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Presented By: LifeGen ® , Inc. ‘ Gene-Guided Precision Nutrition’ 09/23/09 Confidential Information
NOTICE The following information has not been evaluated by the Food and Drug Administration, and is not intended to diagnose, treat, cure or prevent any disease. While LifeGen believes this information is true and accurate, all information is provided “as is, with faults” and the Parties makes no representations or warranties with respect to the compliance of this information with governmental regulations. 09/23/09 Confidential Information
Obesity and Addiction 09/23/09 Confidential Information
Conceptual Framework ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Demystifying Traditional Weight Loss Tactics Old Traditional View 09/23/09 Confidential Information
Obesity Etiology: The Real Causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Obesity Etiology: The Real Causes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Obesity Etiology:  Measuring Weight Loss  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Defining and Understanding Optimal  Health and Wellness ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Body Recomposition Process The ‘Body-Friendly’ Way   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Unlocking the Neurogenetics of  Reward Linked to Optimal Health ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Paradigm Shift Utilizing A multi-pathway “Genetic Positioning Map (GPS)”-  Nutrigenomic Principles ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
09/23/09 Confidential Information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Neurophysiological and Genetic Actions of Gabonectin - Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Genetic Mechanisms 09/23/09 Confidential Information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetic Mechanisms 09/23/09 Confidential Information ,[object Object],[object Object],[object Object],[object Object],[object Object]
09/23/09 Confidential Information Efficacy The Effect of IG on    Leptin (ng/dL) 0 4 weeks 8 weeks 10 weeks Placebo 31.39 ± 1.83 29.39 ± 1.39 28.18 ± 1.84 28.45 ± 1.86 IG 32.96 ± 1.63 18.12 ± 1.38 16.84 ± 1.25 16.91 ± 1.36
09/23/09 Confidential Information Efficacy The Effect of IG on    Leptin
Genetic Mechanisms 09/23/09 Confidential Information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
09/23/09 Confidential Information Efficacy The Effect of IG on    Adiponectin ( µ g/dL) 0 4 weeks 8 weeks 10 weeks Placebo 12.11 ± 3.21 15.18 ± 3.50 14.63 ± 3.47 14.94 ± 3.92 IG 12.16 ± 3.04 24.84 ± 3.81 30.95 ± 3.96 31.59 ± 3.85
09/23/09 Confidential Information Efficacy The Effect of IG on     Adiponectin
Genetic Mechanisms 09/23/09 Confidential Information Effect of IG on PPARγ   in 3T3-L1 adipocytes.
Genetic Mechanisms 09/23/09 Confidential Information Effect of IG Extract on Leptin   in 3T3-L1 adipocytes
Genetic Mechanisms 09/23/09 Confidential Information Effect of IG on Adiponectin   in 3T3-L1 adipocytes.
Genetic Mechanisms 09/23/09 Confidential Information ,[object Object],[object Object],[object Object]
Antioxidant ,[object Object],[object Object],09/23/09 Confidential Information
09/23/09 Confidential Information Efficacy The Effect of IG on     C-Reactive Protein (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 14.62 ± 4.50 14.55 ± 4.11 14.45 ± 3.20 14.45 ± 3.96 IG 14.90 ± 4.12 9.11 ± 4.92 7.12 ± 4.44 7.15 ± 4.49
09/23/09 Confidential Information Efficacy The Effect of IG on    C-Reactive Protein
Efficacy ,[object Object],[object Object],09/23/09 Confidential Information
Efficacy ,[object Object],[object Object],[object Object],09/23/09 Confidential Information
Efficacy ,[object Object],[object Object],09/23/09 Confidential Information
Efficacy ,[object Object],[object Object],[object Object],09/23/09 Confidential Information
Efficacy ,[object Object],[object Object],09/23/09 Confidential Information
Efficacy ,[object Object],[object Object],[object Object],09/23/09 Confidential Information
Efficacy 09/23/09 Confidential Information 0.0% 0.5% 1.0% 1.5% 2.0% 2.5% 3.0% 3.5% 4.0% % Change 2 Weeks 4 Weeks Weight Loss IG Placebo -1.0% -0.5% 0.0% 0.5% 1.0% 1.5% 2.0% % Change 2 Weeks 4 Weeks Fat Loss IG Placebo -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% % Change 2 Weeks 4 Weeks Waist Reduction IG Placebo 0.0% 0.5% 1.0% 1.5% 2.0% 2.5% 3.0% 3.5% 4.0% % Change 2 Weeks 4 Weeks Hip Reduction IG Placebo
09/23/09 Confidential Information Efficacy The use of a Irvingia g. in weight management in human volunteers Julius Oben, Claudia Momo-Nguefack  and Judith Ngondi Laboratory of Nutrition and Nutritional Biochemistry, Faculty of Science, BP 8418, University of Yaounde, Yaounde, Cameroon.
RATIONALE ,[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Protocol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
09/23/09 Confidential Information Efficacy The effect of IG on  Weight (kg) 0 4 weeks 8 weeks 10 weeks Placebo 96.4 ±12.3 95.8 ±8.2 96.1 ±10.6 95.7 ±15.2 IG 97.9  ± 9.1 94.3  ± 5.5 89.7 ± 4.7 85.1 ± 3.1
09/23/09 Confidential Information Efficacy The Effect of IG on  Weight (kg)
09/23/09 Confidential Information Efficacy The Effect of IG on    Fasting Blood Glucose (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 79.42 ±11.61 78.34 ± 10.41 76.53 ± 10.42 77.32 ± 8.90 IG 85.55 ± 5.59 66.64 ± 10.29 62.74 ± 9.25 59.30 ± 4.93
09/23/09 Confidential Information Efficacy The Effect of IG on    Fasting Blood Glucose (% Change)
09/23/09 Confidential Information Efficacy The Effect of IG on    Total Cholesterol (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 146.20 ± 38.14 140.40 ± 11.10 150.06 ± 13.20 149.47 ± 19.16 IG 151.74 ± 18.52 133.74 ± 16.63 120.18 ± 11.97 111.92 ± 5.83
09/23/09 Confidential Information Efficacy The Effect of IG on    Total Cholesterol (% Change)
09/23/09 Confidential Information Efficacy The Effect of IG on    LDL Cholesterol (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 76.13 ± 8.02 79.40 ± 7.51 74.36 ± 9.02 73.87 ± 8.45 IG 82.21 ± 8.06 71.81 ± 5.92 64.73 ± 8.91 59.77 ± 4.98
09/23/09 Confidential Information Efficacy The Effect of IG on    LDL Cholesterol (% Change)
Molecular Mechanisms 09/23/09 Confidential Information α -Amylase Inhibition
09/23/09 Confidential Information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Efficacy
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
Conclusion ,[object Object],[object Object],09/23/09 Confidential Information
09/23/09 Confidential Information ,[object Object],[object Object],Intake Level
Commercialization Issues   09/23/09 Confidential Information ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Commercialization Issues ,[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
LifeGen, Inc. 09/23/09 Confidential Information
Patented Genomic Solution – Novel Exclusive   Optimal Health Nutraceutical ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information
[object Object],[object Object],[object Object],[object Object],[object Object],09/23/09 Confidential Information

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Lifegen

  • 1. Presented By: LifeGen ® , Inc. ‘ Gene-Guided Precision Nutrition’ 09/23/09 Confidential Information
  • 2. NOTICE The following information has not been evaluated by the Food and Drug Administration, and is not intended to diagnose, treat, cure or prevent any disease. While LifeGen believes this information is true and accurate, all information is provided “as is, with faults” and the Parties makes no representations or warranties with respect to the compliance of this information with governmental regulations. 09/23/09 Confidential Information
  • 3. Obesity and Addiction 09/23/09 Confidential Information
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17. 09/23/09 Confidential Information Efficacy The Effect of IG on Leptin (ng/dL) 0 4 weeks 8 weeks 10 weeks Placebo 31.39 ± 1.83 29.39 ± 1.39 28.18 ± 1.84 28.45 ± 1.86 IG 32.96 ± 1.63 18.12 ± 1.38 16.84 ± 1.25 16.91 ± 1.36
  • 18. 09/23/09 Confidential Information Efficacy The Effect of IG on Leptin
  • 19.
  • 20. 09/23/09 Confidential Information Efficacy The Effect of IG on Adiponectin ( µ g/dL) 0 4 weeks 8 weeks 10 weeks Placebo 12.11 ± 3.21 15.18 ± 3.50 14.63 ± 3.47 14.94 ± 3.92 IG 12.16 ± 3.04 24.84 ± 3.81 30.95 ± 3.96 31.59 ± 3.85
  • 21. 09/23/09 Confidential Information Efficacy The Effect of IG on Adiponectin
  • 22. Genetic Mechanisms 09/23/09 Confidential Information Effect of IG on PPARγ in 3T3-L1 adipocytes.
  • 23. Genetic Mechanisms 09/23/09 Confidential Information Effect of IG Extract on Leptin in 3T3-L1 adipocytes
  • 24. Genetic Mechanisms 09/23/09 Confidential Information Effect of IG on Adiponectin in 3T3-L1 adipocytes.
  • 25.
  • 26.
  • 27. 09/23/09 Confidential Information Efficacy The Effect of IG on C-Reactive Protein (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 14.62 ± 4.50 14.55 ± 4.11 14.45 ± 3.20 14.45 ± 3.96 IG 14.90 ± 4.12 9.11 ± 4.92 7.12 ± 4.44 7.15 ± 4.49
  • 28. 09/23/09 Confidential Information Efficacy The Effect of IG on C-Reactive Protein
  • 29.
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 35. Efficacy 09/23/09 Confidential Information 0.0% 0.5% 1.0% 1.5% 2.0% 2.5% 3.0% 3.5% 4.0% % Change 2 Weeks 4 Weeks Weight Loss IG Placebo -1.0% -0.5% 0.0% 0.5% 1.0% 1.5% 2.0% % Change 2 Weeks 4 Weeks Fat Loss IG Placebo -1.0% 0.0% 1.0% 2.0% 3.0% 4.0% 5.0% 6.0% % Change 2 Weeks 4 Weeks Waist Reduction IG Placebo 0.0% 0.5% 1.0% 1.5% 2.0% 2.5% 3.0% 3.5% 4.0% % Change 2 Weeks 4 Weeks Hip Reduction IG Placebo
  • 36. 09/23/09 Confidential Information Efficacy The use of a Irvingia g. in weight management in human volunteers Julius Oben, Claudia Momo-Nguefack and Judith Ngondi Laboratory of Nutrition and Nutritional Biochemistry, Faculty of Science, BP 8418, University of Yaounde, Yaounde, Cameroon.
  • 37.
  • 38.
  • 39. 09/23/09 Confidential Information Efficacy The effect of IG on Weight (kg) 0 4 weeks 8 weeks 10 weeks Placebo 96.4 ±12.3 95.8 ±8.2 96.1 ±10.6 95.7 ±15.2 IG 97.9 ± 9.1 94.3 ± 5.5 89.7 ± 4.7 85.1 ± 3.1
  • 40. 09/23/09 Confidential Information Efficacy The Effect of IG on Weight (kg)
  • 41. 09/23/09 Confidential Information Efficacy The Effect of IG on Fasting Blood Glucose (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 79.42 ±11.61 78.34 ± 10.41 76.53 ± 10.42 77.32 ± 8.90 IG 85.55 ± 5.59 66.64 ± 10.29 62.74 ± 9.25 59.30 ± 4.93
  • 42. 09/23/09 Confidential Information Efficacy The Effect of IG on Fasting Blood Glucose (% Change)
  • 43. 09/23/09 Confidential Information Efficacy The Effect of IG on Total Cholesterol (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 146.20 ± 38.14 140.40 ± 11.10 150.06 ± 13.20 149.47 ± 19.16 IG 151.74 ± 18.52 133.74 ± 16.63 120.18 ± 11.97 111.92 ± 5.83
  • 44. 09/23/09 Confidential Information Efficacy The Effect of IG on Total Cholesterol (% Change)
  • 45. 09/23/09 Confidential Information Efficacy The Effect of IG on LDL Cholesterol (mg/dL) 0 4 weeks 8 weeks 10 weeks Placebo 76.13 ± 8.02 79.40 ± 7.51 74.36 ± 9.02 73.87 ± 8.45 IG 82.21 ± 8.06 71.81 ± 5.92 64.73 ± 8.91 59.77 ± 4.98
  • 46. 09/23/09 Confidential Information Efficacy The Effect of IG on LDL Cholesterol (% Change)
  • 47. Molecular Mechanisms 09/23/09 Confidential Information α -Amylase Inhibition
  • 48.
  • 49.
  • 50.
  • 51.
  • 52.
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