Fran Lockie, a Paediatric Emergency and retrieval specialist, gives an update on paediatric resuscitation. This talk was given at the Bedside Critical Care Conference 2012 on Daydream Island.
Advanced cardiac life support or advanced cardiovascular life support (ACLS) refers to a set of clinical interventions for the urgent treatment of cardiac arrest, stroke and other life-threatening medical emergencies, as well as the knowledge and skills to deploy those interventions.
Fran Lockie, a Paediatric Emergency and retrieval specialist, gives an update on paediatric resuscitation. This talk was given at the Bedside Critical Care Conference 2012 on Daydream Island.
Advanced cardiac life support or advanced cardiovascular life support (ACLS) refers to a set of clinical interventions for the urgent treatment of cardiac arrest, stroke and other life-threatening medical emergencies, as well as the knowledge and skills to deploy those interventions.
Basic Life support is a life saving procedure done to increase the survival of a patient suffering from any life threatening conditions like cardiac arrest, choking etc. this ppt includes BLS for children and how we can save the during cardio-respiratory arrest, choking etc.
Basic Life Support is a life saving procedure ensuring patient survival in various life-threatening conditions. It includes Chain of survival, Cardio-pulmonary Resuscitation (CPR).
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. Introduction
• is a process by which an individual’s basic cardiac and
respiratory functions can be restored and
maintained through a combination of expired air
resuscitation (EAR) and external cardiac
compressions (ECC).
• Cardiopulmonary arrest is the indication for BLS
which mean the state of pulseless apnoea , Most
common cause is hypoxia .
• Bradycardia is a sign of deterioration if you catch it
DON’T WAIT THE ARREST !!!
5. Danger
• Check for Danger
• To you
• To others
• To the Casualty
• Make the area safer or remove yourself and
casualty to an area of safety.
• If an area is too dangerous stand back and call
emergency services.
6.
7. Response
• Check the Child for a response
• Response may vary due to the age of the child.
• Most basic method of assessment is the ‘Talk &
Touch’ approach.
• Can also use the COWS Method.
C an you hear me?
O pen your eyes.
W hat is your name?
Squeeze my hand
• Rubbing on the palms of the hands or soles of an
infant’s feet may elicit a response.
8.
9. Help
• Help can be anyone nearby, but you should aim to contact a healthcare
professional or service as quickly as possible.
10.
11. Airway assessment
• In an unconscious casualty, the maintaining/gaining
a patent airway is the top priority.
• Check the airway is open and clear of obstructions.
• In an unconscious patient, the tongue is the most
common cause of obstruction.
• Also check the airway for blood, vomit & any other
foreign materials.
• If the airway is blocked, the casualty can’t breathe.
12. Airway clearance
• Clearing the airway
1. Turn child on one side.
2. Clearing visible foreign material from
mouth and nostrils.
3. If suction is available use suction to clear
material.
• Back Blows
• Chest Thrust
• Placing the child in the recovery position,
if they are breathing, and post airway
clearance can be useful.
13. Airway maneuver
• Airway manoeuvres and appropriate positioning in children can differ from
adults, dependant upon size.
• Infants (<1yr) should have their head in the horizontal or neutral position.
Head tilt/Chin lift
• Tilt head backwards (not neck)
• Support jaw at the point of the chin
Jaw Thrust
• Good if neck injury is suspected
• Difficulty with obtaining adequate
airway with Head tilt/chin lift.
14.
15. Breathing
Look, Listen & Feel
• Up to 10 secs
• Look for rise and fall of the chest
• Listen for breath sounds or air arising from the
nose or mouth
• Feel for chest wall movement
• If not breathing, and the casualty has a patent
airway, rescue breathing should be commenced.
• In clinical situations use a face mask to deliver
breaths.
16.
17. CPR
• CPR = Compression + Ventilation
• COMPRESSION RATE: 100 compressions/min
• Useful tunes to keep the rate are ‘Staying Alive’ – Bee Gees, Another one bites
the Dust and many more.
• RATIO: 30 Compressions to 2 ventilations (breaths)
• CYCLES: 5 cycles of [30:2] in approximately 2 minutes. Recheck for signs of life
at the end of cycle.
• Pause compressions to allow for ventilation.
18. CPR : Assessment
• Most important step is recognising need for CPR.
• CPR should be commenced immediately in children if;
1. Unresponsive
2. Not breathing normally
3. Not moving, signs of life.
• Lay rescuers should begin CPR, based upon the above
information. Checking for a pulse is not required or
recommended.
• For HCPs, the Brachial or Femoral pulse are typically the
easiest to assess. If pulse not identified within <10
seconds CPR should commence.
19. CPR : Where you should do it ?
• You do Chest Compressions in
approximately the same place right
through from infants to adults.
• Compressions are done in the midline on
the lower half of the sternum or the
‘centre of the chest’.
• The nipples can be used as landmarks to
guide you to where you should be doing
your compressions.
Sternum
Compressions should not be done
over the lower end of the sternum or
abdomen
20. CPR : How to do it
• Push hard and fast, with straight arms.
• Infants (<1yo)
• Use 2 fingers over the centre of the chest.
• Compress to 1/3 depth of chest wall (~4cm).
• Child (1-8yrs)
• Use heel of 1 hand, or alternatively 2 hands,
with one positioned on top of the other.
• Compress 1/3 depth of chest wall (~5cm) in
the centre of the chest.
• Greater than 8yrs = same as adult
21. CPR : Notes
• Don’t stop CPR to check for a response or
breathing – except at the end of a cycle.
• Interruptions to CPR should be minimised.
• If possible change the person giving
compressions every 2 minutes.
• CPR should continue until the casualty becomes
responsive, or a healthcare professional arrives.
22.
23. Defibrillator
• If a Defbrillator (e.g. Automated External
Defibrillator – AED) is available, apply and follow
voice prompts.
• CPR continues until the AED is present, all the pads
are in place and the AED is on.
• AEDs accurately identify heart rhythms as either
‘shockable’ or ‘non-shockable’.
• Remember when shocking the casualty to get
everyone to stand well back. Do not touch them!
24. Defibrillator
• AEDs can be used on children of any age.
• However, for small children & infants, paediatric pads and an AED
with a Paediatric functionality should be used if available.
• Large children can use the normal adults pads & AED.
• Pad Placement
• Most pads have a diagram on them illustrating where to place
them (e.g. right upper chest & left lower side).
• Pads should never be touching each other.
• In small children you can alternatively place one pad on the front
of the chest, and one on the back.