3D bio-printing involves using 3D printers to print biological materials and living cells in a layer-by-layer process to create living tissues and organs. It aims to address the shortage of organs available for transplant by creating organs customized for each patient using their own cells to prevent rejection. While the concept is simple, realizing it is challenging due to the need to print multiple cell types and keep the cells alive during printing. Researchers are working to modify 3D printers to accommodate biological materials and are experimenting with printing tissues like liver and skin as well as structures like human hearts and faces.
This is brief introduction about 3D printer.
I think 3D printer is 4th wave.
First wave: Neolithic revolution
2nd wave: industrial revolution
3rd wave: information age
4th wave: manufacture revolution by 3D printer
hashim salim
hashsalim@gmail.com
Whether due to illness or injury, organ failure is a worldwide problem and its only treatment is organ transplantation or tissue replacement. Although it’s the only solution in these cases, organs demand greatly surpasses the supply. Organs are usually obtained from people who recently have died (up to 24 hours past the cessation of heartbeat) or from people who are clinically brain dead and their body functions are maintained artificially, nevertheless living organ donation is becoming more frequent [1]. The increase of the organ demand has been raising ethical concerns, since this can result in offers or incentives for donation, profit on donated human organs or even exploitation of the disadvantaged. In the developed world most countries have a legal system that oversee organ transplantation, however in poorer countries a black market has been arising, enabling those who can afford to buy organs, exploiting those who are desperate enough to sell them
3D Bio-Printing; Becoming Economically FeasibleJeffrey Funk
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to analyze the increasing economic feasibility of bio-printing. Due to a lack of available kidney and other organ donors for organ transplants, 3D printing has emerged as an important alternative for many people. Bioprinting is done by using a computer model of an individual’s body to generate a data set for an organ that can be printed with a 3D printer and grown in a bio-reactor. The falling cost of materials and 3D printers is improving their economic feasibility.
it is a seminar slide that i prepared on the topic 3d bioprinting. it may be a help to whom taking seminar on that topic. It is not covered its full area only the basics of bio printing ..
This is brief introduction about 3D printer.
I think 3D printer is 4th wave.
First wave: Neolithic revolution
2nd wave: industrial revolution
3rd wave: information age
4th wave: manufacture revolution by 3D printer
hashim salim
hashsalim@gmail.com
Whether due to illness or injury, organ failure is a worldwide problem and its only treatment is organ transplantation or tissue replacement. Although it’s the only solution in these cases, organs demand greatly surpasses the supply. Organs are usually obtained from people who recently have died (up to 24 hours past the cessation of heartbeat) or from people who are clinically brain dead and their body functions are maintained artificially, nevertheless living organ donation is becoming more frequent [1]. The increase of the organ demand has been raising ethical concerns, since this can result in offers or incentives for donation, profit on donated human organs or even exploitation of the disadvantaged. In the developed world most countries have a legal system that oversee organ transplantation, however in poorer countries a black market has been arising, enabling those who can afford to buy organs, exploiting those who are desperate enough to sell them
3D Bio-Printing; Becoming Economically FeasibleJeffrey Funk
These slides use concepts from my (Jeff Funk) course entitled analyzing hi-tech opportunities to analyze the increasing economic feasibility of bio-printing. Due to a lack of available kidney and other organ donors for organ transplants, 3D printing has emerged as an important alternative for many people. Bioprinting is done by using a computer model of an individual’s body to generate a data set for an organ that can be printed with a 3D printer and grown in a bio-reactor. The falling cost of materials and 3D printers is improving their economic feasibility.
it is a seminar slide that i prepared on the topic 3d bioprinting. it may be a help to whom taking seminar on that topic. It is not covered its full area only the basics of bio printing ..
It has been expleined in these slides that how 3D bioprinters work and some of them have been introdused. Also some examples of use 3D bioprinter in reality are introduced.
Finally feature of 3D bioprinters in human life has been explained.
3D Bio-printing of cells, tissue and organs. Bioprinting (also known as 3D bioprinting) is combination of 3D printing with biomaterials to replicate parts that imitate natural tissues, bones, and blood vessels in the body. It is mainly used in connection with drug research and most recently as cell scaffolds to help repair damaged ligaments and joints.
Applications of 3 d printing in biomedical engineeringDebanjan Parbat
This presentation deals with the recent and futuristic trends in the field of 3D Printing technology and its applications in the field of bio engineering and medical applications. The 3D printing technology can change the perception of the whole manufacturing industry to health care applications.
Additive manufacturing or 3D printing is a process of making a three-dimensional solid object of virtually any shape from a digital model. 3D printing is achieved using an additive process, where successive layers of material are laid down in different shapes.
Increasing the efficacy of drugs and at the same time reducing the chances of adverse reaction should be the aim of drug development, which can be achieved by using 3D printing to fabricate personalized medications
Drugs with narrow therapeutic index can easily be prepared using 3D printing; and, by knowing the patient’s pharmacogenetic profile and other characteristics like age, race etc., optimal dosage can be given to the patient.
3D printing technology is a valuable and potential tool for the pharmaceutical sector, leading to personalized medicine focused on the patients’ needs. It offers numerous advantages, such as increasing the cost efficiency and the manufacturing speed. 3D printing has revolutionized the way in which manufacturing is done. It improves the design manufacturing and reduces lead time and tooling cost for new products.
3D-Bioprinting coming of age-from cells to organsDaniel Thomas
Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially.
Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections of how a drug will react in a human patient.
A solution has emerged in the form of 3D-Bioprinting technology, developed for the scalable, accurate and repeatable deposition of biologically active materials. With advances in this biomanufacturing technology, durable biological tissues for use in testing new pharmaceutical products are now being harnessed and refined.
We want to reduce the price of 3D printing.if we make
people know/aware about this technology and use this more and more then someday it’ll be the cheapest tech which will save peoples live and will give injured/wounded people new hope of life.
It has been expleined in these slides that how 3D bioprinters work and some of them have been introdused. Also some examples of use 3D bioprinter in reality are introduced.
Finally feature of 3D bioprinters in human life has been explained.
3D Bio-printing of cells, tissue and organs. Bioprinting (also known as 3D bioprinting) is combination of 3D printing with biomaterials to replicate parts that imitate natural tissues, bones, and blood vessels in the body. It is mainly used in connection with drug research and most recently as cell scaffolds to help repair damaged ligaments and joints.
Applications of 3 d printing in biomedical engineeringDebanjan Parbat
This presentation deals with the recent and futuristic trends in the field of 3D Printing technology and its applications in the field of bio engineering and medical applications. The 3D printing technology can change the perception of the whole manufacturing industry to health care applications.
Additive manufacturing or 3D printing is a process of making a three-dimensional solid object of virtually any shape from a digital model. 3D printing is achieved using an additive process, where successive layers of material are laid down in different shapes.
Increasing the efficacy of drugs and at the same time reducing the chances of adverse reaction should be the aim of drug development, which can be achieved by using 3D printing to fabricate personalized medications
Drugs with narrow therapeutic index can easily be prepared using 3D printing; and, by knowing the patient’s pharmacogenetic profile and other characteristics like age, race etc., optimal dosage can be given to the patient.
3D printing technology is a valuable and potential tool for the pharmaceutical sector, leading to personalized medicine focused on the patients’ needs. It offers numerous advantages, such as increasing the cost efficiency and the manufacturing speed. 3D printing has revolutionized the way in which manufacturing is done. It improves the design manufacturing and reduces lead time and tooling cost for new products.
3D-Bioprinting coming of age-from cells to organsDaniel Thomas
Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially.
Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections of how a drug will react in a human patient.
A solution has emerged in the form of 3D-Bioprinting technology, developed for the scalable, accurate and repeatable deposition of biologically active materials. With advances in this biomanufacturing technology, durable biological tissues for use in testing new pharmaceutical products are now being harnessed and refined.
We want to reduce the price of 3D printing.if we make
people know/aware about this technology and use this more and more then someday it’ll be the cheapest tech which will save peoples live and will give injured/wounded people new hope of life.
Letter to MREC - application to conduct studyAzreen Aj
Application to conduct study on research title 'Awareness and knowledge of oral cancer and precancer among dental outpatient in Klinik Pergigian Merlimau, Melaka'
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Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
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Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
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Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
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PET CT beginners Guide covers some of the underrepresented topics in PET CTMiadAlsulami
This lecture briefly covers some of the underrepresented topics in Molecular imaging with cases , such as:
- Primary pleural tumors and pleural metastases.
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- Urological tumors.
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COVID-19 PCR tests remain a critical component of safe and responsible travel in 2024. They ensure compliance with international travel regulations, help detect and control the spread of new variants, protect vulnerable populations, and provide peace of mind. As we continue to navigate the complexities of global travel during the pandemic, PCR testing stands as a key measure to keep everyone safe and healthy. Whether you are planning a business trip, a family vacation, or an international adventure, incorporating PCR testing into your travel plans is a prudent and necessary step. Visit us at https://www.globaltravelclinics.com/
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Rate Controlled Drug Delivery Systems, Activation Modulated Drug Delivery Systems, Mechanically activated, pH activated, Enzyme activated, Osmotic activated Drug Delivery Systems, Feedback regulated Drug Delivery Systems systems are discussed here.
Cold Sores: Causes, Treatments, and Prevention Strategies | The Lifesciences ...The Lifesciences Magazine
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3. What’s it..?
3D bio-printing is a regenerative science and
process for generating spatially-controlled cell
patterns in 3D, where cell function and viability
are preserved within the printed construct.
Using 3D bio-printing for fabricating biological
constructs typically involves dispensing cells
onto a biocompatible scaffold using a
successive layer-by-layer approach to generate
tissue-like three-dimensional structures.
4. Why..?
Each day 79 receive
organ each day while 18
will die from a lack of one
Most needed organs are
kidneys, livers, lungs,
hearts.
6. Bioprinter
The idea of 3d printers are from inkjet printers, driven by a
motor, moves in horizontal strips across a sheet of paper. As it
moves, ink stored in a cartridge sprays through tiny nozzles
and falls on the page in a series of fine drops. The limitation of
inkjet printers is that they only print in two dimensions -- along
the x- and y-axes. A 3-D printer overcomes this by adding a
mechanism to print along an additional axis, usually labeled
the z-axis in mathematical applications. This mechanism is
an elevator that moves a platform up and down. Fill the
cartridge with plastic, and the printer will output a three-
dimensional plastic widget. Fill it with cells, and it will output a
mass of cells.
7. Continues…
Conceptually, bio-printing is really that simple. In
reality, it's a bit more challenging because an
organ contains more than one type of material.
And because the material is living tissue, it needs
to receive nutrients and oxygen. To
accommodate this, bioprinting companies have
modified their 3-D printers to better serve the
medical community.
8. If you were to pull apart a bio-printer, as we'd love to do, you'd encounter
these basic parts.
Bio-printer Components
9. Print head mount
On a bio-printer, the print heads are
attached to a metal plate running along a
horizontal track. The x-axis motor propels the
metal plate (and the print heads) from side to
side, allowing material to be deposited in
either horizontal direction.
10. Elevator
A metal track running vertically at the
back of the machine, the elevator, driven by
the z-axis motor, moves the print heads up
and down. This makes it possible to stack
successive layers of material, one on top of
the next
11. Platform
A shelf at the bottom of the machine
provides a platform for the organ to rest on
during the production process. The platform
may support a scaffold, a petri dish or a well
plate, which could contain up to 24 small
depressions to hold organ tissue samples for
pharmaceutical testing. A third motor moves
the platform front to back along the y-axis
12. Reservoirs
The reservoirs attach to the print heads
and hold the biomaterial to be deposited
during the printing process. These are
equivalent to the cartridges in your inkjet
printer.
13. Print heads/syringes
A pump forces material from the
reservoirs down through a small nozzle or
syringe, which is positioned just above the
platform. As the material is extruded, it forms a
layer on the platform.
14. Triangulation sensor
A small sensor tracks the tip of each
print head as it moves along the x ,y and z-
axes. Software communicates with the
machine so the precise location of the print
heads is known throughout the process..
15. Micro-gel
Unlike the ink you load into your printer at home,
bio-ink is alive, so it needs food, water and
oxygen to survive. This nurturing environment is
provided by a micro-gel think gelatin enriched
with vitamins, proteins and other life-sustaining
compounds. Researchers either mix cells with the
gel before printing or extrude the cells from one
print head, micro-gel from the other. Either way,
the gel helps the cells stay suspended and
prevents them from settling and clumping.
16. How do they print an organ.
First, doctors make CT or MRI scans of
the desired organ.
Next, they load the images into a
computer and build a corresponding 3-
D blueprint of the structure using CAD
software.
Combining this 3-D data with
histological information collected from
years of microscopic analysis of
tissues, scientists build a slice-by-slice
model of the patient's organ. Each slice
accurately reflects how the unique cells
and the surrounding cellular matrix fit
together in three-dimensional space.
18. Benefits
Artificial organ personalized using
patients own cells
No DNA rejection
Eliminate organ donation
Can give you another life
No waiting period
19. Disadvantages
Printers cost hundreds of thousands of
dollars
Possibly more expensive than regular
organ transplant
Use of stem cells is still controversial
Cost of using stem cells
20. Just look through some bioprinting projects which gonna going to
change the world
3d bio-printing projects
21. Human heart
Researchers at the University
of Louisville in Louisville,
Kentucky said they
have successfully printed parts
of a human heart using by
printing with a combination of
human fat cells and collagen.
22. Human face
A man from Wales in the United
Kingdom was in a motorcycle
accident in 2012 and he has now
received 3D printed implants on
his face that successfully fixed
injuries he sustained. The
project was done by the Centre
for Applied Reconstructive
Technologies in Surgery.
23. Liver tissue
In January, Organovo successfully
printed samples of human liver tissue that
were distributed to an outside laboratory for
testing. The company is aiming for
commercial sales later this year. The sets
of 24 samples take about 30 minutes to
produce. According to the company, the
printed tissue responds to drugs similarly to
a regular human liver.
24. Live tissue
Scientists at Wake Forest School of
Medicine designed a printer that can directly
print skin cells onto burn wounds. The
traditional treatment for severe burns is to
cover them with healthy skin harvested from
another part of the body, but often times
there isn't enough. With this new machine, a
scanner determines the size and depth of the
skin, and layers the appropriate number of
cells on the wound. Doctors only need a
patch of skin one-tenth of the size of the
wound to grow enough for this process.