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Dr. Mohammed Abdalla Egypt, Domiat G Hospital Adenomyosis
definition ,[object Object],[object Object]
[object Object],definition
[object Object],[object Object],[object Object],definition
[object Object],Associated factors Women's Health Center of South Orange County
[object Object],Associated factors Clinica Ostetrica e Ginecologica Luigi Mangiagalli, Department of Obstetrics and Gynaecology, University of Milano, Italy
The typical symptoms   include  ,[object Object],[object Object],[object Object],[object Object],Cyclic, cramping uterine pain beginning later in reproductive life (generally after age 35) and often associated with prolonged and heavy menses classic presentation
Pelvic pain ,[object Object]
[object Object],[object Object],19 with adenomyosis with leiomyomas 39 with leiomyomas alone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Aust N Z J Obstet Gynaecol 1988 Feb
diagnosis ,[object Object],A good gynecologist may suspect adenomyosis based on the clinical factors, but the final diagnosis usually has to wait until hysterectomy is performed . ,[object Object]
pelvic exam
pelvic exam ,[object Object],[object Object]
[object Object],pelvic exam Helen Bickerstaff
[object Object],pelvic exam Azziz R. Adenomyosis: current perspectives. Obsetet Gynecol Clin North Am Seidman JD, Kjerulff KH. Pathological findings from the Maryland Womens Health Study - practice patterns in the diagnosis of of adenomysis. International journal of Gynecolological Pathology 1996, 15:217-221
Hysterography
Hysterography  ,[object Object],[object Object],Marshak RH, Eliasoph J. The roentgen findings in adenomyosis. Radiology 1955; 64:846-51
[object Object],[object Object],Hysterography  Radiological Society of North America , Radiology, Vol 118, 581-586,1976
[object Object],Hysterography  Obstet Gynecol  1989 May;  73 :885-7
Myometrial biopsy laparoscopically or sonographically guided
Myometrial biopsy laparoscopically or sonographically guided ,[object Object],**Popp LW, Schwiedessen JP, Gaetje R. Myometrial biopsy in the diagnosis of adenomyosis uteri. Am J Obstet Gynecol 1993;
CA 125
[object Object],CA 125  Ota H, Maki M, Shidara Y, Kodoma H, Takahashi H, Hayakawa M et al.. Effects of danazol at the immunologic level in patients with adenomoysis, with special reference to autoanyibodies: multicenter cooperative study. Am J Obstet Gynecol 1992; 167:481-6.
[object Object],[object Object],CA 125  Kobayashi H, Ida W, Terao T, Kawashima Y. Molecular characteristics of the CA125 antigen produced by human endometrial epithelial cellls: comparison between eutopic and heterotopic epithelial cells. Am J Obstet Gynecol 1993; 169: 725-30.
TVUS
TVUS ,[object Object]
ULTRASOUND CHARACTERISTICS OF ADENOMYOSIS. ill defined hypoechoic areas hetrogeneous myometrial echotexture small anechioc lakes asymetrical uterine enlargement indistinct endometrial-myometrial border subendometrial halo thickening
areas of decreased signal intensity at (MR bright foci are seen On T2-weighted MR within the myometrium  characterized by the presence of heterotopic endometrial glands and stroma in the myometrium corresponds   to areas of decreased echogenicity on TVS with small echogenic   islands on TVS The ratio of heterotopic endometrial   tissue to smooth muscle  decreased echogenicity  partly determines the imaging appearance   adjacent smooth muscle hyperplasia. histopathologic ultrasonographic ,MRI correlation
normal myometrium ( M ), homogeneous echotexture The subendometrial haloas a thin hypoechoic band (arrows).  The endometrium is uniformly echogenic NORMAL
E  = endometrium myometrium is thickened ventrally and has a heterogeneous echotexture  myometrial cyst (curved arrow).  The echogenicity of the ventral myometrium is decreased relative to that of the dorsal myometrium decreased uterine echogenicity without lobulations, contour abnormality, or mass effects,  excentric endometrial cavity Adenomyosis
ULTRASOUND CHARACTERISTICS OF ADENOMYOSIS. uterine dimensions Symmetry of myometrium echogenicity of the myometrium Brosens and co-workers assessed ultrasonographic details such as: They found that The most predictive is the   ill-defined heterogeneous echotexture within the myometrium.
Accuracy of endovaginal ultrasonography in the diagnosis of diffuse adenomyosis.  20 90 50 86 17/20 (85) Asher et al. (1994) 77 86 75 53 28/56 (50) Brosens et al. (1995) 94 71 86 29/100 (29) Reinhold et al. (1995) 98 68.4 96.2 86 15/175 (86) Atzori et al. (1996) 96 71 89 89 18/119 (24) Reinhold et al. (1996) NPV% PPV% Specificity% Sensitivity% Prevalence % 86
Transvaginal ultrasonography in the differential diagnosis of adenomyoma versus leiomyoma ,[object Object],Fedele L, Bianchi S, Dorta M, Zanotti F, Brioschi D, Carinelli S Am J Obstet Gynecol  1992 Sep; 167:603-6
[object Object],Transvaginal ultrasonography in the differential diagnosis of adenomyoma versus leiomyoma Botsis D, Kassanos D, Antoniou G, Pyrgiotis E, Karakitsos P, Kalogirou D J Clin Ultrasound  1998 Jan; 26:21-5
MRI
MRI ,[object Object]
[object Object],[object Object],MRI
Comparative study MRI / TVUS
20  women with clinically suspected adenomyosis underwent MR imaging and transvaginal Sonography  Pathologic proof was obtained in all cases.  8/17 1/17 9/17 TVUS 1/17 1/17 15/17 MRI False -ve False +ve Correct diag. 17  patients were proved to have adenomyosis.  Department of Radiology, Georgetown University Medical Center,
Comparative study MRI / TVUS
studied  106  consecutive premenopausal women who underwent hysterectomy for benign reasons.  Transvaginal ultrasonography and MRI were compared with histopathologic examination as the golden standard 22  (21%) patients had adenomyosis. Department of Gynecology and Obstetrics, Aarhus University and Aarhus University Hospital, Aarhus, Denmark 60 89 COMBINED 65 68 TVUS 86 70 MRI specificity sensitivity
[object Object],MRI
[object Object],MRI
Sagittal T1-weighted MR image shows a mildly enlarged anteverted uterus. The junctional zone is isointense relative to the myometrium.
Sagittal T2-weighted MR image shows diffuse, even thickening of the junctional zone (arrows), a finding consistent with diffuse  adenomyosis
Extensive involvement of diffuse  adenomyosis  in a 42-year-old woman. Sagittal T2-weighted MR image demonstrates diffuse areas of low signal intensity involving most of the uterus (straight arrows) and punctate high-signal-intensity foci (arrowhead). A few small nabothian cysts (curved arrows) are seen in the uterine cervix.
MANEGMENT
MANEGMENT ,[object Object]
Gonadotropin releasing hormone agonists in the treatment of adenomyosis with infertility   ,[object Object],[object Object],[object Object],Obstetricts and Gynecology Hospital, Shanghai Medical University, Shanghai 200011 Zhonghua Fu Chan Ke Za Zhi  1999 Apr;  34 :214-6
conservative surgery for adenomyosis   ,[object Object],[object Object],Zhongguo Yi Xue Ke Xue Yuan Xue Bao  1998 Dec;  20 :440-4
Uterine arterial embolization in the treatment of adenomyosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Chen C, Liu P, Lu J, Yu L, Ma B, Wang J, Liu P Zhonghua Fu Chan Ke Za Zhi  2002 Feb;  37 :77-9
[object Object],[object Object],Uterine arterial embolization in the treatment of adenomyosis
THANK YOU DR.MOHAMMED ABDALLA EGYPT, DOMIAT G HOSPITAL

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adenomyosis

  • 1. Dr. Mohammed Abdalla Egypt, Domiat G Hospital Adenomyosis
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 13.
  • 14.
  • 15.
  • 17.
  • 18.
  • 19.
  • 20. Myometrial biopsy laparoscopically or sonographically guided
  • 21.
  • 23.
  • 24.
  • 25. TVUS
  • 26.
  • 27. ULTRASOUND CHARACTERISTICS OF ADENOMYOSIS. ill defined hypoechoic areas hetrogeneous myometrial echotexture small anechioc lakes asymetrical uterine enlargement indistinct endometrial-myometrial border subendometrial halo thickening
  • 28. areas of decreased signal intensity at (MR bright foci are seen On T2-weighted MR within the myometrium characterized by the presence of heterotopic endometrial glands and stroma in the myometrium corresponds to areas of decreased echogenicity on TVS with small echogenic islands on TVS The ratio of heterotopic endometrial tissue to smooth muscle decreased echogenicity partly determines the imaging appearance adjacent smooth muscle hyperplasia. histopathologic ultrasonographic ,MRI correlation
  • 29. normal myometrium ( M ), homogeneous echotexture The subendometrial haloas a thin hypoechoic band (arrows). The endometrium is uniformly echogenic NORMAL
  • 30. E = endometrium myometrium is thickened ventrally and has a heterogeneous echotexture myometrial cyst (curved arrow). The echogenicity of the ventral myometrium is decreased relative to that of the dorsal myometrium decreased uterine echogenicity without lobulations, contour abnormality, or mass effects, excentric endometrial cavity Adenomyosis
  • 31. ULTRASOUND CHARACTERISTICS OF ADENOMYOSIS. uterine dimensions Symmetry of myometrium echogenicity of the myometrium Brosens and co-workers assessed ultrasonographic details such as: They found that The most predictive is the ill-defined heterogeneous echotexture within the myometrium.
  • 32. Accuracy of endovaginal ultrasonography in the diagnosis of diffuse adenomyosis. 20 90 50 86 17/20 (85) Asher et al. (1994) 77 86 75 53 28/56 (50) Brosens et al. (1995) 94 71 86 29/100 (29) Reinhold et al. (1995) 98 68.4 96.2 86 15/175 (86) Atzori et al. (1996) 96 71 89 89 18/119 (24) Reinhold et al. (1996) NPV% PPV% Specificity% Sensitivity% Prevalence % 86
  • 33.
  • 34.
  • 35. MRI
  • 36.
  • 37.
  • 39. 20 women with clinically suspected adenomyosis underwent MR imaging and transvaginal Sonography Pathologic proof was obtained in all cases. 8/17 1/17 9/17 TVUS 1/17 1/17 15/17 MRI False -ve False +ve Correct diag. 17 patients were proved to have adenomyosis. Department of Radiology, Georgetown University Medical Center,
  • 41. studied 106 consecutive premenopausal women who underwent hysterectomy for benign reasons. Transvaginal ultrasonography and MRI were compared with histopathologic examination as the golden standard 22 (21%) patients had adenomyosis. Department of Gynecology and Obstetrics, Aarhus University and Aarhus University Hospital, Aarhus, Denmark 60 89 COMBINED 65 68 TVUS 86 70 MRI specificity sensitivity
  • 42.
  • 43.
  • 44. Sagittal T1-weighted MR image shows a mildly enlarged anteverted uterus. The junctional zone is isointense relative to the myometrium.
  • 45. Sagittal T2-weighted MR image shows diffuse, even thickening of the junctional zone (arrows), a finding consistent with diffuse adenomyosis
  • 46. Extensive involvement of diffuse adenomyosis in a 42-year-old woman. Sagittal T2-weighted MR image demonstrates diffuse areas of low signal intensity involving most of the uterus (straight arrows) and punctate high-signal-intensity foci (arrowhead). A few small nabothian cysts (curved arrows) are seen in the uterine cervix.
  • 48.
  • 49.
  • 50.
  • 51.
  • 52.
  • 53. THANK YOU DR.MOHAMMED ABDALLA EGYPT, DOMIAT G HOSPITAL