Your cerebellum is part of your brain that helps coordinate and regulate a wide range of functions and processes in both your brain and body. While it's very small compared to your brain overall, it holds more than half of the neurons (cells that make up your nervous system) in your whole body.
enlists and the description of the different descending tracts of the CNS. cortico spinal tract, cortico bulbar tract, extra pyramidal and pyramiddal tracts, homunculus, vestibulospinal tract, reticulo spinal tracts, tectospinal tract, autonomic tract, uppermotor neuron lesion, lower motor neuron lesion, spinal cord injury, brown sequard syndrome. spinal cord infection, degenerative disorders of spinal cord,
enlists and the description of the different descending tracts of the CNS. cortico spinal tract, cortico bulbar tract, extra pyramidal and pyramiddal tracts, homunculus, vestibulospinal tract, reticulo spinal tracts, tectospinal tract, autonomic tract, uppermotor neuron lesion, lower motor neuron lesion, spinal cord injury, brown sequard syndrome. spinal cord infection, degenerative disorders of spinal cord,
This is the first lecture about the anatomy of the brainstem discussing the definition of the brainstem and the anatomical relations along with the external and internal parts (in general) and listing the major functions of brainstem. Then describing the medulla oblongata with its location, external and internal functions at different levels of sections. Lastly, this lectures discusses the most important clinical syndromes affecting the medulla oblongata.
Anatomy of Cerebellum professor dr saeed abuel makareem _ Relevant Connection...ssuser6e679b
Prof. Ahmed Fathalla Ibrahim
Professor of Anatomy
College of Medicine
King Saud University
E-mail: ahmedfathala@gmail.com
At the end of the lecture, students should:
❑Describe the external features of the cerebellum
(lobes, fissures).
❑Describe briefly the internal structure of the
cerebellum.
❑List the name of cerebellar nuclei.
❑Relate the anatomical to the functional
subdivisions of the cerebellum.
❑Describe the important connections of each
subdivision.
❑Describe briefly the main effects in case of lesion
of the cerebellum
Blood supply of cerebellum
Nerve supply of cerebellum
How to understand anatomy of the brain
Most important information about brain anatomy brain cortex and lobes and gyrus
Visual region in the brain
The thalamus is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex and the regulation of consciousness, sleep, and alertness.
an overview of the ascending tract of the spinal cord....an anatomical approach to understand the somato-sensory pathway.
Prepared as a class presentation .
Anatomical localisation of function is a fundamental principle in the neurosciences. This presentation highlights the basics neuroanatomy and correlate major brain structure with their functions.
Anatomy & functions of the Brainstem & CerebellumRafid Rashid
Provides a good description of the anatomy of the brainstem & cerebellum; their parts, structure, blood supply & a brief description of their functions.
This is the first lecture about the anatomy of the brainstem discussing the definition of the brainstem and the anatomical relations along with the external and internal parts (in general) and listing the major functions of brainstem. Then describing the medulla oblongata with its location, external and internal functions at different levels of sections. Lastly, this lectures discusses the most important clinical syndromes affecting the medulla oblongata.
Anatomy of Cerebellum professor dr saeed abuel makareem _ Relevant Connection...ssuser6e679b
Prof. Ahmed Fathalla Ibrahim
Professor of Anatomy
College of Medicine
King Saud University
E-mail: ahmedfathala@gmail.com
At the end of the lecture, students should:
❑Describe the external features of the cerebellum
(lobes, fissures).
❑Describe briefly the internal structure of the
cerebellum.
❑List the name of cerebellar nuclei.
❑Relate the anatomical to the functional
subdivisions of the cerebellum.
❑Describe the important connections of each
subdivision.
❑Describe briefly the main effects in case of lesion
of the cerebellum
Blood supply of cerebellum
Nerve supply of cerebellum
How to understand anatomy of the brain
Most important information about brain anatomy brain cortex and lobes and gyrus
Visual region in the brain
The thalamus is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex and the regulation of consciousness, sleep, and alertness.
an overview of the ascending tract of the spinal cord....an anatomical approach to understand the somato-sensory pathway.
Prepared as a class presentation .
Anatomical localisation of function is a fundamental principle in the neurosciences. This presentation highlights the basics neuroanatomy and correlate major brain structure with their functions.
Anatomy & functions of the Brainstem & CerebellumRafid Rashid
Provides a good description of the anatomy of the brainstem & cerebellum; their parts, structure, blood supply & a brief description of their functions.
The placenta is formed gradually during the first three months of pregnancy, while, after the fourth month, it grows parallel to the development of the uterus. Once completed, it resembles a spongy disc 20 cm in diameter and 3 cm thick.
The external human face develops between the 4th and 6th week of embryonic development. The development of the face is completed by the 6th week.
Between the 6th and 8th week, the palate begins to develop. Consequently, this causes a distinction between the nasal and oral cavities. This development is completed by the 12th week.
Development of Female Reproductive system.pptxRahul Sharma
the female reproductive system derives from four origins: mesoderm, primordial germ cells, coelomic epithelium, and mesenchyme. The uterus forms during Mullerian organogenesis accompanied by the development of the upper third of the vagina, the cervix, and both fallopian tubes.
An organelle is a subcellular structure that has one or more specific jobs to perform in the cell, much like an organ does in the body. Among the more important cell organelles are the nuclei, which store genetic information; mitochondria, which produce chemical energy; and ribosomes, which assemble proteins.
There are eight carpal bones in each wrist.
There are five metacarpal bones in each hand.
There are proximal, intermediate, and distal phalanges in each digit except for the thumb, which lacks an intermediate phalange.
What is the cardiovascular system? Your heart and many blood vessels in your body make up your cardiovascular system or circulatory system. Your heart uses the far-reaching, intricate network of blood vessels to deliver oxygen and other necessary things to your whole body.
The femoral triangle is a hollow region located in the supero-medial part of the anterior thigh. It appears most prominently with hip flexion, abduction and internal rotation. It is an easily accessible area through which multiple neurovascular structures pass through.
The brachial plexus is the network of nerves that sends signals from the spinal cord to the shoulder, arm and hand. A brachial plexus injury occurs when these nerves are stretched, compressed, or in the most serious cases, ripped apart or torn away from the spinal cord.
The four principal types of bones are long, short, flat and irregular. Bones that are longer than they are wide are called long bones. They consist of a long shaft with two bulky ends or extremities.
The ascending tracts carry sensory information from the body, like pain, for example, up the spinal cord to the brain. Descending tracts carry motor information, like instructions to move the arm, from the brain down the spinal cord to the body.
The anterior triangles refer to bilateral anatomic subdivisions of the neck comprising the anterior surface of the neck, deep to the superficial cervical fascia and platysma muscle. Laterally, the anterior triangle is bounded by the anterior border of the sternocleidomastoid muscle
The floor of the cranial cavity is divided into three distinct depressions. They are known as the anterior cranial fossa, middle cranial fossa and posterior cranial fossa. Each fossa accommodates a different part of the brain
Microtomy is a method for the preparation of thin sections for materials such as bones, minerals and teeth, and an alternative to electropolishing and ion milling. Microtome sections can be made thin enough to section a human hair across its breadth, with section thickness between 50 nm and 100 μm
What is Craniotomy?
What are the Indications for Craniotomy?
What are the Types of Craniotomy?
Equipment used in craniotomy?
What happen to the Bone flap?
What are the Tests Done Prior to Craniotomy?
What happens during surgery?
What are the risks?
References
Gross appearance of cerebellum
Structure of cerebellum
The functional division of the cerebellum
Afferent & efferent pathways
Clinical
MCQ’s
Clinical Vignettes
Seven cervical vertebrae
Identified by the presence of foramen in their transverse processes called foramen transversarium
3rd to 6th are typically have common features
1st, 2nd,and 7th are atypical
Ring-shaped and has no body and no spine
Consists of:
Right and left lateral masses
Short anterior arch and a long curved posterior arch
(c) Right and left transverse processes
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
7. Figure 6-3 A: Flattened view of the cerebellar cortex showing the main cerebellar lobes,
lobules, and fissures.
Functional areas of cerebellar cortex
3 functional areas
1. Cortex of vermis
2. Intermediate zone
3. Lateral zone
8. Intracerebellar nuclei
4 mass of grey matter embedded in white matter
Nuclei
•Dentate
•Emboliform
•Globose
•Fastigial
Intracerebellar nuclei are composed of large multipolar
9. White Matter
Composed of 3 group of fibres
•Intrinsic fibre
1. Do not leave cerebellum
2. Connect different region of organ
•Afferent
1. Form greater part of white matter
2. Enter mainly from inferior & middle
peduncle
•Efferent nerve
1. Output of cerebellum
Note:- dentate, emboliform & globose nuclei fibre leave from superior cerebellar
peduncle and fibres from fastigial leave through inferior cerebellar peduncle
10. Cerebellar Cortical Mechanism
Two main line of input
Mossy fibre
Climbing fibre
Excitatory to
Purkinje cell
What then is the function of other cell of
cerebellum?
Basket cell, stellate cell, golgi cells
11. Cerebellar Afferent Fibers
• From cerebral cortex
1. Corticopontocerebellar pathway
2. Cerebro-olivocerebellar pathway
3. Cerebroreticulocerebellar pathway
Figure 6-10 Cerebellar afferent fibers from the cerebral cortex.
12. Cerebellar afferent fibers from spinal cord
Figure 6-11 Cerebellar afferent fibers from the spinal cord and internal
ear.
•Anterior & Posterior spinocerebellar tract
•Cuneocerebellar tract
•Afferent fibre from vestibular nerve
14. ARTERIAL SUPPLY OF CEREBELLUM
• Superior cerebellar artery
• Anterior inferior cerebellar artery
• Posterior inferior cerebellar artery
15. CLINICAL’S
Lesions of cerebellum:
• Due to trauma, vascular occlusion, tumors.
• Produce a number of signs and symptoms
• Acute lesions differ from those produced by chronic lesions.
16. Following symptoms and signs are characteristic of
Cerebellar dysfunction.
1. Hypotonia
2. Postural Changes and Alteration of Gait
3. Disturbances of Voluntary Movement (Ataxia)
4. Dysdiadochokinesia
5. Disturbances of Reflexes
6. Nystagmus
7. Disorders of Speech
17. Cerebellar Syndromes
Vermis Syndrome
• Common cause of vermis syndrome is medullo
blastoma of vermis
• Involvement of flocculonodular lobe
• Signs and symptoms related to vestibular system
• Muscle incoordination involves head and trunk and
not the limbs
18. Cerebellar Hemisphere Syndrome
• Tumors of cerebellum result cerebellar hemisphere syndrome
• symptoms and signs are usually unilateral
• Ipsilataeral involvment of muscles
• Movements of limbs, especially arms, are disturbed. Swaying
and falling to the side of the lesion often occur.
• Dysarthria and nystagmus
• Lateral involvment of lobe result in delays in initiating
movements and inability to move all limb segments together
in a coordinated manner but show a tendency to move one
joint at a time.
19. MCQ
• Superior cerbellar peduncle contains which of the
following?
a) Posterior spinocerebellar
b) Olivocrebellar tract
c) Vestibulocerebellar
d) Anterior spinocerebellar
Anterior spinocerebellar
BD_Chaurasia’s_Human_Anatomy, Volume 3 - Head-Neck and Brain 6th Edition, pg no 408
20. • Which of the following region of cerebllum is
concerned with planning and programming muscular
activities?
a) Intermediate zone
b) Vermis
c) Lateral zone
d) Flocculonodular zone
Lateral zone
BD_Chaurasia’s_Human_Anatomy, Volume 3 - Head-Neck and Brain 6th Edition, pg no 408
21. • Cerebellum consist numerous lobe, which lobe is the
smallest one?
a) Flocculonodular lobe
b) Middle lobe
c) Anterior lobe
d) Posterior lobe
BD_Chaurasia’s_Human_Anatomy, Volume 3 - Head-Neck and Brain 6th
Edition, pg no 408
a) Flocculonodular lobe
22. Clinical Vignette
• Two physicians are talking in the street when one turns to the
other and says, "Look at that man over there. Look at the way
he is walking. He Is not swinging his right arm at all; it is just
hanging down by his side. I wonder If he has a cerebellar
lesion." Does a person with a unilateral cerebellar hemisphere
tumor tend to hold the arm limply at the side when he walks?
a unillateral lesion involving one cerebellar
hemisphere demonstrates absence of
coordination between different groups of
muscles on the same side of the body
Ans YES