SlideShare a Scribd company logo
GENERAL PATHOLOGY DR NADEEM REYAZ UNIVERSITY OF HEALTH SCIENCES
Where there is love of medicine, there is love of humankind
PATHOLOGY is the scientific study of disease or is the study of structural and functional abnormalities that are expressed as diseases of organ and system
PATHOPHYSIOLOGY ,[object Object]
PATHOGENESIS ,[object Object]
PERSPECTIVE PATHOLOGY ,[object Object]
[object Object]
HYPOXIA ,[object Object]
CAUSES OF HYPOXIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
POOR NUTRITION INFECTIOUS AGENT  eg, Clostridia IMMUNE INJURY   eg, Antibody and T cell  mediated CHEMICAL AGENTS  eg, salts, overwater,  PHYSICAL AGENTS  eg, fire, freezing, electricity, radiation
ATROPHY ,[object Object]
 
Here is the centrilobular portion of liver next to a central vein. The cells have reduced in size or been lost from hypoxia. The pale brown-yellow pigment is lipochrome that has accumulated as the atrophic and dying cells undergo autophagocytosis.
Atrophy; Cardiac Muscle
HYPERTROPHY ,[object Object]
[object Object],[object Object],[object Object]
Hypertrophy of the muscles of a strength athlete                                                         
Hypertrophy of the Uterus
Hypertrophy of cardiac muscles
 
HYPERPLASIA ,[object Object]
 
 
 
METAPLASIA ,[object Object],[object Object],[object Object]
 
DYSPLASIA ,[object Object]
[object Object]
INTRACELLULAR STORAGE  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mallory bodies (the red globular material) composed of cytoskeletal filaments in liver cells
The brown coarsely granular material in macrophages in this alveolus is hemosiderin
These renal tubules contain large amounts of hemosiderin, as demonstrated by the Prussian blue iron stain
Liver:  Fatty change
NECROSIS ,[object Object],[object Object]
Necrosis with inflammatory cells
Many nuclei have become pyknotic (shrunken and dark) and have then undergone karorrhexis (fragmentation) and karyolysis (dissolution). The cytoplasm and cell borders are not recognizable.
[object Object]
 
TYPES OF NECROSIS  ,[object Object],[object Object],[object Object]
COAGULATION NECROSIS ,[object Object]
[object Object]
[object Object]
 
 
Kidney: Coagulative necrosis
APOPTOSIS ,[object Object]
 
[object Object]
LIQUEFACTIVE NECROSIS ,[object Object]
 
The two lung abscesses seen here are examples of liquefactive necrosis in which there is a liquid center in an area of tissue injury. One abscess appears in the upper lobe and one in the lower lobe. Liquefactive necrosis is typical of organs in which the tissues have a lot of lipid (such as brain) or when there is an abscess with lots of acute inflammatory cells whose release of proteolytic enzymes destroys the surrounding tissues.
Lung Abscess:  Microscopic appearance  (Liquefactive Necrosis)
ENZYMATIC FAT NECROSIS  ,[object Object]
 
 
CASEOUS NECROSIS ,[object Object]
[object Object]
 
Caseous necrosis with granulomatous inflammation
Caseous necrosis with Giant cells
GUMMATOUS NECROSIS ,[object Object],[object Object]
FIBRINOID NECROSIS ,[object Object]
 
NECROBIOSIS ,[object Object]
CAVITATION ,[object Object]
GANGRENE ,[object Object]
[object Object]
TYPES OF GANGRENE ,[object Object],[object Object],[object Object]
DRY GANGRENE ,[object Object]
[object Object]
“Dry Gangrene”
WET GANGRENE ,[object Object]
"wet gangrene in patient with Diabetes millitus”
CLOSTRIDIAL GANGRENE ,[object Object]
FOURNIER'S GANGRENE ,[object Object]
 
PATHOLOGICAL  CALCIFICATION   ,[object Object]
[object Object],[object Object]
This is dystrophic calcification in the wall of the stomach. At the far left is an artery with calcification in its wall
“ Metastatic calcification" in the lung of a patient with a very high serum calcium level (hypercalcemia).
HYALINE ,[object Object]
REVERSIBLE CELL INJURY ,[object Object]
IRREVERSIBLE CELL INJURY ,[object Object]
 
FREE RADICALS  ,[object Object]
FREE-RADICAL GENERATION  ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object]
[object Object]

More Related Content

What's hot

Cell injury, apotosis and necrosis(1)
Cell injury, apotosis and necrosis(1)Cell injury, apotosis and necrosis(1)
Cell injury, apotosis and necrosis(1)optometry student
 
Acute and chronic inflammation
Acute and chronic inflammationAcute and chronic inflammation
Acute and chronic inflammationAj Cocjin
 
Pathology of Acute Inflammation
Pathology of Acute InflammationPathology of Acute Inflammation
Pathology of Acute Inflammation
Neyaz Ahmad
 
Cell Injury
Cell InjuryCell Injury
Cell Injury
Amnah Shaukat
 
Pathology - Cell Injury
Pathology - Cell Injury Pathology - Cell Injury
Pathology - Cell Injury
Areej Abu Hanieh
 
Lecture 7 diseases of the vascular system - Pathology
Lecture 7 diseases of the vascular system - Pathology Lecture 7 diseases of the vascular system - Pathology
Lecture 7 diseases of the vascular system - Pathology
Areej Abu Hanieh
 
Robbins Chapter 1.. Cell as a unit of health and disease
Robbins Chapter 1.. Cell as a unit of health and diseaseRobbins Chapter 1.. Cell as a unit of health and disease
Robbins Chapter 1.. Cell as a unit of health and disease
Ashish Jawarkar
 
Inflammation acute + chronic
Inflammation  acute + chronic Inflammation  acute + chronic
Inflammation acute + chronic
Dr Yaseen Khan
 
Morphology of-acute-inflammation
Morphology of-acute-inflammationMorphology of-acute-inflammation
Morphology of-acute-inflammation
dussa vamshikrishna Dr.Vamshikrishna
 
Coagulative Necrosis + Morphology
Coagulative Necrosis + MorphologyCoagulative Necrosis + Morphology
Coagulative Necrosis + Morphology
Mohammed Alawad
 
Hemodynamic disorders
Hemodynamic disorders Hemodynamic disorders
Hemodynamic disorders
Muhammadasif909
 
Suppurative Inflammation
Suppurative InflammationSuppurative Inflammation
Suppurative Inflammationguest806d25
 
Ch 6 diseases of the immune system part 1
Ch 6 diseases of the immune system part 1Ch 6 diseases of the immune system part 1
Ch 6 diseases of the immune system part 1
Ashish Jawarkar
 
Ch 2 adaptations, cell injury, cell death
Ch 2 adaptations, cell injury, cell deathCh 2 adaptations, cell injury, cell death
Ch 2 adaptations, cell injury, cell death
Ashish Jawarkar
 
6 hemodynamic disorders
6  hemodynamic disorders6  hemodynamic disorders
6 hemodynamic disorders
National Academy of Young Scientists
 
Necrosis and apoptosis
Necrosis and apoptosisNecrosis and apoptosis
Necrosis and apoptosis
Aymen Kareem
 

What's hot (20)

Cell injury, apotosis and necrosis(1)
Cell injury, apotosis and necrosis(1)Cell injury, apotosis and necrosis(1)
Cell injury, apotosis and necrosis(1)
 
7
77
7
 
Acute and chronic inflammation
Acute and chronic inflammationAcute and chronic inflammation
Acute and chronic inflammation
 
Pathology of Acute Inflammation
Pathology of Acute InflammationPathology of Acute Inflammation
Pathology of Acute Inflammation
 
Circulatory disturbances
Circulatory disturbancesCirculatory disturbances
Circulatory disturbances
 
Cell Injury
Cell InjuryCell Injury
Cell Injury
 
Pathology - Cell Injury
Pathology - Cell Injury Pathology - Cell Injury
Pathology - Cell Injury
 
Lecture 7 diseases of the vascular system - Pathology
Lecture 7 diseases of the vascular system - Pathology Lecture 7 diseases of the vascular system - Pathology
Lecture 7 diseases of the vascular system - Pathology
 
Cell injury
Cell injuryCell injury
Cell injury
 
Robbins Chapter 1.. Cell as a unit of health and disease
Robbins Chapter 1.. Cell as a unit of health and diseaseRobbins Chapter 1.. Cell as a unit of health and disease
Robbins Chapter 1.. Cell as a unit of health and disease
 
Inflammation acute + chronic
Inflammation  acute + chronic Inflammation  acute + chronic
Inflammation acute + chronic
 
Lect.no.4
Lect.no.4Lect.no.4
Lect.no.4
 
Morphology of-acute-inflammation
Morphology of-acute-inflammationMorphology of-acute-inflammation
Morphology of-acute-inflammation
 
Coagulative Necrosis + Morphology
Coagulative Necrosis + MorphologyCoagulative Necrosis + Morphology
Coagulative Necrosis + Morphology
 
Hemodynamic disorders
Hemodynamic disorders Hemodynamic disorders
Hemodynamic disorders
 
Suppurative Inflammation
Suppurative InflammationSuppurative Inflammation
Suppurative Inflammation
 
Ch 6 diseases of the immune system part 1
Ch 6 diseases of the immune system part 1Ch 6 diseases of the immune system part 1
Ch 6 diseases of the immune system part 1
 
Ch 2 adaptations, cell injury, cell death
Ch 2 adaptations, cell injury, cell deathCh 2 adaptations, cell injury, cell death
Ch 2 adaptations, cell injury, cell death
 
6 hemodynamic disorders
6  hemodynamic disorders6  hemodynamic disorders
6 hemodynamic disorders
 
Necrosis and apoptosis
Necrosis and apoptosisNecrosis and apoptosis
Necrosis and apoptosis
 

Viewers also liked

Cell Injury Patho
Cell Injury PathoCell Injury Patho
Cell Injury Pathoaxix
 
Pathology cell injury i
Pathology   cell injury iPathology   cell injury i
Pathology cell injury i
MBBS IMS MSU
 
Cell Injury And Cell Death (2006)(1)
Cell  Injury And  Cell  Death (2006)(1)Cell  Injury And  Cell  Death (2006)(1)
Cell Injury And Cell Death (2006)(1)axix
 
Cell injury: causes, pathogenesis, Morphology of reversible cell injury
Cell injury: causes, pathogenesis, Morphology of reversible cell injuryCell injury: causes, pathogenesis, Morphology of reversible cell injury
Cell injury: causes, pathogenesis, Morphology of reversible cell injury
Vijay Shankar
 
Basic Pathology : Introduction To Cells & Tissue Damage
Basic Pathology : Introduction To Cells & Tissue DamageBasic Pathology : Introduction To Cells & Tissue Damage
Basic Pathology : Introduction To Cells & Tissue Damage
Sado Anatomist
 
Ischemia,necrosis,hypoxia
Ischemia,necrosis,hypoxiaIschemia,necrosis,hypoxia
Ischemia,necrosis,hypoxia
Muhammad Ammar
 
Cell injuryadaptation 3
Cell injuryadaptation 3Cell injuryadaptation 3
Cell injuryadaptation 3
Prasad CSBR
 
Cystic masses of the breast by xiu
Cystic masses of the breast by xiuCystic masses of the breast by xiu
Cystic masses of the breast by xiuXiu Srithammasit
 
Cell injury: Necrosis and Gangrene
Cell injury: Necrosis and GangreneCell injury: Necrosis and Gangrene
Cell injury: Necrosis and Gangrene
Vijay Shankar
 
Acute pancreatitis SP
Acute pancreatitis SPAcute pancreatitis SP
Acute pancreatitis SP
SHANTI MEMORIAL HOSPITAL PVT LTD
 
The hallucinogenic
The hallucinogenicThe hallucinogenic
The hallucinogenic
apsu09
 
Happiness at Work
Happiness at WorkHappiness at Work
Happiness at Work
April Schatschneider
 
Cns stimulants drugs (1)
Cns stimulants drugs (1)Cns stimulants drugs (1)
Cns stimulants drugs (1)
Faye Marie Cobcoban
 
Avascular necrosis
Avascular necrosisAvascular necrosis
Avascular necrosis
shyamsobti
 
Cell injury
Cell injuryCell injury
Cell injury – cell injury and cell death
Cell injury  – cell injury and cell deathCell injury  – cell injury and cell death
Cell injury – cell injury and cell death
aanchal puri
 
biological effects of radiation
biological effects of radiationbiological effects of radiation
biological effects of radiation
East Sea Pro
 
Biological effects of radiation
Biological effects of radiationBiological effects of radiation
Biological effects of radiationlens130607
 

Viewers also liked (20)

Cell Injury Patho
Cell Injury PathoCell Injury Patho
Cell Injury Patho
 
Pathology cell injury i
Pathology   cell injury iPathology   cell injury i
Pathology cell injury i
 
Cell Injury And Cell Death (2006)(1)
Cell  Injury And  Cell  Death (2006)(1)Cell  Injury And  Cell  Death (2006)(1)
Cell Injury And Cell Death (2006)(1)
 
cell injury
cell injurycell injury
cell injury
 
Cell injury: causes, pathogenesis, Morphology of reversible cell injury
Cell injury: causes, pathogenesis, Morphology of reversible cell injuryCell injury: causes, pathogenesis, Morphology of reversible cell injury
Cell injury: causes, pathogenesis, Morphology of reversible cell injury
 
Basic Pathology : Introduction To Cells & Tissue Damage
Basic Pathology : Introduction To Cells & Tissue DamageBasic Pathology : Introduction To Cells & Tissue Damage
Basic Pathology : Introduction To Cells & Tissue Damage
 
Ischemia,necrosis,hypoxia
Ischemia,necrosis,hypoxiaIschemia,necrosis,hypoxia
Ischemia,necrosis,hypoxia
 
necrosis
necrosisnecrosis
necrosis
 
Cell injuryadaptation 3
Cell injuryadaptation 3Cell injuryadaptation 3
Cell injuryadaptation 3
 
Cystic masses of the breast by xiu
Cystic masses of the breast by xiuCystic masses of the breast by xiu
Cystic masses of the breast by xiu
 
Cell injury: Necrosis and Gangrene
Cell injury: Necrosis and GangreneCell injury: Necrosis and Gangrene
Cell injury: Necrosis and Gangrene
 
Acute pancreatitis SP
Acute pancreatitis SPAcute pancreatitis SP
Acute pancreatitis SP
 
The hallucinogenic
The hallucinogenicThe hallucinogenic
The hallucinogenic
 
Happiness at Work
Happiness at WorkHappiness at Work
Happiness at Work
 
Cns stimulants drugs (1)
Cns stimulants drugs (1)Cns stimulants drugs (1)
Cns stimulants drugs (1)
 
Avascular necrosis
Avascular necrosisAvascular necrosis
Avascular necrosis
 
Cell injury
Cell injuryCell injury
Cell injury
 
Cell injury – cell injury and cell death
Cell injury  – cell injury and cell deathCell injury  – cell injury and cell death
Cell injury – cell injury and cell death
 
biological effects of radiation
biological effects of radiationbiological effects of radiation
biological effects of radiation
 
Biological effects of radiation
Biological effects of radiationBiological effects of radiation
Biological effects of radiation
 

Similar to Cell Injury And Death Lecture I

Cell injury l2 medical sept. 2018
Cell injury l2 medical sept. 2018Cell injury l2 medical sept. 2018
Cell injury l2 medical sept. 2018
Sufia Husain
 
Necrosis and apoptosis
Necrosis and apoptosisNecrosis and apoptosis
Necrosis and apoptosis
Bahauddin Zakariya University lahore
 
2 Cell injury by Ashiq wazir. Ppt
2 Cell injury by Ashiq wazir. Ppt2 Cell injury by Ashiq wazir. Ppt
2 Cell injury by Ashiq wazir. Ppt
AshiqWazir
 
cell injury.pptx
cell injury.pptxcell injury.pptx
cell injury.pptx
IjazKhan505910
 
Cell injury-necrosis
Cell injury-necrosisCell injury-necrosis
Cell injury-necrosis
Armin Eisazaei
 
02-Necrosis and apoptosis-1.ppt
02-Necrosis and apoptosis-1.ppt02-Necrosis and apoptosis-1.ppt
02-Necrosis and apoptosis-1.ppt
MuhammadHassan592508
 
Cell death.pptx
Cell death.pptxCell death.pptx
Cell death.pptx
DavudAhmedzade
 
Cell injury
Cell injuryCell injury
Cell injury
sabahqaysar
 
cell necrosis , apoptosis presentation.pdf
cell necrosis , apoptosis presentation.pdfcell necrosis , apoptosis presentation.pdf
cell necrosis , apoptosis presentation.pdf
jasveer15
 
APOPTOSIS AND NECROSIS.pptx
APOPTOSIS AND NECROSIS.pptxAPOPTOSIS AND NECROSIS.pptx
APOPTOSIS AND NECROSIS.pptx
DRManasaMariyamJacks
 
Causesofcellinjury
Causesofcellinjury Causesofcellinjury
Causesofcellinjury
Sidal hospital
 
Causes of cell injury
Causes of cell injuryCauses of cell injury
Causes of cell injuryAj Cocjin
 
APOPTOSIS pdfb.pptx
APOPTOSIS pdfb.pptxAPOPTOSIS pdfb.pptx
APOPTOSIS pdfb.pptx
rijulkumar7
 
Introduction to pathology
Introduction to pathologyIntroduction to pathology
Introduction to pathology
Jomin George
 
Cell death.pptx
Cell death.pptxCell death.pptx
Cell death.pptx
DavudAhmedzade
 
Cell injury inflammation and repair
Cell injury inflammation and repairCell injury inflammation and repair
Cell injury inflammation and repair
Gaurav Kataria
 
Cell death: Beneficial, Detrimental or No effect
Cell death: Beneficial, Detrimental or No effectCell death: Beneficial, Detrimental or No effect
Cell death: Beneficial, Detrimental or No effect
SabbirHasan37
 
Apoptosis, program cell death
Apoptosis, program cell deathApoptosis, program cell death
Apoptosis, program cell death
KAUSHAL SAHU
 
DPT - Cell injury and Cell death
DPT - Cell injury and Cell deathDPT - Cell injury and Cell death
DPT - Cell injury and Cell death
Areesha Ahmad
 
Necrosis.pathology lecture slideshare.pptx
Necrosis.pathology lecture slideshare.pptxNecrosis.pathology lecture slideshare.pptx
Necrosis.pathology lecture slideshare.pptx
ABIDOFFICIALCHANNEL
 

Similar to Cell Injury And Death Lecture I (20)

Cell injury l2 medical sept. 2018
Cell injury l2 medical sept. 2018Cell injury l2 medical sept. 2018
Cell injury l2 medical sept. 2018
 
Necrosis and apoptosis
Necrosis and apoptosisNecrosis and apoptosis
Necrosis and apoptosis
 
2 Cell injury by Ashiq wazir. Ppt
2 Cell injury by Ashiq wazir. Ppt2 Cell injury by Ashiq wazir. Ppt
2 Cell injury by Ashiq wazir. Ppt
 
cell injury.pptx
cell injury.pptxcell injury.pptx
cell injury.pptx
 
Cell injury-necrosis
Cell injury-necrosisCell injury-necrosis
Cell injury-necrosis
 
02-Necrosis and apoptosis-1.ppt
02-Necrosis and apoptosis-1.ppt02-Necrosis and apoptosis-1.ppt
02-Necrosis and apoptosis-1.ppt
 
Cell death.pptx
Cell death.pptxCell death.pptx
Cell death.pptx
 
Cell injury
Cell injuryCell injury
Cell injury
 
cell necrosis , apoptosis presentation.pdf
cell necrosis , apoptosis presentation.pdfcell necrosis , apoptosis presentation.pdf
cell necrosis , apoptosis presentation.pdf
 
APOPTOSIS AND NECROSIS.pptx
APOPTOSIS AND NECROSIS.pptxAPOPTOSIS AND NECROSIS.pptx
APOPTOSIS AND NECROSIS.pptx
 
Causesofcellinjury
Causesofcellinjury Causesofcellinjury
Causesofcellinjury
 
Causes of cell injury
Causes of cell injuryCauses of cell injury
Causes of cell injury
 
APOPTOSIS pdfb.pptx
APOPTOSIS pdfb.pptxAPOPTOSIS pdfb.pptx
APOPTOSIS pdfb.pptx
 
Introduction to pathology
Introduction to pathologyIntroduction to pathology
Introduction to pathology
 
Cell death.pptx
Cell death.pptxCell death.pptx
Cell death.pptx
 
Cell injury inflammation and repair
Cell injury inflammation and repairCell injury inflammation and repair
Cell injury inflammation and repair
 
Cell death: Beneficial, Detrimental or No effect
Cell death: Beneficial, Detrimental or No effectCell death: Beneficial, Detrimental or No effect
Cell death: Beneficial, Detrimental or No effect
 
Apoptosis, program cell death
Apoptosis, program cell deathApoptosis, program cell death
Apoptosis, program cell death
 
DPT - Cell injury and Cell death
DPT - Cell injury and Cell deathDPT - Cell injury and Cell death
DPT - Cell injury and Cell death
 
Necrosis.pathology lecture slideshare.pptx
Necrosis.pathology lecture slideshare.pptxNecrosis.pathology lecture slideshare.pptx
Necrosis.pathology lecture slideshare.pptx
 

Recently uploaded

Synthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptxSynthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptx
Pavel ( NSTU)
 
Model Attribute Check Company Auto Property
Model Attribute  Check Company Auto PropertyModel Attribute  Check Company Auto Property
Model Attribute Check Company Auto Property
Celine George
 
Francesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptxFrancesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptx
EduSkills OECD
 
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama UniversityNatural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
Akanksha trivedi rama nursing college kanpur.
 
Digital Artifact 2 - Investigating Pavilion Designs
Digital Artifact 2 - Investigating Pavilion DesignsDigital Artifact 2 - Investigating Pavilion Designs
Digital Artifact 2 - Investigating Pavilion Designs
chanes7
 
1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx
JosvitaDsouza2
 
Best Digital Marketing Institute In NOIDA
Best Digital Marketing Institute In NOIDABest Digital Marketing Institute In NOIDA
Best Digital Marketing Institute In NOIDA
deeptiverma2406
 
Marketing internship report file for MBA
Marketing internship report file for MBAMarketing internship report file for MBA
Marketing internship report file for MBA
gb193092
 
MASS MEDIA STUDIES-835-CLASS XI Resource Material.pdf
MASS MEDIA STUDIES-835-CLASS XI Resource Material.pdfMASS MEDIA STUDIES-835-CLASS XI Resource Material.pdf
MASS MEDIA STUDIES-835-CLASS XI Resource Material.pdf
goswamiyash170123
 
Embracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic ImperativeEmbracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic Imperative
Peter Windle
 
The approach at University of Liverpool.pptx
The approach at University of Liverpool.pptxThe approach at University of Liverpool.pptx
The approach at University of Liverpool.pptx
Jisc
 
2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...
Sandy Millin
 
Normal Labour/ Stages of Labour/ Mechanism of Labour
Normal Labour/ Stages of Labour/ Mechanism of LabourNormal Labour/ Stages of Labour/ Mechanism of Labour
Normal Labour/ Stages of Labour/ Mechanism of Labour
Wasim Ak
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
Atul Kumar Singh
 
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Dr. Vinod Kumar Kanvaria
 
The Diamond Necklace by Guy De Maupassant.pptx
The Diamond Necklace by Guy De Maupassant.pptxThe Diamond Necklace by Guy De Maupassant.pptx
The Diamond Necklace by Guy De Maupassant.pptx
DhatriParmar
 
Chapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptxChapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptx
Mohd Adib Abd Muin, Senior Lecturer at Universiti Utara Malaysia
 
Biological Screening of Herbal Drugs in detailed.
Biological Screening of Herbal Drugs in detailed.Biological Screening of Herbal Drugs in detailed.
Biological Screening of Herbal Drugs in detailed.
Ashokrao Mane college of Pharmacy Peth-Vadgaon
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
Vivekanand Anglo Vedic Academy
 
Advantages and Disadvantages of CMS from an SEO Perspective
Advantages and Disadvantages of CMS from an SEO PerspectiveAdvantages and Disadvantages of CMS from an SEO Perspective
Advantages and Disadvantages of CMS from an SEO Perspective
Krisztián Száraz
 

Recently uploaded (20)

Synthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptxSynthetic Fiber Construction in lab .pptx
Synthetic Fiber Construction in lab .pptx
 
Model Attribute Check Company Auto Property
Model Attribute  Check Company Auto PropertyModel Attribute  Check Company Auto Property
Model Attribute Check Company Auto Property
 
Francesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptxFrancesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptx
 
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama UniversityNatural birth techniques - Mrs.Akanksha Trivedi Rama University
Natural birth techniques - Mrs.Akanksha Trivedi Rama University
 
Digital Artifact 2 - Investigating Pavilion Designs
Digital Artifact 2 - Investigating Pavilion DesignsDigital Artifact 2 - Investigating Pavilion Designs
Digital Artifact 2 - Investigating Pavilion Designs
 
1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx
 
Best Digital Marketing Institute In NOIDA
Best Digital Marketing Institute In NOIDABest Digital Marketing Institute In NOIDA
Best Digital Marketing Institute In NOIDA
 
Marketing internship report file for MBA
Marketing internship report file for MBAMarketing internship report file for MBA
Marketing internship report file for MBA
 
MASS MEDIA STUDIES-835-CLASS XI Resource Material.pdf
MASS MEDIA STUDIES-835-CLASS XI Resource Material.pdfMASS MEDIA STUDIES-835-CLASS XI Resource Material.pdf
MASS MEDIA STUDIES-835-CLASS XI Resource Material.pdf
 
Embracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic ImperativeEmbracing GenAI - A Strategic Imperative
Embracing GenAI - A Strategic Imperative
 
The approach at University of Liverpool.pptx
The approach at University of Liverpool.pptxThe approach at University of Liverpool.pptx
The approach at University of Liverpool.pptx
 
2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...
 
Normal Labour/ Stages of Labour/ Mechanism of Labour
Normal Labour/ Stages of Labour/ Mechanism of LabourNormal Labour/ Stages of Labour/ Mechanism of Labour
Normal Labour/ Stages of Labour/ Mechanism of Labour
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
 
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
Exploiting Artificial Intelligence for Empowering Researchers and Faculty, In...
 
The Diamond Necklace by Guy De Maupassant.pptx
The Diamond Necklace by Guy De Maupassant.pptxThe Diamond Necklace by Guy De Maupassant.pptx
The Diamond Necklace by Guy De Maupassant.pptx
 
Chapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptxChapter 3 - Islamic Banking Products and Services.pptx
Chapter 3 - Islamic Banking Products and Services.pptx
 
Biological Screening of Herbal Drugs in detailed.
Biological Screening of Herbal Drugs in detailed.Biological Screening of Herbal Drugs in detailed.
Biological Screening of Herbal Drugs in detailed.
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
 
Advantages and Disadvantages of CMS from an SEO Perspective
Advantages and Disadvantages of CMS from an SEO PerspectiveAdvantages and Disadvantages of CMS from an SEO Perspective
Advantages and Disadvantages of CMS from an SEO Perspective
 

Cell Injury And Death Lecture I

  • 1. GENERAL PATHOLOGY DR NADEEM REYAZ UNIVERSITY OF HEALTH SCIENCES
  • 2. Where there is love of medicine, there is love of humankind
  • 3. PATHOLOGY is the scientific study of disease or is the study of structural and functional abnormalities that are expressed as diseases of organ and system
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. POOR NUTRITION INFECTIOUS AGENT eg, Clostridia IMMUNE INJURY eg, Antibody and T cell mediated CHEMICAL AGENTS eg, salts, overwater, PHYSICAL AGENTS eg, fire, freezing, electricity, radiation
  • 14.
  • 15.  
  • 16. Here is the centrilobular portion of liver next to a central vein. The cells have reduced in size or been lost from hypoxia. The pale brown-yellow pigment is lipochrome that has accumulated as the atrophic and dying cells undergo autophagocytosis.
  • 18.
  • 19.
  • 20. Hypertrophy of the muscles of a strength athlete                                                        
  • 23.  
  • 24.
  • 25.  
  • 26.  
  • 27.  
  • 28.
  • 29.  
  • 30.
  • 31.
  • 32.
  • 33. Mallory bodies (the red globular material) composed of cytoskeletal filaments in liver cells
  • 34. The brown coarsely granular material in macrophages in this alveolus is hemosiderin
  • 35. These renal tubules contain large amounts of hemosiderin, as demonstrated by the Prussian blue iron stain
  • 36. Liver: Fatty change
  • 37.
  • 39. Many nuclei have become pyknotic (shrunken and dark) and have then undergone karorrhexis (fragmentation) and karyolysis (dissolution). The cytoplasm and cell borders are not recognizable.
  • 40.
  • 41.  
  • 42.
  • 43.
  • 44.
  • 45.
  • 46.  
  • 47.  
  • 49.
  • 50.  
  • 51.
  • 52.
  • 53.  
  • 54. The two lung abscesses seen here are examples of liquefactive necrosis in which there is a liquid center in an area of tissue injury. One abscess appears in the upper lobe and one in the lower lobe. Liquefactive necrosis is typical of organs in which the tissues have a lot of lipid (such as brain) or when there is an abscess with lots of acute inflammatory cells whose release of proteolytic enzymes destroys the surrounding tissues.
  • 55. Lung Abscess: Microscopic appearance (Liquefactive Necrosis)
  • 56.
  • 57.  
  • 58.  
  • 59.
  • 60.
  • 61.  
  • 62. Caseous necrosis with granulomatous inflammation
  • 63. Caseous necrosis with Giant cells
  • 64.
  • 65.
  • 66.  
  • 67.
  • 68.
  • 69.
  • 70.
  • 71.
  • 72.
  • 73.
  • 75.
  • 76. "wet gangrene in patient with Diabetes millitus”
  • 77.
  • 78.
  • 79.  
  • 80.
  • 81.
  • 82. This is dystrophic calcification in the wall of the stomach. At the far left is an artery with calcification in its wall
  • 83. “ Metastatic calcification" in the lung of a patient with a very high serum calcium level (hypercalcemia).
  • 84.
  • 85.
  • 86.
  • 87.  
  • 88.
  • 89.
  • 90.
  • 91.
  • 92.