Depression is a common and serious mood disorder that is characterized by depressed mood, loss of interest, feelings of guilt and low self-worth, sleep and appetite disturbances, low energy, and poor concentration. It affects over 121 million people worldwide and can be caused by genetic, environmental, biochemical and other factors. Symptoms of depression can interfere with daily life and functioning. Treatment options include antidepressant medications, psychotherapy, and electroconvulsive therapy for treatment-resistant cases.