Clinical Examination of Nervous System - PPT -- By Prof. Dr. R. R. Deshpande
• This PPT explains how to perform Central Nervous System Examination systematically & step by step .This includes (1) Examination for higher functions (2) Examination of cranial nerves (3) Examination of sensory system (4) Examination of motor system (5) Examination of reflexes (6) Examination of gait (7) Examination of spine and cranium (8) Examination for special signs (such as cerebellar signs)
• Visit – www.ayurvedicfriend.com
• Phone – 922 68 10 630
Clinical Examination of Nervous System - PPT -- By Prof. Dr. R. R. Deshpande
• This PPT explains how to perform Central Nervous System Examination systematically & step by step .This includes (1) Examination for higher functions (2) Examination of cranial nerves (3) Examination of sensory system (4) Examination of motor system (5) Examination of reflexes (6) Examination of gait (7) Examination of spine and cranium (8) Examination for special signs (such as cerebellar signs)
• Visit – www.ayurvedicfriend.com
• Phone – 922 68 10 630
Acute kidney injury (AKI) is a potentially life-threatening
syndrome that occurs primarily in hospitalized patients
and frequently complicates the course of critically ill
patient.
Acute Kidney Injury is is (abrupt) reduction in kidney functions as evidence by changed in laboratory values; serum creatinine, blood urea nitrogen(BUN)and urine output
Cerebellum is the organ that controls tone of muscle and maintains balance of body. It is also responsible for co-ordination of the movements. There are some signs which suggest the abnormalities in Cerebellar functioning.
A presentation that talks about the Human Nervous System, the cranial nerves and the Neuro Assessment required to check if the nervous system is functioning properly.
Acute kidney injury (AKI) is a potentially life-threatening
syndrome that occurs primarily in hospitalized patients
and frequently complicates the course of critically ill
patient.
Acute Kidney Injury is is (abrupt) reduction in kidney functions as evidence by changed in laboratory values; serum creatinine, blood urea nitrogen(BUN)and urine output
Cerebellum is the organ that controls tone of muscle and maintains balance of body. It is also responsible for co-ordination of the movements. There are some signs which suggest the abnormalities in Cerebellar functioning.
A presentation that talks about the Human Nervous System, the cranial nerves and the Neuro Assessment required to check if the nervous system is functioning properly.
Reflexes are important to understand for all medical professional it is an assessment tool for patients with neurological conditions.
a god knowledge of primitive reflexes can be effective for pediatric health care as well. it helps us in identifying any developmental delay in children.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
2. NERVOUS SYSTEM
The nervous system consists of
1. The central nervous system (CNS)
2. The peripheral nervous system
3. The autonomic nervous system
3. STEPS OF ASSESSMENT
History collection
Physical examination
Differential diagnosis
Diagnostic evaluation
Management Plan
4. HISTORY COLLECTION
Past history
H/O Fall or trauma that may have involved the
head or spinal cord.
Family history
Alzheimer’s disease, Epilepsy, Parkinson’s disease,
Spina bifida, etc.
Personal history
Alcohol, medications and illicit drugs.
5. NEUROLOGICAL ASSESSMENT
A complete neurological assessment consists of five steps:
Consciousness and Cognition
Cranial nerves assessment
Motor system
Reflexes
Sensory system
6. CONSCIOUSNESS AND COGNITION
ASSESSMENT
Cerebral abnormalities may cause disturbances in
mental status, intellectual functioning, thought
content and emotional status.
_______________________________________________
Can you measure or calculate the conscious level ?
23. EXAMINING THE MOTOR SYSTEM
Motor ability
Muscle strength
Balance and coordination
24. MOTOR ABILITY
The patient is instructed to walk across the room, if
possible while the examiner observes posture and
gait. the muscles are inspected and palpated if atrophy
or involuntary movements is noted.
25. Muscle strength
Ask client to flex muscle and then resist when you apply
opposing force against the muscles
Compare contralateral sides
Neck, Trapezius, arms (Biceps, Triceps), wrists, fingers, hips,
legs, ankles and feet
26.
27. Balance and Co-ordination
Seat the patient. Instruct him to pat his knees with his
hands, palms down then palms up. Have him alternate
palms down and palms up rapidly.
Watch the patient to notice if his movements are stiff, slow,
non-rhythmic, or jerky.
The movements should be smooth and rhythmic as he does
the task faster.
29. BICEPS REFLEX
1- Have the patient's elbow at about a
90° angle of flexion with the arm
slightly bent down as shown in
figure 2-6.
2- Grasp the elbow with your left hand
so the fingers are behind the elbow
and your abducted thumb presses
the biceps brachial tendon.
3- Strike your thumb a series of blows
with the rubber hammer, varying
your thumb pressure with each
blow until the most satisfactory
response is obtained.
4- Normal reflex is elbow flexion
(bending(
30. TRICEPS REFLEX
Grasp the patient's wrist with
your left hand and pull his
arm across his chest so the
elbow is flexed about 90° and
the forearm is partially bent
down.
Tap the triceps brachial
tendon directly above the
olecranon process. The
normal response is elbow
extension .
Triceps reflex
Triceps jerk with
one arm flexed
Triceps
jerk with
arms
folded
31. BRACHIORADIALIS REFLEX
With the patient’s forearm resting on the lap or across
the abdomen, the brachio-radialis reflex is assessed.
A gentle strike of the hammer 2.5 to 5 cm above the
wrist results in flexion and supination of the forearm.
32. PATELLAR REFLEX
The patellar reflex is elicited by
striking the patellar tendon just
below the patella. The patient
may be in a sitting or a lying
position.
If the patient is supine, the
examiner supports the legs to
facilitate relaxation of the
muscles.
Contraction of the quadriceps
and knee extension are normal
responses.
33. ACHILLES REFLEX
To elicit an achilles reflex, the foot is dorsi-flexed at
the ankle and the hammer strikes the stretched
achilles tendon. This reflex normally produces
flexion
34. Deep tendon reflexes should be
graded on a scale of 0-4
=0 absent despite of reinforcement
=1 present only with reinforcement
=2 normal
=3 increased but normal
=4 markedly hyperactive, with clonus
35. EXAMINING THE SENSORY SYSTEM
Tactile sensation
Superficial pain
Temperature
Vibration and position sense