The document describes Invetech's NovoGen MMX Bioprinter, which is the world's first commercial 3D bioprinter. It can print layers of cell aggregates and biogel to construct tissues and blood vessels. The bioprinter has high precision motion axes and dual print heads to print both biogel and cells. It also has thermal control of the biogel and automated cartridge loading. The bioprinter reduces the time needed for blood vessel printing from over 8 hours previously to less than an hour. It provides precise printing down to 20 microns and uses laser calibration and closed-loop motor control. Examples are given of tissues and applications printed so far, ranging from liver tissue to cartilage
3D Bio-Printing; Becoming Economically FeasibleJeffrey Funk
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to analyze the increasing economic feasibility of bio-printing. Due to a lack of available kidney and other organ donors for organ transplants, 3D printing has emerged as an important alternative for many people. Bioprinting is done by using a computer model of an individual’s body to generate a data set for an organ that can be printed with a 3D printer and grown in a bio-reactor. The falling cost of materials and 3D printers is improving their economic feasibility.
For an Executive Summary of this report please contact ediz.ibrahim@visiongain.com (+44 (0)20 7549 9976) or refer to our website http://www.visiongain.com/Report/1184/3D-Printing-for-Healthcare-R-D-Industry-and-Market-2014-2024
3D Bio-Printing; Becoming Economically FeasibleJeffrey Funk
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to analyze the increasing economic feasibility of bio-printing. Due to a lack of available kidney and other organ donors for organ transplants, 3D printing has emerged as an important alternative for many people. Bioprinting is done by using a computer model of an individual’s body to generate a data set for an organ that can be printed with a 3D printer and grown in a bio-reactor. The falling cost of materials and 3D printers is improving their economic feasibility.
For an Executive Summary of this report please contact ediz.ibrahim@visiongain.com (+44 (0)20 7549 9976) or refer to our website http://www.visiongain.com/Report/1184/3D-Printing-for-Healthcare-R-D-Industry-and-Market-2014-2024
it is a seminar slide that i prepared on the topic 3d bioprinting. it may be a help to whom taking seminar on that topic. It is not covered its full area only the basics of bio printing ..
Bioprinting and 3D printing for educational centresjosbaema
Do you know the benefits for educational centers and universities of integrating 3D printing and bioprinting technologies in their activity? contact us: info@regemat3D.com
Reprinting the law - legal aspects of 3D bioprinting - Ernst-Jan LouwersErnst-Jan Louwers
Presentation on bioprinting, protheses and personalized medicine at 3D Bioprinting Conference held at Maastricht on 19th June 2014. Legal aspects of 3D printing / additive manufacturing: also legally disruptive tech! Don't underestimate or miss disruptive developments like this! Be prepared and share best practices in everyone's best interest.
Bioprinting was defined as the use of material transfer processes for patterning and assembling biologically relevant materials- molecules, cells, tissues, and biodegradable biomaterials with a prescribed organization to accomplish one or more biological function. This is a developmental biology- inspired approach to tissue engineering and is based on the assumption that tissues and organs are self- organizing systems, and that cells and especially micro tissues can undergo biological self- assembly and self- organization without any external influence in the form of instructive, supporting and directing rigid templates or solid scaffolds.
Bioprinting or the biomedical application of rapid prototyping, also defined as layer- by- layer additive biomanufacturing, is an emerging transforming biomimetic technology that has potential for surpassing traditional solid scaffold- based tissue engineering. It is a rapid prototyping technology based on three dimensional, automated, computer-aided deposition of ‘‘bioink particles’’ (multicellular spheroids) into a ‘‘biopaper’’ (biocompatible gel; e.g. collagen) by a bioprinter
Future of 3D Printing in Pharmaceutical & Healthcare SectorPrashant Pandey
3D Printing is a process of making a physical object from a three dimensional digital model typically by layering down many thin layers of a material in succession
It has been expleined in these slides that how 3D bioprinters work and some of them have been introdused. Also some examples of use 3D bioprinter in reality are introduced.
Finally feature of 3D bioprinters in human life has been explained.
3D BIO PRINTING USING TISSUE AND ORGANSsathish sak
3D bio printing is the process of creating cell patterns in a confined space using 3D printing technologies.
3D bio printing is the layer by layer method to deposit materials known as bioinks to create tissue like structure.
Currently, bioprinting can be used to print tissues and organs to help research drug and pills.
Doris Taylor Building New Hearts: Regenerative Medicine Becomes a RealityKim Solez ,
Dr. Doris Taylor presents "Building New Hearts: Regenerative Medicine Becomes a Reality" at the Banff Transplant Pathology meeting in Vancouver October 5, 2015.
Printing of biological organs and tissues.First the concept of 3d printing is known (not in depth),then bioprinting concept is seen.With the help of images the description can be given.
hashim salim
hashsalim@gmail.com
Whether due to illness or injury, organ failure is a worldwide problem and its only treatment is organ transplantation or tissue replacement. Although it’s the only solution in these cases, organs demand greatly surpasses the supply. Organs are usually obtained from people who recently have died (up to 24 hours past the cessation of heartbeat) or from people who are clinically brain dead and their body functions are maintained artificially, nevertheless living organ donation is becoming more frequent [1]. The increase of the organ demand has been raising ethical concerns, since this can result in offers or incentives for donation, profit on donated human organs or even exploitation of the disadvantaged. In the developed world most countries have a legal system that oversee organ transplantation, however in poorer countries a black market has been arising, enabling those who can afford to buy organs, exploiting those who are desperate enough to sell them
it is a seminar slide that i prepared on the topic 3d bioprinting. it may be a help to whom taking seminar on that topic. It is not covered its full area only the basics of bio printing ..
Bioprinting and 3D printing for educational centresjosbaema
Do you know the benefits for educational centers and universities of integrating 3D printing and bioprinting technologies in their activity? contact us: info@regemat3D.com
Reprinting the law - legal aspects of 3D bioprinting - Ernst-Jan LouwersErnst-Jan Louwers
Presentation on bioprinting, protheses and personalized medicine at 3D Bioprinting Conference held at Maastricht on 19th June 2014. Legal aspects of 3D printing / additive manufacturing: also legally disruptive tech! Don't underestimate or miss disruptive developments like this! Be prepared and share best practices in everyone's best interest.
Bioprinting was defined as the use of material transfer processes for patterning and assembling biologically relevant materials- molecules, cells, tissues, and biodegradable biomaterials with a prescribed organization to accomplish one or more biological function. This is a developmental biology- inspired approach to tissue engineering and is based on the assumption that tissues and organs are self- organizing systems, and that cells and especially micro tissues can undergo biological self- assembly and self- organization without any external influence in the form of instructive, supporting and directing rigid templates or solid scaffolds.
Bioprinting or the biomedical application of rapid prototyping, also defined as layer- by- layer additive biomanufacturing, is an emerging transforming biomimetic technology that has potential for surpassing traditional solid scaffold- based tissue engineering. It is a rapid prototyping technology based on three dimensional, automated, computer-aided deposition of ‘‘bioink particles’’ (multicellular spheroids) into a ‘‘biopaper’’ (biocompatible gel; e.g. collagen) by a bioprinter
Future of 3D Printing in Pharmaceutical & Healthcare SectorPrashant Pandey
3D Printing is a process of making a physical object from a three dimensional digital model typically by layering down many thin layers of a material in succession
It has been expleined in these slides that how 3D bioprinters work and some of them have been introdused. Also some examples of use 3D bioprinter in reality are introduced.
Finally feature of 3D bioprinters in human life has been explained.
3D BIO PRINTING USING TISSUE AND ORGANSsathish sak
3D bio printing is the process of creating cell patterns in a confined space using 3D printing technologies.
3D bio printing is the layer by layer method to deposit materials known as bioinks to create tissue like structure.
Currently, bioprinting can be used to print tissues and organs to help research drug and pills.
Doris Taylor Building New Hearts: Regenerative Medicine Becomes a RealityKim Solez ,
Dr. Doris Taylor presents "Building New Hearts: Regenerative Medicine Becomes a Reality" at the Banff Transplant Pathology meeting in Vancouver October 5, 2015.
Printing of biological organs and tissues.First the concept of 3d printing is known (not in depth),then bioprinting concept is seen.With the help of images the description can be given.
hashim salim
hashsalim@gmail.com
Whether due to illness or injury, organ failure is a worldwide problem and its only treatment is organ transplantation or tissue replacement. Although it’s the only solution in these cases, organs demand greatly surpasses the supply. Organs are usually obtained from people who recently have died (up to 24 hours past the cessation of heartbeat) or from people who are clinically brain dead and their body functions are maintained artificially, nevertheless living organ donation is becoming more frequent [1]. The increase of the organ demand has been raising ethical concerns, since this can result in offers or incentives for donation, profit on donated human organs or even exploitation of the disadvantaged. In the developed world most countries have a legal system that oversee organ transplantation, however in poorer countries a black market has been arising, enabling those who can afford to buy organs, exploiting those who are desperate enough to sell them
Applications of 3 d printing in biomedical engineeringDebanjan Parbat
This presentation deals with the recent and futuristic trends in the field of 3D Printing technology and its applications in the field of bio engineering and medical applications. The 3D printing technology can change the perception of the whole manufacturing industry to health care applications.
3D-Bioprinting coming of age-from cells to organsDaniel Thomas
Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially.
Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections of how a drug will react in a human patient.
A solution has emerged in the form of 3D-Bioprinting technology, developed for the scalable, accurate and repeatable deposition of biologically active materials. With advances in this biomanufacturing technology, durable biological tissues for use in testing new pharmaceutical products are now being harnessed and refined.
its about 3D printing and scanning of internal organ , biomolecules and tissues
It is an emerging field in tissue engineering, surgery and transplant of organs
3D Bioprinting in Disease Prevention & Treatment.pdfDoriaFang
Learn about 3D bioprinting in disease prevention and treatment from 3D bioprinting materials, 3D bioprinting technology and 3D bioprinted vaccines, therapeutics and delivery systems.
Increasing the efficacy of drugs and at the same time reducing the chances of adverse reaction should be the aim of drug development, which can be achieved by using 3D printing to fabricate personalized medications
Drugs with narrow therapeutic index can easily be prepared using 3D printing; and, by knowing the patient’s pharmacogenetic profile and other characteristics like age, race etc., optimal dosage can be given to the patient.
3D printing technology is a valuable and potential tool for the pharmaceutical sector, leading to personalized medicine focused on the patients’ needs. It offers numerous advantages, such as increasing the cost efficiency and the manufacturing speed. 3D printing has revolutionized the way in which manufacturing is done. It improves the design manufacturing and reduces lead time and tooling cost for new products.
The role of pe gylated materials in 3 d bioprinting-biochempegDoriaFang
Three dimensional (3D) bioprinting has emerged as a promising new approach for fabricating complex biological constructs in the field of tissue engineering and regenerative medicine. What is 3D Bioprinting? What are bio-ink materials for it? How does it work and what are the applications of it?
The latest Top 10 from the Rassed research program explore different ways in which 3D printing is currently being used across the world.
Anticipated to become a mainstream technology in the near future, these slides show that 3D printing is already having an impact - with more to innovations and benefits envisaged in the coming years.
Additive manufacturing or 3D printing is a process of making a three-dimensional solid object of virtually any shape from a digital model. 3D printing is achieved using an additive process, where successive layers of material are laid down in different shapes.
Similar to Chris Leigh-Lancaster_Inside 3D Printing Melbourne (20)
2. Introducing Invetech
A synergistic mix of biomedical, automation, high
precision, fluid handling and user experience ...
All the right ingredients for bioprinting!
More than 30 years of product realization
Page 2
Diagnostics Cell TherapyPoint of Care
Consumer
& Industrial
8. Page 8
Making Human Tissue
Step 2 – The Bioprinter prints layers of Cell aggregates and BioGel
Extruded BioGel
lines
Cartridge with BioGel
or cell aggregates
3D print
nozzle
9. Page 9
Making Human Tissue
Step 3 – Construct is placed into a bioreactor and incubated
10. The NovoGen MMX Bioprinter™
Key features
Page 10
• 3 high-precision motion
axes
• Dual print heads for
BioGel and cell layers
• Thermal control of the
BioGel
• Semi-automated loading
of print cartridges
• An intuitive GUI for rapid
vessel/tissue design
11. The NovoGen MMX Bioprinter™
Initial blood vessel printing on the Bioprinter
Page 11
500 μm glass
cartridge
dispense tip
BioGel structure
containing BioGel and
cell lines
Blood vessel
geometry within the
BioGel structure
12. Simple Operation
Intuitive graphical user interface (GUI)
Page 12
WPF-based flexible GUI - customisable for future applications
Key focus is easy translation of simple tissue designs into real tissue
“mine sweeper” style designer for developing 2D geometric forms
Built-in scripting language for design of more complex 3D constructs
13. Simple Operation
Cartridge loading & alignment
Page 13
Before the Bioprinter …
Blood vessel printing took 8 hours or more
With the Bioprinter – less than an hour
Cartridge loading & alignment took up to 45 mins
With the Bioprinter - less than 1 minute
Thanks to ...
Intuitive cartridge loading with precision
alignment
Automatic positive displacement dispense
Automatic laser calibration of cartridge tip
position
14. Precision Printing
What’s needed for successful printing?
Page 14
Positional precision of better than ± 20 microns
Re-calibration of tip positions for each cartridge
Smooth dispense of cells and BioGel
Bio-compatible operation
100 µm human hair
15. Precision Printing
How it’s done …
Page 15
Optical-grade robotic axes with single micron precision
Novel 3D laser tip calibration using custom interpolation algorithms
Closed loop micro-stepping motor control to minimize vibration
Designed for the bio-safety cabinet
16. From Science to Application
A timeline from the first blood vessel
Page 16
December 2010
First human blood vessel
Time Magazine’s Best Inventions of 2010
Mar 2011
Partnerships with big pharma
Nov 2011
Australian Engineering Innovation Award.
Dec 2012
Autodesk partnership
Feb 2013
Refined Bioprinters delivered to Organovo
17. From Science to Application
A timeline from the first blood vessel
Page 17
Apr 2013
First 3D liver tissue. Life span increases from 5 to 40 days
Apr 2014
Contracting for 3D liver tissue toxicity testing
The Near Future
3D tissue constructs replace existing pre-clinical trial methods for drug screening.
Simple tissues start being used for direct surgical therapy
18. Alternate Blood Vessel Manufacturing
Page 18
“Off the shelf” human veins for use in life-saving vascular surgery
Humacyte Artificial Vascular Graft (HAVGTM)