A complete review of carbohydrates. definition, source of carbohydrates. Importance, function of carbohydrates. translocation of carbohydrates in plants.
A complete review of carbohydrates. definition, source of carbohydrates. Importance, function of carbohydrates. translocation of carbohydrates in plants.
This presentation is made for F.Y.Bsc. Students.
The presentation includes the General Properties of Carbohydrate and the classification of carbohydrates.
Lipids, classification, digestion and absorptionHu--da
Introduction of lipids
Sources of lipids
Classification of lipids
Trans fat
Alteration of dietary fats during food processing
Digestion, absorption of lipids
Absorption of cholesterol
Lipid transport
Lipid metabolism
Biosynthesis of fatty acids
Essential fatty acids
Oxidation of fatty acids
Impact of diet on fatty acids synthesis
Cholesterol synthesis and excretion
This module describes the types of minerals present in food. in nature we have several minerals which are generally classified into two as Major and Minor minerals. it also describes the recommended dietary allowance by ICMR 2020. Here you will be able to find the functions, sources and deficiency of each minerals.
This presentation is made for F.Y.Bsc. Students.
The presentation includes the General Properties of Carbohydrate and the classification of carbohydrates.
Lipids, classification, digestion and absorptionHu--da
Introduction of lipids
Sources of lipids
Classification of lipids
Trans fat
Alteration of dietary fats during food processing
Digestion, absorption of lipids
Absorption of cholesterol
Lipid transport
Lipid metabolism
Biosynthesis of fatty acids
Essential fatty acids
Oxidation of fatty acids
Impact of diet on fatty acids synthesis
Cholesterol synthesis and excretion
This module describes the types of minerals present in food. in nature we have several minerals which are generally classified into two as Major and Minor minerals. it also describes the recommended dietary allowance by ICMR 2020. Here you will be able to find the functions, sources and deficiency of each minerals.
Optimal Health Workshop
This presentation gives knowledge about Anti Aging ,Balance diet, and Life style related disease. and also shows the preventive solution for that.
Industrial production of lactic acid & monosodium glutamateWishal Butt
Widely occurring organic acid
Applications in industry, food , textile, pharmaceutical
White in solid
Extremely soluble
DISCOVERY:-
In 1780 discovered by a Swedish chemist SCHEELE by sour milk.
1839, FERMY from sugar , milk , starch , dextrin.
1857 , PASTEUR, discovered that it is not a component of milk , but a metabolite that certain microorganisms produced by fermentation.Monosodium glutamate (MSG, also known as sodium glutamate) is the sodium salt of glutamic acid,
one of the most abundant naturally occurring non-essential amino acids.
It is commonly known as Ajinomoto.
It is found naturally in tomatoes, cheese and other foods.
It is used in the food industry as a flavor enhancer.
Fermentation is a natural process, occurs when microorganisms consume susceptible organic substrate as part of their own metabolic processes. Also referred to the bulk growth of microorganisms in a growth medium with the goal of producing a specific chemical product. The science of fermentation is called zymology. It mainly takes place when the electron transport chain unusable. Extract energy but do not consume O₂ or change the concentration of NAD⁺ or NADH.
Sweeteners are naturally found in plants due to photosynthetic processes. Various plants naturally synthesize sugar which is much sweeter than sugar that we eat (artificially processed) Discover an array of plants that can be good alternative for patients having diabetes
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
2. Carbohydrates
Hydrates of carbon
Chemical composition of (CH2O)n
Primary source of energy for our bodies
Good source of fiber and vitamins
Rich in phytonutrients
Participate in many essential body functions
Two types -simple and complex
6. Benedict's Test
Used to test for presence of reducing sugars
all monosaccharides
disaccharides: lactose and maltose
Requires use of Benedict's Reagent
prepared from CuSO4, NaOH, tartaric acid
7. Benedict's Test
1.Dissolve food sample in water
2.Add small amount of Benedict's Reagent
3.Heat in water bath from 4 -10 minutes
4.Positive test indicated by a brick red solution
8. Iodine Test
Used to test for starch
Requires use of Iodine solution
dissolve iodine in potassium
iodide
How to test
1.Add Iodine solution directly to
food sample
2.A dark blue-black colour
indicates presence of starch
9. Carbohydrate Digestion
Break down carbohydrate
into glucose
able to be absorbed and used
by body
Starch -extensive breakdown
Disaccharides -broken down
once
Monosaccharides -need not
be broken down
Occurs throughout digestive
system
Begins in mouth
chewing releases saliva
starch broken down by
enzymes into
polysaccharides and maltose
10. Digestion in the Stomach
No enzymes available for starch breakdown
Acid does minor breakdown
Fibers provide feeling of "fullness“
Digestion in the Small Intestine
Primary site of carbohydrate digestion
Pancreatic enzyme reduces carbohydrates into glucose chains or
disaccharides
Specific enzymes are present to fully reduce disaccharides
Digestion in the Large Intestine
1 to 4 hours for sugars and starches to be fully digested
Only fibers remain
retain water to soften stool