Coulson and Moffitt proposed that the carbon-carbon bonds in cyclopropane rings are bent based on quantum mechanical calculations. This idea of bent bonds is supported by electron density maps from X-ray studies. Molecular orbital theory explains that the overlap of orbital axes is maximized in cyclohexane, resulting in stronger carbon-carbon bonds, whereas in cyclopropane the orbital overlap is less, making the bonds weaker and allowing for ring-opening. Factors like bond angle strain from deviations from normal tetrahedral angles, torsional strain from non-staggered conformations, and steric strain from van der Waals repulsion between non-bonded atoms all contribute to the relative stability of different molecular conformations
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Acidity of Phenols/OC -II PCI Syllabus/Effect of substituents on acidity of phenols
Hi dear students, in this video I had explained about acidity of Phenols and Effect of substituents on acidity of phenols. I had tried to explain all the points by animations. So don't hasitate to study now, See this video and you will come to know the facts about acidity and basicity of organic compounds. After watching this video it will be very easy to answer the following questions,
What are phenols?
what about acidity of phenols?
factors affecting acidity of phenols?
Pka of phenols?
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INCLUDES SPREADING COEFFICIENT AND ITS THEORY AND ALSO FEW OF ITS APPLICATION IN PHARMACEUTICAL FIELD
WILL BE HELPFUL FOR B PHARMACY STUDENTS
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Introduction to benzene, orbital picture, resonance in benzene, Huckel‟s rule
Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel- Craft‟s alkylation- reactivity, limitations, Friedel-Craft‟s acylation.
Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction.
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
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Benzene and its derivatives- According to PCI Syllabus Ganesh Mote
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Hi dear students, in this video I had explained about acidity of Phenols and Effect of substituents on acidity of phenols. I had tried to explain all the points by animations. So don't hasitate to study now, See this video and you will come to know the facts about acidity and basicity of organic compounds. After watching this video it will be very easy to answer the following questions,
What are phenols?
what about acidity of phenols?
factors affecting acidity of phenols?
Pka of phenols?
Please do subscribe Online ustaad and share this video to as many as possible.
Online Ustaad
https://www.youtube.com/channel/UCzCN5UTEjFAtCBtrcNOWbyA
Qualitative analysis of fats and oils
https://youtu.be/WXO6Ggdjwvo
you can also see
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Keep watching your own channel online ustaad and give me your suggestions in comment box.
if you find this video helpful then like it, share it and subscribe online ustaad for more helpful & informational videos.
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For B.Pharm 4th sem student
The isomerism which occurs due to difference of the positions of the substituents about a double bond or a ring due to restricted rotation is called geometric isomerism.
They do not rotate the plane of polarised light (unless they also happen to be chiral), and do not have identical properties.
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2. C. A. Coulson and W, A. Moffitt (of Oxford
University) proposed bent bonds between
carbon atoms of cyclopropane rings based on
the basis of quantum mechanical calculations.
Bent bonds between carbon atoms of
cyclopropane rings; this idea is supported by
electron density maps based on X-ray studies.
4. Molecular orbital theory
• Stability of cyclohexane in terms of
Molecular orbital theory.
• Covalent bond between two atoms is
formed by overlap of orbitals of the
atoms.
• The greater the extent of overlap the
stronger is the bond formed.
5. • The atomic orbitals overlap to the
maximum extent if they overlap the
stronger is the bond formed.
• The atomic orbital overlap to maximum
extent if they overlap along this axes.
• Axes of SP3 orbital are at 109 28 to each
other C-C bond and C-C-C have their
maximum strength.
6. • In cyclopropane –C-C-C bond angle is 60
• In cyclobutane –C-C-C- bond angle is 90
• In higher cyclohexane –C-C-C bond angle
is 109 28
• In cyclopropane the overlap of SP3
orbitals of carbon is less than the overlap
of SP3 orbitals of carbon in alkane.
7. • Carbon uses sp2 orbitals for carbon-hydrogen
bonds (which are short and strong).
• The high p character of these carbon-carbon
bonds, and their location largely outside the
ring.
• Ring-opening is due to the weakness of the
carbon-carbon bonds,
12. • Overlap of SP3 orbitals of carbon in cyclo pentane
or cyclohexane is maximum because in these case
it is possible for the SP3 orbital to overlap along
their axes. The bond angle being approximately
equal to 109 28
• It implies cyclo propane are weaker than cyclo
butane. It undergoes ring opening readily and
drastic condition required to bring clevage in
cyclo butane.
• The higher cyclo alkanes behave like alkanes.
13. Ring-opening is due to the weakness of the
carbon-carbon bonds, but the way in which it
happens reflects the unusual nature of the
bonds; all this stains ultimately from the
geometry of the rings and angle strain.
14. Factors affecting stability of
conformations
• Any atom tends to have bond angles that
match those of its bonding orbitals:
tetrahedral (109.5) for SP3-hybridized carbon,
for example. Any deviations from the
"normal" bond angles are accompanied by
angle strain.
15. Any pair of tetrahedral carbons attached to each
other tend to have their bonds staggered. That is to
say, any ethane-like portion of a molecule tends,
like ethane, to take up a staggered conformation.
Any deviations from the staggered arrangement are
accompanied by torsional strain
16. Nonbonded interaction-steric strain
• Non-bonded atoms (or groups) that just touch
each other that is, that are about as far apart as
the sum of their van der Waals radii attract each
other. If brought any closer together, they repel
each other: such crowding together is
accompanied by van der Waals strain (steric
strain).
• These non-bonded interactions can be either
repulsive or attractive,and the result can be
either destabilization or stabilization of the
conformation.
18. All these factors, working together or opposing each
other, determine the net stability of a conformation.
To figure out what the most stable conformation of a
particular molecule should be, one ideally should
consider all possible combinations of bond angles, angles
of rotation, and even bond lengths, and see which
combination results in the lowest energy content.
A start in this direction feasible only by use of computers
has been made, most notably by ProfessorJames F.
Hendrickson (of Brandeis University).