This chapter discusses the classification and etiology of malocclusion. Malocclusion can result from genetic factors, environmental factors, or a combination. Environmental influences include habits like digit-sucking and premature tooth loss from caries or trauma. Several commonly used classification systems are described, including Angle's classification (Classes I, II, III based on molar relationship), the British Standards Institute classification (based on incisor relationship), and the Index of Orthodontic Treatment Need (IOTN) which evaluates dental health and psychosocial impacts. The goal of orthodontic treatment is a functional occlusion without interference or pathology, though lack of an ideal occlusion may not cause long-term issues.