The document discusses bipolar disorder, also known as manic-depressive disorder. It is characterized by periods of elevated mood and periods of depression. During manic episodes, symptoms may include distractibility, insomnia, grandiosity, flight of ideas, increased activity or psychomotor agitation, risky behavior, and talkativeness. The causes of bipolar disorder are thought to include genetic, physiological, environmental, neurological, and neuroendocrine factors. Treatment involves hospitalization during severe episodes, as well as mood stabilizers, antipsychotics, antidepressants, ECT, psychotherapy, lifestyle changes, and substance abuse treatment.
Neurocognitive disorders includes : Delirium and Dementia.
This presentation focuses on causes, risk factors, management and how to prevent its complication
A presentation about depressive disorder. The presentation composed of the definition, causes, types, clinical feature, diagnosis, prognosis, treatment and prevention of depression
Classification in Psychiatry
The concept, reliability, validity, advantages and disadvantages of different classification systems, controversies in psychiatry classification
Neurocognitive disorders includes : Delirium and Dementia.
This presentation focuses on causes, risk factors, management and how to prevent its complication
A presentation about depressive disorder. The presentation composed of the definition, causes, types, clinical feature, diagnosis, prognosis, treatment and prevention of depression
Classification in Psychiatry
The concept, reliability, validity, advantages and disadvantages of different classification systems, controversies in psychiatry classification
This is a project for a high school AP psychology course. This is a fictionalized account of having a psychological ailment. For questions about this blog project or it’s content please email the teacher Chris Jocham: jocham@fultonschools.org.
The recognition of bipolar disorder in primary careNick Stafford
Bipolar disorder and the complexities of screening and diagnosis in primary care. How more accurate detection and an integrated care pathway with secondary care can improve the diagnosis and outcome of the treatment of the disorder.
There are various treatment methods for bipolar disorder, including; drug therapy, psychotherapy, mental health supplements and ect. http://mentalhealthlivingwithbipolar.blogspot.com/p/blog-page_27.html
Effective treatment for Bipolar disorder at Mindheal homeopathyShewta shetty
"Personalised online consultancy & treatments provided at our clinic by efficient panel of doctors in our center at mumbai,Bombay,Chembur, India.Contact us."
Mood disorders, also known as affective disorders, are a category of mental health conditions characterized by significant changes in mood that affect a person's daily functioning, emotions, and overall quality of life. There are several types of mood disorders, with the most common being depression and bipolar disorder. this ppt contains mood disorders which is useful for the students of Basic B.Sc. Nursing.
Mood disorder characterized by disturbance of mood. it includes mania or depressive syndrome. it includes definition, causes, sign and symptoms, treatment and nursing diagnosis etc.
This is a ppt explaining the symptoms and diagnostic criteria of schizophrenia, along with possible treatment methods. The information provided is based entirey on DSM-5.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. F31 BIPOLAR DISORDER
Bipolar disorder, also known as bipolar
affective disorder or manic depression, is
a mental disorder characterized by periods of
elevated mood and periods of
depression.[1][2] The elevated mood is
significant and is known
as mania or hypomania depending on the
severity or whether there is psychosis
3.
4. German psychiatrist Emil Kraepelin first distinguished between
manic–depressive illness and "dementia praecox" (now known
as schizophrenia) in the late 19th century
5.
6.
7.
8.
9.
10. Bipolar I Disorder, Most Recent Episode
_______
A) Currently in a ________ Episode
B) At least one Manic, Major Depressed, or Mixed
Episode
C) Symptoms cause significant distress or
impairment in social, occupational, or other
functioning.
D) The symptoms are not better accounted for by
Schizoaffective Disorder, Schizophrenia,
Schizophreniform Disorder, Delusional Disorder, or
Psychotic Disorder NOS.
E) The Symptoms are not better accounted for by a
substance or general medical condition.
11. Bipolar II Disorder
Manic or Mixed Episode rules out this disorder
Presence of a Hypomanic Episode defferinates
between the two conditions.
Symptoms must cause impairment
Sometimes hypomanic symptoms may not cause
impairment
More common in women
Women with the disorder are at risk for developing
episodes during postpartum.
12. Cyclothymic Disorder
Milder symptoms
Considered a chronic condition
Symptoms more consistent
Clients with only depressive symptoms should
not be diagnosed with Cyclothymic Disorder
13. Bipolar Disorder Not Otherwise Specified
Disorders with bipolar features not meeting criteria
Examples:
1. Rapid alternation (over days) between manic and
depressive symptoms that meet symptom criteria but not
minimal duration for Manic, Hympmanic or Major
Depressive Episodes.
2. Recurrent Hypomanic Episodes without depressive
symptoms.
3. A Manic or Mixed Episode superimposed on Delusional
Disorder, residual Schizophrenia, or Psychotic Disorder
NOS.
4. Hypomanic Episodes, along with chronic depressive
symptoms, that are too infrequent for Cyclothymic Disorder
5. When the clinician believes Bipolar Disorder is present but
is unable to determine rule out medical condition or
substance
22. PHYSIOLOGICAL
According to the "kindling" hypothesis, when
people who are genetically predisposed toward
bipolar disorder experience stressful events, the
stress threshold at which mood changes occur
becomes progressively lower, until the episodes
eventually start (and recur) spontaneously.
There is evidence supporting an association
between early-life stress and dysfunction of
the hypothalamic-pituitary-adrenal axis (HPA
axis) leading to its over activation, which may
play a role in the pathogenesis of bipolar
disorder
23. ENVIRONMENTAL
Evidence suggests that environmental
factors play a significant role in the
development and course of bipolar disorder,
and that individual psychosocial variables
may interact with genetic dispositions
24. NEUROLOGICAL
Less commonly bipolar disorder or a bipolar-
like disorder may occur as a result of or in
association with a neurological condition or
injury. Such conditions and injuries include
(but are not limited to) stroke, traumatic brain
injury, HIV infection,multiple
sclerosis, porphyria, and rarely temporal lobe
epilepsy
25. NEUROENDOCRINOLOGICAL
The dopamine hypothesis states that the increase in dopamine
results in secondary homeostatic down regulation of key systems
and receptors such as an increase in dopamine mediated G
protein-coupled receptors. This results in decreased dopamine
transmission characteristic of the depressive phase.The
depressive phase ends with homeostatic up regulation potentially
restarting the cycle over again.
Glutamate is significantly increased within the left dorsolateral
prefrontal cortex during the manic phase of bipolar disorder, and
returns to normal levels once the phase is over.[54] The increase
in GABA is possibly caused by a disturbance in early
development causing a disturbance of cell migration and the
formation of normal lamination, the layering of brain structures
commonly associated with the cerebral cortex
33. SCREENING QUESTIONS
Have you ever had a period of a week or so
when you felt so happy and energetic that
your friends told you that you were talking
too fast or that you were behaving differently
and strangely?
Has there been a period when you were so
hyper and irritable that you got into
arguments with people?
Has anyone ever called you manic before?
37. F30 MANIC EPISODE
A manic episodes is typically characterized
by the following features
Which should last for at least one week and
Cause disruption to occupation and social
activities
38. HYPOMANIA F30.0
Hypomania is a lowered state of mania that does little
to impair function or decrease quality of life.
It may, in fact, increase productivity and creativity. In
hypomania, there is less need for sleep and both
goal-motivated behaviour and metabolism increase.
Though the elevated mood and energy level typical of
hypomania could be seen as a benefit,
mania itself generally has many undesirable
consequences including suicidal tendencies, and
hypomania can, if the prominent mood is irritable
rather than euphoric, be a rather unpleasant
experience.
39. STAGES
1. Euphoria : mild elevation of mood
2. Elation: moderate elevation of mood
3. Exaltation: severe elevation of mood
4.Ecstasy: very severe elevation of mood
40. CAUSES
The biological mechanism by which mania occurs is not yet known.
Based on the mechanism of action of antimanic agents (such as
antipsychotics, valproate, tamoxifen, lithium, carbamazepine, etc.) and
abnormalities seen in patients experiencing a manic episode the
following is theorised to be involved in the pathophysiology of mania:
Dopamine D2 receptor overactivity (which is a pharmacologic
mechanism of antipsychotics in mania)
GSK-3 overactivity
Protein kinase C overactivity
Inositol monophosphatase overactivity
Increased arachidonic acid turnover
Increased cytokine synthesis
Imaging studies have shown that the left amygdala is more active
in women who are manic and the orbitofrontal cortex is less
active.Pachygyria may be associated with mania also
41. SYMPTOMS OF MANIA— DIG FAST
Distractibility
Insomnia (↓ need for sleep)
Grandiosity (↑ selfesteem)/more Goal
directed
Flight of ideas (or racing thoughts)
Activities/psychomotor Agitation
Sexual indiscretions/ othepleasurable
activities
Talkativeness/pressured speech
42. DISTRACTABILITY
Were you having trouble thinking or
concentrating?
Was this because things around you or even
your thoughts were getting you off track?
43. INDISCRETION
During the period we were talking about, how
were you spending your time?
Were you doing things that caused trouble
for you or your family?
Were you doing things that showed a lack of
judgment, such as driving too fast, running
red lights, or spending too much?
Were you doing sexual things during this this
period that was unusual for you?
44. GRANDIOUSITY
During this period did you feel so confidant
that you felt you could conquer the world?
What was your best idea when you felt that
way?
Did you feel that you had special powers or
abilities?
Did you feel more religious than normal for
you?
45. FLIGHT OF IDEAS
During this period did you have so many
thoughts, or were they so fast, that you could
barely keep up to them?
Did it feel like your thoughts were racing?
46. ACTIVITY INCREASE
During that period, were you more active
than usual?
Were you constantly starting new projects
and hobbies, working into the night?
47. SLEEP DEFICIT
During that period, did you need less sleep?
Did you ever stay up all night doing all kinds
of things, like working on projects or phoning
people?
Did your sleep duration become reduced and
still you had lots of energy?
48. TALKATIVENESS
During this period, were you talking more
than usual for you?
Were you talking so much that people had to
interrupt you to speak to you?
Were you using the phone more than usual
for you
51. TREATMENT OPTIONS
Hospitalization for mania, severe depression
Mood stabilizers, antipsychotics and
antidepressants
ECT – most effective treatment
Supportive psychotherapy and CBT
Lifestyle change
Substance abuse treatment
52.
53. PSYCHOSOCIAL
Psychotherapy is aimed at alleviating core symptoms,
recognizing episode triggers, reducing negative expressed
emotion in relationships, recognizing prodromal symptoms before
full-blown recurrence, and, practicing the factors that lead to
maintenance of remission
Cognitive behavioral therapy, family-focused therapy,
and psychoeducation have the most evidence for efficacy in
regard to relapse prevention, while interpersonal and social
rhythm therapy and cognitive-behavioral therapy appear the most
effective in regard to residual depressive symptoms. Most studies
have been based only on bipolar I, however, and treatment during
the acute phase can be a particular challenge. Some clinicians
emphasize the need to talk with individuals experiencing mania,
to develop a therapeutic alliance in support of recovery
57. VALPROATE
500 – 2000 mg/d; Highest blood level for
effect. Highest dose is 60 mg/kg/d
SE’s – GI upset, weight gain, alopecia,
teratogenicity, liver problems
Best for mixed states, rapid cycling,
secondary mania. Ineffective for depression
Selenium for hair loss
58. LAMOTRIGINE
Anticonvulsant, best for Bipolar depression
Improved cognition, excellent tolerance,
serious autoimmune rash
Valproate interaction
12.5 to 25 mg/wk increments. Dose range of
75 to 300mg/d
59. GABAPENTIN
May cause persistent sedation
Excreted by kidneys only, no drug interaction
1200 to 4000 mg/dAnticonvulsant, least
effective new drug
Most helpful with anxiety, insomnia, pain
60. ATYPICAL ANTIPSYCHOTICS
Olanzepine – 2.5-20 mg/d; very effective;
significant wt gain and lipid problems in some
Risperdal - .5-4.0 mg/d; more EPS and
increased prolactin in some
Clozapine - For truly refractory patient, but
can be remarkably effective. Slow response,
serious SE profile and significant wt gain
61. NEVER GIVE UP
It will help patient to be
inspired by us, rather than the
other way around