about canine distemper a deadly disease of dogs

1. CANINE DISTEMPER
MORBILLI VIRUS
OF
PARAMYXOVIRIDAE

2. • Complicated by secondary bacterial
invaders like Bordtella bronchiseptica and
Salmonella species producing respiratory
gastrointestinal symptoms

3. DIPHASIC FEVER CURVE
3-4th day
High fever
due to
viraemia
11th –
12th
13th day high fever
due to secondary
bacterial infections

4. Mucous secretion from
conjuctiva
Ulceration of cornea
Panopthalmitis
Retinal atrophy of all layers –
OLD DOG ENCEPHALITIS

5. NORMAL PAWS AFFECTED PAWS
HYPERKERATOSIS OF THE DIGITAL
PADS

6. EPILEPTIC SEIZURES AND EXCESSIVE CHEWING
MOVEMENTS ACCOMPANIED BY SALIVATION

7. CANINE DISTEMPER VIRUS
CAUSES INTERSTITIAL
PNEUMONIA AND SECOND
INFECTIONS DUE TO
BACTERIA CAUSES
BRONCHO PNEUMONIA

8. Interstitial
pneumonia
Broncho-pneumonia

9. Nut meg liver

10. Both intracytoplasmic and
intranuclear inclusion bodies

11. DEMEYELINATION OF NEURONS
Canine distemper virus infection is also associated with
demyelination
Probable reasons are
virus itself
cytotoxic immune responses to virus-infected cells
autoimmune reactions to neural elements (e.g. myelin)
The vacuolated
appearance of the white
matter (WM) which is due
to demyelination.

12. GITTER CELLS
areas of white matter where
demyelination has changed to
necrosis (malacia) as seen in this
photomicrograph.
MICROGLIA PHAGOCYTIZE THE
MYELIN AND FORM GITTER
CELLS

13. GEMISTOCYTES
Gemistocytes are
hypertrophied astrocytes. They
are often prominent in
distemper and often contain
intranuclear inclusion bodies.
One gemistocyte is pointed out
in this brain from a dog with
distemper