It consist of Rib Cage:Sternum Thoracic vertebrae Ribs KINEMATICS
Ribs and manubriosternum
Ribs and thoracic vertebrae
MUSCLES ASSOCIATED WITH RIB CAGE
Primary muscles of ventilation
Secondary muscles of ventilation
PATHO-MECHANICS
Elbow complex is designed to serve hand.
They provide MOBILITY for Hand in space by apparent shortening and Lengthening of upper extremity.
They provide Stability for skillful and forceful movements
Elbow complex is designed to serve hand.
They provide MOBILITY for Hand in space by apparent shortening and Lengthening of upper extremity.
They provide Stability for skillful and forceful movements
THis PPT will give you knowledge about the principles of shoulder; articulating surface, motions, ligamentous structure and musculature structure that related to shoulder region.
Thoracic and rib cage anatomy, biomechanics, and pathomechanicsRadhika Chintamani
This slide show describes about thoracic and rib cage in detail with its anatomy, kinetics and kinematics along with force couple. the slideshow also describes about the pathology and pathomechanics related to the topic
THis PPT will give you knowledge about the principles of shoulder; articulating surface, motions, ligamentous structure and musculature structure that related to shoulder region.
Thoracic and rib cage anatomy, biomechanics, and pathomechanicsRadhika Chintamani
This slide show describes about thoracic and rib cage in detail with its anatomy, kinetics and kinematics along with force couple. the slideshow also describes about the pathology and pathomechanics related to the topic
USMLE MSK L002 Back Ligamnets and muscles of back.pdfAHMED ASHOUR
The anatomy of the back is complex and involves a combination of bones, muscles, nerves, and other structures that provide support, protection, and mobility.
The back is generally divided into several regions, including the cervical, thoracic, lumbar, sacral, and coccygeal regions.
Understanding the anatomy of the back is essential for healthcare professionals, including orthopedic specialists, physical therapists, and chiropractors, as well as for individuals interested in maintaining back health and preventing injuries.
This video explains Lumbar Disc Replacement in Detail. When degenerative disc disease begins to affect the spine this is called degenerative disc disease. This video highlights the history, epidemiology, and treatment options both conservative and surgical. If you or someone you know needs to be seen in regards to Lumbar Disc Replacement feel free to look us up online www.beverlyspine.com or www.santamonicaspine.com OR call toll free 1-8SPINECAL-1
USMLE RESP 05 thoracic wall anatomy medical chest .pdfAHMED ASHOUR
The thoracic wall refers to the skeletal and muscular structures that form the outer boundary of the thoracic cavity, providing protection to the organs within the chest in addition to running vessels and nerves.
The thoracic wall plays a crucial role in protecting the vital organs of the chest, including the heart and lungs. The coordinated action of the ribs, sternum, muscles, and diaphragm allows for the expansion and contraction of the thoracic cavity during respiration. The bony and muscular structures also contribute to the overall stability and integrity of the chest region.
Bones of Trunk (Human Anatomy)
by DR RAI M. AMMAR
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\It is a condition of the lung characterized by permanent dilatation of the air spaces distal to the terminal bronchioles with destruction of the walls of these airways.
Chronic Bronchitis
It is a disease characterized by daily cough with sputum for at least 3 months of the year for at least 2 consecutive years and airway obstruction which is irreversible.
These are cardiac anomalies arising as a result of a defect in the structure or function of the heart and great vessels which is present at birth
These lesions either obstruct blood flow in the heart or vessels near it, or alter the pathway of blood circulating through the heart
Burn is coagulative necrosis of the skin’s tissues, usually caused by excessive heat
Excess heat causes rapid protein denaturation and cell damage
Wet heat (scald) travels more rapidly into tissue than dry heat (flame)
A surface temperature of over 60˚C produces immediate cell death as well as vessel thrombosis
The dead skin tissue is known as Eschar
Modified Sweat gland
Lies in the deep pectoral
fascia
Boundaries:
clavicle superiorly,
the lateral border of the latissimus muscle laterally,
the sternum medially
inframammary fold inferiorly
Pre- Operative Assessment
Detailed History (Obsteritic & Gynecological h/o)
Chest assessment
Lung function tests (PFT)
Stage of cancer, extent of the disease
Surgical plan should be documented -length & duration of surgery, type of incision & details of the flap used for reconstruction
Assess the involvement of lymph nodes, posture, mobility
Checking of the Exercise capacity considering the patient’s tolerance
AMPUTATION:
“Surgical removal of limb or part of the limb through a bone or multiple bones”
DISARTICULATION:
“Surgical removal of hole limb or part of the limb through a joint”
Establishing the need for a surgical intervention
Confirmation of relevant physical findings and review of the clinical history and laboratory investigations that support the need of surgical intervention
Type of approach- Benefits & Risks of surgical procedure
The incision site- ease of surgery as well as cosmetic considerations
Type of anesthesia
Pulmonary rehabilitation is a comprehensive intervention based on a thorough patient assessment followed by patient tailored therapies that include, but are not limited to, exercise training, education, and behavior change, designed to improve the physical and psychological condition of people with chronic respiratory disease and to promote the long-term adherence to health-enhancing behaviors”
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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20. Movement of rib cage is a combination of
geometry governed by:
Angle of the articulation
Movement of Manubriosternum
Elasticity of the Costal Cartilage
20Dr.Nidhi Ahya(Asst Prof,COPT)
21. It is believed that CV and CT joints are mechanically
interlinked
Single axis passing through the centre both joints
Axis of upper ribs lies close to frontal plane
(allows motion in sagittal plane)
Axis of lower ribs lies close to sagittal plane
(allows motion in frontal plane)
21Dr.Nidhi Ahya(Asst Prof,COPT)
23. Anteriorly :
Thicker anterior articulation
Costal cartilage is stiffer than the
others
1st chondrosternal joint is
synchondrosis
Limit mobility
Posteriorly:
CV joint has only one facet
Increase mobility 23Dr.Nidhi Ahya(Asst Prof,COPT)
24. Take place at anterior aspect of ribs at coronal
axis
Costal cartilage become more horizontal
Ribs pushes sternum ventrally and superiorly
Excursion of manubrium is less than the body
1st rib has shortest length
Length increase caudally till 7th rib
This discrepancy cause movement at MS joint
24Dr.Nidhi Ahya(Asst Prof,COPT)
26. Elevation occurs about axis of motion lying nearly in
the sagittal plane
Have more angled shape (obliquity increases 1st-10th)
Indirect attachment anteriorly to the sternum
These factors allow the lower ribs more motion at the
lateral aspect of the rib cage
Increase the transverse diameter (BUCKLE HANDLE) 26Dr.Nidhi Ahya(Asst Prof,COPT)
28. Depends up on the orientation of the zygoepiphyseal
(ZP) joints orientation
Orientation of ZP joints are in 20* off the frontal
plane
28Dr.Nidhi Ahya(Asst Prof,COPT)
30. Recruited for quite ventilation
Diaphragm
Intercostals (Parasternals)
Sclaene
These muscle promote inspiration
Expiration is a passive process
30Dr.Nidhi Ahya(Asst Prof,COPT)
31. Accounts for 70-80% of inspiration during quite
breathing
Circular set of muscles arises from:
Sternum
Costal cartilage
Ribs
Vertebral bodies
31Dr.Nidhi Ahya(Asst Prof,COPT)
33. External and internal intercostals
Only parasternal portion are considerd as primary
muscles of ventilation
Sub costal group of muscles
Connects adjacent ribs to one another
33Dr.Nidhi Ahya(Asst Prof,COPT)
35. Attaches the rib cage to shoulder girdle, head, vertrbral
column, or pelvis
Assist with inspiration or expiration in situation of stress
When trunk is stabilized, they moves:
Vertebral column
Arm
head
35Dr.Nidhi Ahya(Asst Prof,COPT)
37. The newborn has a cartilaginous, and therefore
extremely compliant, chest wall
Chest wall muscles must act as stabilizers, rather than
mobilizers
Rib cage has more horizontal alignment of the ribs
Angle of insertion of the costal fibers of the
diaphragm also more horizontal
37Dr.Nidhi Ahya(Asst Prof,COPT)
38. Many of the articulations of the chest wall undergo
fibrosis with advancing age:
The inter-chondral and costochondral joints can fibrose,
Xiphisternal junction usually ossifies after age 40
True synovial joints may undergo morphologic changes
associated with aging, which results in reduced
mobility
Costal cartilages ossify, which interferes with their
axial rotation
Increased kyphosis: Decreases the mobility of thoracic spine
and the rib cage
38Dr.Nidhi Ahya(Asst Prof,COPT)
39. GENERAL STRUCTURE
Rib Cage:
Sternum
Thoracic vertebrae
Ribs
KINEMATICS
Ribs and manubriosternum
Ribs and thoracic vertebrae
MUSCLES ASSOCIATED WITH RIB CAGE
Primary muscles of ventilation
Secondary muscles of ventilation
39Dr.Nidhi Ahya(Asst Prof,COPT)
40. 1. Write the kinematics of the thorax? 3mrks
2. Write the upper ribs movement? 3mrks
3. Write in detail muscles of ventilation? 5mrks
40Dr.Nidhi Ahya(Asst Prof,COPT)