The document discusses how genetic testing and nutrigenetics can be used to personalize nutrition by adapting diets based on individuals' genetic profiles. It provides examples of how polymorphisms in various genes like LCT, AMY1, PPARG, APOC3, CYP1A2, GSTM1, SOD2, IL6 and TNF can influence dietary needs and recommendations. The goal of nutrigenetics is to develop personalized diets and nutrition advice tailored to people's unique genetic makeup.
Nanjing 2 2013 Lecture "Nutrigenomics part 2" From healthy to too much: The r...Norwich Research Park
1. The lecture discusses the role of the small intestine in metabolic flexibility and how its function is affected by dietary factors like saturated and unsaturated fats. Microarray analysis showed high-fat diets significantly impact gene expression in the small intestine, especially related to lipid metabolism.
2. Unsaturated fats are more efficiently taken up in the small intestine by activating nutrient sensing pathways like PPARs, helping prevent early pathology from a high-fat diet. Saturated fats stimulate obesity, hepatic steatosis, and affect the gut microbiota composition.
3. A systems genetics study of mouse strains found a genetically determined set point for obesity. Certain strains showed robust, strain-specific changes in obesity traits from a
You can not change your genome but can influence how it is used by healthy food patterns and lifestyle. This talk focuses on the gut as a primary gatekeeper between foods, the microbiota and the immuno-metabolic system of the host. The underlying biology is complex but well regulated if the system is not chronically overloaded.
From Nutrigenomics to Systems Nutrition - The role of nutrition in metabolic...Norwich Research Park
1) The document discusses moving beyond traditional nutrition science to a systems approach to understand the complex interactions between diet, genes, microbiome, and health.
2) A healthy gut microbiome is essential for overall health, and nutrition plays a key role in shaping the microbiome.
3) While no single "superfood" exists, eating a variety of plants foods along with minimizing highly processed foods can help maintain a flexible system and optimal health.
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...Norwich Research Park
1. The document discusses the role of nutrition challenges and sensing mechanisms in adaptation and disease. It summarizes research on how different diets affect gene expression, organ function, and disease development using mouse models.
2. One study found that a weekly alternating diet between calorie restriction and a medium-fat diet in mice protected the liver from fatty liver disease compared to mice fed a constant medium-fat or calorie-restricted diet.
3. The research suggests unsaturated fats may be more efficiently taken up in the small intestine, activating nutrient sensing pathways and preventing organ overload and early disease development, compared to saturated fats.
This document provides an overview of nutrigenomics and molecular nutrition research. It discusses:
1) The objectives of the Nutrition, Metabolism and Genomics group, which are to understand how nutrition influences metabolic health at the molecular level and to characterize the role of nutrition and lifestyle factors on translating genotype to phenotype.
2) The research lines of the group, which include metabolic health, the role of epigenetics in aging, and developing infrastructure like databases and omics technologies.
3) The challenges of aging healthily, determining what is healthy, dealing with the rise in diet-related diseases, and how our modern diets interact with our ancient genetics.
4) The concept that
We are what we eat - The role of diets in the gut-microbiota-health interactionNorwich Research Park
Lecture at Summer School Nutrigenomics in Camerino Italy Sept. 2016.
The (small) intestine has increasingly been recognized to play a key role in the early phase of pro-inflammatory disturbances e.g. by enhanced overflow of dietary components to the distal intestine (ileum, colon) and affecting the gut microbiota & their metabolites (e.g. bile acids, short chain fatty acids). Transcription factors e.g. PPARγ, FXR, AHR or NRF2 are involved in host sensing mechanisms of microbial metabolites. Strong impact of dietary composition on small and large intestinal microbiota and their metabolic functions.
Targeting the (small) intestine and its microbiota with (plant) foods, bioactives, probiotics and drugs will improve gut and liver functions with strong implications for human health during life.
My recent introduction talk for the Nutrigenomics Masterclass 2011in Wageningen (The Netherlands):
How to use Nutrigenomics & molecular nutrition? From challenges to solutions
1) The document discusses nutrigenomics research on the effects of different types of dietary fats on human health. Certain long chain saturated fats are described as potentially pro-inflammatory, while unsaturated fats like omega-3 PUFAs are anti-inflammatory.
2) Studies in mice found that a high-fat diet led to heterogeneity in liver responses, with some mice developing non-alcoholic steatohepatitis (NASH) due to interactions between dysfunctional adipose tissue and the liver. Certain plasma proteins were identified as potential early biomarkers for NASH.
3) Human studies found that saturated fat-rich diets induced pro-inflammatory gene expression in adipose tissue and blood cells
Nanjing 2 2013 Lecture "Nutrigenomics part 2" From healthy to too much: The r...Norwich Research Park
1. The lecture discusses the role of the small intestine in metabolic flexibility and how its function is affected by dietary factors like saturated and unsaturated fats. Microarray analysis showed high-fat diets significantly impact gene expression in the small intestine, especially related to lipid metabolism.
2. Unsaturated fats are more efficiently taken up in the small intestine by activating nutrient sensing pathways like PPARs, helping prevent early pathology from a high-fat diet. Saturated fats stimulate obesity, hepatic steatosis, and affect the gut microbiota composition.
3. A systems genetics study of mouse strains found a genetically determined set point for obesity. Certain strains showed robust, strain-specific changes in obesity traits from a
You can not change your genome but can influence how it is used by healthy food patterns and lifestyle. This talk focuses on the gut as a primary gatekeeper between foods, the microbiota and the immuno-metabolic system of the host. The underlying biology is complex but well regulated if the system is not chronically overloaded.
From Nutrigenomics to Systems Nutrition - The role of nutrition in metabolic...Norwich Research Park
1) The document discusses moving beyond traditional nutrition science to a systems approach to understand the complex interactions between diet, genes, microbiome, and health.
2) A healthy gut microbiome is essential for overall health, and nutrition plays a key role in shaping the microbiome.
3) While no single "superfood" exists, eating a variety of plants foods along with minimizing highly processed foods can help maintain a flexible system and optimal health.
‘From Molecular to Systems Nutrition. Lessons from mouse to man’ NUGO Dublin...Norwich Research Park
1. The document discusses the role of nutrition challenges and sensing mechanisms in adaptation and disease. It summarizes research on how different diets affect gene expression, organ function, and disease development using mouse models.
2. One study found that a weekly alternating diet between calorie restriction and a medium-fat diet in mice protected the liver from fatty liver disease compared to mice fed a constant medium-fat or calorie-restricted diet.
3. The research suggests unsaturated fats may be more efficiently taken up in the small intestine, activating nutrient sensing pathways and preventing organ overload and early disease development, compared to saturated fats.
This document provides an overview of nutrigenomics and molecular nutrition research. It discusses:
1) The objectives of the Nutrition, Metabolism and Genomics group, which are to understand how nutrition influences metabolic health at the molecular level and to characterize the role of nutrition and lifestyle factors on translating genotype to phenotype.
2) The research lines of the group, which include metabolic health, the role of epigenetics in aging, and developing infrastructure like databases and omics technologies.
3) The challenges of aging healthily, determining what is healthy, dealing with the rise in diet-related diseases, and how our modern diets interact with our ancient genetics.
4) The concept that
We are what we eat - The role of diets in the gut-microbiota-health interactionNorwich Research Park
Lecture at Summer School Nutrigenomics in Camerino Italy Sept. 2016.
The (small) intestine has increasingly been recognized to play a key role in the early phase of pro-inflammatory disturbances e.g. by enhanced overflow of dietary components to the distal intestine (ileum, colon) and affecting the gut microbiota & their metabolites (e.g. bile acids, short chain fatty acids). Transcription factors e.g. PPARγ, FXR, AHR or NRF2 are involved in host sensing mechanisms of microbial metabolites. Strong impact of dietary composition on small and large intestinal microbiota and their metabolic functions.
Targeting the (small) intestine and its microbiota with (plant) foods, bioactives, probiotics and drugs will improve gut and liver functions with strong implications for human health during life.
My recent introduction talk for the Nutrigenomics Masterclass 2011in Wageningen (The Netherlands):
How to use Nutrigenomics & molecular nutrition? From challenges to solutions
1) The document discusses nutrigenomics research on the effects of different types of dietary fats on human health. Certain long chain saturated fats are described as potentially pro-inflammatory, while unsaturated fats like omega-3 PUFAs are anti-inflammatory.
2) Studies in mice found that a high-fat diet led to heterogeneity in liver responses, with some mice developing non-alcoholic steatohepatitis (NASH) due to interactions between dysfunctional adipose tissue and the liver. Certain plasma proteins were identified as potential early biomarkers for NASH.
3) Human studies found that saturated fat-rich diets induced pro-inflammatory gene expression in adipose tissue and blood cells
What is health? NUGO International nutrigenomics Conference Wageningen Sept 9...Norwich Research Park
What is health? Can Nutrigenomics allow to quantify metabolic health? (YES)
My very personal conclusions of a wonderful conference (NUGO Week 2011) in Wageningen (The Netherlands) that we organized.
Costa rica Lecture 3. on 4 Oct 2012 Nutrigenomics: We are what we eat - why?Norwich Research Park
Nutrigenomics is the study of how nutrients and foods impact gene expression and phenotype. A high protein diet was shown to prevent non-alcoholic fatty liver disease in mice by enhancing lipid secretion and reducing energy utilization from food. High protein diets modulate lipid handling in the small intestine and alter the gut microbiota. Deeper genomic profiling and systems biology approaches are needed to better understand metabolic flexibility and personalize nutrition recommendations.
This document summarizes a lecture on nutrigenomics given by Michael Müller. It discusses how nutrigenomics allows quantification of the interplay between genetics, lifestyle, nutrition, and the environment in determining phenotypes. Specifically, it highlights how genome-wide transcriptome analysis can identify target genes of nutrients and biomarkers of organ health and resilience. It also provides examples of human nutrigenomics studies examining how diets high in saturated fat or polyunsaturated fat alter gene expression and inflammation. The summary concludes that nutrigenomics is enabling a transition to nutritional science 2.0 through comprehensive, integrated applications and system biology analyses.
- Diet, physical exercise, and other factors can shape the composition of the human gut microbiome. A diet high in microbiota-accessible carbohydrates promotes a diverse microbiome that supports metabolic health. Physical exercise is also able to modify the gut microbiota in beneficial ways. Visceral fat accumulation has been linked to the microbiome, and diet and microbiota may synergistically impact host visceral fat mass. Recommendations include consuming a diet rich in fibers, vitamins, and minerals that require gut microbiota to aid absorption.
Nutrigenomics imerging face of aquaculture nutritionDr. Smit Lende
Nutrigenomics is the emerging application of genomics tools to nutritional research. It allows studying how foods affect genes and how genetic differences impact nutrient responses. This is important for aquaculture, which has lagged medical research in genetics but is now a rapidly changing field. Recent nutrigenomics studies in fish include examining gene expression changes from replacing fish oil/meal with vegetable alternatives, and identifying genes involved in lipid metabolism and digestion to inform sustainable aquaculture feed development. The high-throughput data requires bioinformatics analysis to develop diets that optimize production economics and animal welfare.
This document discusses nutrigenomics, which is the study of how genes are affected by nutrients and dietary components. It covers how individual genetic variations influence nutrient metabolism and disease risk, with the goal of developing personalized diets. Key applications of nutrigenomics discussed include cardiovascular disease, bone health, diabetes, Alzheimer's, and cancer. Advances in high-throughput omics technologies and bioinformatics are enabling more comprehensive analysis of gene-diet interactions.
This document discusses nutrigenomics, which is defined as the study of how foods and their constituents affect gene expression. It provides definitions of nutrigenomics and related terms like nutrigenetics, epigenetics, and single nucleotide polymorphisms (SNPs). The document also examines how nutrigenomics research can provide insights into gene-diet interactions and their relationships to diseases like cancer, cardiovascular disease, obesity, and type 2 diabetes. Finally, it discusses some advantages and disadvantages of nutrigenomics as well as future directions for this area of research.
From Nutrigenomics to nutritional systems biology of fatty acid sensingNorwich Research Park
- The document discusses research into understanding the cellular responses to dietary lipids and fatty acids through nutrigenomics approaches such as transcriptomics.
- Key findings include identifying transcription factors like PPARs that sense fatty acids and regulate gene expression, as well as species-specific and tissue-specific differences in these responses.
- Models are being developed to better understand how nutrients regulate genes and pathways involved in lipid metabolism and energy homeostasis in different metabolic organs like the liver and intestine.
For over 25 years, ALCAT has been the pioneer in developing kits used for testing of gluten allergy. A gluten allergy kit from ALCAT is capable of determining the extent of allergy that a patient has to the 350 plus chemicals that cause gluten sensitivity.
This document discusses nutrigenomics, an emerging field that examines the relationship between nutrients and the human genome using modern "omics" technologies like transcriptomics, metabolomics, epigenomics, and proteomics. It provides an overview of nutrigenomics and related fields like nutrigenetics, describes some of the experimental approaches and technologies used in nutrigenomics research, and gives examples of specific research findings like how coffee and cigarettes may help combat rare liver diseases.
This document provides an overview of nutritional genomics, which combines molecular biology, genetics, and nutrition. Nutritional genomics examines how diet, nutrients, and food components interact with an individual's genetic makeup to influence health and disease. It discusses key concepts like nutrigenomics, which focuses on how nutrients affect genes and metabolic processes, and nutrigenetics, which examines how genetic variations influence interactions between diet and health. The document also outlines some tools and techniques used in nutritional genomics, such as analyzing single nucleotide polymorphisms to understand individual responses to nutrients.
Nutrigenomics is the study of how nutrients and other food components influence gene expression and health. It considers how an individual's genetic makeup influences their response to different diets. The main concepts are that specific diets can modulate health by influencing gene expression, genetic factors affect disease risk, and personalized diets based on genetics may lower risk. Improper diets are linked to disease risk, while certain foods and chemicals can alter gene expression or genome structure. An individual's response depends on their genetic profile, like single nucleotide polymorphisms. Nutrigenomics studies seek to develop personalized diets to prevent diseases based on genetic risk factors.
This study explored how a high-fat diet and gut microbiomes affect RIP140 knockdown mice that are resistant to diet-induced type 2 diabetes. The researchers hypothesized that a high-fat diet would increase inflammation and insulin resistance in wild type mice but not knockdown mice. They also hypothesized that transplanting gut microbiomes from knockdown mice to wild type mice would make the wild type mice less susceptible to diet-induced diabetes. The researchers fed different groups of wild type and knockdown mice normal and high-fat diets, and transplanted gut microbiomes between groups. They found that transplanting gut microbiomes from knockdown mice prevented diet-induced metabolic disorders in wild type mice. The researchers concluded that RIP140
Nutrigenetics: Possibilities and limitations in the treatment of overweight...Diana Gessner
1) The document discusses nutrigenetics and its potential role in treating overweight and obesity. It outlines several candidate genes associated with obesity like FTO and genes involved in the leptin/melanocortin pathway.
2) Large genome-wide studies have identified hundreds of genetic loci associated with obesity but genetics only accounts for a small percentage of BMI variation. Environmental factors are still the major driver of obesity.
3) While leptin therapy reduced weight in leptin-deficient individuals, it did not significantly reduce weight in common obesity cases. Further research is still needed to determine nutrigenetic approaches for obesity treatment and prevention.
Nutrigenomics is an emerging scientific discipline that studies the effects of foods and dietary components on gene expression. It explores how nutrients and bioactive compounds in food can turn genes on and off and influence our health. Some key points covered in the document include:
- Nutrigenomics uses tools from fields like genetics, molecular biology, and genomics to study nutrient-gene interactions.
- Certain nutrients consumed during critical periods of development can modulate gene imprinting and influence long-term health outcomes.
- Omega-3 fatty acids from foods like fish have been shown to downregulate genes associated with heart disease and upregulate genes related to cardiovascular health.
- Nutrigenomics research is providing insights into personalized
The document discusses the nutrigenomic effects of zinc and selenium. It provides an overview of nutrigenomics and how nutrients can regulate gene expression and body functions. It then focuses on the specific roles of zinc and selenium from a nutrigenomic perspective. Zinc is shown to play roles in gene expression, appetite control, fat absorption and antioxidant defense by regulating genes like metallothionein. Studies demonstrate how zinc deficiency and supplementation impact insulin signaling and inflammation-related gene expression. Similarly, selenium is incorporated into selenoproteins that are involved in antioxidant functions. Studies examine how selenium intake influences transcription factors and selenoprotein expression levels in different tissues.
This document discusses nutrigenomics, which examines how diet interacts with an individual's genes and health. It describes how macronutrients and micronutrients can influence gene expression and molecular pathways related to energy homeostasis, nutrient absorption, cell proliferation, growth, immunity and normal body function. Specific examples are given of how fatty acids and glucose impact liver and adipose gene expression related to metabolism. The document also outlines techniques used in nutrigenomics research like RT-PCR, microarrays, and reporter systems that allow analysis of gene expression and regulation in response to dietary components.
Nutrigenomics is the study of how nutrients and bioactive food components influence gene expression and how genetic variations affect individual responses to specific foods or nutrients. It seeks to understand how diet influences health and disease risk based on a person's genetic makeup. Key concepts include that specific diets can modulate health by influencing gene expression, genetic polymorphisms affect disease risk and response to diet, and personalized diets based on genetics may lower disease risk. Nutrigenomics research is providing insights into relationships between nutrition, genes, and chronic diseases like obesity, cardiovascular disease, and cancer.
The document discusses nutrigenomics and nutrigenetics. It begins with important terms related to omics fields like genomics, nutrigenomics, and epigenetics. It then provides a basic understanding of nutrigenomics and nutrigenetics, including how genetic diversity and environmental factors affect nutrient metabolism and health outcomes. The goals of nutrigenomics are discussed, including customizing nutrition based on an individual's genetics. Experimental approaches like genomics, transcriptomics and metabolomics are used to study these fields. Examples are provided on how nutrigenomics has clarified roles of specific dietary factors and potential applications in disease prevention.
Nutrigenomics is the study of how genetic variation affects the interaction between diet and health, with the goal of improving health through tailored diets and lifestyles. It analyzes how foods and their components influence genes, while nutrigenetics focuses on genetic variants that result in different responses to nutrients. Advances in molecular biology now enable analyzing these interactions through transcriptomics, proteomics and metabolomics. While nutrigenomic testing promises personalized nutrition, concerns remain regarding its effectiveness and implications.
What is health? NUGO International nutrigenomics Conference Wageningen Sept 9...Norwich Research Park
What is health? Can Nutrigenomics allow to quantify metabolic health? (YES)
My very personal conclusions of a wonderful conference (NUGO Week 2011) in Wageningen (The Netherlands) that we organized.
Costa rica Lecture 3. on 4 Oct 2012 Nutrigenomics: We are what we eat - why?Norwich Research Park
Nutrigenomics is the study of how nutrients and foods impact gene expression and phenotype. A high protein diet was shown to prevent non-alcoholic fatty liver disease in mice by enhancing lipid secretion and reducing energy utilization from food. High protein diets modulate lipid handling in the small intestine and alter the gut microbiota. Deeper genomic profiling and systems biology approaches are needed to better understand metabolic flexibility and personalize nutrition recommendations.
This document summarizes a lecture on nutrigenomics given by Michael Müller. It discusses how nutrigenomics allows quantification of the interplay between genetics, lifestyle, nutrition, and the environment in determining phenotypes. Specifically, it highlights how genome-wide transcriptome analysis can identify target genes of nutrients and biomarkers of organ health and resilience. It also provides examples of human nutrigenomics studies examining how diets high in saturated fat or polyunsaturated fat alter gene expression and inflammation. The summary concludes that nutrigenomics is enabling a transition to nutritional science 2.0 through comprehensive, integrated applications and system biology analyses.
- Diet, physical exercise, and other factors can shape the composition of the human gut microbiome. A diet high in microbiota-accessible carbohydrates promotes a diverse microbiome that supports metabolic health. Physical exercise is also able to modify the gut microbiota in beneficial ways. Visceral fat accumulation has been linked to the microbiome, and diet and microbiota may synergistically impact host visceral fat mass. Recommendations include consuming a diet rich in fibers, vitamins, and minerals that require gut microbiota to aid absorption.
Nutrigenomics imerging face of aquaculture nutritionDr. Smit Lende
Nutrigenomics is the emerging application of genomics tools to nutritional research. It allows studying how foods affect genes and how genetic differences impact nutrient responses. This is important for aquaculture, which has lagged medical research in genetics but is now a rapidly changing field. Recent nutrigenomics studies in fish include examining gene expression changes from replacing fish oil/meal with vegetable alternatives, and identifying genes involved in lipid metabolism and digestion to inform sustainable aquaculture feed development. The high-throughput data requires bioinformatics analysis to develop diets that optimize production economics and animal welfare.
This document discusses nutrigenomics, which is the study of how genes are affected by nutrients and dietary components. It covers how individual genetic variations influence nutrient metabolism and disease risk, with the goal of developing personalized diets. Key applications of nutrigenomics discussed include cardiovascular disease, bone health, diabetes, Alzheimer's, and cancer. Advances in high-throughput omics technologies and bioinformatics are enabling more comprehensive analysis of gene-diet interactions.
This document discusses nutrigenomics, which is defined as the study of how foods and their constituents affect gene expression. It provides definitions of nutrigenomics and related terms like nutrigenetics, epigenetics, and single nucleotide polymorphisms (SNPs). The document also examines how nutrigenomics research can provide insights into gene-diet interactions and their relationships to diseases like cancer, cardiovascular disease, obesity, and type 2 diabetes. Finally, it discusses some advantages and disadvantages of nutrigenomics as well as future directions for this area of research.
From Nutrigenomics to nutritional systems biology of fatty acid sensingNorwich Research Park
- The document discusses research into understanding the cellular responses to dietary lipids and fatty acids through nutrigenomics approaches such as transcriptomics.
- Key findings include identifying transcription factors like PPARs that sense fatty acids and regulate gene expression, as well as species-specific and tissue-specific differences in these responses.
- Models are being developed to better understand how nutrients regulate genes and pathways involved in lipid metabolism and energy homeostasis in different metabolic organs like the liver and intestine.
For over 25 years, ALCAT has been the pioneer in developing kits used for testing of gluten allergy. A gluten allergy kit from ALCAT is capable of determining the extent of allergy that a patient has to the 350 plus chemicals that cause gluten sensitivity.
This document discusses nutrigenomics, an emerging field that examines the relationship between nutrients and the human genome using modern "omics" technologies like transcriptomics, metabolomics, epigenomics, and proteomics. It provides an overview of nutrigenomics and related fields like nutrigenetics, describes some of the experimental approaches and technologies used in nutrigenomics research, and gives examples of specific research findings like how coffee and cigarettes may help combat rare liver diseases.
This document provides an overview of nutritional genomics, which combines molecular biology, genetics, and nutrition. Nutritional genomics examines how diet, nutrients, and food components interact with an individual's genetic makeup to influence health and disease. It discusses key concepts like nutrigenomics, which focuses on how nutrients affect genes and metabolic processes, and nutrigenetics, which examines how genetic variations influence interactions between diet and health. The document also outlines some tools and techniques used in nutritional genomics, such as analyzing single nucleotide polymorphisms to understand individual responses to nutrients.
Nutrigenomics is the study of how nutrients and other food components influence gene expression and health. It considers how an individual's genetic makeup influences their response to different diets. The main concepts are that specific diets can modulate health by influencing gene expression, genetic factors affect disease risk, and personalized diets based on genetics may lower risk. Improper diets are linked to disease risk, while certain foods and chemicals can alter gene expression or genome structure. An individual's response depends on their genetic profile, like single nucleotide polymorphisms. Nutrigenomics studies seek to develop personalized diets to prevent diseases based on genetic risk factors.
This study explored how a high-fat diet and gut microbiomes affect RIP140 knockdown mice that are resistant to diet-induced type 2 diabetes. The researchers hypothesized that a high-fat diet would increase inflammation and insulin resistance in wild type mice but not knockdown mice. They also hypothesized that transplanting gut microbiomes from knockdown mice to wild type mice would make the wild type mice less susceptible to diet-induced diabetes. The researchers fed different groups of wild type and knockdown mice normal and high-fat diets, and transplanted gut microbiomes between groups. They found that transplanting gut microbiomes from knockdown mice prevented diet-induced metabolic disorders in wild type mice. The researchers concluded that RIP140
Nutrigenetics: Possibilities and limitations in the treatment of overweight...Diana Gessner
1) The document discusses nutrigenetics and its potential role in treating overweight and obesity. It outlines several candidate genes associated with obesity like FTO and genes involved in the leptin/melanocortin pathway.
2) Large genome-wide studies have identified hundreds of genetic loci associated with obesity but genetics only accounts for a small percentage of BMI variation. Environmental factors are still the major driver of obesity.
3) While leptin therapy reduced weight in leptin-deficient individuals, it did not significantly reduce weight in common obesity cases. Further research is still needed to determine nutrigenetic approaches for obesity treatment and prevention.
Nutrigenomics is an emerging scientific discipline that studies the effects of foods and dietary components on gene expression. It explores how nutrients and bioactive compounds in food can turn genes on and off and influence our health. Some key points covered in the document include:
- Nutrigenomics uses tools from fields like genetics, molecular biology, and genomics to study nutrient-gene interactions.
- Certain nutrients consumed during critical periods of development can modulate gene imprinting and influence long-term health outcomes.
- Omega-3 fatty acids from foods like fish have been shown to downregulate genes associated with heart disease and upregulate genes related to cardiovascular health.
- Nutrigenomics research is providing insights into personalized
The document discusses the nutrigenomic effects of zinc and selenium. It provides an overview of nutrigenomics and how nutrients can regulate gene expression and body functions. It then focuses on the specific roles of zinc and selenium from a nutrigenomic perspective. Zinc is shown to play roles in gene expression, appetite control, fat absorption and antioxidant defense by regulating genes like metallothionein. Studies demonstrate how zinc deficiency and supplementation impact insulin signaling and inflammation-related gene expression. Similarly, selenium is incorporated into selenoproteins that are involved in antioxidant functions. Studies examine how selenium intake influences transcription factors and selenoprotein expression levels in different tissues.
This document discusses nutrigenomics, which examines how diet interacts with an individual's genes and health. It describes how macronutrients and micronutrients can influence gene expression and molecular pathways related to energy homeostasis, nutrient absorption, cell proliferation, growth, immunity and normal body function. Specific examples are given of how fatty acids and glucose impact liver and adipose gene expression related to metabolism. The document also outlines techniques used in nutrigenomics research like RT-PCR, microarrays, and reporter systems that allow analysis of gene expression and regulation in response to dietary components.
Nutrigenomics is the study of how nutrients and bioactive food components influence gene expression and how genetic variations affect individual responses to specific foods or nutrients. It seeks to understand how diet influences health and disease risk based on a person's genetic makeup. Key concepts include that specific diets can modulate health by influencing gene expression, genetic polymorphisms affect disease risk and response to diet, and personalized diets based on genetics may lower disease risk. Nutrigenomics research is providing insights into relationships between nutrition, genes, and chronic diseases like obesity, cardiovascular disease, and cancer.
The document discusses nutrigenomics and nutrigenetics. It begins with important terms related to omics fields like genomics, nutrigenomics, and epigenetics. It then provides a basic understanding of nutrigenomics and nutrigenetics, including how genetic diversity and environmental factors affect nutrient metabolism and health outcomes. The goals of nutrigenomics are discussed, including customizing nutrition based on an individual's genetics. Experimental approaches like genomics, transcriptomics and metabolomics are used to study these fields. Examples are provided on how nutrigenomics has clarified roles of specific dietary factors and potential applications in disease prevention.
Nutrigenomics is the study of how genetic variation affects the interaction between diet and health, with the goal of improving health through tailored diets and lifestyles. It analyzes how foods and their components influence genes, while nutrigenetics focuses on genetic variants that result in different responses to nutrients. Advances in molecular biology now enable analyzing these interactions through transcriptomics, proteomics and metabolomics. While nutrigenomic testing promises personalized nutrition, concerns remain regarding its effectiveness and implications.
Nutrigenomics is the study of how nutrients and foods affect gene expression. It examines the interactions between an individual's genetics, diet, and health. The summary discusses three key areas:
1. Nutrigenomics research focuses on preventing chronic diseases like cancer, cardiovascular disease, and obesity by deactivating disease signaling pathways through nutrient supplements.
2. Specific nutrients can prevent these diseases. For example, polyunsaturated fatty acids can prevent cancer by regulating genes involved in cell growth, inflammation, and proliferation.
3. Personalized nutrition is an outcome of nutrigenomics and can be used to promote health through prevention and treatment of diseases, weight control, and immunity improvement.
The document discusses insights from nutrigenomics research on how diet shapes our health. It makes three key points:
1) Our "paleolithic" hunter-gatherer genes interact with modern diets high in processed foods and lack of challenges from varied whole foods. This mismatch may contribute to disease.
2) Components in plant foods like fibers can have anti-inflammatory effects and influence the gut microbiome in ways that promote health. Dietary challenges from varied whole foods that activate genes like PPARg are more beneficial than safe but nutritionally "empty" processed foods.
3) The gut microbiome plays an important role in mediating the effects of diet on health and disease. For example
This document summarizes research on the impact of dietary lipids on intestinal and systemic responses. The research found that:
1) PPARα plays a major role in intestinal fatty acid sensing and regulates target genes in response to unsaturated and monounsaturated fatty acids.
2) Genes involved in dietary lipid metabolism are regulated longitudinally along the intestine in response to PPARα activation.
3) The intestine responds to different doses of dietary fat in a robust and concentration-dependent manner by differentially regulating lipid metabolism genes.
4) Saturated fat stimulates obesity and hepatic steatosis by enhancing overflow of dietary fat to the distal intestine, affecting gut microbiota composition.
5)
Nutrigenomics is the application of genomics to nutritional research to understand how foods and dietary components influence gene expression. It studies the interactions between nutrition, genes, and health on a genome-wide scale. The goals of nutrigenomics are to identify dietary signals, understand how they interact with genes and signaling pathways, characterize target genes, and use this information to develop personalized diets that can help prevent diseases. Future applications include using nutrigenomics approaches to better understand polygenic diseases and create customized diets based on an individual's genetic profile.
The document discusses proteomics, which is the large-scale study of proteins, including their structure, function, and interactions. Proteomics uses techniques like two-dimensional gel electrophoresis and mass spectrometry to separate and identify the full complement of proteins in a cell or organism. Applications of proteomics include studying tumor metastasis, diagnosing renal disease, researching neurology and diabetes, developing new drugs, and advancing nutrition research. Proteomics is a powerful approach that provides insights into biological pathways and disease mechanisms.
This document discusses nutrigenomics, which is the study of how nutrients and bioactive compounds in food affect gene expression. It provides examples of how different nutrients like carbohydrates, fat, protein, minerals and vitamins can regulate gene expression. Key techniques in nutrigenomics like transcriptomics, proteomics and metabolomics are also summarized. The document outlines several potential applications of nutrigenomics like developing customized feeds tailored to an animal's genotype, selecting nutrients to fine-tune gene activity, and gaining insights into performance and disease.
Nutrigenomics is the science that examines the response of individuals to food compounds using post-genomic and related technologies (e.g. genomics, transcriptomics, proteomics, metabol/nomic etc.). The long-term aim of nutrigenomics is to understand how the whole body responds to real foods using an integrated approach termed 'systems biology'. The huge advantage in this approach is that the studies can examine people (i.e. populations, sub-populations - based on genes or disease - and individuals), food, life-stage and life-style without preconceived ideas.
Systems Nutrition of the Gut-Liver Axis and the Role of the MicrobiomeNorwich Research Park
This document summarizes a presentation on systems nutrition and the role of the gut-liver axis and microbiome. It discusses how the small intestine plays a key role in early pro-inflammatory disturbances by affecting the gut microbiota and their metabolites. The gut microbiota influences the intestinal and systemic metabolome and host metabolic regulation through transcription factors like PPARγ, FXR, and AHR. Beneficial bacteria like Akkermansia muciniphila may lose benefits under certain dietary conditions like heme. Targeting the small intestine and microbiota with foods, bioactives, probiotics or drugs could improve gut and liver health.
Nutrigenomics is the study of how nutrients and other food components interact with an individual's genome to affect gene expression. It examines how diet influences cellular processes and looks at individual variability in responses to foods based on genetic makeup. The main concepts are that specific diets can modulate health and disease by impacting gene expression, genetic polymorphisms influence disease risk and diet response, and personalized diets may help reduce risk for genetically predisposed individuals. Key applications of nutrigenomics include understanding how diet relates to obesity, type 2 diabetes, cardiovascular disease, cancer, and other chronic health conditions by studying gene-diet interactions and genetic variations.
Nutrigenomics attempts to study how nutrition influences gene expression and metabolic pathways. It examines the dietary signatures - patterns of gene, protein, and metabolite expression - produced in cells and tissues in response to specific nutrients. Nutrigenomics seeks to understand how these signatures impact homeostasis and may help identify early biomarkers for conditions like insulin resistance. It takes a holistic approach using omics technologies like transcriptomics, proteomics, and metabolomics. Nutrigenomics also examines how genetics and environment interact to influence nutritional needs and responses.
Metagenomics is the study of genomic material obtained directly from environmental samples rather than from isolated cultures. It allows researchers to study the 99% of microorganisms that cannot be cultured using traditional methods. There are two main approaches - sequence-driven metagenomics sequences environmental DNA and compares taxonomic relationships, while function-driven metagenomics expresses cloned genes to compare metabolic relationships and discover new enzymes/chemicals. Metagenomics has been applied to study microbes in ocean water, human gut, acid mine drainage and more extreme habitats, identifying novel genes and furthering understanding of microbial communities. Future applications include discovering new antibiotics and enzymes, studying human microbiomes and antibiotic resistance.
The document discusses the human microbiome, which refers to the trillions of microorganisms that inhabit various parts of the human body. It notes that the microbiome contains over 100 trillion bacterial cells and has more genes than the human genome. The largest and most dense microbiome is located in the gut, where microbes help break down nutrients and support human metabolism. While microbiome compositions vary between individuals and change over time, they perform similar important functions for human health.
This document provides an overview of genomics and metagenomics. It begins with an introduction to genomics, describing genome assembly, validation, and metabolic reconstruction. It then covers metagenomics, discussing its history, pitfalls, and potentials. Key points include that genomics analyzes the parts list of a single genome, while metagenomics analyzes the collective genomes of an entire microbial community. Metagenomics has been used to explore novel sequences from various environments, perform comparative analyses between ecosystems, and extract genomes from low-abundance species.
The document discusses the gut microbiota. It states that the gut contains trillions of microbes including bacteria, archaea, fungi and viruses. These microbes help digest food, harvest energy, regulate the immune system and prevent diseases like IBS and cancer. Techniques to study the gut microbiota include culturing, PCR, fluorescence in situ hybridization and direct sequencing of the 16S rRNA gene. Pyrosequencing provides high throughput sequencing of the 16S rRNA gene and allows identification of unknown bacterial species. Stool samples are commonly used to study the gut microbiota as they are easier to collect than biopsy samples.
Dr. Shamalamma S. presented on DNA microarrays. DNA microarrays allow thousands of genes to be compared simultaneously by attaching DNA probes to a chip which fluorescently labeled samples can bind to. The chip is then scanned to analyze gene expression levels. Applications include disease diagnosis, toxicology studies, and pharmacogenomics. While a powerful tool, microarrays have limitations such as lack of knowledge about many genes and lack of standardization.
This document discusses the potentials and pitfalls of metagenomics. It begins with an introduction to metagenomics and its history. It describes some of the early applications of metagenomics including exploration of microbial communities and identification of specific functions. Potential pitfalls of metagenomics are then outlined, including issues related to DNA extraction, sequencing depth, and biases. The major pitfall discussed is the incompleteness of databases for assigning taxonomy and functions. The document concludes by describing some of the potentials of metagenomics, including hunting for novel antibiotic resistance genes using functional metagenomics and extracting genomes from metagenomes through reducing microdiversity and binning sequences from multiple related samples.
Human nutrition, gut microbiome and immune system S'eclairer
Dr Zahida Chaudnary talks with the students about nutrition, gut microbiomes, and nutrition as we look at diseases and how your body reacts to what you eat.
Check out the slideshow by itself here.
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A review report on detailed study of research endeavours, undertaken on Human Microbiome, its composition, its implications, applications, disease and other role.
INTRODUCTION TO NUTRIGENETICS- GENES AND ITS FUNCTIONSAgilandeswariAT
1. The document provides an introduction to concepts in nutrigenetics including how genes influence an individual's response to nutrients. It discusses DNA variations like SNPs and how these variations make each person unique.
2. Key concepts covered include the roles of nutrigenomics, nutrigenetics, epigenetics and how environmental factors like nutrition can influence gene expression and impact health. Several gene-nutrient interactions are examined like genes involved in appetite regulation and weight management.
3. The document analyzes specific genes like FTO, ADIPOQ and APOE and how variants in these genes may impact traits like obesity risk, cholesterol levels and response to different diets. It stresses the potential for nutrigenet
This document discusses genetic factors that influence obesity and eating behaviors. It begins by outlining learning objectives around understanding the molecular basis of obesity and evaluating genetic influences on food attitudes and satiety. It then provides background on the global prevalence of obesity in various countries. The rest of the document discusses several specific genes like LCT, TCF7L2, PPARG, and ACE that influence traits like lactose intolerance and response to dieting. It emphasizes that genetics can help tailor diets and lifestyle recommendations based on an individual's genetic profile to increase success with weight loss and management.
Gabonectin Presentation 8 3 09 Power Point Fileparmoni
The document presents information on a company called LifeGen that has developed a precision nutrition approach using gene-guided nutrition. It discusses obesity and traditional weight loss approaches. It then summarizes research on the effects of the plant extract Irvingia gabonensis (IG), showing that it down regulates genes involved in fat storage and cravings while up regulating genes related to fat breakdown and insulin sensitivity. Clinical trials demonstrate IG's effects in reducing weight, blood lipids, glucose levels, and inflammation markers in both animals and humans.
The document discusses a presentation by LifeGen on their research into using genetic testing and personalized nutrition to address obesity and other health issues. It outlines their approach of using a "Genetic Positioning Map" to identify genetic predispositions and formulate nutrient dosages to normalize gene expression and compensate for metabolic imbalances. The document also reviews research on how the compound Gabonectin from the plant Irvingia gabonensis impacts genes involved in metabolic processes like PPARγ, leptin, and adiponectin expression.
The document summarizes research on Irvingia gabonensis (IG), an African plant. Studies found that IG extract:
- Reduced body weight and fat in animal and human trials by down-regulating obesity genes like PPARγ and leptin, and up-regulating adiponectin.
- Lowered blood glucose, lipids, and C-reactive protein in diabetic and hyperlipidemic models.
- Showed antioxidant effects that may protect against cardiovascular diseases.
- May help control appetite and food cravings by influencing obesity and appetite regulation genes in the brain.
Advanced Glycation Endproducts and diabetes gowri shanker
This document discusses advanced glycation end products (AGEs), which are compounds formed when sugars bind to proteins or lipids. AGEs accumulate in tissues over time and can promote oxidative stress and inflammation. The document notes that AGEs can enter the body through diet, as many cooking methods promote AGE formation, and through smoking. It explores the mechanisms by which AGEs may contribute to diseases like diabetes through depletion of antioxidant defenses. The document also discusses evidence that a low-AGE diet can help reduce circulating AGE levels and markers of oxidative stress and inflammation.
1. Nutrigenomics is the study of how nutrients and other food components influence gene expression and health. It seeks to understand how an individual's genetic makeup determines their response to different diets.
2. Specific dietary components can modulate the balance between health and disease by directly or indirectly impacting gene expression. An individual's genetic profile, including polymorphisms in nutrient-regulated genes, affects their risk of diseases.
3. Personalized diets tailored to one's genotype may help lower disease risk in genetically predisposed groups by accounting for how genetics influence the body's response to different nutrients.
Nutrigenomics is the study of how nutrients and other food components influence gene expression. It seeks to understand how nutrition impacts homeostasis at the cellular and genetic levels. The main concepts are that specific diets can modulate health and disease by affecting gene expression, an individual's genetic makeup influences their response to diet and disease risk, and personalized diets based on genetics may lower risk. Nutrigenomics examines how nutrients directly or indirectly regulate genes and how genetic variations impact nutrient metabolism and disease. It studies relationships between diet, genes and chronic diseases like obesity, diabetes, cancer and cardiovascular disease.
The document discusses how omega-3 fatty acids, specifically DHA, can affect gene expression. It explains that DHA intake can up-regulate genes involved in fatty acid oxidation while down-regulating genes involved in cholesterol and fatty acid synthesis. The document also outlines recommended daily intakes of DHA and how understanding these gene interactions is relevant for dietitians in helping to reduce chronic disease risk.
Nutrigenomics is the study of how foods and their components affect gene expression. It explores how an individual's genetic makeup influences their nutritional requirements and response to foods. Single nucleotide polymorphisms, which are small genetic differences between individuals, can change how one metabolizes and responds to diet, and influence disease risk patterns. Understanding nutrigenomics may help prevent diseases by developing personalized diets and promoting healthy lifestyle choices based on one's genetics.
This document provides information on various metabolic inborn errors including phenylketonuria, maple syrup urine disease, homocystinuria, tyrosinemia, galactosemia, glycogen storage diseases, and Niemann-Pick disease. It defines metabolic inborn errors as disorders caused by single gene defects that block metabolism. For each condition, it describes the genetic cause, signs and symptoms, diagnosis, and treatment. The document is presented as part of a biochemistry assignment on metabolic inborn errors for a health sciences university in Central America.
The Impact of Nutrition and Environmental EpigeneticsDalia Al-Rousan
1. Nutrition and environmental exposures can impact human health and disease through epigenetic mechanisms. Maternal diet and pollution exposure during pregnancy can result in epigenetic changes in offspring that affect disease risk.
2. Endocrine disrupting chemicals and other pollutants are epigenetic toxins that can cause global and gene-specific changes to DNA methylation and histone modifications, interfering with normal development and increasing cancer risk.
3. Dietary factors like nutrients from the Mediterranean diet have been associated with reduced disease risk and positive neurodevelopmental outcomes in children through epigenetic effects.
This document discusses the genetics of eating behavior and its relationship to obesity. It begins by outlining that eating behavior is influenced by physiological, psychological, social, and genetic factors. It then reviews several specific genetic influences on eating behavior, including Prader-Willi syndrome, LEP and LEPR genes associated with monogenic obesity, MC4R gene mutations linked to increased appetite and food intake, and variants in the FTO and GAD2 genes associated with obesity risk. Additional sections cover the genetics of taste preferences and their influence on food choices, as well as how genes related to hormones like ghrelin and CCK may impact meal size and selection. The document concludes that personalized treatment approaches targeting genetic mutations and behaviors could help
The document summarizes research on factors influencing cancer risk across the lifespan, from fetal development through adulthood. It discusses how characteristics like birth weight, adult height and weight, and physical activity levels impact cancer risk. Early life nutrition is particularly important, as it can program metabolic and hormonal regulation in ways that affect cancer vulnerability later in life. Maintaining the right balance of nutrients, including amino acids like glycine, appears key to supporting health and minimizing cancer risk.
The document provides information about insulin resistance and related mechanisms. It discusses how insulin resistance is caused by factors like obesity, inflammation, oxidative stress, and microbial dysbiosis. It outlines key regulators of insulin sensitivity including PPARγ, mTOR, AMPK, sirtuins, and miRNAs. The document promotes QIAGEN products for analyzing gene expression and signaling pathways involved in insulin resistance and related conditions.
This document provides an introduction to nutrigenomics and its applications. It discusses how nutrigenomics is the study of how dietary components interact with genes and alter gene expression. There are different types of food-gene interactions, including direct interactions where nutrients directly bind to receptors and regulate genes, and epigenetic interactions where nutrients can alter DNA structure and chronically change gene expression. Nutrigenomics helps understand how an individual's genetic makeup can influence their susceptibility to diet-related diseases and how personalized diets based on genetics can be used for disease prevention and treatment. The document outlines several examples of how nutrigenomics provides insights into cardiovascular, cancer, obesity and hypertension by studying genetic factors and their interaction with diet.
1. The document discusses how epigenetic mechanisms can link early life diet to cancer risk later in life.
2. It provides examples of how nutrition and environment during critical periods like prenatal, neonatal, and puberty can cause epigenetic changes that alter gene expression and disease susceptibility long-term.
3. Detecting epigenetic marks like DNA methylation in early life may help predict future disease risk, including some cancers, though more research is still needed.
Nutrigenomics: The Genome food interfacesharadabgowda
This document provides an overview of nutrigenomics, including:
- The definition of nutrigenomics as studying the relationship between human genome, nutrition and health.
- How nutrients can interact with genes through direct interaction, epigenetic interactions, and genetic variations.
- Tools and databases used in nutrigenomics research like BioConductor and the Nutritional Phenotype database.
- Examples of how nutrigenomics research can inform plant breeding to develop crops with improved nutritional profiles through approaches like marker-assisted selection and genome editing.
- Maternal nutrition and environmental exposures during pregnancy can impact the fetal epigenome through DNA methylation, histone modifications, and microRNAs. This may increase disease risk later in life.
- Certain phytochemicals from foods like epigallocatechin gallate, resveratrol, genistein, and curcumin have been shown to modulate the epigenome through effects on enzymes involved in DNA methylation and histone modification.
- A variety of dietary phytochemicals from foods commonly consumed during pregnancy may be able to cross the placenta and influence the fetal epigenome, potentially providing protection against disease programming. Further research is still needed.
- Maternal nutrition and environmental exposures during pregnancy can impact the fetal epigenome through DNA methylation, histone modifications, and microRNAs. This can increase the risk of health issues like metabolic syndrome later in life.
- Certain phytochemicals from foods like epigallocatechin gallate, resveratrol, genistein, and curcumin may beneficially influence the fetal epigenome by regulating enzymes involved in epigenetic modifications.
- Adequate intake of nutrients like vitamins, minerals, and phytochemicals during pregnancy and lactation may help protect the offspring by modulating the fetal epigenome.
NUTRIGENETICS AND PERSONALZIED NUTRITION DUBAI 2021 draft.pptxMARIA VRANCEANU
This document discusses using nutrigenetics and nutrigenomics in clinical practice for personalized nutrition and disease prevention. It provides learning objectives around understanding the molecular basis of nutrition and single nucleotide polymorphisms (SNPs) that affect dietary requirements and disease predisposition. Several examples are given of SNPs related to lactose intolerance, celiac disease, and type 2 diabetes risk. The importance of considering a person's genetic profile to design customized diets and supplement plans to prevent diseases like diabetes is emphasized.
NUTRIGENETICS AND PERSONALZIED NUTRITION DUBAI 2020.pptxMARIA VRANCEANU
This document discusses personalized nutrition using nutrigenetics and nutrigenomics in clinical practice. It describes how genetic testing can be used to understand an individual's nutritional needs and disease risks based on their genetic variations and single nucleotide polymorphisms (SNPs). SNPs may help predict disease susceptibility, dietary requirements, and drug responses. Understanding a person's genomic background through genetic testing can help design personalized diets and supplement plans tailored to their individual genetics.
Role of genetic factors in sport performance, short course MARIA VRANCEANU
This document discusses the role of genetic factors in sport performance. It outlines that genetics and heredity play an important role in determining aspects of sport performance. Family studies have shown high heritability for aerobic performance, muscular fitness, body composition and other performance related phenotypes. Certain ethnic groups like those from Kenya frequently dominate long distance running events, likely due to genetic advantages. The document examines key performance genes and how genetic testing and variations can provide insights into injury risk, nutrition needs and potential for performance enhancement.
Nutraceuticals, gene expression and healthy agingMARIA VRANCEANU
The document discusses healthy aging and the effects of nutraceuticals on gene expression. It covers several topics related to aging including the hallmarks of aging like inflammation, glycation, methylation, and oxidative stress. It provides information on maintaining healthy aging through diet, nutraceutical supplementation, and exercise. Tips are given on anti-inflammatory herbs, foods rich in omega-3, and ways to reduce advanced glycation end products and chronic inflammation.
Nutrigenetics and nutrigenomics analyze how genes influence nutrition and can be used to develop personalized nutrition plans. As genetic testing becomes more widespread, it may be possible to use sensors to recommend optimal diets based on an individual's genotype. Several genes like FTO, CCK, and CYP1A2 influence factors like appetite, meal size, and metabolism of certain foods. Understanding these gene-diet interactions could help reduce risk of diseases like cardiovascular disease, obesity, and cancer by tailoring diets. While nutrigenetic testing shows promise for personalized healthcare, consumer attitudes toward genetic testing will influence its future applications.
GENETIC DIET- Maria vranceanu dubai nutrition conferenceMARIA VRANCEANU
This 2-year study compared the effects of a ketogenic diet versus a nutrigenetic diet on weight loss and clinical parameters in 114 obese subjects. The nutrigenetic diet was personalized based on each subject's genetic test results. After 2 years, the nutrigenetic group had greater BMI loss (25.03% vs 17.62%), larger decreases in total cholesterol and blood glucose, and higher HDL levels compared to the ketogenic group. The study concludes that a nutrigenetically matched diet may be more effective than a standard ketogenic diet for long-term weight management and improvement of metabolic health markers.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
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Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
3. ASPECTS OF PERSONALIZED
NUTRITION. ADAPTING DIET
TO GENETIC PROFIL
What is Nutrigenetics?
Nutrigenomics studies how individual
differences in genes influence the
body's response to diet and nutrition.
With modern genomic data, severe
gene mutations with less severe
effects are being explored to
determine whether dietary practices
can be more closely personalized to
4. ASPECTS OF PERSONALIZED
NUTRITION. ADAPTING DIET
TO GENETIC PROFIL
Nutrigenetics: the
science of the effect of
genetic variation on
dietary response
Nutrigenomics: the
science of the effect of
nutrients and bioactive
components on gene
expression
Aim is to obtain a better
understanding of
nutrient/gene
interactions depending
on the genotype
Ultimate goal is to
develop personalized
5. The Human Genome Project(HGP)
The Human Genome Project (HGP)
was one of the great feats of
exploration in history - an inward
voyage of discovery rather than an
outward exploration of the planet
or the cosmos; an international
research effort to sequence and
map all of the genes - together
known as the genome - of
members of our species, Homo
sapiens. Completed in April 2003,
the HGP gave us the ability, for
the first time, to read nature's
complete genetic blueprint for
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
6. Let food be thy medicine andLet food be thy medicine and
medicine be thy food.medicine be thy food.
HippocrateHippocrate
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
7. When people say things like
“Heart disease runs in my
family” and “My parents had
cancer, so I’m afraid I will, too,”
it confirms our suspicions that
DNA is destiny.
The truth, however, is that it
doesn’t have to be: The DNA we
inherited from our parents does
not necessarily determine our
fate. In fact, we can modify the
behavior of our DNA and genes
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
8. Adapting diet toAdapting diet to
genetic profil?genetic profil?
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
9. Milk and LactoseMilk and Lactose
intoleranceintolerance
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
10. LCT gene
SNP
SNPs have been associated
with lactase
expressionC−13910 (C at
position -13910 upstream of
the gene LCT) and G−22018 (G
at position -22018) are related
to lactase nonpersistence
While T−13910 and A−22018
11. Lactose Intolerance – 4Lactose Intolerance – 4
kindskinds
Primary lactase
deficiency,
Secondary lactase
deficiency
Developmental lactase
deficiency
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
13. Genetics of alcohol metabolism
Alcohol metabolism occurs mainly via
hepatic oxidation and is governed by the
catalytic properties of the alcohol-
metabolizing enzymes, alcohol
dehydrogenase (ADH), and aldehyde
dehydrogenase (ALDH2).
Genetic polymorphisms in ADH1B and
ALDH2 ,
and ethnic differences in the prevalence of
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
14. Genetics of alcohol metabolism
Polymorphisms in ADH1B result in variants that
code for isozymes that tend to show a faster
rate of alcohol metabolism, ALDH2*2
polymorphism results in a “deficient” form of
ALDH2 that causes an accumulation of
acetaldehyde and its associated physiological
effects.
ADH and ALDH polymorphisms are also
associated with a protective effect on the
development of alcoholism.
The allele frequencies of ADH1B*2 , ADH1B*3 ,
and ALDH2*2 are significantly lower in
individuals diagnosed with alcohol dependence
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
15. Genetics of alcohol metabolism
Further evaluation of the factors, both
genetic and environmental, regulating the
rates of alcohol and acetaldehyde
metabolism, will help improve our
understanding of the metabolic basis and
consequences of alcohol’s effects, including
the risk and consequences of alcohol-
related organ damage, developmental
problems, as well as alcohol dependence.
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
16. The efficiency of our saliva
AMY1 provides the information for the
body to make amylase in saliva, which
is used to process carbohydrates.
People with more of this enzyme seem
to gain more nutrition from bread and
vegetables — so much so that those in
the top 10 per cent for the number of
AMY1 "copy number variations" are
eight times more likely to be obese
than those in the bottom.
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
17. The efficiency of our saliva
"People with extra copies of this amylase
gene are able more efficiently to digest
carbohydrates and starch," said Professor
Spector. “ By a small percentage difference,
over time they put on more calories than
those who have less copies — even if given
the same food.”
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
18. Testul GenoMav full nutrition
Obesity
Stress oxidative
Detoxification
Inflammation
Metabolism of vitamins, salt, lipids,
caffeine
Bone health
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
22. BMI - easy to
understand graphic
and suggestions….
«NUTRIGENETIC TESTING »
23. In Europe, this genetic variation
determines the persistence of
lactase which enables digest
lactose in all stages of life.
LCT gene
Lactose is digested by
the enzyme lactase.
In many regions of the
world its presence
decreases significantly
with age, so digesting
lactose becomes
difficult.
Polymorphism C / C
means that the person
does not possess
genetic variant that
allows durability
lactase therefore will
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
25. Diet prescription Refined
carbohydrate diet = reduction and
glycemic load (GL) <80 g / day.
PPARG gene and ACE gene
PPARG gene encoding is a
transcription factor that
influences the glucose
levels and insulin levels.
Due to the presence or
absence of polymorphism
allele Pro12 Ala influence
gene expression, and
therefore, the amount of
protein produced.
It was shown that
heterozygous individuals
for alleles Ala have
beneficial effects on blood
glucose levels and insulin.
In the case of a genotype
Pro homozygous alleles for
genotype I / I ACE gene it
is recommended reducing
consumption of refined
carbohydrates and sugars,
eating foods with low GI
(whole grains), with the
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
27. BMI - easy to
understand
grafic and
suggestions…
.
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
28. APOC3 gene and gene
LPL
Recent studies have
shown an interaction
between these two
genes and nutrition.
Apolipoprotein C3 is a
very low density
lipoprotein a (VLDL) and
consists mainly of
triglycerides. It inhibits
lipoprotein lipase APOC3
(LPL) and slows
catabolism of
triglycerides.
Genotype G / G APOC3
is associated with
elevated levels of TG.
The resulting LPL gene
(CC) contributes to
changing the lipid
profile and is associated
with low levels of HDL
Diet prescription = reducing dietary
saturated fat below 16 grams per
day, eliminating trans fats,
substituting them with a greater
amount of olive oil
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
29. CYP1A2 * 1F gene =
5
CYP1A2 is the gene
coding for the
cytochrome P450
enzyme involved in
phase I (activation)
the elimination of
toxins - such as
carcinogens of
meat and smoke -
and caffeine
metabolism . The
genotype of the
homozygous alleles
A (AA) coding for
the enzyme activity
rapidly and
therefore would be
activated quickly
prepared meat
potentially toxic
Diet perscription = drastic reduction in the
consumption of grilled meats and smoked
maximum once a week. As for caffeine, this
form of the enzyme metabolizes well.
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
30. GSTM1 Gene
GSTM1 is the gene
coding for the enzyme
glutathione S-
transferase family of
detoxifying isozymes ,
which catalyze the
conjugation different
toxic molecules with
glutathione in order
to make them less
reactive and easily
removed from the
body.
GSTM1 gene
polymorphism type
insertion / deletion, I /
D, causes loss of
enzymatic
functionality.
Diet prescription =
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
32. SOD2 gene
SOD2 is the gene coding for the
enzyme manganese superoxide
dismutase MnSOD. Located in
the mitochondrial matrix , and
is the first line of defense of
cells against free radicals (ROS)
MnSOD catalyzes dismutases of
superoxide into oxygen and
hydrogen peroxide, thereby
removing free radicals from
source.
Free radicals, although
evolutionary were appointed to
assist in the maintenance of
cellular homeostasis are toxic
molecules able to induce
oxidative damage to biological
macromolecules
indiscriminately, and are
primarily responsible for certain
pathological conditions and
aging. The genetic test
demonstrated heterozygosity for
this enzyme.
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
34. gene IL6 and TNF gene
IL6 and genaTNF are
gene, coding for pro-
inflammatory cytokines
homonyms and are
involved in the
regulation of immune
response.
Polymorphisms
present in these genes,
IL-6-174G / C and TNF-
308G / A, affect the
amount of cytokines
produced.
Polymorphism in the
gene IL-6, GC, is the
substitution of a G
(guanine) and C
(cytosine), lead to a
tendency of the
increase in the
synthesis of the
cytokines same name ,
guanine, cytosine
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
35. MTHFR gene
MTHRF is the
gene coding for
the enzyme that
is involved in the
metabolism and
use of folic acid
and vitamins B6
and B12.
This enzyme
plays a central
role in DNA
synthesis and
methylation.
The genotype of
677C / T codes for
an for less
efficient enzyme
associated wit h
increased plasma
levels of
homocysteine.
Diet prescription
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
37. VDR gene
VDR gene is
coding for the
vitamin D receptor
which affects the
production of
various proteins,
some of which are
involved in the
use of calcium.
The genotype
heterozygous for
the allele C (CT),
has been shown to
influence the
absorption of
calcium and the
bone structure.
Diet prescription=
increasing
amounts of
ASPECTS OF A
PERSONALIZED NUTRITION.
ADAPTING DIET TO GENETIC
PROFIL
39. ACE gene
ACE gene, which is coding
for the homonymous enzyme
ACE that plays a key role in
cardiovascular
homeostasis.
Gene polymorphism is
present in type insertion /
deletion (allelesI-insertion-
deletion allele D) and which
affects the enzymatic
activity.
Recent studies have
highlighted the link
between genotype I / I, I / D
and sensitivity to salt.
Test further showed that
genotype I / I are
predisposed to hypertension
when salt intake is
excessive.
It is recommended to not
consume more than 5.5
grams of salt per day, which
corresponds to 2.2 grams of
Na, the molecule
responsible for the taste of
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
41. ADH1C gene
Achohol dehydrogenase 1C
metabolizes to form
acetaldehyde, the toxic
compound responsible for the
negative effects of excessive
consumption.
In turn, acetaldehyde is
metabolized by the enzyme
aldehyde dehydrogenase in
non-toxic compounds.
The gene variant tested
produce changes in amino
acid sequence which
modifies enzyme efficiency.
For example, in the case of
the homozygous genotype A /
A alleles Ile (Ile-Ile), which
his characterized by the
presence of isoleucine in a
specific position of the
sequence amino acid,
enzyme catalytic efficiency
is elevated metabolizing
alcohol more quickly than
Val genotype.
Diet prescription = reduce
ASPECTS OF A PERSONALIZED
NUTRITION. ADAPTING DIET TO
GENETIC PROFIL
54. 10 REASONS WHY
GENETIC TESTING IS
IMPORTANT
1. Genetic testing can help determine your
course of treatment
2. Genetic testing can also help determine
screening measures for your family
3. Genetic testing as a part of newborn
screening
4-5. Genetic testing in the prenatal period.
55. 10 REASONS WHY
GENETIC TESTING IS
IMPORTANT
6. Genetic testing can qualify you for
clinical trials
7. Genetic testing can qualify you for
screening and prophylactic surgeries
8. Genetic testing can give you peace of
mind
9. Genetic testing can help scientists
create cures and medicines
10. Genetic testing may save your life
56. THE CHALLENGES OF AN
EXCITING INDUSTRY — PITFALLS
AND SELF-REGULATION IN
CONSUMER GENETICS
57. The world of consumer genetics is
an industry that presents daily
challenges. In giving any level of
personal genetic information to the
general public, there exists strict
standards to which one must hold
oneself, and crucially these
standards have to be self-
regulated.
10 REASONS WHY
GENETIC TESTING IS
IMPORTANT
58. Rebecca Robbins at STAT put together her
incredibly in-depth and commendably
researched piece looking at 5 consumer
genetic testing kits, pitting them against
each other, with the aim of finding out if:
a) there was truth in what these reports
said
b) they would explain why she was good
at certain sports
c) all the companies relayed the same
information pertaining to the genetic
markers
d) the research was sound (this wasn’t
10 REASONS WHY
GENETIC TESTING IS
IMPORTANT
59. •Is there a proven connection
between the test results and the
condition which the test predicts?
•How strong is this connection: is
it plausible, probable, or reliable?
•How large was the sample
population on which the
association was based?
•Has the evidence for this
CHOOSING THE DNA TEST
60. “I have all these great genes,
but they're recessive. That's
the problem here.”
Bill Watterson,
The Complete Calvin and Hobbes