Dyslipidaemia and its treatment
This poster summarizes lipid metabolism pathways in the body and how genetic mutations and lifestyle factors can lead to dyslipidaemia. It displays the classes of lipoproteins that transport lipids in plasma and the factors involved in their assembly, conversion, and breakdown. Therapeutic targets for treating dyslipidaemia are identified, such as statins that inhibit cholesterol synthesis, PCSK9 inhibitors that increase LDL receptor expression, and cholesterol absorption inhibitors like ezetimibe. Clinical trials have shown that reducing LDL cholesterol levels with these drugs can lower cardiovascular risk. The poster provides an overview of lipid metabolism and strategies for rational management of dyslipidemia.
Plasma Proteins For Therapeutic Use; An Introduction to Blood PLASMA & its Se...Maryam Pazireh
An INTRODUCTION TO PLASMA & its Separation Methods;
what is Plasma & its composition, What does it do in the body, and Plasma Proteins as pharmaceutical crops
Serum Protein and Albumin-Globulin RatioASHIKH SEETHY
For MBBS Biochemistry Practical. Explains various methods of protein estimation and estimation of AG ratio, conditions leading to alterations in AG ratio etc.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
Plasma Proteins For Therapeutic Use; An Introduction to Blood PLASMA & its Se...Maryam Pazireh
An INTRODUCTION TO PLASMA & its Separation Methods;
what is Plasma & its composition, What does it do in the body, and Plasma Proteins as pharmaceutical crops
Serum Protein and Albumin-Globulin RatioASHIKH SEETHY
For MBBS Biochemistry Practical. Explains various methods of protein estimation and estimation of AG ratio, conditions leading to alterations in AG ratio etc.
ALT is an enzyme present in liver, heart skeletal muscles, highest concentration is present in Liver. it value increases when there is abnormality in liver, ALT is an amino transferase which transfer one amino group from an amino acid and transfer to another substance for production of non essential amino acid
Las ventajas de ser invisible, como también la conocemos, es una historia gira entorno a Charlie, un simple adolescente que abre las puertas de su mundo quien originalmente le da la bienvenida al lector a través de cartas dedicadas a un remitente desconocido
Statins are highly effective LDL-c lowering agents that actually reduce clinical cardiovascular events. The 2013 ACC/AHA guidelines on the management of blood cholesterol recommend high-intensity statin therapy in individuals with high cardiovascular risk as assessed by the 10-year atherosclerotic cardiovascular disease risk calculator. However, a significant number of individuals do not tolerate or respond adequately to statins, and continue to have residual risk in spite of high intensity statin therapy.
There are some exciting developments in the field of lipidology. This decade has been labeled “The PCSK9 decade”. A new class of monoclonal antibodies directed against the PCSK9 glycoproteins appears very promising in further lowering LDL cholesterol and thereby cardiovascular risk. Evolocumab and alirucomab are novel PCSK9 inhibitors that can be given subcutaneously once or twice in a month, and have the potential to reduce LDL-cholesterol to very low levels without any major adverse effects.
Other classes of drugs like Apo-B antisense oligonucleotides (mipomersen), CETP inhibitors (especially anacetrapib), microsomal transfer protein inhibitors (lomitapide) also hold some promise. The future of lipid lowering therapy looks reassuring with these new developments.
Shashikiran Umakanth presented this at the Egyptian Association of Endocrinology, Diabetes & Atherosclerosis (EAEDA) 2014 conference at Alexandria, Egypt. This conference was help in association with Endocrine Society, USA and the European Association for the Study of Diabetes (EASD).
Strategic Infrastructure: Steps to Operate and Maintain Infrastructure Effici...Boston Consulting Group
Against the backdrop of increasing user demand, constrained financing, and an aging asset base, it is imperative for governments to make the most of their existing infrastructure assets–specifically, to increase their productivity and longevity. This slideshow recommends ways of doing just that.
For more information, please check out the full report from The World Economic Forum with BCG, "Strategic Infrastructure: Steps to Operate and Maintain Infrastructure Efficiently and Effectively" (http://on.bcg.com/1lnDqv7).
To be able to describe:
Cholesterol synthesis, source & metabolism
Hyperlipidemia – definition & normal values.
Anti hyperlipidemic drugs: its classification, mechanism of action & side effects.
The natural history of atherosclerosis might involve coronary plaque rupture / erosion, thrombus formation and vessel lumen occlusion, clinically recognized as acute coronary syndrome (ACS). International guidelines strongly recommend early statin administration in patients admitted for ACS. In addition to lowering circulating levels of low-density lipoprotein cholesterol (LDL-c), statin treatment was shown to promote plaque stabilization or regression in several ways, including reduction in necrotic lipid core, anti-inflammatory effects and improvement in endothelial function.
Update on the efficacy of statin treatment in acute coronary syndromes by Rosa, Gian Marco; Carbone, Federico; Parodi, Antonello; Massimelli, Elena A; Brunelli, Claudio; Mach, François (more...) European journal of clinical investigation, 05/2014, Volume 44, Issue 5, 501 - 515
Hyperlipidemia , dyslipidemia , and drug therapy
also Fat transport and metabolisim and pathophysiology of lipoprotein
clincal importance of
1. Hypertriglycredemia
2. Hypercholesterolemia
3.Combined hyperlipidemia
4. Some other lipoprotein disorders
Including disorder of HDL_C
Κλούρας Ε, Λυμπερόπουλος Ε, Ελισάφ Μ. Αναστολή της PCSK9: Μια νέα προσέγγιση...MedicalWeb.gr
Κλούρας Ε, Λυμπερόπουλος Ε, Ελισάφ Μ.
Αναστολή της PCSK9: Μια νέα προσέγγιση στην υπολιπιδαιμική αγωγή. Ελληνική Επιθεώρηση Αθηροσκλήρωσης 2014, 5(3):168–176
A detailed information about the cholesterol types, its absorption, conversion and drugs used to lower the levels of LDL, VLDL and Triglycerides - classification, mechanism of action, side effects, dosage and indications.