This document discusses how researchers can take a more open and collaborative "hacker" approach to conducting research in the face of declining government funding. It promotes sharing resources through cloud-based research apps and data services, as well as adopting open-source tools and techniques. The document highlights examples of research communities that have formed around 3D printing and software skills who have helped researchers improve designs, save costs and time through collaboration and open knowledge sharing. It envisions growing these communities to support more researchers and establish best practices for areas like CAD, imaging and simulation.