This document provides an overview of depression including its definition, causes, symptoms, types, risk factors, and treatment. Depression is defined as a persistent feeling of sadness and loss of interest that affects how one feels, thinks, and behaves. It can be caused by genetic, biological, environmental, and psychological factors. Common symptoms include feelings of sadness, hopelessness, and lack of enjoyment. Types of depression include major depressive disorder, persistent depressive disorder, perinatal depression, psychotic depression, seasonal affective disorder, and bipolar disorder. Risk factors include personal or family history of depression and major life changes. Treatment involves medication, psychotherapy, or a combination of both.