Depression is more than just feeling sad - it involves a lack of pleasure or interest in activities, changes in appetite and sleep, low energy, poor concentration, and feelings of worthlessness. It is a common mental disorder but is treatable with therapy and antidepressant medication. Brain scans show physical differences between depressed and non-depressed brains, though they do not explain what causes depression. Treatment involves medication prescribed by a doctor and may also include psychotherapy with a mental health professional.