Cerebellar degeneration is the degeneration of nerves in the cerebellum, the part of the brain that controls balance and muscle coordination. Symptoms include impaired balance, unsteady walking, tremors, and slurred speech. It can be caused by head trauma, stroke, tumors, infections like chickenpox, or autoimmune diseases like multiple sclerosis. The diagnosis involves testing balance, reflexes, coordination and other functions controlled by the cerebellum. Treatment depends on the underlying cause but may include surgery, antibiotics, medications to reduce inflammation, or blood thinners.

2. Cerebellar degeneration

3. Degeneration of nerves in the part of
the brain called the cerebellum which
controls balance and muscle
coordination.
Definition:-

4. Symptoms
• Impaired balance
• Wide-legged walk
• Lurching walk
• Unsteady walk
• Tremor
• Jerky limb movements
• Slow limb movements
• Unsteady limb
movements
• Slurred speech
• Nystagmus
• Incoordination

5. Causes
o Head trauma. ...
o Stroke. ...
o Transient ischemic attack (TIA). ...
o Cerebral palsy. ...
o Multiple sclerosis (MS). ...
o Chickenpox. ...
o Paraneoplastic syndromes. ...
o Tumor.

6. Transient ischemic attack (TIA)
pathogenesis
Transient Ischemic Attack (TIA) A TIA is similar to a stroke,
but the interruption of blood flow is temporary. The clot
resolves sporadically. The symptoms are relatively the same
as a stroke but last less than 24 hours, whereas stroke
symptoms persist for greater than 24 hours.

7. Cerebral palsy
It is the leading cause of CP in preterm infants. PVL is
discussed in the Pathophysiologysection below.
Intraventricular hemorrhage (IVH) is predominantly
associated with prematurity and is due to fragility of
developing blood vessels in the infant's brain. IVH may
cause PVL or ischemia in other parts of the brain.

8. Multiple sclerosis (MS) pathogenesis
Multiple sclerosis (MS) is a chronic inflammatory
autoimmune demyelinating disease of the central
nervous system. ... There are four clinical forms
of MS, of which relapsing remitting type is the
most common. As the etiology of MS is unknown,
finding a cure will remain challenging.

9. Diagnose
 hearing
 memory
 balance
 vision
 concentration
 reflexes
 coordination

10. Treatment
 You may need surgery if your condition is the result of
bleeding in the cerebellum.
 You may need antibiotics if you have an infection.
 Blood thinners can help if a stroke caused your ACA.
 There are also medications you can take that directly treat
inflammation of the cerebellum.

11. Complication
Patients with paraneoplastic neurological syndrome
(PNS) most often present with neurologic symptoms
before an underlying tumor is detected. ...
Paraneoplastic cerebellar degeneration is a rare
nonmetastatic complication of a carcinoma,
typically mediated by antibodies generated against
tumor antigens (proteins).

12. Associated diseases
• ischemic or hemorrhagic stroke, when there is lack of
blood flow or oxygen to the cerebellum
• cerebellar cortical atrophy, multisystem atrophy, and
olivopontocerebellar degeneration, progressive
degenerative disorders in which cerebellar degeneration
is a key feature
• Friedreich’s ataxia, and other spinocerebellar ataxias,
which are caused by inherited genetic mutations that
result in ongoing loss of neurons in the cerebellum, brain
stem, and spinal cord
• transmissible spongiform encephalopathies (such as
Creutzfeldt-Jakob disease)
• multiple sclerosis