1. 2014 WINTER WEBINAR SERIES
SHEEP & GOAT HEALTH
PART III:
DIAGNOSIS AND TREATMENT OF DISEASES
SUSAN SCHOENIAN & JEFF SEMLER – UNIVERSITY OF MARYLAND EXTENSION
2. DIAGNOSIS AND TREATMENT OF DISEASES
DIAGNOSIS
TREATMENT
Sometimes, we can’t identify the disease or causative organism;
Sometimes, all we can do is treat symptoms. Sometimes, we never know.
3. THERE ARE SEVERAL WAYS TO DIAGNOSE
DISEASE PROBLEMS IN SMALL RUMINANTS.
• Clinical signs (symptoms)
• Physical exam
• Case history
• Response to treatment
• Serology (blood testing)
• Other tests
• Necropsy (post-mortem)
4. MOST (BUT NOT ALL) DISEASES HAVE CLINICAL SIGNS
(SYMPTOMS). KEEN OBSERVATION IS THE KEY.
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Appetite
Behavior
Gait
Recumbency
Body condition
Discharges (vaginal, nasal)
Hair or wool loss
Fecal consistency (dagginess)
Color of mucous membranes
Lesions
Abscesses
Swelling
Pus
Pain
Breathing
Sheep and goats are generally slow to show clinical signs.
7. MANY DISEASES ARE DIAGNOSED AFTER A
THOROUGH PHYSICAL EXAM IS CONDUCTED.
• Arthritis
• Hoof diseases
• Bloat
• Mastitis
• Club lamb fungus (ringworm)
• Ovine progressive pneumonia (OPP)
• Dystocia (malpresentation)
• Pink eye
• Dystocia (ringwomb)
• Pneumonia
• Epididymitis
• Skin diseases
• External parasites
• Sore mouth
• Hernia
• Urinary calculi (kidney stones)
8. CASE HISTORIES ARE USEFUL FOR DIAGNOSING
DISEASE PROBLEMS.
• Weight, age, and of animal
• Other animals affected
• Other deaths
• Other symptoms
• Nutritional management
• Changes in feed and management
• Vaccination history
• Treatment history
• Reproductive management
9. SOME DISEASES ARE CONFIRMED BASED ON
THE RESPONSE TO TREATMENT.
• Floppy kid syndrome
(sodium bicarbonate)
• Grass tetany
(magnesium)
• Milk fever
(calcium)
• Polioencephalomalacia
(thiamine)
• Pregnancy toxemia
(glucose)
Milk fever or pregnancy toxemia?
10. FECAL TESTS ARE AN IMPORTANT DIAGNOSTIC
TOOL FOR SMALL RUMINANT PRODUCERS.
GASTRO-INTESTINAL PARASITES
OTHER DISEASE CONDITIONS
• Simple fecal flotation
• Infectious diarrhea (scours)
• Fecal egg count (FEC)
• Johne’s disease
• Fecal oocyte count (FOC)
• Fecal egg count reduction test (FECRT)
• DrenchRite® larval development assay
• Fecal coproculture (larvae ID)
• Leptin staining test
12. MANY OTHER TESTS CAN BE CONDUCTED TO
MAKE OR CONFIRM A DISEASE DIAGNOSIS.
• Acidosis, indigestion
Rumen pH
• Pregnancy toxemia
Urine - ketone bodies
• Caseous lymphadentitis (CL)
Pus - culture superficial abscess
• Scrapie
Rectal biopsy
Third eyelid test
• Club lamb fungus (ringworm)
hair, skin samples
• Epididymitis
Semen - B. ovis
• Listeriosis (circling disease)
Cerebral spinal fluid
• Mastitis - milk
California Mastitis Test - SCCs
Culture and antibiotic sensitivity
• Skin diseases
Skin scrapings
• Toxicities and deficiencies
Tissue culture: liver, kidney
Feed, water, and soil analysis
13. SOME DISEASES CAN ONLY BE DIAGNOSED OR
CONFIRMED BY NECROPSY (POST MORTEM EXAM).
• Abortion (many kinds)
• Listeriosis (circling disease)
• Caseous lymphadenitis (CL)
internal abscesses
• Lungworms
• Coccidiosis
(nodules on small intestines)
• Plant toxicities
• Meningeal worm (deer, brain worm)
• Diarrhea
• Pneumonia
• Enterotoxemia (Clostridia)
• Polioencephalomalacia (pneumonia)
• Rabies
Many times, a necropsy is unable to
determine the cause of death.
• Scrapie (brain tissue)
• Stomach worms
14. NECROPSIES
• If a flock or herd experiences too many unexplained
deaths, specimens should be submitted to a diagnostic
laboratory.
• Fresh specimens increase the probability of getting a
diagnosis.
• A complete clinical history should be provided with the
specimen(s).
• Ideally, you should work with your veterinarian when
submitting samples to a state diagnostic lab.
• Producers can learn to do simple on-farm necropsies,
“digital” necropsies, and/or harvest tissues for testing
15. TREATING DISEASES
• Anthelmintics
• Antibiotics
• Anti-inflammatories
• Other injectable medications
• Other medications and treatments
• Home remedies
• Homeopathic remedies
16. ANTHELMINTICS (DEWORMERS)
Indications
Trade name
Drug
Class
Round
worms
Tape
worms
Lung
worms
Flukes
Larvae
Hypobiotic
External
Drug
Resistance
FDA approval
Sheep
Cydectin®
Moxidectin
ML
*
✗
**
Ivomec®
Ivermectin
ML
nasal bots
****
Prohibit®
Levamisole
IMID
?
?
*
Rumatel ®
Morantel
IMID
SafeGuard ®
Fenbendazole
BZ
*
Valbazen ®
Albendazole
BZ
Zolvix®
Monepantel
AAD
Goats
•
•
•
•
?
****
****
0
flukes
Not available yet
All dewormers should be administered orally, using drench formulations.
Goats should be given 1.5 to 2x the sheep dose.
Fenbendazole and ivermectin are the drugs of choice for the meningeal worm.
Drug resistance varies by geographic region and individual farm. You must test to figure it out for your farm.
17. ANTIBIOTICS
Tradename
Drug
Indications
Sheep
Goats
Aureomycin®
Chlortetracycline
Vibrionic abortion (Camplylobacter)
OTC
OTC Rx
Di-methox,
Albon®
Sulfadimethoxine
Streptococcus, staphylococcus, some e. coli and salmonella, and coccidia
organisms
OTC Rx
Excenel®
Ceftioflur Hydrochoride
Broad spectrum antibiotic
Rx
Rx
Gallimycin®
Erythromycin
Upper respiratory infections and lamb dysentery
OTC
OTC Rx
LA-200®
Oxy-200
Oxytetracycline
General bacterial infections, pneumonia, diarrhea, footrot, uterine infections and
pink eye
OTC Rx
OTC Rx
Naxcel®
Ceftiofur
General bacterial infections including pneumonia
Rx
Rx
Salmonella, e. coli, clostridium, and camplyobacter
OTC
OTC
Pneumonia and upper respiratory infections
Rx
Rx
General bacterial infections, pneumonia, and mastitis
OTC
OTC Rx
Neomycin
Nuflor®
Florfenicol
Penicillin G Procaine
OTC Rx
Spectam®
Spectinomycin
Scours and other infections
OTC Rx
OTC Rx
Sulmet®
Sulfamethazine
General bacterial infections, pneumonia, diarrhea, and uterine infections
OTC Rx
OTC Rx
Terramycin®
Oxytetracycline
Bacterial enteritis, bacterial pneumonia
OTC
OTC Rx
Today®
Cephapirin sodium
Intramammary treatment for clinical and sub-clinical mastitis
OTC Rx
OTC Rx
Tomorrow®
Cephapirin
Intramammary treatment of dry animal for mastitis
OTC Rx
OTC Rx
Tylan®
Tylosin
Respiratory and general bacterial infections
OTC Rx
OTC Rx
18. ANTI-INFLAMMATORY DRUGS
Trade name
Drug
Indications
Sheep
Goats
Aspirin
Acetylsalicylic acid
Where pain relief or fever reduction is
needed (infection, muscle damage,
arthritis, joint pain)
OTC
OTC
Banamine®
Flunixin
meglumine
Use for fever, mastitis, bacterial infection
muscle damage, intestinal or stomach
pain.
Rx
Rx
Phenylbutazone
Where pain relief or fever reduction is
needed (infection, muscle damage,
arthritis, joint pain)
Rx
Rx
Steroid anti-inflammatory.
Stronger than prednisone .
Use when severe inflammation or pain.
Rx
Rx
Bute
Dexamethasone
19. OTHER INJECTABLE MEDICATIONS
Tradename
Drug
Indications
Bo-Se®
Selenium
and vitamin E
Prevent retained placentas and treat muscle/tendon
problems or white muscle disease due to selenium deficiency
Rx
Rx
Cal-Dextro®
Calcium
Treat milk fever and grass tetany
Rx
Rx
CMPK
Calcium
Treat milk fever and grass tetanus
Rx or OTC
Rx or OTC
Allergic reactions
Rx
Rx
Induce abortion or parturition
Rx
Rx
Induce labor, contract uterus
Rx
Rx
Treat thiamine deficiency (polioencephalomalacia
Rx
Rx
Vitamin A-D-E
Increase vitamin A, D, and E status of animals
OTC
OTC
Vitamin B complex
Stimulate appetite
OTC
Rx
Epinephrine
Lutalyse®
PGF2A
Oxytocin
Thiamine HCL
Vitamin B1
Sheep
Goats
20. OTHER MEDICATIONS / TREATMENTS
Drug
Indications
Sheep
Goats
Bimusal
(Pepto Bismal)
Non-infectious diarrhea
OTC
OTC
Kaolin Pectin
(Kaopectate)
Non-infectious diarrhea
OTC
OTC
Mineral oil
Constipation and acidosis
OTC
OTC
Nutri-drench
Nutritional supplement
OCT
OCT
Probios®
Appetite stimulant
OCT
OCT
Propylene glycol
Liquid source of energy.
Treat pregnancy toxemia, rumenitis
OTC
OTC
Red Cell
Nutritional supplement for horses
OTC
OTC
Therabloat
Treat bloat
OTC
OTC
Zinc sulfate
Treat foot rot and scald
OTC
OTC
21. COMMON HOME REMEDIES
Drug
Indications
Antacid
Neutralize acid in rumen, treat bloat
Baking soda
Neutralize acid in rumen
Corn oil
Homemade “nutri-drench”
Gatorade
Electrolytes
Honey
Source of energy
Karo syrup
Source of energy
Homemade “nutri-drench”
Molasses
Source of energy
Pedialyte
Electrolytes
Vegetable oil
Treat bloat
Yogurt
Restore health bacteria to rumen.
Treat non-infectious diarrhea
Stimulate appetite
Treat stress
22. EXTRA-LABEL DRUG USE
• Few drugs are FDA-approved for use in sheep; even
fewer for goats.
• Sheep and goat producers depend on extra-label drug
use to treat their animals.
• Any use of a drug that is inconsistent with its label
must meet the requirements of the extra-label drug
use law (ELDU).
1. Different species
Example: deworming a goat with Cydectin®
2. Different dosage
Example: doubling SafeGuard® dosage for goats
3. Different route of administration
Example: administering Penicillin to sheep subcutaneously (SQ)
23. EXTRA-LABEL DRUG USE
• Only a licensed veterinarian may
administer, prescribe, or dispense a
drug extra-labelly.
• Extra-label drug use (ELDU) law
• A valid veterinarian-client patient
relationship must exist.
• The animal’s health must be threatened.
• There is no approved drug that contains the
same active ingredient in the required
dosage form and concentration.
• Substantially extended withdrawal period.
• Extra-label drug use must not create a
violative residue.