This document discusses 3rd generation cephalosporins, including their mechanism of action, mechanisms of bacterial resistance, spectrum of activity, clinical uses, doses, adverse effects, and cautions. Key points include:
- They prevent bacterial cell wall synthesis by binding to penicillin binding proteins. They have concentration-independent bactericidal activity.
- Common mechanisms of resistance include beta-lactamase production and altered binding affinity of the drugs.
- They are very active against gram-negative aerobes and adequate for oral anaerobes. Ceftazidime is preferred for Pseudomonas infections.
- Common uses include gram-negative infections, gonorrhea, UTIs.
A PowerPoint presentation on "NSAIDS" suitable for reading by UG and PG Medical/Paramedical students of Pharmacology and Pharmacy sciences. This Ppt. is prepared for academic purpose only and already presented to my students in one of the theory classes of mine.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones
Sulphonamides Pharmacology For Pharmacy studentsMalay Pandya
This is the PowerPoint presentation of the Antimicrobial drug - SULPHOANMIDE.
Sulphonamide is the first antimicrobial agent
It Can be employed for suppressive therapy of chronic urinary tract infection, streptococcal pharyngitis and gum infection.
Combined with trimethoprim (cotrimoxazole) sulfamethoxazole is used for many bacterial infections.
This will be useful to all Pharmacy Student ...
A PowerPoint presentation on "NSAIDS" suitable for reading by UG and PG Medical/Paramedical students of Pharmacology and Pharmacy sciences. This Ppt. is prepared for academic purpose only and already presented to my students in one of the theory classes of mine.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones
Sulphonamides Pharmacology For Pharmacy studentsMalay Pandya
This is the PowerPoint presentation of the Antimicrobial drug - SULPHOANMIDE.
Sulphonamide is the first antimicrobial agent
It Can be employed for suppressive therapy of chronic urinary tract infection, streptococcal pharyngitis and gum infection.
Combined with trimethoprim (cotrimoxazole) sulfamethoxazole is used for many bacterial infections.
This will be useful to all Pharmacy Student ...
A nice introduction to Cephalosporins, how they work, the different generations, spectrum, uses, side effects, pharmacokinetics and common trade names in Egyptian market.
Ciprofloxacin 500mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Ciprofloxacin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects -: Indications, Side Effects, Warnings, Ciprofloxacin - Drug Information - Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin Taj Pharma Ciprofloxacin 500mg Film-coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Ciprofloxacin Tablets USP 250mg/500mg/750mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ciprofloxacin Dosage & Rx Info | Ciprofloxacin Uses, Side Effects Ciprofloxacin : Indications, Side Effects, Warnings, Ciprofloxacin -Drug Information –Taj Pharma, Ciprofloxacin dose Taj pharmaceuticals Ciprofloxacin interactions, Taj Pharmaceutical Ciprofloxacin contraindications, Ciprofloxacin price, Ciprofloxacin Taj Pharma Ciprofloxacin SmPC-Taj Pharma Stay connected to all updated on Ciprofloxacin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body.
is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox)), herpes zoster
lecture presented at 5th. March 2024 as part of the newly pharmacist training course about patient safety program
high alert medications
look alike sound alike medication
lecture presented at 3rd. March 2024 about the Iraqi pharmacovigilance system as part of the newly appointed pharmacist training course (2024),
Update was performed depending on the latest version of the (Iraqi Pharmacovigilance Guidelines for Healthcare Professionals) 2024
IPhVC recommendations & monitoring requirement of biosimilars, Worldwide & Iraq control of Bioproducts & biosimiliars, as well as references enlisted adverse reactions to common products used in our hospital
Lecture presented at the 31st Jan 2024 in our hospital
Systemic & inhaled Quinolone antibiotic EMA/MAHRA update considering when not to administr this groups of antibiotics
According to the Iraqi Pharmacovigilance Centre instructions
Benzyl alcohol as parenteral drugs additives
Their effects on specialist populations like pediatrics, pregnant and lactating females
With possible prepartaions were they are added
According to the Iraqi Pharmacovigilance Centre instructions
Antibiotic stewardship, Clinical pharmacyDrug information Centre, Medication...Alaa Fadhel Hassan Alwazni
Training workshop held at Al-Mahmoudiya General Hospital in 18/10/2023
about work & duties of different comittes & units realted to the clinical pharmacy & pharmacovigilance
lecture presented at Al-Mahmoudiya General hospital in the 30th Aug 2023
based upon recent governmental protocols of antibiotic selection, dosage forms conversion by MOH 2023
IV drug additives
Updated on 1st Aug 2023
Refrences:
British National Formulary, (Sep. 2022) v3.1.6 android application
* Medscape, (July, 2023) v1131.0 & v181.0 android application
**Others: Elsevier’s Intravenous Medications: A Handbook for Nurses and Health Professionals,
Mosby’s Drug Reference for Health Professions,
Drugs.com website, Professionals, AFHS Monographs,
Electronic Medicines Compendium (emc) website,
& MMS home website, Drugs, Info.
The medical ethics lecture was presented online as part of the newly - employed pharmacists training course on 23/5/2023
Al-Mahmoudiya General Hospital
High alert medications (HAM)
Lecture presented in the unit of clinical pharmacy, Al-Mahmoudiya General Hospital
As part of the training course for clinical pharmacy 22/5/2023
brief review on clinical pharmacy, drug information centre & patient safety program
The lecture was presented at Al-Mahmoudiya General Hospital as part of the training course for fresh appointed pharmacist at 16/5/2023 at 11 & 15/5/2023
Intravenous dextrose (glucose water) available conc., doses, side effects, precautions & direction for adm.
presented at Al-Mahmoudiya General Hospital on 20/12/2022
Resistant culture for the bacterial isolate of Al-Mahmoudiya G.Hospital as part of antibiotic stewardship mission
presented on 23/11/2022 at our hospital
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. MECHANISM OF ACTION
Prevents cell wall synthesis by binding to enzymes called
penicillin binding proteins (PBPs) which are essential for the
synthesis of the bacterial cell wall
They have concentration-independent bactericidal activity,
with maximal killing at 4-5 times the MIC of the organism
Clinically significant post-antibiotic effect is not observed
MECHANISMS OF BACTERIAL RESISTANCE
Destruction of beta-lactam ring by beta-lactamases; (an intact
beta-lactam ring is essential for antibacterial activity
Altered affinity of cephalosporins for their target site, the
penicillin binding proteins
Decreased penetration of antibiotic to the target site, the PBPs
(This is only applicable to gram-negative bacteria)
SPECTRUM OF ACTIVITY
Gram-positive aerobic cocci: Cefotaxime, ceftriaxone, and
ceftizoxime are active against methicillin-susceptible
Staphylococcus aureus (though less than 1st and some 2nd
generation agents), very active against Groups A and B streptococci,
and viridians streptococci.
Cefotaxime and ceftriaxone are more active than ceftizoxime
against Streptococcus pneumoniae, particularly intermediately-
penicillin resistant species
None are active against methicillin-resistant Staphylococci,
Enterococci, and Listeria monocytogenes
3. Gram-negative aerobes: Very active against Haemophilus
influenzae, Moraxella catarrhalis, Neisseria meningitides, and
Enterobacteriaceae (ex: Escherichia coli, Klebsiella species, Proteus
mirabilis, Providencia) found in hospital and community-acquired
infections
Some Enterobacter species have a tendency to become resistant
during cephalosporin therapy, and thus cephalosporins are not the
drugs of choice for Enterobacter infections.
Only ceftazidime and cefoperazone are active against Pseudomonas
aeruginosa & the 1st is preferred because it is more potent than
cefoperazone against gram-negative bacteria
Anaerobes: Cefotaxime, ceftriaxone, and ceftizoxime are adequate
for oral anaerobes
Clinical Uses
Gram negative septicemia & other serious Gm –ve inf.
Pseudomonas aeruginosa infections (Ceftazidime - 90%
effective)
Gram negative meningitis - Cefotaxime, Ceftriaxone, for
empiric therapy add vancomycin ± rifampin to cover
resistant Streptococcus pneumoniae
Gonorrhea - Single shot of Ceftriaxone is drug of choice
also oral cefixime and ceftibuten are ok
Complicated urinary tract infections, pyelonephritis
Osteomyelitis & Lyme disease - Ceftriaxone in home
health care situations
4. Inappropriate Uses (yet widely prescribed)
Surgical prophylaxis (use 1st or 2nd generation agents)
Otitis media, URIs – (Cefixime & ceftibuten) have poor Gm
+ve activity
Uncomplicated UTIs
Doses
Cefotaxime
Adults: 1-2 g q 8 h for moderate to severe infections.
For life-threatening infections: 2 g q 4 h
Gonorrhea: 1 g IM as single dose.
Children (1 month - 12 yrs): 50-180 mg/kg/day in 4-6 divided doses
Children (1-4 weeks): 50 mg/kg q 8 hrs.
Children (<1 week): 50 mg/kg q 12 h
Ceftriaxone
Adults: 1-2 g once a day.
Gonorrhea (uncomplicated): 250 mg single IM dose plus doxycycline
or erythromycin (if pregnant)
Children( <45kg) : 125 mg IM once.
Surgical prophylaxis: Single 1 g dose 0.5-2 hours before surgery.
Children: 50-75 mg/kg/day (not to exceed 2 g) in divided doses q 12
h for serious infections.
Meningitis: 100 mg/kg/day (not to exceed 4 g) every 12 hour, with
or without a loading dose of 75 mg/kg
Ceftizoxime sodium
Adults: 1-2 g q 8-12 h IM or IV
For life-threatening infections 3-4 g q 8 h
Uncomplicated UTIs: 500 mg q 12 h
Children (⩾6 months): 50 mg/kg q 6-8 h
Cefoperazone sodium
Adults: 2-4 g/day in equally divided doses q 12 h
For severe infections: 6-12 g/day
5. Ceftazidime
Adults: 1g q 8-12 h
For life-threatening infections 2 g IV q 8 h
Uncomplicated UTIs: 250 mg q 12 h
Complicated UTIs: 500 mg q 8-12 h
Pseudomonal lung infections in cystic fibrosis patients: 30-50 mg/kg
IV to a maximum of 6 g/day
Infants and children (1month-12 yrs): 30-50 mg/kg IV q 8 h to a
maximum of 6 g/day.
Neonates ⩾4 weeks: 30 mg/kg IV q 12 h
Cefixime.
Adults: 400 mg/day (for gonococcal inf.) or 200 mg b.i.d
Children: 8 mg/kg/day as single dose or 4 mg/kg q 12 h
Ceftibuten
Adults: 400 mg/day
Children: 9 mg/kg/ day for pharyngitis, tonsillitis or otitis media
due to Streptococcus pyogenes and for otitis media due to
Haemophilus influenzae and Moraxella catarrhalis
Cefdinir
Adults: 600 mg once daily or 300 mg BID – use BID dosing for
pneumonia and skin infections
Children: 14 mg/kg once daily or 7 mg/kg BID for otitis media,
sinusitis, or pharyngitis due to Streptococcus pyogenes
ADVERSE EFFECTS & CAUTIONS
Coagulation defect & bleeding
6. Caused by moxalactam &cefoperazone doses higher than 4g/day
,also occur with Ceftriaxone (due to presence of N-methyl
thiotriazone) but still here controversial
Antibiotic produced hypobrothrombinemia
This observed with moxalactam doses higher than 4g/day for
1week, No demonstrable effected noticed with ceftriaxone or
ceftazidime even at doses as 6g/day
Hypersensitivity reactions
Immune mediated hematologic reactions
Described with Ceftriaxone (falsely +ve coombs test), while
Leucopenia was reported with high dose cephalosporins for 2-
3 weeks duration specially with Ceftriaxone & cefotaxime
Gastrointestinal side effects
Symptoms includes nausea, vomiting, anorexia,
abdominal cramps and diarrhea
Attributed to:
+direct irritation of intestinal mucosa
+increased bile salt secretion in intestine
+changes in fecal flora (lead to both vit. K synthesis impair as
well as super infection),that’s mostly marked change with
Ceftriaxone & cefoperazone while least with cefotaxime
Hepatic & biliary system
Mild reversible abnormalities in liver function test was
observed in patients treated with cephalosporins
7. Ceftriaxone has unique property of causing sludge
(pseudolithiasis) to form in the gallbladder particularly in
children(when given as bolus dose over 3-5 minutes)
Associated symptoms: nausea, epigastric distress, colic,
tenderness to palpitation or fist percussion in the right
upper quadrant which resembles cholecystitis in clinical
picture
The sludge has uncertain composition, mobile & best
detected using ultrasonography however this syndrome
subsides & sludge dissolve when treatment discontinued
Also Ceftriaxone in circulation binds to serum proteins
causing highly displacement of bilirubin from its protein
binding site leading to hyperbilirubinemia (frequent
increasing noticed specially with already hyperbilirubinemic
neonates (so it should be avoided)
Superinfections
Due to their broad spectrum of microbial activity a profound
changes in normal flora occurs at various site of the body like
vagina, GIT, skin & upper respiratory tract causes increased
rate of mucocutaneous & systemic infections
Also 3rd generation treated patients may have facilitated
acquisition of pathogens from exogenous nosocomial sources
Reported bacterial agents
Pseudomonas aeruginosa, Enterobacter cloacae
8. Citrobacter, Serratia, Proteus spp.
Providancia & Acinctobacter
As well as fungal infections (candidiasis) reported
Nephrotoxicity
Agents causes renal injury either by
hypersensitivity induced interstitial nephritis (direct toxicity
to renal tubules)
synergistic action with other nephrotoxic agents
(Still nephrotoxic potential is non-significant & low)
Neurotoxicity
Associated headache, paresthesias & other mild CNS side
effects reported with these agents, seizures reported in cases
treated with ceftazidime (but neither Ceftriaxone, ceftizoxime
nor cefotaxime)
Disulfiram like reaction
Occurred with patients consuming ethanol and receiving
3rd generation agents that contains methylthiotrazol side
chain at position 3 at the nucleus
Here agents binds to the hepatic enzyme aldehyde
dehydrogenase that metabolizes acetaldehyde(the break
down product of ethanol) to water and carbon dioxide
causing aldehyde accumulation in the liver
Aggravating factors :elixir and cough preparations which
contains alcohol