Natural binders

1. SVPM's College Of
Pharmacy, Baramati
By-Jitlal Koram
SUBJECT - HERBLE
DRUG TECHNOLOGY
Guided By-
Prof. R
N.Kale sir

2. Overview
Natural excipients
* Able to know After this chapter
completion Natural excipients...
1.Definition.
2.Functions.
3.Ideal properties.
4.Types of natural excipients.
5 natural binders & its examples.

3. Types of
excipients
 Natural colorants
 Natural sweeteners
 Natural binders
 Natural diluents
 Viscosity builders
 Disintegrating agents
 Natural perfumes & flavoring agents

4. PHARMACEUTICAL EXCIPIENTS..
• Accordingto International Pharmaceutical Excipients Council:-
"substance other than the active drug substance which has been appropriately
evaluated for safety & are included in a drug delivery system to either aid the
processing of the drug delivery system during its manufacture, protect, support or
enhance stability, bioavailability, assist in product identification, or enhance any other
attributes of the overall safety & effectiveness of the drug delivery system during
storage or use."
• Pharmaceutical excipients are inactive substances added to medicinally active
compounds to formulate dosage form.

5. FUNCTION OF EXCIPIENTS :
• Add bulk to the formulation
• During manufacturing, helps to handle API.
• Assist in drug administration
• Enhance patient compliance
• Enhance drug solubility & bioavailability.
• Avoid drug degradation
• Modify the pH & osmolarity of liquid dosage form.
• Helps in particle dispersion
• Helps to mask unpleasant taste, odor, color.
• Helps to maintain stability.

6. IDEAL PROPERTIES OF EXCIPIENTS
 • They can be used practically.
 • They should be non toxic & nonirritant
 • Should be non volatile in nature.
 • Should not be affected by temperature, light & hydrolysis.
 • Should be easily available & cheap.
 • Should not have specific color, odor & taste.
 • Should possess good water & lipid solubility.
 • Should be compatible with active ingredient in the Preparation
 • Should be pharmacologically inert.

7. Natural
excipients --
NATURAL BINDERS
• Binders are excipient which binds all ingredients used in formulation to form
suitable dosage form.
Binders
Solution binder
eg. Gelatin, cellulose
Dry binders
eg. MC, PEG.
• Natural binders are less toxic, can be degraded naturally, economic, available
easily & abundantly & enhance stability & texture to dosage form.

8.  Natural binders
1. ACACIA
• Synonym: Indian gum, Babul.
• B/S: it is dried gummy exudation from the
stems & branches of Acacia arabica, A.
senegal, Fam- Leguminoseae.
• Description: it occurs as yellowish white or white flakes,
spherical spheres, powder, granules, or spray dried powder. .
C/C: Arabinose, galactose, rhamnose, & glycuronic acid.
• Chemical test: When acacia powder is treated with lead sub acetate, it gelatinizes
the aqueous solution.
Use: As a natural binder for tablets, suspending agent, emulsifying agent, thickener. As
base in pastilles & lozenges.

9.  Natural binders
1
4
3
2
2.TRAGACANTH
• Synonym: Gum tragacanth, Persian tragacanth•
B/S: dried gum obtained from plant Astragalus gummifer,
Fam- Fabaceae.
• G/S: Iraq, Iran, Syria, Turkey, Afghanistan, Pakistan & Russia.
• Description: Tragacanth has flat, lamellated, curved fragments, or straight
or spirally twisted linear pieces. It is white to yellowish in colour, translucent,
odourless with mucilagenous taste.

10. 2.TRAGACANTH
• C/C: water soluble
& water insoluble
polysacharides. Bassorin, cellulose, starch, protein & ash
•
Chemical test: when strong iodine solution is added to tragacanth,
it developes olive green colour.
• Use: used to make various
pharmaceutical formulations like creams, gels, & emulsions.

11.  Natural binders 3. STARCH
Synonym: Amido, Amidon, Amylum
• B/S: it is polysaccharide obtained
from grains like corn (Zea mays) Fam- Gramineae,
potato (Solanum tuberosum) Fam-Solanaveae,
wheat (Triticum aestivum) &
rice (Oryza sativa), fam- Poaceae.
• Description: odourless, tasteless, fine white coloured powder.
Practically insoluble in cold ethanol & in cold water.
• C/C: Amylose & amylopectin & a-glucose.

12. STARCH
• Chemical test: starch solution is heated
with HCI & then neutralized by NaOH,
the solution is heated with Fehling's solution,
brick red ppt is produced.
• Use: it is a binder of choice in wet granulation & tablet
formulation. Has wide applications in nasal, oral, periodontal novel
drug delivery system & to get site specific drug delivery.

13. NATURAL BINDERS..
• Synonym: Byco, Cryogel, Instagel, Solugel
• B/S: it is a protein obtained by partial acid or alkaline hydrolysis of
animal collagen tissues like bone, skin, tendon & ligaments. • Description:
faintly yellow amber coloured vitreous, brittle solid. Odourless & tasteless.
Practically insoluble in water, most of organic solvents, fixed oils & volatile
oils. soluble in hot water, glycerol, & acetic acid.
• C/C: Glycine (25-27%), alanine, glutamic acid, proline, arginine, aspartic
acid, hydroxy proline, isoleucine, leucine, phenylalanine & tryptophn.
4.GELATIN

14. 4.GELATIN
• Chemical test: gelatin powder, when heated with soda lime,
evolves
ammonia gas.
• Use: used in implantable delivery systems, mainly hard & soft
gelatin capsule. In formulation of suppositories, pastilles,
pessaries, pastes. Absorbable gelatin sponge acts as haemostatic
agent.also used in food industry & in photographic emulsion.

15. Any questions.......?????
.
.
.

16. Thank you....