Captopril is a drug used to treat hypertension and heart failure. It works by inhibiting the angiotensin converting enzyme (ACE), which prevents the conversion of angiotensin I to angiotensin II. Captopril was the first ACE inhibitor developed based on studying peptides from snake venom that inhibit ACE. It binds to the active site of ACE through interactions between its thiol group, carbonyl group, and carboxylate group with zinc and histidine residues on the enzyme. Captopril is well absorbed orally and has a short half-life of around 2 hours.