The cardiovascular system consists of the heart and blood vessels. The heart, made of strong cardiac muscle, has four chambers and pumps blood through two circuits. Deoxygenated blood enters the right atrium, travels to the right ventricle and lungs, then the left atrium and ventricle before being pumped through arteries like the aorta to the body. Oxygen-depleted blood returns via veins like the vena cava to the heart.