Medical neuroscience

1. Domina Petric, MD
Central visual
processing

2. • The ganglion cell axons from the nasal retina go via the medial
part of the optic nerve and cross the midline to project in
contralateral targets in diencephalon and midbrain.
• The ganglion cell axons from the temporal retina go via the
lateral part of the optic nerve and remain on the ipsilateral side
of the brain.
• Lateral geniculate nucleus is a target where ganglion cell
axons synapse and from there rise the optic radiations.
• Optic radiations go around the lateral ventricle to supply upper
and lower parts of the calcarine sulcus where is the primary
visual cortex.
Introduction

3. The ganglion cell axons from the nasal retina
cross the midline in optic chiasm.
Optic
chiasm
Synapse in contralateral
lateral geniculate nucleus.
The ganglion cell
axons from the
temporal retina
stay ipsilateral.
Synapse in ipsilateral
lateral geniculate nucleus.
From the other eye...

4. http://www.visembryo.com
Lateral
geniculate
nucleus
Optic radiations

5. Stria of Gennari: area 17 or the striate cortex.
Orientation selectivity of receptive field in V1 is
preferred response to a bar of a particular orientation.
Direction selectivity of receptive field in V1 is preferred
response to a bar of a particular direction of motion.
Primary visual cortex (V1)

6. http://www.smbs.buffalo.edu
Stria Gennari

7. Receptive fields in retina and thalamus
Receptive fields in visual cortex
And so on...

8. • Two inner layers in the lateral geniculate nucleus:
layer one recieves inputs from the contralateral eye
and layer two from the ipsilateral eye.
• Four outer layers in the lateral geniculate nucleus:
layers 4 and 6 are recieving inputs from the
contralateral eye and layers 3 and 5 from the
ipsilateral eye.
• Ocular dominance layers: information from both eyes
is mixed first time in the V1 (striate) cortex.
Ocular dominance in V1 cortex

9. Lateral geniculate nucleus

10. Fixation point is going to be projected
on the non corresponding areas of the
retinas.
That is the mechanism of depth
perception: near and far disparities that
project to the visual cortex.
Stereopsis

11. • P ganglion cell (the
smallest)
• M ganglion cell (the
largest)
• K ganglion cell (medium
size)
Types of
retinal
ganglion
cells:
Parallel pathways

12. Axonal projections from small P ganglion cells terminate
among small cell layers in the lateral geniculate nucleus: the
parvocellular layers (layers 3 to 6 ).
Axonal projections from large M ganglion cells terminate in
the first two layers of lateral geniculate nucleus
(magnocellular layers).
Axonal projections from K ganglion cells terminate in a zone
between the layers: koniocellular layers.
Parallel pathways

13. Axons from parvocellular layers synapse into the bottom part
of layer 4 in the visual cortex (4Cβ).
Axons from magnocellular layers synapse into the layer 4C .
Axons from koniocellular layers synapse into the layer 3, in
the zones rich with oxidative metabolism.
Parvocellular layers are concerned with shape and color,
magnocellular layers with broad patterns of motion.
Parallel pathways

14. Layer 5
Layer 4
Layer 3
Layer 6
Layer 2
Layer 1
Parvocellular layers project
to layer C4β of the visual cortex
and those cells and axons
are concerned with shape
and color of objects.
Magnocellular layers project
to layer C4 of the visual cortex
and those cells and
axons are concerned with
motion of objects.
Koniocellular layers synapse in the zones rich
with oxidative metabolism in the layer 3 of the
visual cortex. Their function is unknown.

15. • Those are rings of higher order visual areas.
• MT plus region is rich of motion sensitive cells (spatial
analysis) and it is part of dorsal processing stream.
• Dorsal processing stream is concerned with spatial analysis
and answers the question WHERE am I looking at?
• Dorsal processing stream goes towards the parietal lobe.
• Ventral processing stream adresses the question WHAT or
WHO am I looking at?
• Ventral processing stream goes towards the temporal lobe.
Extrastriate visual cortex

16. http://sciencewise.anu.edu.au
Magnocellular pathway is
the dorsal processing stream or WHERE pathway.
Parvocellular pathway is
the ventral processing stream or
WHAT (WHO) pathway.

17. Region of posterior occipitotemporal
gyrus is called the fusiform gyrus.
Damage of the fusiform gyrus causes
the inability to recognise faces and that
is called PROSOPAGNOSIA.
Prosopagnosia

18. •https://www.coursera.org/learn/medic
al-neuroscience/lecture: Leonard E.
White, PhD, Duke University
•http://www.visembryo.com
•http://www.smbs.buffalo.edu
•http://sciencewise.anu.edu.au
Literature