2. ā¢ Dewormers are compounds used
to destroy parasitic worms and
expel them from the body.
ā¢ They are meant to treat NOT
prevent internal parasitism.
Therapeutic NOT prophylactic!
ā¢ Different classes of dewormers
have different chemistries and
methods of killing worms. They
usually starve or paralyze them.
ā¢ When there is resistance to one
drug in a class, there is usually
cross (or side) resistance to drugs
in the same class.
3. There are THREE classes of dewormers currently
available for use in small ruminants in the US.
BENZIMIDAZOLES (BZ)
āwhite dewormersā
ā¢ Thiabendazole
TBZĀ®
1. Albendazole
ValbazenĀ®
2. Fenbendazole
Safe-GuardĀ®, PanacurĀ®
3. Oxfendazole
SynathicĀ®
MACROCYCLIC
LACTONES (ML)
1. Avermectins
a) Ivermectin (IvomecĀ®)
b) Doramectin (DectomaxĀ®)
c) Eprinomectin (EprinexĀ®)
2. Milbemycins
a) Moxidecin
CydectinĀ® oral drench
QuestĀ® gel
1
IMADAZOTHIAZOLE
TETRAHYDROPYRIMIDINE
1. IMID
a) Levamisole
ProhibitĀ®, Leva-MedĀ®
2. TETRA
a) Morantel tartrate
RumatelĀ®
Positive PelletĀ®
Goat Dewormer
b) Pyrantel pamoate
Strongid
2 3
4. Fenbendazole:
SafeGuardĀ®
ā¢ Ready-to-use liquid suspension for goats.
ā¢ Works better with increased exposure.
ā¢ Not effective against tapeworms at
labeled dosage (must increase to 3x).
ā¢ Labeled for goats
Not labeled for sheep or camelids.
ā¢ Usually very high level of resistance.
ā¢ Dewormer of choice for meningeal worm
(due to its penetration of CNS).
5. Albendazole:
ValbazenĀ®
ā¢ Usually more effective than fenbendazole
(SafeGuardĀ®).
ā¢ Only dewormer labeled for the removal of
tapeworms (heads and segments).
ā¢ Also has efficacy against adult liver flukes.
ļ Should not be given during the first trimester of
pregnancy (or within 45 days of removal of male).
ā¢ Labeled for sheep.
Labeled for goats for liver fluke removal
Not labeled for camelids.
ā¢ Usually very high level of resistance.
ā¢ Should be included in combination treatment
(if/when 3 dewormers are given).
6. Avermectins:
Ivermectin-like drugs
ā¢ Ready-to-use drench for sheep.
Do not use other formulations.
ā¢ Closely related to moxidectin (CydectinĀ®),
but less potent at killing worms.
ā¢ Effective against external parasites.
Labeled for all stages of nasal bots.
ā¢ Used to treat meningeal worm before
parasite crosses blood-brain barrier (may
also cross a damaged blood-brain barrier)
ā¢ Labeled for sheep
Not labeled for goats or camelids
ā¢ Usually high level of resistance.
ā¢ Negative effect on dung beetles.
7. Moxidectin:
CydectinĀ®
ā¢ Ready-to-use drench for sheep
Do not use other formulations.
ā¢ The most potent ML: closely related to ivermectin.
ā¢ Persistent activity: provides protection against
worms for about 14 days.
ā¢ Effective against some blood-sucking ectoparasites
(not labeled), but not as effective as ivermectin.
ā¢ Labeled for sheep
Not labeled for goats or camelids.
ā¢ Still works on many farms, but resistance is
increasing.
ā¢ Should be included in combination treatment(s).
ā¢ Negative effect on dung beetles, but not as bad as
ivermectin.
8. Levamisole
ProhibitĀ®, Leva-MedĀ®
ā¢ Must be mixed with water before using; need to
follow labeled instructions carefully.
ā Dewormer with narrowest margin of safety (3x).
ā¢ Wider margin of safety if drug is further diluted.
ā¢ Avoid giving to goats in late pregnancy.
ā¢ Usually most effective dewormer*****
ā¢ Labeled for sheep, but not goats or camelids.
ā¢ All combination treatments should include
levamisole.
9. Morantel tartrate:
RumatelĀ® and Positive
Pellet Goat Dewormer
ā¢ Crumbles: top dress or mix in feed
(not the preferred method of deworming)
ā¢ Different products have different
formulations, so be sure to read label
carefully to ensure proper dosage.
ā¢ Kills mature worms only
ā¢ Labeled for goats, but not sheep or
camelids.
ā Zero withdrawal for milk
30-day withdrawal for meat
ā¢ Less is known about resistance, but
limited data suggests there is resistance.
10. Extra label drug
use (ELDU)
ā¢ Using a drug in a manner that is not
on the label:
ā¢ Different species
ā¢ Different dosage
ā¢ Different disease (reason)
ā¢ Different dosage frequency
ā¢ Different route of administration
ā¢ Different withdrawal period
ā¢ Only a licensed veterinarian has the legal right
to use or prescribe drugs extra-label.
ā¢ Certain conditions must be met even for the
veterinarian to use drugs extra label.
ā¢ Extra label drug use is usually required for
effective deworming of goats and camelids.
11. Veterinarian-
client-patient
relationship
(VCPR)
ā¢ You must have a valid
veterinarian-client-
patient-relationship in
order to use drugs
extra label.
ā¢ A VCPR means the vet
has knowledge of the
animals he/she is
treating (must visit
farm*).
ā¢ A VCPR is now required
to use antibiotics, too.
*Frequency varies by vet.
12. Dewormer
resistance
ā¢ When a dewormer loses some or all of its
effectiveness against a worm population.
ā¢ Less than 95% reduction in fecal egg count.
May be effective as sole treatment at lower
fecal egg count reduction, e.g., 60-95%
ā¢ Resistance is a worldwide and growing
problem. It varies by geographic area and
farm and is a result of past deworming
practices.
ā¢ Worms have developed resistance to all
dewormers and dewormers classes.
ā¢ Dewormers need to be used more
selectively to preserve their efficacy.
13. Determining dewormer resistance
FECAL EGG COUNT REDUCTION TEST
ā¢ Before and after fecal egg counts from the
same 10-15 animals.
ā¢ Levamisole, benzimidazoles (10-14 days)
ā¢ Avermectins (14-17 days)
ā¢ Moxidectin (17-21 days)
ā¢ Combination (drug with longest interval)
ā¢ Must test each dewormer or combination
separately.
ā¢ Can use pooled or individual fecal samples.
ā¢ New protocols announced recently.
ā¢ Can learn to do yourself.
ā¢ Some universities offer low-cost fecal egg
counting (wormx.info/lowcostfec)
DRENCHRIGHTĀ® LARVAL ASSAY
ā¢ Laboratory test that uses worm larvae to
determine resistance to all dewormers
simultaneously using a pooled fecal
sample from 10-12 animals.
ā¢ Expensive test
One time cost of ~$500 per sample
ā¢ Louisiana State University only place that
does test Not yet available after
University of Georgia did for many years.
14. Practices which
accelerate(d)
resistance to
dewormers
1. Frequent deworming
2. Underdosing
ā¢ Treating everyone in the group and
moving them to a clean pasture.
ā¢ Using wrong drug formulations
(e.g., injectables and pour-ons).
ā¢ Using dewormers past their
expiration dates.
ā¢ Storing dewormers improperly.
ā¢ Using improper deworming
techniques.
ā¢ Using long-acting or persistent-
activity dewormers.
15. Targeted Selective
Treatment (TST)
or non-treatment
ā¢ Only treating those animals which
require or (would benefit from)
treatment.
ā¢ Reduces amount of deworming.
ā¢ Increases REFUGIA: worms on farm
that have not been exposed to the
drugs; therefore, remain susceptible
to deworming with drug(s).
ā¢ Prolongs drug efficacy.
ā¢ Helps to identify resistance and
susceptible animals.
17. ā¢ Developed in the 1990ās by
South African researchers in
response to ever-growing
dewormer resistance.
ā¢ Developed for sheep originally.
ā¢ Validated (by the ACSRPC) for
sheep, goats, and camelids in
the US.
ā¢ Named for one of the South
African researchers: FAffa
MAlan CHArt ā
21. Performance
criteria
1. Happy FactorĀ® or gain
Deworm individuals that fail
to meet expectations for
average daily gain (ADG).
2. Age of dam
Deworm yearling dams
3. Number of offspring
Deworm dams with 3 or
more offspring
(goats-twins?).
4. Milk production
Deworm high producing
dairy does
22. Fecal egg counts
(FEC; epg)
ā¢ Should not be used as the sole criteria for making
deworming decisions (esp. for H. contortus).
ā¢ Can be used to support deworming decisions.
Why?
ļ§ FEC not highly correlated to worm load.
ļ§ Many factors cause variability in egg production.
ļ§ Whatās āhighā is variable.
ļ§ No agreed-upon treatment thresholds for treatment.
23. Fecal egg counts
Instead use fecal egg counts to:
1. To determine effectiveness of deworming
treatment.
2. Test for dewormer resistance.
3. Select animals that are more resistant to
internal parasitism.
4. Cull animals that are more susceptible to
internal parasitism and are responsible for
contaminating pastures (70:30 rule).
5. Monitor pasture contamination.
26. Copper oxide wire
particles (COWP)
ā¢ Tiny metal rods of copper oxide
put in a capsule.
ā¢ Least absorbable form of copper
(vs. copper sulfate and the copper
in chelated minerals).
ā¢ Proven to be an effective
treatment for barber pole worm
infections in sheep/goats.
ā¢ Important to know copper status
of animals, especially sheep (risk
of copper toxicity).
29. Proper deworming
techniques
ā¢ Oral dosing only with drench
formulations (exception is morantel
tartrate).
ā¢ Use oral dosing syringe or drench gun
with long metal nozzle.
ā¢ Make sure syringe or gun is properly
calibrated.
ā¢ Deposit liquid drug over tongue.
ā¢ Dose based on accurate weight of
animal (scale or weigh tape).
31. When deworming
is not enough?
Animal may need supportive therapy.
ā¢ Remove from pasture
(permanently?)
ā¢ Increase nutrition plane
ā¢ Protein supplementation
ā¢ B-vitamins, thiamine
ā¢ Vitamin K
ā¢ Red CellĀ®
ā¢ Iron supplementation
ā¢ Nutri-DrenchĀ®
ā¢ Electrolytes
ā¢ OTC diarrhea medications
ā¢ Transfusion (extreme cases)
32. Questions?
Comments?
SUSAN SCHOENIAN
Sheep & Goat Specialist Emeritus
University of Maryland Extension
sschoen@umd.edu
www.wormx.info
www.sheepandgoat.com
www.sheep101.info
facebook.com/MDSmallRuminant/