Greeting everyone, This is a Crisp overview of 3D Printing that was presented by me in a seminar. Looking forward to improve the same, Any suggestion, comment, questions are welcome.
Thank You.
EU GMP Annex 1 Draft: Implications on Sterilizing Grade Filter ValidationMerck Life Sciences
Watch the presentation of this webinar here: https://bit.ly/3kk0Qs1
In this webinar, you will learn:
- About the GMP Annex 1 draft regulatory overview
- How to incorporate the integrity testing & PUPSIT in the filtration systems validation
- How to design a bacterial retention test in terms of organism selection and single vs multiple use validation
Detailed description:
In this webinar we will discuss the implications of the EU GMP Annex 1 draft on the filtration of medicinal products and how this impacts the validation studies.
Bacterial Retention Testing is a critical part of the manufacturing validation process and is required by all regulatory bodies worldwide. Using case studies, our experts will explain how the Annex 1 draft is incorporated into the filtration systems validation exercise, specifically for integrity testing & PUPSIT (Pre-Use Post Sterilization Integrity Testing), the selection and justification of the appropriate test organism, and validation implications of single versus multiple use.
Temporary Crown and Bridge Resins by Dr Rashid HassanDr Rashid Hassan
A comprehensive lecture by Dr Rashid Hassan on Temporary crown and bridge resins . The lecture covers the materials used as temporary crown & bridge, the technique of using and the general properties of materials used.
Presentation complied by Drug Regulations – a not for profit organization from publicly available material form FDA , EMA, EDQM . WHO and similar organizations.
Visit www.drugregulations.org for the latest in Pharmaceuticals
The process of self-healing of cracks or self-filling up of cracks by the help of bacterial reaction in the concrete after hardening is known as Self-Healing Concrete. It can be observed that small cracks that occur in a structure of width in the range of 0.05 to 0.1mm gets completely sealed in repetitive dry and wet cycles.
Validation of Tangential Flow Filtration in Biotech ProcessesMerck Life Sciences
Watch the presentation of this webinar here: https://bit.ly/3hUKfd7
The objective of validation of a unit operation is to demonstrate with a high degree of confidence that the process performs consistently. The present seminar will focus on the validation of the unit operation of TFF and will provide an overview of the regulatory landscape, the validation master plan, approaches to membrane re-use, cleaning validation, and best practices.
In this webinar, you will learn:
• Validation of TFF
• Validation master plan
• Membrane reuse and cleaning
• TFF scale down models
Speaker: Dr. Subhasis Banerjee,
Principal Technical Application Expert, Bioprocessing APAC
EU GMP Annex 1 Draft: Implications on Sterilizing Grade Filter ValidationMerck Life Sciences
Watch the presentation of this webinar here: https://bit.ly/3kk0Qs1
In this webinar, you will learn:
- About the GMP Annex 1 draft regulatory overview
- How to incorporate the integrity testing & PUPSIT in the filtration systems validation
- How to design a bacterial retention test in terms of organism selection and single vs multiple use validation
Detailed description:
In this webinar we will discuss the implications of the EU GMP Annex 1 draft on the filtration of medicinal products and how this impacts the validation studies.
Bacterial Retention Testing is a critical part of the manufacturing validation process and is required by all regulatory bodies worldwide. Using case studies, our experts will explain how the Annex 1 draft is incorporated into the filtration systems validation exercise, specifically for integrity testing & PUPSIT (Pre-Use Post Sterilization Integrity Testing), the selection and justification of the appropriate test organism, and validation implications of single versus multiple use.
Temporary Crown and Bridge Resins by Dr Rashid HassanDr Rashid Hassan
A comprehensive lecture by Dr Rashid Hassan on Temporary crown and bridge resins . The lecture covers the materials used as temporary crown & bridge, the technique of using and the general properties of materials used.
Presentation complied by Drug Regulations – a not for profit organization from publicly available material form FDA , EMA, EDQM . WHO and similar organizations.
Visit www.drugregulations.org for the latest in Pharmaceuticals
The process of self-healing of cracks or self-filling up of cracks by the help of bacterial reaction in the concrete after hardening is known as Self-Healing Concrete. It can be observed that small cracks that occur in a structure of width in the range of 0.05 to 0.1mm gets completely sealed in repetitive dry and wet cycles.
Validation of Tangential Flow Filtration in Biotech ProcessesMerck Life Sciences
Watch the presentation of this webinar here: https://bit.ly/3hUKfd7
The objective of validation of a unit operation is to demonstrate with a high degree of confidence that the process performs consistently. The present seminar will focus on the validation of the unit operation of TFF and will provide an overview of the regulatory landscape, the validation master plan, approaches to membrane re-use, cleaning validation, and best practices.
In this webinar, you will learn:
• Validation of TFF
• Validation master plan
• Membrane reuse and cleaning
• TFF scale down models
Speaker: Dr. Subhasis Banerjee,
Principal Technical Application Expert, Bioprocessing APAC
An introduction to the international cleanroom standard ISO 14644 and the 2015 revisions to Parts 1 and 2. The focus is on particulate and contamination control.
Single-Use Tangential Flow Filtration for Closed ProcessingMerck Life Sciences
Watch the presentation of this webinar here: https://bit.ly/3b7vD60
Closed processing involves use of physical barriers to separate processing fluid from the external environment. This approach reduces capital expenditures and clean room classification while accelerating time to market. This webinar will present a TFF process run in a closed mode.
Closed processing with single-use technologies is a critical enabler for efficient and robust manufacturing for novel modalities as well as continuous biomanufacturing processing. It can also reduce the dependence on classified clean rooms for traditional modalities. This approach helps to mitigate the risk of contamination by adventitious agents while enhancing operator safety.
In this presentation, we discuss the implementation of closed processing for downstream applications and present the design and performance testing of a single use manufacturing-scale tangential flow filtration system to be able to operate in both functionally and fully closed mode.
In this webinar, you will learn:
• The context of closed processing
• Differences between closed and functionally closed processing
• The drivers for adoption
• Its practical implementation to a TFF step
Fracture and failure analyses of plastics and reinforced plasticsPadmanabhan Krishnan
This ppt describes the structure property correlationship between structure, microstructure and the observed properties of plastics and reinforced plastics./ Fracture , failure analysis and fractography are discussed in details.
This presentation provides a nice introduction to Failure Mode, Effects and Criticality Analysis (FMECA). Includes history and background, definitions, timelines for implementing and describes the FMEA methodology.
Normal Flow Filtration: Design and Scale UpMilliporeSigma
This presentation explores bioprocessing filtration best practices, including design and scale up methods. You will learn:
• What is filtration?
• Filter capacity and fouling models
• Filter sizing approaches
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/remotevisit
Optimization of Tangential Flow Filtration Applications and Scale Up Consider...Merck Life Sciences
This presentation provides an introduction to tangential flow filtration applications for AAV and lentivirus and will review:
• Basics of tangential flow filtration (TFF)
• TFF AAV and lentivirus process overview
• Operating parameters optimization: flux-controlled microfiltration
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/remotevisit
EU GMP Annex 1 Draft: Implications on Sterilizing Grade Filter ValidationMilliporeSigma
Watch the presentation of this webinar here: https://bit.ly/3kk0Qs1
In this webinar, you will learn:
- About the GMP Annex 1 draft regulatory overview
- How to incorporate the integrity testing & PUPSIT in the filtration systems validation
- How to design a bacterial retention test in terms of organism selection and single vs multiple use validation
Detailed description:
In this webinar we will discuss the implications of the EU GMP Annex 1 draft on the filtration of medicinal products and how this impacts the validation studies.
Bacterial Retention Testing is a critical part of the manufacturing validation process and is required by all regulatory bodies worldwide. Using case studies, our experts will explain how the Annex 1 draft is incorporated into the filtration systems validation exercise, specifically for integrity testing & PUPSIT (Pre-Use Post Sterilization Integrity Testing), the selection and justification of the appropriate test organism, and validation implications of single versus multiple use.
Single-Pass Tangential Flow Filtration (SPTFF) Theory and PracticeMilliporeSigma
This data-driven presentation explores the theoretical and practical implications of single-pass tangential flow filtration in bioprocessing and will address the following:
• What is single-pass TFF and how does it work?
• How does SPTFF improve process economics?
• How can single-use technology be utilized for speed and safety?
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/mlab
Additive manufacturing or 3D printing is a process of making a three-dimensional solid object of virtually any shape from a digital model. 3D printing is achieved using an additive process, where successive layers of material are laid down in different shapes.
An introduction to the international cleanroom standard ISO 14644 and the 2015 revisions to Parts 1 and 2. The focus is on particulate and contamination control.
Single-Use Tangential Flow Filtration for Closed ProcessingMerck Life Sciences
Watch the presentation of this webinar here: https://bit.ly/3b7vD60
Closed processing involves use of physical barriers to separate processing fluid from the external environment. This approach reduces capital expenditures and clean room classification while accelerating time to market. This webinar will present a TFF process run in a closed mode.
Closed processing with single-use technologies is a critical enabler for efficient and robust manufacturing for novel modalities as well as continuous biomanufacturing processing. It can also reduce the dependence on classified clean rooms for traditional modalities. This approach helps to mitigate the risk of contamination by adventitious agents while enhancing operator safety.
In this presentation, we discuss the implementation of closed processing for downstream applications and present the design and performance testing of a single use manufacturing-scale tangential flow filtration system to be able to operate in both functionally and fully closed mode.
In this webinar, you will learn:
• The context of closed processing
• Differences between closed and functionally closed processing
• The drivers for adoption
• Its practical implementation to a TFF step
Fracture and failure analyses of plastics and reinforced plasticsPadmanabhan Krishnan
This ppt describes the structure property correlationship between structure, microstructure and the observed properties of plastics and reinforced plastics./ Fracture , failure analysis and fractography are discussed in details.
This presentation provides a nice introduction to Failure Mode, Effects and Criticality Analysis (FMECA). Includes history and background, definitions, timelines for implementing and describes the FMEA methodology.
Normal Flow Filtration: Design and Scale UpMilliporeSigma
This presentation explores bioprocessing filtration best practices, including design and scale up methods. You will learn:
• What is filtration?
• Filter capacity and fouling models
• Filter sizing approaches
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/remotevisit
Optimization of Tangential Flow Filtration Applications and Scale Up Consider...Merck Life Sciences
This presentation provides an introduction to tangential flow filtration applications for AAV and lentivirus and will review:
• Basics of tangential flow filtration (TFF)
• TFF AAV and lentivirus process overview
• Operating parameters optimization: flux-controlled microfiltration
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.merckmillipore.com/remotevisit
EU GMP Annex 1 Draft: Implications on Sterilizing Grade Filter ValidationMilliporeSigma
Watch the presentation of this webinar here: https://bit.ly/3kk0Qs1
In this webinar, you will learn:
- About the GMP Annex 1 draft regulatory overview
- How to incorporate the integrity testing & PUPSIT in the filtration systems validation
- How to design a bacterial retention test in terms of organism selection and single vs multiple use validation
Detailed description:
In this webinar we will discuss the implications of the EU GMP Annex 1 draft on the filtration of medicinal products and how this impacts the validation studies.
Bacterial Retention Testing is a critical part of the manufacturing validation process and is required by all regulatory bodies worldwide. Using case studies, our experts will explain how the Annex 1 draft is incorporated into the filtration systems validation exercise, specifically for integrity testing & PUPSIT (Pre-Use Post Sterilization Integrity Testing), the selection and justification of the appropriate test organism, and validation implications of single versus multiple use.
Single-Pass Tangential Flow Filtration (SPTFF) Theory and PracticeMilliporeSigma
This data-driven presentation explores the theoretical and practical implications of single-pass tangential flow filtration in bioprocessing and will address the following:
• What is single-pass TFF and how does it work?
• How does SPTFF improve process economics?
• How can single-use technology be utilized for speed and safety?
To learn more about this topic or collaborate with our technical experts, schedule an in-person or remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/mlab
Additive manufacturing or 3D printing is a process of making a three-dimensional solid object of virtually any shape from a digital model. 3D printing is achieved using an additive process, where successive layers of material are laid down in different shapes.
Future of 3D Printing in Pharmaceutical & Healthcare SectorPrashant Pandey
3D Printing is a process of making a physical object from a three dimensional digital model typically by layering down many thin layers of a material in succession
Platform for Tissue Engineering and 3D Printing at La Paz University Hospital...DanielCermeno1
The Tissue Engineering and 3D Printing Platform purpose is to promote the development of research and solutions based on tissue engineering and bioprinting and offer different services as computer imaging, virtual planning, computer aided design, and 3D printing technologies to researchers and clinicians in the fields of Reconstructive and Regenerative Medicine.
Increasing the efficacy of drugs and at the same time reducing the chances of adverse reaction should be the aim of drug development, which can be achieved by using 3D printing to fabricate personalized medications
Drugs with narrow therapeutic index can easily be prepared using 3D printing; and, by knowing the patient’s pharmacogenetic profile and other characteristics like age, race etc., optimal dosage can be given to the patient.
3D printing technology is a valuable and potential tool for the pharmaceutical sector, leading to personalized medicine focused on the patients’ needs. It offers numerous advantages, such as increasing the cost efficiency and the manufacturing speed. 3D printing has revolutionized the way in which manufacturing is done. It improves the design manufacturing and reduces lead time and tooling cost for new products.
3d printing on how it can help people with learning disabilities. it can help people with life it can also print body limbs so people can have an arm or a leg if they lost their arm or leg. it really has an impact on the world to make that one simple change and make the world better.
Role of 3D printing & 3D model in Complex Total Hip Replacement Queen Mary Hospital
Role of 3D printing & 3D model in Complex Total Hip Replacement
Dr. Kalaivanan Kanniyan
for queries - drkkbriyan@gmail.com / drkkbriyan@outlook.com
Asian Joint Reconstruction Institute
AJRI
chennai
India
Tamil nadu
complex hip replacement , knee replacment, knee navigation
Contains all information you need for an introduction to 3d printing. Includes:
What is 3d printing?
Why use 3d printing?
When did it begin?
How does it work? + 2 small videos to show the same
Recent developments and future
this teaches about how 3D printing can be used to help other people and fun ways to teach and learn. It also includes how people make 3D printing designs, art shows, and medical uses.
It has been expleined in these slides that how 3D bioprinters work and some of them have been introdused. Also some examples of use 3D bioprinter in reality are introduced.
Finally feature of 3D bioprinters in human life has been explained.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
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Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
3D Printing in healthcare system a crisp overview
1. Presented By: Mehul Rohit
Profession: Pharmacist (M.Pharm, Pharmaceutics)
Contact: mehulrohit1299@gmail.com
3D Printing in Healthcare
system : A Crisp overview
3. 3
A brief introduction
History and Present
Basic Components of a 3D-
Printing unit
3D-Printing Methods
Material for 3DP
Applications
Future aspects
4. 4
Introduction
It can be defined as a “process or method that enables fabrication of
objects through the deposition of a material using a print head, nozzle,
or another printer technology”
“3D printing is an additive manufacturing process which constructs an object
in a layer-by-layer manner using a digital design”
Synonym
Additive Manufacturing
Rapid Prototyping
Solid free form fabrication
layered manufacturing
6. 6
History
Dr. Hideo Kodama
• Inventor of RAPID PROTYPING, using photopolymer. 1980
• Applied for patent in Japan but failed to show working model
due to funding issues. Hence his patent was revoked.
• Later published two fundamental research and review to
support his experiments.
7. 7
Automatic Method for Fabricating a Three-Dimensional Plastic Model with
PhotoHardening Polymer, in Review of Scientific Instruments.
Three-Dimensional Data Display by Automatic Preparation of a Three-
Dimensional Model
8. Chuck Hull
• Invented Stereolithographiy, 1983
• File’s Patent for SLA , 1984
• Co-Founder of the FIRST 3DP company called as the 3D System, 1986
• Commercializes first 3D printer SLA-1, 1987 and is issued Patent in
1989 for SLS (selective laser sintering)
8
9. 9
Scot Crump
Patented FDM technology in 1989.
Created First fully functional FDM Printer 1992.
Found Stratasys in 1988, with his wife Lisa Crump.
11. 11
RepRap
• Project initiated at University of Bath, United Kingdom
• Working Self-Replicating 3D Printer,2007
• Replicating-Rapid Prototyping
• First child “Printed”28 May, 2008”
• Invented by Adrian Bowyer
Image Courtesy: reprap.org
12. 12
Printing Our self?
Organovo
(San Diego, California)
Inkjet Printing of viable cells, Patented By Dr. Thomas Boland, 2003
Commercializes exVive3D™ Human Liver Tissue, 2014
Commercializes exVive3D™ Human Kidney Tissue, 2016
Currently Working on, 3DP for Skeletal Muscle Tissue, for research purpose
Other industries:
Cyfuse Biomedical
Biobots
3D Bioprinting solutions
Aspect Biosystems
Rokit
14. 14
Dr. Anthony Atala
Wake Forest Institution for Regenerative Medicine
Biotechnology and Regenerative Medicine.
Gave the concept of full-scale body printing and organ printing.
19. 7
Print Bed
Outer Chassis
Inner Chassis
Instrument Panel
Main Deck
Motion Control
Printing Head
Non-Sticky, Heated or Cooled
Bed leveling gauges
20. 7
Print Bed
Outer Chassis
Inner Chassis
Instrument Panel
Main Deck
Motion Control
Printing Head
Basic Protection and enforcement (SS, Plastic, Forged Steel etc.)
Acrylic Compartment, Sealed door, Clear and transparent for viewing.
21. 7
Print Bed
Outer Chassis
Inner Chassis
Instrument Panel
Main Deck
Motion Control
Printing Head
Act as frame for Motion Control.
Must be sturdy to minimize vibrations.
22. 7
Print Bed
Outer Chassis
Inner Chassis
Instrument Panel
Main Deck
Motion Control
Printing Head
Controls Motion of the Printing Head.
Two Types
Cartesian & Delta
32. 32
Materials for Bio-printing
Ideal Properties: In One word “Bio-Inert”
Non-Irritating
Non-Corrosive
No Local or Systematic effect of itself except the
one (or more) function that its designed for.
Nil Debris or lesser wear and tear.
Chemical resistant
Should degrade in non-toxic Compound after
use.
material is IDEAL”“NO
33. Materials for Bio-printing
Material Currently used in
Titanium alloy
Pacemaker cans, Dental implants, fracture plate,
Spinal cage
Platinum Alloy Electrodes
NiTiNOL
(Nickle-Titanium Alloy)
Shape memory alloy
SS
(Stainless Steel)
Stents, Implants
Calcium Phosphate Bone substitutes
PEEK
(Polyether
EtherKetone)
Spinal cages
PMMA
(Polymethyl
Methacrylate)
Bone cement
Polyurerthane Insulation
34. Materials for Pharmaceutical
Natural Polymers
Hyaluronic acid, Alginic acid, Pectin, Chitosan, Collagen, Dextran,
Agarose, Pullulan.
Synthetic and their combinations:
PEG-PLA-PEG
PEG-PLGA-PEG
PLA-PEG-PLA
Reported Polymers used in formulations are
HPMC, HPEC, PEO, Starch, PEGDA (Polyethyleneglycol Diacrylate),
Polycaprolactone (PCL),
35. For Biomedical Use:
Already done?
• Liver
• Kidney
• Implants
• Fracture plates
(Organs are used only for clinical research purpose)
Working on?
Fully functional organs for transplant in humans.
Repairing of Disease or damage organs.
36. For Pharmaceutical Use:
Already done?
Fast dissolving tablets of Levitiracetam (Spitram) by Aprecia
Pharmaceuticals (ZipDoseTM Technology).
Dose Loading Up to 1000mg (1gm).
What else can be done?
Oral Thin Film
Face mask
Patches
Multilayer Tablets…
37. Medical supervisor, Pharmacist and Patient
• Print Medicine bed side as required for the patient.
• No more waiting for organ donor.
• Print The fracture plate and joints as per requirement and direct installment.
• Convenience for medical supervisor and the patient in terms of giving and
receiving treatment.
• Take’s Pharmacist back to old time; Compounding and Dispensing, instead of
just DISPENSING
38. • Ease of printing any time.
• Design a product and print at a click.
• Accuracy way much better than conventional
• Efficient
• Software design enable user to change the specification (Dimension and
composition) in real time.
• Design change can be varied infinite time.
• Helps in visualizing product before its formed. (Digital Design)
39. • Yet Not fully developed for every component in our industry. (Institution
level. R&D and F&D is good)
• Large scale manufacturing is slower than conventional
• Printers still needs some major advances to print complex organs.
• Use of Non-Bio-Compatible material is more and hence a major limitation
40. 4D Printing.
4D is helping an organ or tissue grow to a full scale of itself at cellular level by
providing essentials.
That means developing a fully functional and exact copy of the existing organ
and tissues
May sound like a futuristic movie!
But remember
“Some people belived that earth is flat”
41. 41
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