This document outlines safety procedures for working with pesticides. It discusses proper classification, storage, transportation, and disposal of pesticides. Personal protective equipment like goggles and gloves are recommended to prevent exposure through inhalation, skin contact, or ingestion. Employers must maintain safety registers of pesticides, provide training to employees, and ensure proper labeling and material safety data sheets are available. Health checks for workers are also advised to monitor risks from pesticide exposure.
This document discusses pesticide toxicity and exposure. It explains that toxicity is determined by an pesticide's ability to cause harm, while exposure depends on how the pesticide enters the body through skin, mouth, lungs, or eyes. Common pesticides like organophosphates and carbamates interfere with the nervous system and can cause acute or chronic health effects from both large and small repeated exposures. Proper use of personal protective equipment and understanding pesticide labels is important for minimizing health risks.
The document discusses how workplace safety is a key element of sustainability efforts and corporate responsibility. It states that a workplace can be considered sustainable, ethical, and goal-oriented when the safety of workers, families, and communities is a priority. The document also outlines steps for companies to incorporate environmental, health, and safety practices and sustainability standards. It notes that effective EHS management through digital solutions can help reduce costs and risks while improving profitability and transparency. Finally, it promotes the EHS software and services from ASK-EHS for helping companies achieve their sustainability goals.
This document introduces the bow-tie risk analysis methodology. It describes how a bow-tie diagram visually maps the relationship between an undesirable event, its potential causes, consequences, and the barriers that prevent or mitigate these. The document provides examples of how to construct a bow-tie diagram by defining the hazard, threats, barriers, escalation factors, recovery measures, and critical safety tasks. It emphasizes that bow-tie analysis can help demonstrate control effectiveness and is a versatile structured approach to risk analysis.
This document provides background information on combustible dust hazards and explosions. It discusses the conditions required for a dust explosion (combustible dust, oxygen, ignition source, and dispersion/confinement), and summarizes several catastrophic dust explosions that have occurred since 1995 involving metals, plastics, fibers, and other combustible materials. Key hazard mitigation techniques are identified, including controlling dust accumulations, ignition sources, and implementing designs to contain damage from potential explosions. Common processing equipment that poses dust explosion risks such as dust collectors, blenders, dryers and conveying systems are also outlined.
The document discusses chemical hazards and provides several examples. It covers three main types of chemical hazards: flammability, reactivity, and health hazards. Flammable substances readily catch fire and burn in air. Reactive chemicals involve the release of energy and can explode under certain conditions. Contact with chemicals can result in adverse health effects depending on factors like the substance, route of exposure, and dose. Examples of hazardous chemicals include flammable substances like gasoline, irritants like acids and paint fumes, and gases that interfere with oxygen transport like carbon monoxide. The Bhopal gas disaster released methyl isocyanides, killing thousands in India and exposing hundreds of thousands more.
Like manufacturers in all industries, pharmaceutical manufacturers and their employees face real and serious health and safety issues. In some cases, the hazards are the same ones we find in most manufacturing facilities. In other cases, the hazards are more specific to pharmaceutical manufacturing. Likewise, pharmaceutical manufacturers use hazard controls and risk mitigations that are common to many industries as well as more specific to pharmaceutical manufacturing, including all levels of the hierarchy of controls, from elimination down to administrative controls such as training for pharmaceutical safety and the use of PPE.
This document outlines safety procedures for working with pesticides. It discusses proper classification, storage, transportation, and disposal of pesticides. Personal protective equipment like goggles and gloves are recommended to prevent exposure through inhalation, skin contact, or ingestion. Employers must maintain safety registers of pesticides, provide training to employees, and ensure proper labeling and material safety data sheets are available. Health checks for workers are also advised to monitor risks from pesticide exposure.
This document discusses pesticide toxicity and exposure. It explains that toxicity is determined by an pesticide's ability to cause harm, while exposure depends on how the pesticide enters the body through skin, mouth, lungs, or eyes. Common pesticides like organophosphates and carbamates interfere with the nervous system and can cause acute or chronic health effects from both large and small repeated exposures. Proper use of personal protective equipment and understanding pesticide labels is important for minimizing health risks.
The document discusses how workplace safety is a key element of sustainability efforts and corporate responsibility. It states that a workplace can be considered sustainable, ethical, and goal-oriented when the safety of workers, families, and communities is a priority. The document also outlines steps for companies to incorporate environmental, health, and safety practices and sustainability standards. It notes that effective EHS management through digital solutions can help reduce costs and risks while improving profitability and transparency. Finally, it promotes the EHS software and services from ASK-EHS for helping companies achieve their sustainability goals.
This document introduces the bow-tie risk analysis methodology. It describes how a bow-tie diagram visually maps the relationship between an undesirable event, its potential causes, consequences, and the barriers that prevent or mitigate these. The document provides examples of how to construct a bow-tie diagram by defining the hazard, threats, barriers, escalation factors, recovery measures, and critical safety tasks. It emphasizes that bow-tie analysis can help demonstrate control effectiveness and is a versatile structured approach to risk analysis.
This document provides background information on combustible dust hazards and explosions. It discusses the conditions required for a dust explosion (combustible dust, oxygen, ignition source, and dispersion/confinement), and summarizes several catastrophic dust explosions that have occurred since 1995 involving metals, plastics, fibers, and other combustible materials. Key hazard mitigation techniques are identified, including controlling dust accumulations, ignition sources, and implementing designs to contain damage from potential explosions. Common processing equipment that poses dust explosion risks such as dust collectors, blenders, dryers and conveying systems are also outlined.
The document discusses chemical hazards and provides several examples. It covers three main types of chemical hazards: flammability, reactivity, and health hazards. Flammable substances readily catch fire and burn in air. Reactive chemicals involve the release of energy and can explode under certain conditions. Contact with chemicals can result in adverse health effects depending on factors like the substance, route of exposure, and dose. Examples of hazardous chemicals include flammable substances like gasoline, irritants like acids and paint fumes, and gases that interfere with oxygen transport like carbon monoxide. The Bhopal gas disaster released methyl isocyanides, killing thousands in India and exposing hundreds of thousands more.
Like manufacturers in all industries, pharmaceutical manufacturers and their employees face real and serious health and safety issues. In some cases, the hazards are the same ones we find in most manufacturing facilities. In other cases, the hazards are more specific to pharmaceutical manufacturing. Likewise, pharmaceutical manufacturers use hazard controls and risk mitigations that are common to many industries as well as more specific to pharmaceutical manufacturing, including all levels of the hierarchy of controls, from elimination down to administrative controls such as training for pharmaceutical safety and the use of PPE.
Chemical disasters can harm human health and the environment through the unintentional release of hazardous substances. The document discusses the 1984 Bhopal disaster in India, where a leak of methyl isocyanate (MIC) gas from a Union Carbide pesticide plant killed thousands. MIC is an intermediate chemical used to produce carbaryl insecticide. Exposure to the toxic gas caused many deaths in the days following and ongoing health issues. The disaster highlights the dangers of chemical accidents and their long-term human and environmental impacts.
This document provides information on hazard analysis. It defines a hazard and lists common types of hazards including chemical, physical, biological, ergonomic, and noise hazards. It then discusses what hazard analysis is and different methods used, including job hazard analysis, hazard and operability study, fault tree analysis, and process hazard analysis. As a case study, it summarizes a 2005 fire and explosion at a Formosa Plastics plant in Texas, caused by a forklift pulling a valve from a propylene line. Lessons learned include considering vehicle impacts and remote isolation in hazard analyses.
On site and offsite emergency plans on chemicalShahrukh Vahora
This document discusses on-site and off-site emergency plans for chemical disasters. It notes that emergency planning is required by law to minimize harm to people, property and the environment. On-site plans address incidents confined to the factory, while off-site plans are needed if effects spread outside. Off-site plans involve risk assessment and committees to control incidents, provide medical support, and restore normal operations when a disaster affects the surrounding community. Regular training and drills are important to ensure emergency plans are effective.
This document discusses major accident hazards control and emergency preparedness plans for hazardous industries. It outlines that factories must provide a disaster management plan that includes a medical emergency preparedness plan. The medical plan should identify the chemicals on site, model their dispersion in an accident, calculate the affected population, and plan for triaging and transporting victims. It describes categorizing victims based on injury severity, tagging them, and prioritizing their transport and treatment. The factory must have an emergency response team and plans to work with local hospitals, ambulances, and officials.
Industrial accidents can originate from manufacturing, storage, transportation, and other areas and cause fires, explosions, toxic releases, and other hazards. Major threats include process deviations, hardware failures, and runaway reactions. Probable causes are electrical failures, cutting/welding, fires, carelessness, sabotage, and more. Impacts include loss of life, injuries, environmental pollution, and financial losses. Notable past accidents include the Bhopal gas tragedy, which killed thousands and continues affecting over 100,000 people with health issues. Risk control measures that could prevent losses include physical protection systems, strict safety procedures and standards, educational protection of workers and the public, and emergency preparedness plans.
This document discusses occupational hygiene and toxicology. It defines occupational hygiene as anticipating, recognizing, evaluating, controlling and preventing workplace hazards that can cause injury or illness. Toxicology is the study of adverse health effects from exposures to toxins. The document discusses measuring toxicity through various methods including LD50 tests on animals. It also covers classifying substances and toxins based on their health and environmental hazards.
The document provides information on industrial hazards and plant safety. It discusses various types of industrial hazards including fire and explosion, electrical, chemical, gas, mechanical, and dust hazards. For each hazard type, it describes causes and preventive measures. It also provides details on specific hazards like industrial pollution and its effects. The document aims to create awareness about common industrial hazards and safety practices to prevent accidents and protect workers' health.
Industrial toxicology deals with the toxic properties of substances that people are exposed to in occupational and non-occupational settings. Toxicity is the study of how the body responds to toxic substances. Toxic effects can be acute or chronic and result from inhalation, ingestion, skin/eye contact, or other routes of exposure. Setting workplace standards involves understanding chemical toxicity through methods like chemical analogy, animal experimentation, and establishing exposure limits based on a substance's toxic properties.
The document discusses Material Safety Data Sheets (MSDS), which contain information about the health effects of exposure to chemicals and safe handling procedures. An MSDS includes 16 sections with details like product information, hazards, first aid measures, and disposal considerations. Employers must make MSDSs available to workers exposed to hazardous materials and ensure they are understandable. The document also outlines key aspects of industrial health and safety, including identifying occupational hazards from plants, equipment, materials and tasks in order to implement controls to reduce risks. Hazard analysis methods are used to systematically identify potential issues.
The document provides information on the M.Tech. (Industrial Safety Engineering) program offered by the Department of Mechanical Engineering at the National Institute of Technology in Tiruchirappalli, India. It includes details of the syllabus, course structure over 4 semesters with 63 total credits required. The first two semesters include core courses in areas like safety management, occupational health and hygiene, regulations, and electives. The third and fourth semesters involve project work. The document also lists the various elective courses that can be taken.
This document discusses occupational health hazards, specifically chemical hazards. It defines occupational health as recognizing, evaluating, and controlling workplace hazards that can cause illness. It then discusses the main types of chemical hazards: dusts, fumes, mists, fibers, gases, and vapors. For each hazard type, it provides examples of chemicals that fall into that category. It also discusses acute and chronic health effects of chemical exposures. Threshold limit values and time-weighted average concentrations are defined as metrics for safe chemical exposure levels. Specific health and safety information is then provided for sulfuric acid and sodium hydroxide, two common industrial chemicals.
The document discusses environmental health and safety awareness. It covers topics like signage, risk assessments, hazards, risks, health risks, safety task analysis, a health and safety management system, and ISO 14001 components. Risk assessments are used to reduce accidents through planning, organization, control, monitoring and review. Hazards are things that have potential to cause harm, while risks are the likelihood of hazards causing harm. A health and safety management system includes a policy, planning, implementation, checking and corrective action, and management reviews.
This document discusses emergency response to chemical casualties and hospital preparedness. It covers lessons learned from past incidents, requirements for incident response, medical management of hazardous materials victims, and decontamination procedures. The key points are:
1) Hospitals need plans for rapid decontamination and surge capacity to treat potential casualties from chemical incidents while protecting staff and facilities.
2) Most victims will arrive by private means and need decontamination at the hospital rather than the scene. Dry decontamination by removing clothing is suitable for many.
3) The medical management of hazardous materials victims includes initial assessment and resuscitation, decontamination, further assessment, and treatment specific to the poisoning.
This document discusses safety and health in the chemical industry, with a focus on IFFCO Aonla Unit in India. It outlines various risks in chemical plants like fires, explosions, exposure to hazardous materials. It describes safety measures at IFFCO Aonla like the site location, construction design with protection zones, process safety systems, and total safety management program. Key aspects of the ammonia production process and associated occupational health hazards are also summarized.
This document discusses industrial safety management and accident prevention. It outlines objectives of industrial safety such as minimizing hazards and accidents. It defines types of industrial accidents and discusses their common causes such as unsafe conditions and acts. It also describes how accidents are measured using frequency and severity rates. Reasons for preventing accidents include protecting human life, reducing costs, and complying with legislation. The document advocates for safety programs that identify hazards, provide safety equipment/facilities, develop policies, and provide training to employees.
This document discusses the toxicity of chemicals commonly found in cosmetic products. It begins with defining cosmetics and cosmetic toxicity. It then outlines chemicals of concern like parabens, fragrance, heavy metals, and 1,4-dioxane. These chemicals are found in products like soap, lipstick, toothpaste, and can have health effects like endocrine disruption, carcinogenicity, and organ toxicity. The document provides details on the specific toxicities of these ingredients and recommends consumers be aware of them to minimize health risks from daily cosmetic use.
This document discusses the toxicity of ingredients commonly found in cosmetic products. Researchers have identified over 10,500 industrial chemicals used in cosmetics, many of which are carcinogens, pesticides, and endocrine disruptors. The average woman uses 13 cosmetic products per day, most containing around 20 ingredients, many of which are harmful. Some of the most toxic ingredients identified include fragrances, lead acetate, phthalates, hydroquinone, and nanoparticles. Common cosmetic products like shampoo, lipstick, deodorant, and perfume can contain ingredients like sodium lauryl sulfate, polymethyl methacrylate, isopropyl myristate, and benzaldehyde that are linked to issues like irritation,
The Historical hygiene assessment of National Semiconductor UKRetired
This document summarizes a historical hygiene assessment of National Semiconductor UK that was conducted to investigate potential occupational exposures. The study reviewed plant records and interviewed former employees to characterize job tasks, hazardous agents like radiation and chemicals, and exposure controls over time. While some early monitoring found exposures above limits, later processes were redesigned with additional protections. An epidemiological follow-up found reduced cancer rates of initial interest and no consistent evidence that cases were more exposed than controls.
Chemical disasters can harm human health and the environment through the unintentional release of hazardous substances. The document discusses the 1984 Bhopal disaster in India, where a leak of methyl isocyanate (MIC) gas from a Union Carbide pesticide plant killed thousands. MIC is an intermediate chemical used to produce carbaryl insecticide. Exposure to the toxic gas caused many deaths in the days following and ongoing health issues. The disaster highlights the dangers of chemical accidents and their long-term human and environmental impacts.
This document provides information on hazard analysis. It defines a hazard and lists common types of hazards including chemical, physical, biological, ergonomic, and noise hazards. It then discusses what hazard analysis is and different methods used, including job hazard analysis, hazard and operability study, fault tree analysis, and process hazard analysis. As a case study, it summarizes a 2005 fire and explosion at a Formosa Plastics plant in Texas, caused by a forklift pulling a valve from a propylene line. Lessons learned include considering vehicle impacts and remote isolation in hazard analyses.
On site and offsite emergency plans on chemicalShahrukh Vahora
This document discusses on-site and off-site emergency plans for chemical disasters. It notes that emergency planning is required by law to minimize harm to people, property and the environment. On-site plans address incidents confined to the factory, while off-site plans are needed if effects spread outside. Off-site plans involve risk assessment and committees to control incidents, provide medical support, and restore normal operations when a disaster affects the surrounding community. Regular training and drills are important to ensure emergency plans are effective.
This document discusses major accident hazards control and emergency preparedness plans for hazardous industries. It outlines that factories must provide a disaster management plan that includes a medical emergency preparedness plan. The medical plan should identify the chemicals on site, model their dispersion in an accident, calculate the affected population, and plan for triaging and transporting victims. It describes categorizing victims based on injury severity, tagging them, and prioritizing their transport and treatment. The factory must have an emergency response team and plans to work with local hospitals, ambulances, and officials.
Industrial accidents can originate from manufacturing, storage, transportation, and other areas and cause fires, explosions, toxic releases, and other hazards. Major threats include process deviations, hardware failures, and runaway reactions. Probable causes are electrical failures, cutting/welding, fires, carelessness, sabotage, and more. Impacts include loss of life, injuries, environmental pollution, and financial losses. Notable past accidents include the Bhopal gas tragedy, which killed thousands and continues affecting over 100,000 people with health issues. Risk control measures that could prevent losses include physical protection systems, strict safety procedures and standards, educational protection of workers and the public, and emergency preparedness plans.
This document discusses occupational hygiene and toxicology. It defines occupational hygiene as anticipating, recognizing, evaluating, controlling and preventing workplace hazards that can cause injury or illness. Toxicology is the study of adverse health effects from exposures to toxins. The document discusses measuring toxicity through various methods including LD50 tests on animals. It also covers classifying substances and toxins based on their health and environmental hazards.
The document provides information on industrial hazards and plant safety. It discusses various types of industrial hazards including fire and explosion, electrical, chemical, gas, mechanical, and dust hazards. For each hazard type, it describes causes and preventive measures. It also provides details on specific hazards like industrial pollution and its effects. The document aims to create awareness about common industrial hazards and safety practices to prevent accidents and protect workers' health.
Industrial toxicology deals with the toxic properties of substances that people are exposed to in occupational and non-occupational settings. Toxicity is the study of how the body responds to toxic substances. Toxic effects can be acute or chronic and result from inhalation, ingestion, skin/eye contact, or other routes of exposure. Setting workplace standards involves understanding chemical toxicity through methods like chemical analogy, animal experimentation, and establishing exposure limits based on a substance's toxic properties.
The document discusses Material Safety Data Sheets (MSDS), which contain information about the health effects of exposure to chemicals and safe handling procedures. An MSDS includes 16 sections with details like product information, hazards, first aid measures, and disposal considerations. Employers must make MSDSs available to workers exposed to hazardous materials and ensure they are understandable. The document also outlines key aspects of industrial health and safety, including identifying occupational hazards from plants, equipment, materials and tasks in order to implement controls to reduce risks. Hazard analysis methods are used to systematically identify potential issues.
The document provides information on the M.Tech. (Industrial Safety Engineering) program offered by the Department of Mechanical Engineering at the National Institute of Technology in Tiruchirappalli, India. It includes details of the syllabus, course structure over 4 semesters with 63 total credits required. The first two semesters include core courses in areas like safety management, occupational health and hygiene, regulations, and electives. The third and fourth semesters involve project work. The document also lists the various elective courses that can be taken.
This document discusses occupational health hazards, specifically chemical hazards. It defines occupational health as recognizing, evaluating, and controlling workplace hazards that can cause illness. It then discusses the main types of chemical hazards: dusts, fumes, mists, fibers, gases, and vapors. For each hazard type, it provides examples of chemicals that fall into that category. It also discusses acute and chronic health effects of chemical exposures. Threshold limit values and time-weighted average concentrations are defined as metrics for safe chemical exposure levels. Specific health and safety information is then provided for sulfuric acid and sodium hydroxide, two common industrial chemicals.
The document discusses environmental health and safety awareness. It covers topics like signage, risk assessments, hazards, risks, health risks, safety task analysis, a health and safety management system, and ISO 14001 components. Risk assessments are used to reduce accidents through planning, organization, control, monitoring and review. Hazards are things that have potential to cause harm, while risks are the likelihood of hazards causing harm. A health and safety management system includes a policy, planning, implementation, checking and corrective action, and management reviews.
This document discusses emergency response to chemical casualties and hospital preparedness. It covers lessons learned from past incidents, requirements for incident response, medical management of hazardous materials victims, and decontamination procedures. The key points are:
1) Hospitals need plans for rapid decontamination and surge capacity to treat potential casualties from chemical incidents while protecting staff and facilities.
2) Most victims will arrive by private means and need decontamination at the hospital rather than the scene. Dry decontamination by removing clothing is suitable for many.
3) The medical management of hazardous materials victims includes initial assessment and resuscitation, decontamination, further assessment, and treatment specific to the poisoning.
This document discusses safety and health in the chemical industry, with a focus on IFFCO Aonla Unit in India. It outlines various risks in chemical plants like fires, explosions, exposure to hazardous materials. It describes safety measures at IFFCO Aonla like the site location, construction design with protection zones, process safety systems, and total safety management program. Key aspects of the ammonia production process and associated occupational health hazards are also summarized.
This document discusses industrial safety management and accident prevention. It outlines objectives of industrial safety such as minimizing hazards and accidents. It defines types of industrial accidents and discusses their common causes such as unsafe conditions and acts. It also describes how accidents are measured using frequency and severity rates. Reasons for preventing accidents include protecting human life, reducing costs, and complying with legislation. The document advocates for safety programs that identify hazards, provide safety equipment/facilities, develop policies, and provide training to employees.
This document discusses the toxicity of chemicals commonly found in cosmetic products. It begins with defining cosmetics and cosmetic toxicity. It then outlines chemicals of concern like parabens, fragrance, heavy metals, and 1,4-dioxane. These chemicals are found in products like soap, lipstick, toothpaste, and can have health effects like endocrine disruption, carcinogenicity, and organ toxicity. The document provides details on the specific toxicities of these ingredients and recommends consumers be aware of them to minimize health risks from daily cosmetic use.
This document discusses the toxicity of ingredients commonly found in cosmetic products. Researchers have identified over 10,500 industrial chemicals used in cosmetics, many of which are carcinogens, pesticides, and endocrine disruptors. The average woman uses 13 cosmetic products per day, most containing around 20 ingredients, many of which are harmful. Some of the most toxic ingredients identified include fragrances, lead acetate, phthalates, hydroquinone, and nanoparticles. Common cosmetic products like shampoo, lipstick, deodorant, and perfume can contain ingredients like sodium lauryl sulfate, polymethyl methacrylate, isopropyl myristate, and benzaldehyde that are linked to issues like irritation,
The Historical hygiene assessment of National Semiconductor UKRetired
This document summarizes a historical hygiene assessment of National Semiconductor UK that was conducted to investigate potential occupational exposures. The study reviewed plant records and interviewed former employees to characterize job tasks, hazardous agents like radiation and chemicals, and exposure controls over time. While some early monitoring found exposures above limits, later processes were redesigned with additional protections. An epidemiological follow-up found reduced cancer rates of initial interest and no consistent evidence that cases were more exposed than controls.
Health and safety regulatory trends in the UK semiconductor industry Retired
This document summarizes current trends and the future regulatory framework for exposure assessment in the UK semiconductor industry. It discusses the UK government's low priority on health and safety, recent HSE inspections of semiconductor sites, new guidance on good control practices from COSHH and the Microelectronics Joint Working Group, and emerging EU directives on issues like ergonomics, electromagnetic fields, carcinogens, and shift work.
The First Hong Kong Total Diet Study analyzed pesticide residues in 600 composite food samples between 2010-2014. Pesticide residues were detected in 33% of samples, mainly in plant-based foods, at low levels well below safety standards. Estimated dietary exposures for the population were low, with average exposures contributing less than 5.2% of acceptable daily intakes. The study concluded pesticide residues in the Hong Kong diet pose minimal health risks and reaffirmed the safety of a balanced diet including fruits and vegetables. Recommendations included farmers adopting good agricultural practices and the public washing produce.
The document provides information about photography concepts like exposure, aperture, shutter speed, ISO, metering modes, and camera modes. It explains that exposure is determined by aperture, shutter speed, and ISO, which make up the exposure triangle. Aperture controls the amount of light, shutter speed controls the duration of light, and ISO controls the camera's sensitivity. It also discusses metering modes like spot metering and partial metering, and camera modes like manual, aperture priority, shutter priority, and programmed auto. The document aims to educate photographers about fundamental technical aspects of photography.
This document discusses drug interactions, defining them as when the effect of one drug is modified by another drug taken at the same time. It notes several key risk factors for interactions like polypharmacy and lists common outcomes like increased or decreased therapeutic effects and toxicity. The main mechanisms of interactions are pharmacokinetic, involving absorption, distribution, metabolism and excretion, or pharmacodynamic involving the drugs' pharmacological effects. Several examples of interaction mechanisms are provided like enzyme induction/inhibition altering metabolism or drug complexes reducing absorption. Managing interactions may require dose changes or avoiding certain combinations depending on severity.
1) The document discusses several key concepts in pharmacology including bioavailability, bioequivalence, therapeutic index, plasma half-life, dose response curves, area under the curve, and volume of distribution. Definitions and examples are provided for each topic.
2) Bioavailability refers to the fraction of an administered dose that reaches systemic circulation. Bioequivalence exists between two drug preparations that have similar bioavailability. Therapeutic index represents the safety of a drug based on the difference between toxic and therapeutic concentrations.
3) Plasma half-life is the time for a drug concentration to reduce by half, and is determined by clearance and volume of distribution. Dose response curves relate the effect of varying
A guide to exposure determination and the impact of artworkWilliam Shorter
An overview of how exposure and the artwork process can affect the durability and the quality of the image that you are printing. Presented by William Shorter.
This document summarizes OSHA regulations regarding personal protective equipment (PPE) under Subpart I of the OSHA standards. It discusses requirements for employers to provide, use, maintain, and train employees on PPE to protect against workplace hazards. Specific PPE addressed includes eye and face protection, head protection, foot protection, hand protection, respiratory protection, and protective clothing. Medical evaluations are required for respirator use. Hazard assessments must be conducted to determine appropriate PPE for each job.
This document provides an overview of a lecture series on human resource management. It discusses definitions of HRM and strategic HRM. It also summarizes several models of linking HRM with business strategy, including the matching model, map of HRM territory model, lifecycle model, and competitive advantage model. These models examine how HRM strategies and practices can be aligned with and support a company's strategic goals and competitive positioning. The document also notes debates around "best fit" versus "best practice" approaches to HRM.
This document describes key concepts related to dose-response relationships and drug interactions. It defines dose-response relationships and curves, and explains how drug potency, efficacy, selectivity, and therapeutic index are determined based on these curves. It also discusses how drugs can have synergistic or antagonistic effects when combined, including competitive and non-competitive receptor antagonism. The overall intent is to explain important pharmacological concepts for understanding how drug effects are produced at varying doses both alone and when administered together with other drugs.
The document discusses the health effects of radiation exposure. It provides an overview of radiation sources and the types of radiation. Ionizing radiation can damage DNA and lead to cancer or other health issues. The risk of cancer increases with higher radiation exposure but some risk exists even at low doses according to linear no-threshold models. Medical imaging is a major source of radiation exposure from diagnostic tests like CT scans.
The document discusses various radiographic exposure factors and how they influence the quantity and quality of x-radiation exposure to patients. It describes how factors like kVp, mA, and exposure time determine the radiation dose and beam quality. It also discusses how the design of the x-ray machine like focal spot size, filtration, and high voltage generation impact technical settings. Film factors like sensitometry, contrast, and processing also influence radiographic image quality.
The document summarizes the Environment Protection Act of 1986 and the Air (Prevention and Control of Pollution) Act of 1981 in India. The key points are:
1) The Environment Protection Act was introduced after the Bhopal gas tragedy to provide for protecting and improving the environment and preventing environmental pollution.
2) The Air Act aims to protect air quality and public health while allowing industry to choose how to meet pollution standards.
3) Both acts empower regulatory boards and agencies to establish standards, monitor pollution levels, declare air pollution control areas, and penalize non-compliance.
Foreign exchange risk and exposure refer to how changes in exchange rates can affect the value of a firm's assets, liabilities, and profits. Exposure is the sensitivity of a firm's value to exchange rate changes, while risk is the variability of a firm's value due to uncertain exchange rate changes. There are three main types of exposures - transaction, translation, and economic. Firms can use hedging strategies like forward contracts and options to manage their foreign exchange risk and exposure by locking in exchange rates for future transactions.
Slides for a lecture given at the University of Vienna postgraduate course on Toxicology/Science of Chemical Safety (Universitätslehrgang Toxikologie/Chemical Safety für Postgraduierte). See... http://www.meduniwien.ac.at/krebsforschung/research/research-units/chemical-safety-and-cancer-prevention/en/
Dermal exposure science: it’s not skin-deep Retired
This document summarizes research on dermal exposure science. It discusses seminal papers from 1993 that described methods for measuring dermal exposure, including interception and removal of chemicals on the skin. Simple experiments were used to study these processes. More advanced methods like SysDEA and biologically relevant samplers were later developed to better assess dermal uptake. Theoretical models have also been proposed to conceptualize dermal exposure. The document emphasizes that behavior is a major factor influencing dermal exposure through actions like touching surfaces, handwashing, and protective equipment use.
1) The document discusses modelling dermal (skin) exposure to chemicals and outlines some common tier 1 tools used. It also discusses the DREAM method, a semi-quantitative method for dermal exposure assessment.
2) The study aimed to develop a validated method to measure dermal exposure to heavy fuel oil, collect exposure data, and apply the DREAM model to compare measured vs estimated exposures.
3) Preliminary results found production and distribution sites had higher dermal exposures than use sites like power plants. DREAM estimates were reasonably consistent with measured exposures.
This document provides an overview of chemical safety in the workplace. It discusses common chemicals that are hazardous, how chemicals can enter the body, and the importance of risk assessment. The key steps for risk assessment are outlined, including making an inventory, collecting safety information, assessing exposure, and implementing controls. Control methods like substitution, engineering controls, administrative controls and PPE are described. Proper chemical storage, labeling, training and emergency response are important for effective chemical management.
This document provides questions, answers, and summaries related to NEBOSH Unit-IB on chemical control, toxicology, and epidemiology. It includes:
1. Questions on human epidemiology and animal studies for investigating carcinogenic substances, including the advantages and disadvantages of each.
2. A question involving calculating the respirable crystalline silica exposure from sampling data, and outlining potential errors.
3. Questions covering the structure of skin, how substances enter the body through skin, contact dermatitis, and advice to a salon manager on preventing dermatitis.
4. A question involving using particle size data to determine where powders will deposit in the respiratory tract and how the body
This document provides questions, answers, and summaries related to NEBOSH Unit-IB. It includes:
1. Questions and answers on principles of chemical control, toxicology, and epidemiology including human and animal studies for investigating carcinogens, and advantages and disadvantages of each.
2. A worked example calculating respirable crystalline silica exposure from sampling data including potential errors.
3. Advice on contact dermatitis prevention for a hair salon addressing likely causes and control measures.
4. Summaries of particle deposition in the respiratory tract and body defenses against inhaled dusts.
5. Control measures for minimizing powder exposure during paint manufacturing.
6. Explanations
Nebosh International Diploma Unit B Question MatrixCiske Berrington
This document provides questions, answers, and summaries related to NEBOSH Unit-IB on chemical control, toxicology, and epidemiology. It includes:
1. Questions on human epidemiology and animal studies for investigating carcinogenic substances.
2. A question calculating the respirable crystalline silica exposure from sampling data.
3. Questions on the structure of skin, contact dermatitis, and advice for preventing dermatitis in a hair salon.
4. A question identifying where different grades of an industrial chemical powder may deposit in the respiratory tract.
5. Questions on how the body defends against inhaled dusts and controlling powder exposure during mixing.
6.
The document discusses uncertainties in modeling human and ecological risks from chemicals, nanomaterials, and microplastics in the environment. Current risk management is reactive, substance-by-substance, and resource intensive. Modeling risks considers sources, emission, fate, exposure, and effects, but faces many uncertainties. For chemicals, better use and spatially explicit emissions data is needed. Fate modeling requires improved degradation data, especially for ionizing compounds. Effect modeling needs more data on mixtures, genomics, and untested substances. For nanomaterials and microplastics, long-term fate and effects are particularly uncertain due to degradation questions and lack of data.
- A method was developed to calculate the direct impact on human health from dermal absorption of chemicals in consumer products during use, called the Product Intake Fraction (PiF).
- The PiF considers key variables like the rate at which chemicals leach from the product and the skin permeability coefficient.
- Direct impacts calculated for a pacifier, hand soap, and shampoo were found to be of similar or higher magnitude than indirect life cycle impacts from product emissions and use.
- This work introduces a novel method for including dermal exposure in life cycle assessment, which is currently an important pathway not fully addressed.
This document summarizes occupational health risk assessment and management practices in Britain. It discusses how risk is defined, relevant legislation, and responsibilities of various parties. It also describes approaches used in Britain like control banding and the COSHH Essentials tool. Measurement of exposures is important, and both active and passive sampling methods are used. Exposure levels have generally decreased over time for many hazards due to improved controls.
The document discusses India's management of hazardous waste. It provides context on the growth of industry and pollution in India. It outlines the key rules and regulations for hazardous waste management, including the Hazardous Wastes Management Rules. It discusses the amounts and sources of hazardous waste produced annually in India. It also lists concentration limits and classes of hazardous substances, as well as processes that generate hazardous wastes, as defined by India's Hazardous Wastes Management rules.
This document provides an overview of transdermal drug delivery systems (TDDS). It discusses how TDDS were first introduced in the 1950s and became commercially available in the 1980s. The key advantages of TDDS include avoiding first-pass hepatic metabolism and providing constant drug levels. The document outlines the anatomy and physiology of the skin, ideal drug properties, components of TDDS, types of patches including passive and active systems, and recent advancements like iontophoresis, electroporation, microneedles, and sonophoresis.
EPC introduction.pptx it is a environment pollution and controlSakiShaikh
This document outlines the objectives, outcomes, and units of a course on environmental pollution and control. The key points are:
- The course aims to teach students about water and wastewater treatment systems, air pollution control, and environmental management and policies.
- After completing the course, students will understand water quality, pollution sources, air pollution assessment, and solid waste management techniques.
- The course covers topics like environmental pollutants, natural water and air purification processes, water and air pollution control methods, and pollution control in industries.
It has been concluded that the management of radiation accidents is a very challenging process and that nuclear medicine physicians have to be well organized in.
Similar to An introduction to dermal exposure assessment (20)
A holistic approach to managing workplace exposure to solar UVRetired
- There are health benefits and risks associated with both too much and too little UV exposure from the sun. Managing this requires a nuanced approach.
- Workers should aim to get some sun exposure daily in summer to maintain sufficient vitamin D levels, while avoiding sunburn and limiting exposure to minimize skin cancer risk.
- Employers can help by monitoring personal UV exposure and vitamin D levels, providing shade and protective equipment, and using behavioral interventions like phone messages to influence positive sun safety habits.
Keynote presentation on Current and Future Trends in Exposure Science Retired
Slides from my keynote at the ISES workshop in Bilthoven. I discuss the role of exposure science in improving population health, in the past and in the future. I cover lead poisoning and air pollution and show that we have solved these problems. The future will present new and different problems. We need to use the exposome paradigm to guide future research.
Exposure assessment for occupational epidemiology part 2Retired
The aim of this lecture is to provide an introduction to occupational exposures and the strategies used in epidemiological studies to assess exposure of subjects.
Exposure assessment for occupational epidemiology part 1Retired
The aim of this lecture is to provide an introduction to occupational exposures and the strategies used in epidemiological studies to assess exposure of subjects.
The document discusses the concept of the exposome and how it can be used to better understand occupational exposures and disease causation. It proposes measuring the exposome using internal biomonitoring through omics technologies and external monitoring using sensors to track location, activity, and environmental exposures. Challenges include the complexity of measuring all exposures from birth to death and integrating diverse exposure data. The document advocates establishing new occupational cohorts studied using an exposome approach to gain better insight into work-related health risks.
This document discusses control banding, an approach for managing chemical exposure risks. It provides:
1) An overview of the origins and development of control banding, including the COSHH Essentials model and tools like Stoffenmanager and Advanced REACH Tool.
2) Evidence that validation studies have found control banding tools can reliably predict exposures when used correctly, but training is needed for effective implementation.
3) Suggestions that control banding tools could be improved by more strongly encouraging continuous improvement through a "Kaizen" approach, providing better guidance to "nudge" protective actions, and integrating exposure measurement data.
Use of sensors in occupational exposure assessment Retired
This document discusses the use of low-cost sensors in occupational exposure assessment. It describes how direct-reading sensors can be used to monitor workplace exposures, activity monitors to track worker movement and location sensors to identify where workers spend their time. The document outlines criteria for a good sensor system, including being unobtrusive, low-cost, able to collect and transmit real-time data, usable by workers, and meeting quality assurance standards.
The document discusses the implications of the exposome paradigm for occupational hygiene. It notes that traditional approaches only examine part of the problem and that new 'omics' tools can provide novel ways to investigate workplace exposures. However, accuracy is not everything and tools need calibration. Tracking location and behavior provides additional exposure data, though confidentiality issues remain. A citizen science revolution in exposure assessment is on the horizon. The document provides resources on the exposome from the National Academy of Sciences, NIOSH, and a primer book. It acknowledges funding from the European Union for the HEALS project on exposure assessment.
The document discusses the concept of the "occupational exposome", which aims to better study occupational diseases through prospectively collecting and storing exposure and health data from workers. It notes most people work during their lives, and while jobs have changed, many occupational diseases remain problems. Implementing an occupational exposome approach and total worker health programs could help realize the potential for work to positively impact health by better understanding and preventing work-related illnesses and injuries through integrated health protection and promotion efforts.
This document outlines a session to design an occupational exposome study, where participants will break into groups to plan how to set up a study investigating health risks among offshore workers. The groups will consider what information, measurements, and biobanking should be included in the study, and estimate the overall cost. After working for an hour, each group will present their plan for 30 minutes, followed by general discussion and a coffee break.
5. IOHA - biomarkers and the internal exposomeRetired
Biomarkers can indicate either exposure to environmental agents or health effects. It is important to distinguish these to understand causality. Studies discussed used various biomarkers of exposure to isocyanates and other chemicals in multiple populations. Omics techniques can measure many biological variables without targeting specific ones, helping uncover new exposure-disease links. Proper timing, collection, and long-term storage of samples are important to enable future analyses as technologies advance.
John Cherrie discusses low-cost sensors that can measure elements of the external exposome. He describes several types of portable sensors that can measure air pollution levels like gases, particles, and noise inexpensively. While sensor technology is improving with smaller sizes, lower power usage, and increased computing ability, issues around calibration, data processing, and battery life still need to be addressed before widespread use in exposome studies.
The document discusses the practical challenges of conducting an exposome study from birth to death. It notes that while tracking internal and external exposures is difficult, location and physical activity data collected from devices like smartphones and fitness trackers provide a practical starting point for exposome research. Effective data management is also a major challenge for long-term exposome studies.
The document discusses the concept of the exposome and causal relationships between exposures and disease. It defines the exposome as comprising all environmental exposures from conception to death, including processes inside and outside the body. Most disease is caused by multiple environmental and genetic factors interacting. Identifying causal relationships requires considering guidelines like temporal relationship and exposure-response. A new paradigm of systematically studying the full exposome may help uncover currently unknown disease causes, and this approach could also be relevant for workplace exposures.
This document outlines the agenda for a day-long session on measuring the exposome and its application in workplace settings. The session will include introductions, definitions of the exposome, methods for tracking personal locations and activities, low-cost sensors for measuring external exposures, biomarkers for internal exposures, constructing human exposome studies, characterizing the occupational exposome, and future applications of exposome measurements. The overall goals are to understand the exposome paradigm and how its concepts could help quantify workplace exposures and manage risks.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
1. INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org
Exposure Judgment: Improving
Inhalation, Dermal & Noise Assessment
Dermal exposure
John Cherrie
2. Summary…
• The skin and chemicals
• Adverse effects
• Routes of exposure and uptake
• Solids, liquids and gases
• A conceptual model of skin
exposure
• Measuring dermal exposure
• Modeling exposure and uptake
• Control and personal protection
3. The skin…
• Two-way protective
barrier
• About 2m2 area for an
adult
• Hands comprise about
5% and arms 15% of
area
• Complex structure that
is metabolically active
5. Dermal permeation of
chemicals…
• Uptake by diffusion
• Maximum flux at steady-state (Jmax,ss)
Where, Sscis the saturated concentration of
solute in the stratum corneum
D is the diffusion coefficient
hthe thickness of the stratum corneum
6. Flux and molecular
weight…
Magnusson, Anissimov,
Cross, and Roberts.
Molecular Size as the
Main Determinant of
Solute Maximum Flux
Across the Skin. J Invest
Dermatol 122:993 –999,
2004.
7. Solids, liquids and gases
• Solids
• Must dissolve in sweat before being taken up
• Or, particles must be small and skin barrier
disrupted
• Liquids
• Must be less than about 500 Dalton
• Volatile liquids may evaporate quickly
• Gases and vapors
• Almost always have very low dermal uptake
• Some exceptions: e.g. 1-methoxy-2-propanol
and 2-butoxyethanol
Kielhorn J, Melching-Kollmub S, Mangelsdorf I (2006) Dermal absorption. EHC 235.
8. Key factors for uptake…
• Mass on skin
• Concentration of contaminant
• Area exposed
• Duration of exposure
• Skin condition
9. Key factors for uptake…
• Mass on skin
• Concentration of contaminant
• Area exposed
• Duration of exposure
• Skin condition
10. Key factors for uptake…
• Concentration of contaminant
• Mass on skin
• Area exposed
• Duration of exposure
• Skin condition
11. Key factors for uptake…
• Mass on skin
• Concentration of contaminant
• Area exposed
• Duration of exposure
• Skin condition
Washed off
12. Key factors for uptake…
• Mass on skin
• Concentration of contaminant
• Area exposed
• Duration of exposure
• Skin condition
14. Systemic effects…
• Some chemicals can pass through the
unbroken skin and contribute to total
body burden
• Solvents, metals, pesticides…
• No dermal workplace exposure limits
• Many chemicals show a theoretical
potential for dermal absorption or
toxicity, only but only a small fraction
have a skin notation (Sk)
• NIOSH has new publications on skin
notation
15. Workplaces where dermal
exposure is important
• Painters
• Petrochemicals
• Dry cleaners
• Farmers
• Crop-harvesters
• Shoe manufacturers
• Engineers
• Hairdressers, nurses and
many, many more…
16. Routes of exposure…
• Inhalation exposure
(mg/m3)
• Ingestion (mg/day)
• Dermal exposure (mg
or mg/cm2)
Inhalation
Ingestion
Skin
uptake
• Ideally, we would
have all measures on
the same basis, i.e.
uptake (mg) into the
body
17. A conceptual model…
Surface contamination
layer Air compartment
Clothing outer layer
Skin contamination layer
Source
Clothing inner layer
Schneider et al. Conceptual model for assessment of dermal exposure. Occup Environ
Med (1999) vol. 56 (11) pp. 765-73
18. Rubber industry study…
• Identified the exposure pathways in
rubber manufacturing
• They measured…
• Air concentration – both near and far-field
• Dermal loading
• They showed that…
• Hand (wrist) contamination was on average
highest
• Strong correlation between hand (wrist) and
whole body contamination
Vermeulen R, Heideman J, Bos RP, Kromhout H. (2000) Identification of dermal exposure pathways in
the rubber manufacturing industry. Ann Occup Hyg.;44(7):533-541.
20. Inhalation and dermal
exposure…
• Searching Scopus database for entries
since 2000
• Search query: (inhalation) AND (dermal)
AND (exposure) AND (occupational OR
worker)
• 361 papers
• Screening on title gave about 60 possibly
informative papers
• Screening on abstract identified more than
half of these as uninformative
• Final assessment based on about 20
papers
21. Inhalation and dermal
exposure
Authors Substance Workplace Corr Comment
Fent et al (2008) HDI Spray
painters
0.79 Log transformed data
Day et al (2007) Beryllium Cu-Be alloy
plant
0.63
McClean et al (2004) PAH Asphalt
workers
0.59 Based on pyrene
analysis
Hughson et al (2010) Nickel Various Ni
production
0.48 Long-transformed
hand data
Sobus et al (2009) PAH Asphalt
workers
0.32 Not statistically
significant
Cocker et al (2009) MbOCA Polyurethane
elastomers
None
Aprea et al (2009) Imidacloprid Greenhouse None
21
22. Fent et al (2008)
Fent K, Jayaraj K, Ball LM, Nylander-French L. (2008) Quantitative monitoring of dermal and inhalation
exposure to 1,6-hexamethylene diisocyanate monomer and oligomers. J. Environ. Monit.;10(4):500-507.
23. Contribution to all exposure…
Authors Substance Workplace %
skin
Comment
Borak et al (2002) PAH Creosote impregnation >90
%
Aprea et al (2009) Imidacloprid Greenhouse work >78
%
Est. absorbed
dose
Sheenan et al (2008) Benzene Cleaning ≈50% Low levels
Bader et al (2008) NMP Simulation 47% Vapour uptake
at rest
Chen et al (2008) PAH Metal machining 37%
Lindsay et al (2006) Toluene Coating work <9%
Kim et al (2007) Jet fuel Fuel cell maintenance 4% PBTK model
Chao et al (2006) Jet fuel Fuel cell maintenance 3%
Wang et al (2013) Flameretard
ant
Recycling 1% Most from diet
Xing et al (2011) PCB Recycling 0% Most from diet
24. How do we measure?
• Interception (e.g. patches)
• The mass of chemical that lands on the skin
over the sampling time (integrated flux)
• Removal (e.g. wipe/wash)
• The mass of contaminant left on the skin
• In-situ (e.g. fluorescence)
• The mass of a surrogate
compound retained on
the skin
25. Interception sampling…
• „Generic‟ protocols that
prescribe sizes, numbers,
location and method of
attachment of patches
are given by WHO, US-
EPA, OECD
• Possible to use whole
suit, gloves, hood,
socks…
• “actual” and “potential”
exposure
28. Tools for estimating
exposure…
• ConsExpo (by RIVM)
• Estimates dermal exposure to consumer products
• http://www.rivm.nl/en/healthanddisease/productsafety/Co
nsExpo.jsp
• ECETOC TRA (Targeted Risk Assessment for
REACH), variant of EASE
• http://www.ecetoc.org/tra
• RISKOFDERM (TNO, task-based approach relying
on similar dermal exposure operation units)
• Incorporated in www.StoffenManager.nl
• DREAM (DeRmal Exposure Assessment Method)
• Derived from Schneider’s conceptual model
• Generates a relative index of exposure
29. Tools for estimating
uptake…
• NIOSH Skin Permation Calculator
• http://www.cdc.gov/niosh/topics/skin/skinPermCalc.html
• IH SkinPerm
• http://www.aiha.org/get-
involved/VolunteerGroups/Pages/Exposure-Assessment-
Strategies-Committee.aspx
• These models are
based on maximum
flux from an area
of skin exposed not
mass loading
30. Preventing dermal exposure…
• Elimination of the dermal hazard
• Change the work method so exposure
is no longer necessary
• Substituting with lower hazard
materials
• Using a different form of the material
to prevent exposure
• Safe working distance
• Total enclosure
• Partial enclosure
• Local exhaust ventilation
• Process changes
• Administrative changes
• PPE
31. Safe Working Distance
• Use a tool to prevent
contact between hands
and fluid
• Scrubbing brush
• Scoop
• Long handles
• Avoid immersion events
• Use gloves if SWD not
possible
• Avoid repeated cycles
of wet/dry
• Can work be batched
rather than continuous
32. Protective clothing…
• Any protective clothing between the skin,
or normal clothing, and the outside world
• gloves
• overalls
• boots
• hoods
• chemical suits
• Clothing is less
effective in practice
than might be expected from
laboratory tests
33. Conclusions…
• Dermal exposure may contribute
importantly to total exposure
• We understand the skin exposure at a
conceptual level
• Skin exposure may or may not be
associated with inhalation exposure
• Interpreting measurements is not
straightforward
• Control can be more than protective
clothing
Dermatitis can be very uncomfortable and have a big social impactThese are extreme examples
Page 28 of Bob’s book
Where to look…What’s your experience?Show tables (P26) in book
The methods that we have available have been around for a long time and they are all very practical pragmatic techniques. We can either reply on interception, removal or in-situ assessments (Questionnaires, which one might reasonably include here are going to be dealt with by Dr Bello in the next talk).Not all techniques are applicable in all situations. Clearly relying on washing or wiping for materials that are either rapidly transferred into the body or are lost to the environment would not be sensible. A lot of work has been done on sampling recovery, the distribution of exposure across the body, the appropriateness of sampling only part of the skin. For wiping and washing there are also issues about the number and timing of samples collected.
Discuss psychological aspects – gloves make people think they are “protected”What will happen when things go wrong – they put their hand in?Hazard perception