Carboxylic acids contain a carboxyl (-COOH) functional group. They are classified as monocarboxylic, dicarboxylic, or tricarboxylic based on the number of carboxyl groups. Carboxylic acids are named using IUPAC or common names. They are resonance stabilized and can form hydrogen bonds. Carboxylic acids are acidic due to the stability of the conjugate base. They undergo characteristic reactions like forming salts, anhydrides, esters, amides, and undergoing oxidation, reduction, decarboxylation. Common carboxylic acids and their uses include acetic acid, lactic acid, citric acid, benzoic acid, and aspirin.
This content is pharmaceutical organic chemistry -1 ,contains about aliphatic amines classification,properties and reactions of aliphatic amines dedicated to all pharmacy & healthcare ,life science students.
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C=O. It is common to several classes of organic compounds, as part of many larger functional groups. A compound containing a carbonyl group is often referred to as a carbonyl compound.
This content is pharmaceutical organic chemistry -1 ,contains about aliphatic amines classification,properties and reactions of aliphatic amines dedicated to all pharmacy & healthcare ,life science students.
In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C=O. It is common to several classes of organic compounds, as part of many larger functional groups. A compound containing a carbonyl group is often referred to as a carbonyl compound.
B.Pharm I Year II Sem. SN1 and SN2 reactions, kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols, Qualitative tests for Alcohol, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosterylalcohol, Benzyl alcohol, Glycerol, Propylene glycol
THIS SLIDE CONTAIN ABOUT QUALITATIVE TEST, STRUCTURE AND USES OF DIFFERENT CARBONYL COMPOUNDS LIKE FORMALDEHYDE, PARALDEHYDE, ACETONE, CHLORAL HYDRATE, HEXAMINE, BENZALDEHYDE, VANILIN AND CINNAMALDEHYDE
Preparation, reactions, Acidity, effect of substituents on acidity, structure and uses of carboxylic acid and identification tests for carboxylic acid, amide and ester
The combination of a carbonyl group and a hydroxyl on the same carbon atom is called a carboxyl group. Compounds containing the carboxyl group are called carboxylic acids. The carboxyl group is one of the most widely occurring functional groups in organic chemistry.
Aromatic Carboxylic acids: Carboxylic acids have an aryl group bound to the carboxyl group is known as aromatic carboxylic acids. The general formula of an aliphatic aromatic carboxylic acid is Ar-COOH.
Acidity of carboxylic acid:
A carboxylic acid may dissociate in water to give a proton and a carboxylate ion. Dissociation of a carboxylic acid involves breaking an O-H bond gives a carboxylate ion with the negative charge spread out equally over two oxygen atoms, compared with just one oxygen atom in an alkoxide ion. The delocalized charge makes the carboxylate ion more stable therefore; dissociation of a carboxylic acid to a carboxylate ion is less endothermic.
Preparation Methods:
1. Oxidation:
The oxidation of aldehyde with oxidizing agents such as CrO3 to forms carboxylic acids containing the same numbers of carbon atoms with a oxidizing agents like chromic acid, chromium trioxide. The silver oxide (Ag2O) in aqueous ammonia solution (Tollen’s reagent) is mild reagent give good yield at room temperature. E.g. Acetaldehyde reacts with CrO3 in aqueous acid to give acetic acid.
2. Grignard reagents (from CO2):
Carboxylic acid can be prepared by the reaction of Grignard reagent (alkyl magnesium halide) with carbon dioxide (CO2) in presence of dry ether. Grignard reagents react with carbon dioxide to forms a magnesium carboxylates which on hydrolysis by dilute HCl produces carboxylic acids.
3. Hydrolysis of nitrile:
The hydrolysis of nitrile or cyanide in presence of dilute acid to forms a carboxylic acid. In this reaction –CN group is converted to a –COOH group.
4. Hydrolysis Reactions:
All the carboxylic acid derivatives can be hydrolyzed into the carboxylic acid in the acidic or basic media; the hydrolysis reaction is fast and occurs in presence of water with no acid or base catalyst.
1. From Ester (Hydrolysis of ester): Ester can be hydrolyzed in either acidic or basic medium to yield carboxylic acid. The ester is heated with an excess of water contains strong acid or base catalyst.
Properties of Carboxylic Acids:
1. Low molecular weights carboxylic acids are colourless liquid at room temperature i.e. lower member ate liquid up to C9 and have characteristic odors whereas higher members are solid.
2. Carboxylic acids are polar organic compound. Low molecular weight carboxylic acids (first four members) are soluble in water whereas solubility in water decrease as molecular weight and chain lengthing increases.
3. Aromatic acids are insoluble in water.
4. Carboxylic acids have higher melting and boiling point due to their capacity to readily form stable hydrogen-bonded dimers.
B.Pharm I Year II Sem. SN1 and SN2 reactions, kinetics, order of reactivity of alkyl halides, stereochemistry and rearrangement of carbocations.
SN1 versus SN2 reactions, Factors affecting SN1 and SN2 reactions.
Structure and uses of ethylchloride, Chloroform, trichloroethylene, tetrachloroethylene,
dichloromethane, tetrachloromethane and iodoform.
Alcohols, Qualitative tests for Alcohol, Structure and uses of Ethyl alcohol, chlorobutanol, Cetosterylalcohol, Benzyl alcohol, Glycerol, Propylene glycol
THIS SLIDE CONTAIN ABOUT QUALITATIVE TEST, STRUCTURE AND USES OF DIFFERENT CARBONYL COMPOUNDS LIKE FORMALDEHYDE, PARALDEHYDE, ACETONE, CHLORAL HYDRATE, HEXAMINE, BENZALDEHYDE, VANILIN AND CINNAMALDEHYDE
Preparation, reactions, Acidity, effect of substituents on acidity, structure and uses of carboxylic acid and identification tests for carboxylic acid, amide and ester
The combination of a carbonyl group and a hydroxyl on the same carbon atom is called a carboxyl group. Compounds containing the carboxyl group are called carboxylic acids. The carboxyl group is one of the most widely occurring functional groups in organic chemistry.
Aromatic Carboxylic acids: Carboxylic acids have an aryl group bound to the carboxyl group is known as aromatic carboxylic acids. The general formula of an aliphatic aromatic carboxylic acid is Ar-COOH.
Acidity of carboxylic acid:
A carboxylic acid may dissociate in water to give a proton and a carboxylate ion. Dissociation of a carboxylic acid involves breaking an O-H bond gives a carboxylate ion with the negative charge spread out equally over two oxygen atoms, compared with just one oxygen atom in an alkoxide ion. The delocalized charge makes the carboxylate ion more stable therefore; dissociation of a carboxylic acid to a carboxylate ion is less endothermic.
Preparation Methods:
1. Oxidation:
The oxidation of aldehyde with oxidizing agents such as CrO3 to forms carboxylic acids containing the same numbers of carbon atoms with a oxidizing agents like chromic acid, chromium trioxide. The silver oxide (Ag2O) in aqueous ammonia solution (Tollen’s reagent) is mild reagent give good yield at room temperature. E.g. Acetaldehyde reacts with CrO3 in aqueous acid to give acetic acid.
2. Grignard reagents (from CO2):
Carboxylic acid can be prepared by the reaction of Grignard reagent (alkyl magnesium halide) with carbon dioxide (CO2) in presence of dry ether. Grignard reagents react with carbon dioxide to forms a magnesium carboxylates which on hydrolysis by dilute HCl produces carboxylic acids.
3. Hydrolysis of nitrile:
The hydrolysis of nitrile or cyanide in presence of dilute acid to forms a carboxylic acid. In this reaction –CN group is converted to a –COOH group.
4. Hydrolysis Reactions:
All the carboxylic acid derivatives can be hydrolyzed into the carboxylic acid in the acidic or basic media; the hydrolysis reaction is fast and occurs in presence of water with no acid or base catalyst.
1. From Ester (Hydrolysis of ester): Ester can be hydrolyzed in either acidic or basic medium to yield carboxylic acid. The ester is heated with an excess of water contains strong acid or base catalyst.
Properties of Carboxylic Acids:
1. Low molecular weights carboxylic acids are colourless liquid at room temperature i.e. lower member ate liquid up to C9 and have characteristic odors whereas higher members are solid.
2. Carboxylic acids are polar organic compound. Low molecular weight carboxylic acids (first four members) are soluble in water whereas solubility in water decrease as molecular weight and chain lengthing increases.
3. Aromatic acids are insoluble in water.
4. Carboxylic acids have higher melting and boiling point due to their capacity to readily form stable hydrogen-bonded dimers.
Alkanes, Alkenes, Alkynes, Alkyl Halides, Alicyclic Hydrocarbons, Alcohols,
Ethers and Epoxides, Aldehydes and Ketones, Carboxylic Acids and their
Functional Derivatives
12 Aldehydes Ketones and Carboxylic Acids 1.pptxNarendra Chinna
It is useful for intermediate students and for prepare who are write Emcet and intermediate and jee students for all ఆర్గానిక్ కెమిస్ట్రీ ఇస్ మోస్ట్ ఇంపార్టెంట్ కెమిస్ట్రీ అండ్ దిస్ ఇస్ ద చాప్టర్ మెయిన్స్ లాట్ ఆఫ్ క్యూస్షన్స్ విత్ అదర్
The current presentation explains basics of chromophore and auxochrome concept, types of absorption shift, effect of solvent, its polarity and effect of conjugation on absorption in uv-visible spectroscopy.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
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A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
2. • Organic compounds containing –COOH group.
• Based on number of carboxyl groups; acids can be
monocarboxylic acids, dicarboxylic acids or tricarboxyic
acids.
Nomenclature of carboxylic acids:
• Many carboxylic acids are known by their common names.
• These common names are often formed by adding the suffix
“ic” + acid to the common names for aldehydes and ketones.
OR
OH
3. • In IUPAC Nomenclature system, suffix –oic acid is used after
parent hydrocarbon chain name.
Structure of carboxylic acids:
Carboxylic acid is a resonance hybrid of structure I and II
OR
O
OR
O
H
I II
H
OR
OH
resonance hybrid
4. • After removal of hydrogen, carboxylate ion is formed that is
more resonance stabilized.
• Due to the formation of more stable carboxylate ion,
carboxylic compounds exhibit acidic behaviour.
OR
OH
-H+
OR
O
OR
O
OR
O
5. Method of Preparation
1. Oxidation of primary alcohols:
2. Oxidation of aldehydes:
3. Hydrolysis of nitriles:
R OH
K2Cr2O7/H+
R OH
O
R H
KMnO4/H+
R OH
OO
N
2H2O+
(i) OH-
(ii) H+ OH
O
+ NH3
6. 4. From Grignard reagent:
5. Arndt Eistert Reaction: increases no. of c-atoms
Mg
Br
+ O C O
O
O
MgBr
H3O+
OH
O
R OH
O
R Cl
O
R CHN2
O
R
OH
O
SOCl2
CH2N2
Ag2O / H2O
7. Physical properties
• Aliphatic acids up to C4 are water soluble and higher acids are
generally insoluble in water due to larger alkyl chains.
• Acids generally have high boiling points than corresponding
alcohols due to their ability to make stronger hydrogen bonds.
• Carboxylic acids mainly exists as cyclic dimer by forming H-
bond in solutions.
R O
O
H
RO
O
H
8. Chemical Properties
1. Acidic Character:
Carboxylic acids make salts with bases.
The acid strength mainly depends on following factors:
– conjugate acid base pairs
– Polarity of O-H bond
– Relative stabilities of conjugate bases
The greater is the stability of acid anion (conjugate base),
greater will be the acidity of corresponding carboxylic acid.
OH
O
+ NaOH
O
O
Na + H2O
9. • The relative stability of acid anion depends on the following
factors:
– Resonance effect
– Inductive effect
– Intramolecular hydrogen bonding
– Solvation effect
– Ortho effect
1. Resonance Effect
• The acidity depends on number of contributing resonance
structures.
• Greater is the number of contributing structures, more is the
stability of resonance hybrid and greater is the delocalization
of electrons
10. 2. Inductive Effect
In general, electron withdrawing groups (-I) increase the
acidity and electron releasing groups (+I) decrease the acidity
of carboxylic acids.
Electron releasing (+I) groups tend to increase the negative
charge on carboxylate ion and hence destabilize it and decrease
acidity of corresponding acid.
OR
OH
-H+
OR
O
OR
O
OR
O
11. Electron withdrawing (-I) groups tend to decrease and neutralize
the negative charge on carboxylate ion and hence stabilize it
and increase acidity of corresponding acid.
H OH
O
OH
O
pKa : 3.77 4.74
H3C OH
O
C
H2
OH
O
pKa : 4.74 2.86 1.25
Cl
CH OH
O
Cl
Cl
12. 3. Intramolecular H-bonding
Intramolecular hydrogen bonding stabilizes the acids and
decrease the dissociation of proton and hence decrease acidity.
In acid anion, intramolecular hydrogen bonding stabilize it,
and hence increase the acidity of corresponding acid.
O
H
O
O
Intramolecular H bond in acid anion
13. 4. Solvation Effect
If the acid anion is more solvated than parent acid, its stability
is increased and hence acidity is also increased.
Example; acetic acid is stronger acid than propionic acid in
aqueous solution because acetate ion is more solvated than
propionate ion due to small size. The propionic acid is more
stronger acid in gas phase where solvation is not observed.
14. 5. Ortho Effect
The ortho substituent to carboxylic acid always increase the
acidity of acid. e.g., ortho substituted benzoic acids are
stronger acid than benzoic acid whether the ortho group is
electron withdrawing or electron releasing in nature. This
effect is known as ortho effect.
This is observed due to combined application of inductive
effect, steric effect and intramolecular hydrogen bonding.
This effect is more prominent with OH, Cl or NO2
15. 2. Reaction with metals:
3. Conversion to acid derivatives:
Acid chlorides:
+ Zn (CH3COO)2Zn + H2
2 CH3COOH
R
O
OH
SoCl2 / PCl5 / PCl3
R
O
Cl
acid chloride
R
O
OH R
O
NH2
amide
NH3
-H2O
R
O
NH2
amide
NH3
-HCl
R
O
OH
SoCl2
R
O
Cl
acid chloride
Amides:
16. R
O
OH
R'-OH + H+
R
O
O
Ester
H2OR' +
R'-OH
R
O
O
Ester
R'-HCl
R
O
OH
SoCl2
R
O
Cl
acid chloride
R
O
OH
+
R'
O
Cl
acid chloride
R O
O
R'
O
acid anhydridecarboxylic acid
pyridine
-HCl
Acid Anhydrides:
Esters:
R
O
ONa
+
R'
O
Cl
acid chloride
R O
O
R'
O
acid anhydridecarboxylic acid salt
-NaCl
17. 4. Reduction to alcohols:
5. Hunsdiecker Reaction: to get alkyl halides
6. Curtius Reaction: to get primary amine with one carbon less
R
C
OH
O
LiAlH4
R
H2
C
OH
R
C
OAg
O
Br2 + CCl4
R-Br + AgBr + CO2
R
O
N3
acyl azide
NaN3
R
O
OH
SoCl2
R
O
Cl
acid chloride
-N2
N C OR
isocyanate
R-NH2 + CO2
hydrolysis
24. Qualitative tests of carboxylic acids
a) Litmus Test: Place a drop of solution of carboxylic acid
sample on a blue litmus paper. If blue litmus turns red, it
indicates the presence of acid.
b) Sodium Bicarbonate test: carboxylic acids reacts with
sodium bicarbonate to produce salt of acid with the
evolution of carbon dioxide gas in the form of
effervescence.
Add saturated sodium bicarbonate solution to aq. solution
of sample, brisk effervescence indicates the presence of
acid.
R OH
O
NaHCO3
R ONa
O
+ CO2+H2O
25. c) Ester Formation Test: Heat gently 0.5g of acid sample with 1
ml of ethanol i.p.o. few drops of conc. Sulphuric acid for about
one minute. Cool and pour into water and note the odour. The
fruit like odor indicates the formation of ester and hence
presence of carboxylic acid in sample.
R
O
OH
R'-OH + H+
R
O
O
Ester
H2OR' +
Fruity odor
26. Qualitative tests of amides
a) Alkali Test: primary amides can be decomposed by boiling with
alkali and ammonia is evolved.
Boil 0.5g of sample with 5 ml of 10% NaOH solution and
observe the odor. If ammonia like odor is observed, the sample is
contains amide group.
b) Biuret Reaction: When aliphatic diamide is heated at temperature
above its m.p., ammonia is evolved and crystalline biuret is
formed which in alkaline medium gives a violet color with
CuSO4 solution.
R
O
NH2 R
O
O
NH3Na +
10% NaOH
2 NH2CONH2
H2N N
H
NH2
O O
+ NH3
Biuret
CuSO4
violet color complex
27. c) Hydroxamic acid Test: to identify primary aromatic amines.
Hydrogen peroxide reacts with aromatic primary amides to
form the hydroxamic acid, which then reacts with ferric
chloride to form ferric hydroxamate complex having violet
color.
28. Qualitative tests of Esters
a) Hydroxamic acid Test: Esters upon reaction with
hydroxylamine yields hydroxamic acid, which upon treatment
with ferric chloride forms ferric hydroxamate complex with
bluish red / violet color.
b) Hydrolysis Test: alkaline hydrolysis of esters converts ester into
acid salt and alcohol.
29. Structures and Uses
1. Acetic Acid:
Structure:
Uses:
Used as polar protic solvent.
Used in the synthesis of vinyl acetate, which is used to prepare poly vinyl
acetate (PVA) used in paints and adhesives.
Used in the preparation of acetic anhydride.
Used to preserve food e.g. vinegar is an 4-8% solution.
Used to prepare esters such as ethyl acetate, butyl acetate.
H3C OH
O
30. 2. Lactic Acid:
Structure:
Uses:
Used in topical preparations and cosmetics to adjust acidity and for its
disinfectant properties.
Used in milk products.
Lactic acid along with ammonium bicarbonate is used in mosquito attractant.
3. Tartaric Acid:
Structure:
Uses:
Potassium hydrogen tartarate is a componant of baking powder.
Sodium potassium tartarate (Rochelle salt) is an important componant of
fehling’s solution used to detect aldehydes.
Tartar emetic is used as emetic.
CH OH
O
H3C
OH
CH OH
O
CH
OH
OH
HO
O
31. 4. Citric Acid:
Structure:
Uses:
Used in confectionary and food items.
Used in benedict’s reagent.
Its magnesium salt is used as laxative.
Used as preservative in food and beverages.
5. Succinic Acid:
Structure:
Uses:
Used as precursor to polyesters.
Food additive and dietary supplement.
Used as excipient in pharmaceutical preparations to control acidity.
Used in food and beverages as acidity regulator.
CH2COOH
CH2COOH
COOHHO
HO
O
OH
O
32. 6. Oxalic Acid:
Structure:
Uses:
Used in cleaning and bleaching for removal of rust by forming ferric oxalate with Fe3+.
Used in preparation of formic acid.
Used in redox tritrations as primary standard solution.
Used to remove ink stains
7. Salicylic Acid:
Structure:
Uses:
Used to treat warts, psoriasis, dandruff and acne.
Used in the synthesis of aspirin.
Methyl salicylate is used in muscle and joint pain removing ointments and gels.
Used in preparation of azo dye.
Used in preparation of salol, an intestinal antiseptic.
HO
O
O
OH
COOH
OH
33. 8. Benzoic Acid:
Structure:
Uses:
Food preservative
Used in antifungal skin preparations.
Used as main component of gum benzoin, tincture of benzoin.
Used to prepare benzoyl chloride.
Preservative
9. Benzyl Benzoate:
Structure:
Uses:
Used topically to treat scabies.
Used in some asthma and whooping cough preparations due to vasodilating effects..
Used as mosquito repellent.
Used as solvent for cellulose derivatives, plasticizer.
COOH
O
O
34. 10. Dimethyl phthalate:
Structure:
Uses:
Used as ectoparasiticide.
Used as mosquito and flies repellent.
11. Methyl Salicylate:
Structure:
Uses:
Used as rubefacient and analgesic.
Flavouring agent
Used in antiseptic mouthwashes.
Used to mask odor of organophosphate pesticides.
O
O
O
O
CH3
CH3
OH
O
O
CH3
35. 12. Acetyl salicylic acid (Aspirin):
Structure:
Uses:
Analgesic
Antipyretic
Anti-inflammatory
Used as platlet aggregation inhibitor
In myocardial infarction
O
OH
O
CH3O