The PreciseMatch Program aims to ensure all patients have access to precisely matched blood when needed. About 5% of transfusions require precise antigen matching to avoid potentially life-threatening reactions. The program identifies unique antigen combinations in donor blood to match to patients in need through ongoing recruitment, education, testing over 600 donors per week, and filling over 1,800 requests for matched blood annually from hospitals despite being unable to fulfill some needs. More donor recruitment is needed to support the diverse patient population.