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THE NERVOUS 
SYSTEM 
Part -1 
DAWN V TOMY M.Pharm 
Asst.Professor 
Dept. Of Pharmacology 
St.JOSEPH’S COLLEGE OF PHARMACY, 
CHERTHALA.
2 
Divisions of the 
Nervous System 
• Central Nervous System (CNS) 
• Brain. 
• Spinal cord. 
• Peripheral Nervous System (PNS) consists of the cranial nerves 
and spinal nerves. The 3 divisions of PNS are: 
1. Somatic Nervous System (SNS) 
2. Autonomic Nervous System (ANS) and 
3. Enteric Nervous System.
3 
Divisions of Peripheral Nervous 
System 
• Sensory Division 
• Picks up sensory information and delivers it to the CNS 
• Motor Division 
• Carries information to muscles and glands 
• Divisions of the Motor Neurons: 
• Somatic Neurons – carries information to skeletal 
muscle. 
• Autonomic Neurons – carries information to smooth 
muscle, cardiac muscle, and glands.
5 
Divisions Nervous System 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Sensory division Sensory receptors 
Motor division 
Skeletal muscle 
Brain 
Cranial 
nerves 
Spinal 
cord Spinal 
nerves 
Central Nervous System 
(brain and spinal cord) 
(a) (b) 
Peripheral Nervous System 
(cranial and spinal nerves) 
Smooth muscle 
Cardiac muscle 
Glands 
Somatic 
Nervous 
System 
Autonomic 
Nervous 
System
Nuclei of 
neuroglia 
7 
Histology of Nerve cells 
• Cell types in neural tissue: 
• Neurons 
• Neuroglial cells (also 
known as neuroglia, glia, 
and glial cells) 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Dendrites 
Cell body 
Axon 
© Ed Reschke
8 
The Neurons 
• Neurons may vary in size and shape. 
• They may differ in length and size of their axons and dendrites. 
• Neurons share certain features: 
• Dendrites 
• A cell body 
• An axon
9 
Neuron Structure 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Chromatophilic 
substance 
(Nissl bodies) 
Cell body 
Nucleus 
Dendrites 
Impulse 
Nodes of Ranvier 
Myelin (cut) 
Axon 
Axon 
Axonal 
hillock 
Axon collateral 
Schwann 
cell 
Synaptic knob of 
axon terminal
12 
Classification of Neurons 
and Neuroglia 
• Neurons vary in function 
• They can be sensory, motor, or integrative neurons 
• Neurons vary in size and shape, and in the number of axons 
and dendrites that they may have 
• Due to structural differences, neurons can be classified into 
three (3) major groups: 
• Bipolar neurons 
• Unipolar neurons 
• Multipolar neurons
13 
Classification of Neurons: 
Structural Differences 
• Bipolar neurons 
• Two processes 
• Eyes, ears, nose 
• Unipolar neurons 
• One process 
• Ganglia of PNS 
• Sensory 
• Multipolar neurons 
• 99% of neurons 
• Many processes 
• Most neurons of 
CNS 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Dendrites 
Axon Axon 
Axon 
Direction 
of impulse 
(a) Multipolar 
Peripheral 
process 
Central 
process 
(b) Bipolar (c) Unipolar
Sensory 
receptor 
15 
Classification of Neurons: Functional 
Differences 
• Sensory Neurons 
• Afferent 
• Carry impulse to CNS 
• Most are unipolar 
• Some are bipolar 
• Interneurons 
• Link neurons 
• Aka association neurons 
or internuncial neurons 
• Multipolar 
• Located in CNS 
• Motor Neurons 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Central nervous system Peripheral nervous system 
Cell body 
Interneurons 
• Multipolar 
• Carry impulses away from CNS 
• Carry impulses to effectors 
Dendrites 
Axon 
Axon 
Sensory (afferent) neuron 
Motor (efferent) neuron 
Cell body 
Axon 
(central process) 
Axon 
(peripheral process) 
Effector 
(muscle or gland) 
Axon 
terminal
16 
Types of Neuroglial Cells 
in the CNS 
2) Astrocytes 
• CNS 
• Scar tissue 
• Mop up excess ions. 
• Induce synapse formation 
• Connect neurons to blood vessels 
•Part of Blood Brain Barrier 
3) Oligodendrocytes 
• CNS 
• Myelinating cell 
4) Ependyma or ependymal 
• CNS 
• Ciliated 
• Line central canal of spinal 
cord 
• Line ventricles of brain 
1) Microglia 
• CNS 
• Phagocytic cell
18 
Types of Neuroglial Cells 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Microglial cell 
Axon 
Oligodendrocyte 
Astrocyte 
Fluid-filled cavity 
of the brain or 
spinal cord 
Capillary 
Neuron 
Myelin 
sheath (cut) 
Node of 
Ranvier 
Ependymal 
cell
19 
Types of Neuroglial Cells 
in the PNS 
1) Schwann Cells 
• Produce myelin found on peripheral myelinated neurons 
• Speed up neurotransmission 
2) Satellite Cells 
• Support clusters of neuron cell bodies (ganglia)
21 
Regeneration of A Nerve Axon 
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
Axon 
Site of injury Schwann cells 
Changes 
over time 
(a) 
(b) 
(c) 
(d) 
(e) 
Motor neuron 
cell body 
Distal portion of 
axon degenerates 
Proximal end of injured axon 
regenerates into tube of sheath cells 
Schwann cells 
degenerate 
Schwann cells 
proliferate 
Former connection 
reestablished 
Skeletal 
muscle fiber
22 
General Functions of 
the Nervous System 
• The three general functions of the nervous system: 
• Receiving stimuli = sensory function 
• Deciding about stimuli = integrative function 
• Reacting to stimuli = motor function
23 
Functions of Nervous System 
• Sensory Function 
• Sensory receptors gather information 
• Information is carried to the CNS 
• Integrative Function 
• Sensory information used to create: 
• Sensations 
• Memory 
• Thoughts 
• Decisions 
• Motor Function 
• Decisions are acted upon 
• Impulses are carried to effectors
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 
24 
Myelination of Axons 
•White Matter 
• Contains myelinated 
axons 
• Considered fiber tracts 
• Gray Matter 
• Contains unmyelinated 
structures 
• Cell bodies, dendrites 
Dendrite 
Myelinated region of axon 
Node of Ranvier 
Axon 
(a) 
Unmyelinated 
region of axon 
Neuron 
cell body 
Neuron 
nucleus 
(c) 
Enveloping 
Schwann cell 
Schwann 
cell nucleus 
Unmyelinated 
axon 
Longitudinal 
groove
The nervous system presentation dawn part 1
The nervous system presentation dawn part 1
The nervous system presentation dawn part 1
The nervous system presentation dawn part 1
The nervous system presentation dawn part 1
The nervous system presentation dawn part 1

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The nervous system presentation dawn part 1

  • 1. THE NERVOUS SYSTEM Part -1 DAWN V TOMY M.Pharm Asst.Professor Dept. Of Pharmacology St.JOSEPH’S COLLEGE OF PHARMACY, CHERTHALA.
  • 2. 2 Divisions of the Nervous System • Central Nervous System (CNS) • Brain. • Spinal cord. • Peripheral Nervous System (PNS) consists of the cranial nerves and spinal nerves. The 3 divisions of PNS are: 1. Somatic Nervous System (SNS) 2. Autonomic Nervous System (ANS) and 3. Enteric Nervous System.
  • 3. 3 Divisions of Peripheral Nervous System • Sensory Division • Picks up sensory information and delivers it to the CNS • Motor Division • Carries information to muscles and glands • Divisions of the Motor Neurons: • Somatic Neurons – carries information to skeletal muscle. • Autonomic Neurons – carries information to smooth muscle, cardiac muscle, and glands.
  • 4.
  • 5. 5 Divisions Nervous System Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Sensory division Sensory receptors Motor division Skeletal muscle Brain Cranial nerves Spinal cord Spinal nerves Central Nervous System (brain and spinal cord) (a) (b) Peripheral Nervous System (cranial and spinal nerves) Smooth muscle Cardiac muscle Glands Somatic Nervous System Autonomic Nervous System
  • 6.
  • 7. Nuclei of neuroglia 7 Histology of Nerve cells • Cell types in neural tissue: • Neurons • Neuroglial cells (also known as neuroglia, glia, and glial cells) Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Dendrites Cell body Axon © Ed Reschke
  • 8. 8 The Neurons • Neurons may vary in size and shape. • They may differ in length and size of their axons and dendrites. • Neurons share certain features: • Dendrites • A cell body • An axon
  • 9. 9 Neuron Structure Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Chromatophilic substance (Nissl bodies) Cell body Nucleus Dendrites Impulse Nodes of Ranvier Myelin (cut) Axon Axon Axonal hillock Axon collateral Schwann cell Synaptic knob of axon terminal
  • 10.
  • 11.
  • 12. 12 Classification of Neurons and Neuroglia • Neurons vary in function • They can be sensory, motor, or integrative neurons • Neurons vary in size and shape, and in the number of axons and dendrites that they may have • Due to structural differences, neurons can be classified into three (3) major groups: • Bipolar neurons • Unipolar neurons • Multipolar neurons
  • 13. 13 Classification of Neurons: Structural Differences • Bipolar neurons • Two processes • Eyes, ears, nose • Unipolar neurons • One process • Ganglia of PNS • Sensory • Multipolar neurons • 99% of neurons • Many processes • Most neurons of CNS Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Dendrites Axon Axon Axon Direction of impulse (a) Multipolar Peripheral process Central process (b) Bipolar (c) Unipolar
  • 14.
  • 15. Sensory receptor 15 Classification of Neurons: Functional Differences • Sensory Neurons • Afferent • Carry impulse to CNS • Most are unipolar • Some are bipolar • Interneurons • Link neurons • Aka association neurons or internuncial neurons • Multipolar • Located in CNS • Motor Neurons Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Central nervous system Peripheral nervous system Cell body Interneurons • Multipolar • Carry impulses away from CNS • Carry impulses to effectors Dendrites Axon Axon Sensory (afferent) neuron Motor (efferent) neuron Cell body Axon (central process) Axon (peripheral process) Effector (muscle or gland) Axon terminal
  • 16. 16 Types of Neuroglial Cells in the CNS 2) Astrocytes • CNS • Scar tissue • Mop up excess ions. • Induce synapse formation • Connect neurons to blood vessels •Part of Blood Brain Barrier 3) Oligodendrocytes • CNS • Myelinating cell 4) Ependyma or ependymal • CNS • Ciliated • Line central canal of spinal cord • Line ventricles of brain 1) Microglia • CNS • Phagocytic cell
  • 17.
  • 18. 18 Types of Neuroglial Cells Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Microglial cell Axon Oligodendrocyte Astrocyte Fluid-filled cavity of the brain or spinal cord Capillary Neuron Myelin sheath (cut) Node of Ranvier Ependymal cell
  • 19. 19 Types of Neuroglial Cells in the PNS 1) Schwann Cells • Produce myelin found on peripheral myelinated neurons • Speed up neurotransmission 2) Satellite Cells • Support clusters of neuron cell bodies (ganglia)
  • 20.
  • 21. 21 Regeneration of A Nerve Axon Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Axon Site of injury Schwann cells Changes over time (a) (b) (c) (d) (e) Motor neuron cell body Distal portion of axon degenerates Proximal end of injured axon regenerates into tube of sheath cells Schwann cells degenerate Schwann cells proliferate Former connection reestablished Skeletal muscle fiber
  • 22. 22 General Functions of the Nervous System • The three general functions of the nervous system: • Receiving stimuli = sensory function • Deciding about stimuli = integrative function • Reacting to stimuli = motor function
  • 23. 23 Functions of Nervous System • Sensory Function • Sensory receptors gather information • Information is carried to the CNS • Integrative Function • Sensory information used to create: • Sensations • Memory • Thoughts • Decisions • Motor Function • Decisions are acted upon • Impulses are carried to effectors
  • 24. Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 24 Myelination of Axons •White Matter • Contains myelinated axons • Considered fiber tracts • Gray Matter • Contains unmyelinated structures • Cell bodies, dendrites Dendrite Myelinated region of axon Node of Ranvier Axon (a) Unmyelinated region of axon Neuron cell body Neuron nucleus (c) Enveloping Schwann cell Schwann cell nucleus Unmyelinated axon Longitudinal groove

Editor's Notes

  1. SLIDE.NO.:
  2. SLIDE.NO.: MAJOR STRUCTURES OF THE NERVOUS SYSTEM – Brain and cranial nerves, spinal cord and spinal nerves, ganglia, enteric plexuses and sensory receptors.
  3. SLIDE.NO.: HISTOLOGY OF NEURONS -
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  5. Unipolar neurons have dendrites and one axon that are fused together to form a continuous process that emerges from the cell body. Bipolar neurons have one main dendrite and one axon. They are found in the retina of the eye, in the inner ear, and in the olfactory (olfact to smell) area of the brain. Multipolar neurons usually have several dendrites and one axon. Most neurons in the brain and spinal cord are of this type.
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