirus B19 has a special tropism for erythroid progenitor cells present in adult bone marrow and foetal liver as it binds to blood group P antigen as receptors; which are present on the RBC surface.
This results in red cell destruction and inhibition of erythropoiesis
Erythema infectiosum (or fifth disease)
Transient aplastic crisis
Pure red cell aplasia
Non-immune hydrops fetalis
Papular-purpuric gloves and socks syndrome
Known to cause foetal loss through hydrops fetalis; severe anaemia, congestive heart failure, generalized oedema and foetal death
No evidence of teratogenicity.
Risk of foetal death highest when infection occurs during the second trimester of pregnancy (12%).
Molecular methods:
PCR - detects viral DNA (e.g. genes coding for VP1 and VP2) from serum, tissue or respiratory secretions.
Real time PCR - used for quantification of viral load in blood, during acute infections
Antibody detection: ELISA – detecting antibodies against VP1 and VP2 antigens. IgM appears early - recent infection and remains elevated for 2–3 months
Antigen detection: Immunohistochemistry - detect viral antigens in fetal tissues and bone marrow.
No antiviral drug is available
Symptomatic treatment is given
Immunoglobulins containing neutralizing antibodies to human parvovirus are available commercially
No antiviral drug is available
Symptomatic treatment is given
Immunoglobulins containing neutralizing antibodies to human parvovirus are available commercially
Measles is an acute, highly contagious childhood disease characterized by fever & respiratory symptoms, followed by typical maculopapular rash.
Transmission
Droplets inhalation over short distances and, less commonly,
Small-particle aerosols - remain suspended especially in schools, hospitals, and enclosed public places in the air for longer period.
Spread-The virus multiplies locally in the respiratory tract; then spreads to the regional lymph nodes → enter into the bloodstream in infected monocytes (primary viremia)→further multiply in reticuloendothelial system → spills over into blo
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Viral exanthems
1.
2. An acute viral disease
Highly contagious
Measles virus is a single-stranded, lipid-enveloped
RNA virus in the family Paramyxoviridae and
genus Morbillivirus
Humans are the only host of measles virus
Maintenance of >90% immunity through vaccination-
NO OUTBREAKS
3. Necrosis of the respiratory tract epithelium & an
accompanying lymphocytic infiltrate
Small vessel vasculitis on the skin and on the oral
mucous membranes
Warthin-Finkeldey giant cells: pathognomonic for
measles, formed by fusion of infected cells, with up
to 100 nuclei and intracytoplasmic and intranuclear
inclusions
Measles virus also infects CD4+ T cells, resulting in
suppression of the Th1 immune response
5. Incubation period: measles virus migrates to
regional lymph nodes primary viremia-
disseminates the virus to the
reticuloendothelial system secondary
viremia spreads virus to body surfaces
The prodromal illness begins after the
secondary viremia; associated with epithelial
necrosis, giant cell formation & virus shedding
With onset of the rash, antibody production
begins & viral replication & symptoms begin to
subside
6. Through the respiratory tract or conjunctivae
Following contact with large droplets or small-
droplet aerosols in which the virus is suspended
Patients are infectious from 3-4 days before to up
to 4-6 days after the onset of rash
7. High fever, an enanthem, cough, coryza,
conjunctivitis & a prominent exanthem
Incubation period: 8-12 days
Prodromal phase: mild fever, conjunctivitis with
photophobia, coryza, a prominent cough and KOPLIK’S
SPOTS
Koplik spots: enanthem & the pathognomonic sign of
measles
Appear 1 to 4 days prior to the onset of the rash
Discrete red lesions with bluish-white spots in the
center on the inner aspects of the cheeks at the level
of the premolars
8. Koplick’s spots: spread
to involve the lips,
hard palate & gingiva
They also may occur
in conjunctival folds
9. Temperature rises abruptly as rash appears & may
reach upto 40OC
Measles rash: generalized, maculopapular,
erythematous, confluent
The rash begins on the face around
the hairline & behind the ears
It then spreads downward
to the neck, trunk, arms, legs
and feet over next 24-48 hours
10. The rash fades over about 7 days in the same
progression as it evolved
Leaves a fine, browny, branny desquamation of skin
Severity of disease: related to the extent and
confluence of rash
Rash: may be absent in immuno-compromised
children
Hemorrhagic measles (black measles): bleeding from
mouth, nose or bowels
11. Diarrhoea: more common in malnourished and small
children
Severe cases: generalized lymphadenopathy
including cervical & mesenteric lymph nodes
Mild splenomegaly
12. Almost always based on clinical and epidemiologic
findings (history of contact)
Fever of at least 3 days with at least one of three C
(cough, coryza, conjuctivitis)
Decreased total white blood cell count, with relative
lymphocytosis
13. IgM antibody in serum: appears 1-2 days after the
onset of the rash & remains detectable for about
1 mo
Demonstration of a fourfold rise in IgG antibodies in
acute & convalescent specimens collected 2-4 wk
later
Viral isolation from blood, urine or respiratory
secretions by culture or rt-PCR
14. Rubella-rashes & fever are less striking
Roseola infantum (exanthem subitum)- rash appear
as the fever disappears
Echovirus
Coxsachie
Adenovirus
Infectious mononucleosis
Scarlet fever-diffuse fleshy papular rash with
“goose flesh” texture
15. Meningococcemia-rashes are similar but NO
conjuctivitis & cough
Kawasaki disease- no cough, elevations of
neutrophils and acute-phase reactants; the
characteristic thrombocytosis
Drug fever
16. Due to the pathogenic effects of the virus on the
respiratory tract and immune system
Risk factors for complications
Children <5 years of age & adults >20 years of age
Severe malnutrition
Vitamin A deficiency
Immuno-compromised persons
17. Pneumonia- giant cell pneumonia (direct viral
infection) or super-imposed bacterial infection
(Streptococcus pneumoniae, Haemophilus
influenzae & Staphylococcus aureus)
Croup, tracheitis or bronchiolitis
Acute otitis media
Sinusitis and mastoiditis
Retropharyngeal abscess
Activation of pulmonary tuberculosis
18. Diarrhea & vomiting
Appendicitis- obstruction of the appendiceal lumen
by lymphoid hyperplasia
Febrile seizures
Encephalitis- 1-3/1,000 cases of measles;
postinfectious, immunologically mediated process,
not due to a direct viral effect
19. Measles encephalitis in immunocompromised
patients-from direct damage to the brain by the
virus
Thrombocytopenia
Myocarditis
Bacteremia, cellulitis & toxic shock syndrome
Measles during pregnancy-high maternal morbidity,
fetal wastage & stillbirths & congenital
malformations in 3% of live born infants
20. Fatal degenerative disease of central nervous
system
Chronic complication of measles
Result from a persistent infection with an altered
measles virus that is harbored intracellularly in the
CNS for several years
Usually after 7-10 year the virus apparently regains
virulence & attacks the cells in the CNS
Change in personality, gradual onset of mental
deterioration and myoclonus
Measles vaccination protects against SSPE
21. SUPPORTIVE
Maintenance of hydration, oxygenation and comfort
Antipyretics-comfort and fever control
Vitamin A supplementation-reduced morbidity and
mortality from measles
Single dose of 200,000 IU orally for children
≥1 yr of age (100,000 IU for children 6 mo–1 yr
of age and 50,000 IU for infants <6 mo of age)
22. Isolation- from 7 days after exposure to 4-6 days
after the onset of rash
Vaccine or immunoglobulin- vaccine is effective in
prevention or modification of measles only if given
within 72 hr of exposure. Immune globulin may be
given up to 6 days after exposure to prevent or modify
infection.
Immune globulin-for susceptible household contacts
younger than 6 months of age, pregnant women and
immunocompromised persons
Immunization during an outbreak-immunize infant as
young as 6 months of age; additional dose at 12-15
months of age
23. Rubella (German measles or 3-day measles)
Mild exanthematous disease of infants and children
Major clinical significance- fetal damage as part of
the congenital rubella syndrome
Etiology: Rubella virus; RNA virus of genus Rubivirus
under family Togaviridae
Humans are the only known host.
24. Transmission-through oral droplet or transplacental
route
Virus is shed in nasopharyngeal secretions 7 days
before exanthem & upto 7-8 days after its
disappearance
Rubella susceptibility among women of child bearing
age in India- 4%-43%
25. Infection virus replication in the respiratory
epithelium spreads to regional lymph nodes
viremia viral shedding from the nasopharynx
Cellular and tissue damage in the infected fetus:
tissue necrosis, reduced cellular multiplication time,
chromosomal breaks & production of a protein
inhibitor causing mitotic arrests
Most distinctive feature of congenital rubella:
chronicity
Ongoing tissue damage and reactivation
26. Risk factor for severe congenital defects: stage of
gestation at the time of infection
Maternal infection during the 1st 8 wk of gestation:
most severe & widespread defects
Risk for congenital defects: 90% for maternal
infection before 11 wk of gestation, 33% at 11-
12 wk, 11% at 13-14 wk & 24% at 15-16 wk
After 16 wk of gestation: defects uncommon
27. POSTNATAL INFECTION
Incubation period: 14-21 days
Prodrome: low-grade fever, sore throat, red eyes
with or without eye pain, headache, malaise, anorexia
& lymphadenopathy (suboccipital, postauricular &
anterior cervical lymph nodes)
Rash: begins on the face & neck as small, irregular
pink macules that coalesce and it spreads
centrifugally to involve the torso and extremities,
where it tends to occur as discrete macules
28. Rash: fades from the face as it extends to the rest
of the body so that the whole body may not be
involved at any 1 time
The duration of the rash is generally 3 days & it
resolves without desquamation
29. About the time of onset of the rash, examination of
the oropharynx- reveal tiny, rose-colored lesions
(Forchheimer spots) or petechial hemorrhages on the
soft palate
Subclinical infections are common (25-40%)
Polyarthritis or arthralgia-common in adult females
Lab findings: Leukopenia, neutropenia & mild
thrombocytopenia
30. Mild form of measles
Scarlet fever
Roseola infantum
Enteroviral infections
Drug fever
Infectoius mononucleosis
Erythema infectiosum
31. Supportive history of exposure or consistent clinical
findings
Rubella specific IgM enzyme immunosorbent assay (4-
72 days)
Fourfold rise in IgG in sequential sera
Rubella virus culture from nasopharynx & blood by
tissue culture system or PCR
WHO definition of PROBABLE infection: fever,
maculopapular rash, lymphadenopathy or
arthralgia/arthritis
WHO definition of CONFORMED infection: probable
case with IgM positivity within 28 days of onset of rash
32. Postinfectious thrombocytopenia
Arthritis- classically involves the small joints of the
hands
Encephalitis-a postinfectious syndrome following
acute rubella & a rare progressive panencephalitis
manifesting as a neurodegenerative disorder years
following rubella
Guillain-Barré syndrome, peripheral neuritis
Myocarditis
33. Result of in utero fetal infection
Classical CRS triad: cataract, sensorineural hearing
loss and congenital heart disease
Clinical manifestations:
Intrauterine growth restriction, postnatal mental and
motor retardation
Bilateral/unilateral cataract, salt-and-pepper
retinopathy, microphthalmia
Nerve deafness
Meningoencephalitis at birth
35. No specific treatment available for either acquired
rubella or CRS
Supportive treatment- antipyretics and analgesics
Intravenous immunoglobulin or corticosteroids-for
severe, nonremitting thrombocytopenia
Hearing screening- important, early intervention
improve outcomes
36. Management of exposed pregnant women
Rubella antibody status is tested immediately
result positive mother is immune no further
action
Rubella antibody status negative repeat samples
after 1-2 weeks negative 1st specimen & positive
test result in either the 2nd or 3rd specimen
seroconversion suggesting recent infection
termination of pregnancy
37. Management of congenital rubella syndrome
Children with CRS may excrete the virus in
respiratory secretions up to 1 yr of age
Isolation & contact precautions maintained unless
repeated cultures of urine and pharyngeal secretions
have negative results
Isolation at home my be required for 1 year
Care of CRS infants require multidisciplinary team
Prognosis poor
PREVENTION by IMMUNIZATION
38. Varicella is an acute febrile rash illness
Caused by VZV which is a neurotropic human α-
herpesvirus
Secondary attack rate: 90%
Transmission: by airborne spread or through direct
contact with skin lesions
Varicella results from inoculation of the virus onto the
mucosa of the upper respiratory tract and tonsillar
lymphoid tissue
39. Incubation period (10-21 days): replication
in the local lymphoid tissue primary
viremia-disseminates the virus to the
reticuloendothelial system secondary
viremia spreads virus to body surfaces
leading to widespread cutaneous lesions
During the late incubation period-VZV
transported back to the mucosa of the upper
respiratory tract & oropharynx, permitting
spread to susceptible contacts 1-2 days
before the appearance of rash
Host immune responses limit viral replication
and facilitate recovery from infection
Immunocompromised child-continued viral
replication -disseminated infection
40. Transportation of virus in a retrograde manner
through sensory axons to the dorsal root ganglia
throughout the spinal cord establishment of
virus latent infection in the neurons
subsequent reactivation
herpes zoster, a vesicular rash that usually is
dermatomal in distribution
41. Prodromal symptoms: fever (moderate), malaise,
anorexia, headache and occasionally mild abdominal
pain, 24-48 hours before the rash appears
These symptoms resolve within 2-4 days after the
onset of the rash
Varicella rash often appear first on the scalp, face, or
trunk
The initial exanthem consists of intensely pruritic
erythematous macules that evolve through the papular
stage to form clear, fluid-filled vesicles
Clouding & umbilication of the lesions begin in 24-
48 hr
42. While the initial lesions are crusting, new crops form
on the trunk & then the extremities
The simultaneous presence of lesions in various
stages of evolution is characteristic of varicella
The distribution of the rash is predominantly central
or centripetal
Pearl on a rose patel
43. The average number of varicella lesions is about 300
(10-1500)
Hypopigmentation or hyperpigmentation of lesion sites
persists for days to weeks in some children
Severe scarring is unusual unless the lesions were
secondarily infected
44. Vesicular rashes caused by
Herpes simplex virus
Enterovirus
Rickettsial pox
S. aureus
Drug reactions
Contact dermatitis
Insect bites
45. CLINICAL
Leukopenia during the 1st 72 hours after onset of
rash; followed by a relative & absolute lymphocytosis
Elevated hepatic enzymes
Specific diagnosis of VZV infection: needed in
immunocompromised children
47. Orchitis
Secondary bacterial infections of the skin (group A
streptococci & S. aureus): impetigo, cellulitis,
lymphadenitis & subcutaneous abscesses; varicella
gangrenosa- more invasive skin infections
48. In infants born to women who have varicella before
20 wk of gestation
Characterized by
Cicatricial skin scarring in a zoster-like distribution,
limb hypoplasia
Neurologic abnormalities: microcephaly, cortical
atrophy, seizures & mental retardation
Eye abnormalities: chorioretinitis, microphthalmia &
cataracts
Renal abnormalities: hydroureter & hydronephrosis
Autonomic nervous system abnormalities: neurogenic
bladder, swallowing dysfunction & aspiration pneumonia
49. If a baby is born <4 days after onset of maternal
varicella or upto 2 days before the onset: high risk
for severe varicella & a high mortality rate
50. Supportive treatment for fever & itching
Indications for acyclovir in children:
Malignancies
BMT
Chmotherapy or high dose steroid treatment
HIV infection
Severe varicella
Chronic skin disease
Long term salicylate therapy
Chlidren >12 years
Treatment should be initiated within 24 hr of the
onset of rash
51. Foscarnet is the only drug for the treatment of
acyclovir-resistant VZV infections (in children infected
with HIV)