Depressive disorders interfere with daily life and functioning, causing pain for those suffering and their loved ones. They include major depression, dysthymic disorder, psychotic depression, postpartum depression, and seasonal affective disorder. Symptoms include persistent sadness, hopelessness, fatigue, and changes in appetite or sleep. Depressive disorders are caused by biological and chemical differences in the brain as well as inherited traits, hormones, traumatic life events, other health conditions, and substance abuse. Effective treatments include medications like SSRIs and SNRIs as well as psychotherapy to help patients adjust difficulties, develop healthy behaviors and coping strategies, and set realistic goals.